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Elsevier

Quercetin in Drug Discovery

  • 1st Edition - March 1, 2027
  • Latest edition
  • Editors: Gautam Sethi, Fabio Fusi, Lekshmi R. Nath
  • Language: English

Quercetin in Drug Discovery is a detailed reference exploring the multifaceted pharmacological potential of quercetin, a naturally occurring flavonoid with significant therap… Read more

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Description

Quercetin in Drug Discovery is a detailed reference exploring the multifaceted pharmacological potential of quercetin, a naturally occurring flavonoid with significant therapeutic promise. Addressing the critical need for consolidated knowledge, this guide highlights quercetin’s diverse biological activities and the translational challenges limiting its clinical applications, making it essential for researchers and pharmaceutical scientists. The comprehensive table of contents covers quercetin’s pharmacological properties, molecular docking studies, and ADME profiles, alongside therapeutic applications in cardiovascular diseases, cancer, and other conditions. It further examines bioavailability enhancement strategies, drug formulation, innovative delivery systems, and clinical trial evidence. Contributions from leading experts provide detailed insights into signaling pathways, molecular targets, and synthetic derivatives. Quercetin in Drug Discovery equips pharmacologists, medicinal chemists, and pharmaceutical scientists with critical information to advance research and drug development. By addressing bioavailability issues and regulatory considerations, this reference supports the translation of quercetin from bench to bedside, fostering innovation in natural product-based therapeutics.

Key features

  • Offers comprehensive coverage of quercetin’s pharmacological properties and therapeutic potential
  • Provides detailed analysis of bioavailability challenges and innovative delivery systems
  • Discusses the integration of molecular docking, ADME, and network pharmacology insights
  • Includes in-depth review of clinical trials and translational research
  • Highlights contributions from globally recognized experts across multiple disciplines

Readership

Pharmacologists and pharmaceutical scientists in academia and industry

Table of contents

Part I – Introduction to Quercetin Research

1. An overview of Quercetin in Drug Discovery

2. Pharmacological Properties

3. Quercetin and ion channels: the good, the bad and the not so ugly

Part II - Therapeutic Applications: focus on cardiovascular diseases

4. Integrative AI and Bioinformatic Strategies to Elucidate Quercetin’s Cardiovascular Pharmacological Profile

5. How to improve quercetin cardiovascular and antidiabetic activity through structural modification

6. The effect of quercetin on lipid metabolism

Part III - Therapeutic Applications: Focus on Cardiovascular diseases

7. Antioxidant, anti-inflammatory, and anticancer activities

8. Multitarget inhibitory properties - Signaling pathways and molecular targets

9. Anti-proliferative, anti-metastatic and anti- angiogenic effects of quercetin

10. Mechanisms of chemopreventative action of quercetin

Part IV - Other Therapeutic Applications

11. Dermatology, gastroenterology and ophthalmology

12. Role of quercetin in treatment of inflammatory diseases

13. Quercetin in Obesity Management: Biological Actions, Preclinical Insights, and Translational Challenges

14. Alzheimer’s Disease

Part V - Drug Development

15. Augmented quercetin: synthetic derivatives and prodrugs

16. Bioavailability

17. Drug formulation and delivery

Part VI - Clinical Application

18. Quercetin in Human Health

Product details

  • Edition: 1
  • Latest edition
  • Published: March 1, 2027
  • Language: English

About the editors

GS

Gautam Sethi

Dr. Gautam Sethi is a tenured Associate Professor in the Department of Pharmacology at the Yong Loo Lin School of Medicine, National University of Singapore. His research focuses on elucidating the molecular mechanisms underlying cancer initiation and progression, particularly the activation of oncogenic transcription factors by carcinogens and inflammatory agents, and the identification of novel therapeutic inhibitors. Dr. Sethi has made substantial and direct scholarly contributions to the fields of gut microbiota, cancer pathophysiology, and host–microbiome interactions, with particular emphasis on immunotherapy, tumor microenvironment modulation, metabolic signaling, and therapy response prediction. He has authored numerous peer‑reviewed research and review articles in high‑impact journals, received multiple international awards, and serves on the editorial boards of more than 15 international journals.
Affiliations and expertise
Associate Professor, Yong Loo Lin School of Medicine, National University of Singapore, Singapore

FF

Fabio Fusi

Dr. Fabio Fusi is an Associate Professor of Pharmacology at the Department of Biotechnology, Chemistry and Pharmacy at the University of Siena, Italy. With over 30 years of research experience, he has authored and co-authored more than 100 peer-reviewed publications, with significant contributions to the understanding of quercetin’s mechanisms in vascular smooth muscle. His collaborative research has also uncovered quercetin's role in modulating vascular reactivity through PKG-mediated KCa1.1 channel stimulation and its impact on perivascular adipose tissue signaling. As a principal investigator, he has led international projects on medicinal plants and natural product pharmacology with institutions in South Africa, Vietnam, and Slovakia. Dr. Fusi serves as Associate Editor for Frontiers in Pharmacology and is a member of the PhD program in Biochemistry and Molecular Biology at the University of Siena. His ongoing research continues to bridge molecular pharmacology and nutraceutical innovation, positioning him as a leading expert in the therapeutic potential of quercetin and related compounds
Affiliations and expertise
Associate Professor, University of Siena, Department of Biotechnology, Chemistry and Pharmacy, Siena, Italy

LN

Lekshmi R. Nath

Dr Lekshmi R. Nath is working as an Associate Professor in the Department of Pharmacognosy at Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, India. She pursued her PhD. in Cancer Research Program. She has more than 50 publications and has been invited as a resource person to many national and international conferences. She is the editorial board member and reviewer of high-impact scientific journals. Her current research interest includes the study of signalling events associated with the fatty liver to Hepatocellular carcinoma, elucidating the role of plant-derived pure compounds in cancer chemoprevention, chemo sensitization, and chemotherapy. She is also exploring the potential of traditional knowledge for cancer and various infectious diseases, their mechanism of action and validation through pre-clinical models
Affiliations and expertise
Associate Professor, Department of Pharmacognosy, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, India