Skip to main content
Elsevier

Books in Life sciences

  • Botulinum Neurotoxin and Tetanus Toxin

    • 1st Edition
    • Lance Simpson
    • English
    Botulinum Neurotoxin and Tetanus Toxin covers the mechanism of action, pathogenesis, and treatment of clostridial neurotoxins. The book is organized into four parts encompassing 18 chapters that discuss the origin, structure, pharmacology, toxicology, immunology, assays, and clinical issues of botulinum and tetanus neurotoxins. The introductory part of the book discusses the discovery and production of neurotoxins in various strains of Clostridium bacteria. This text also describes how specific bacteriophages and plasmids mediate the pathogenicity of some types of Clostridium botulinum and Clostridium tetani. The subsequent part provides an overview of issues related to toxin binding, including toxins that may serve as models for botulinum and tetanus neurotoxins. Discussions on the peripheral and central aspects of poisoning transport in the central nervous system and on the antagonistic drugs for clostridial neurotoxins are provided. The third part of the book addresses the antibodies against botulinum neurotoxin. Bioassay in mice and highly sensitive immunoassays, such as reversed passive hemagglutination, reversed passive latex agglutination, radioimmunoassay, and enzyme-linked immunosorbent assay, are presented. The concluding part covers the animal models for these toxins and discusses the diagnosis and treatment of botulism and tetanus in human. The clinical use of Clostridium botulinum toxin type A in ocular and neuromuscular disease is also examined. This book will be of value to protein chemists, microbiologists, virologists, pharmacologists, immunologists, and clinicians.

  • Calcification and Physiology

    • 2nd Edition
    • Geoffrey Bourne
    • English
    The Biochemistry and Physiology of Bone, Second Edition: Volume IV: Calcification and Physiology explores the biochemical and physiological aspects of bone calcification. It discusses the comparative physiology of bone, the organelles involved in the local mechanism of calcification, bone tracer uptake and removal, and matrix vesicles of cartilage and bone. It explains the parathyroid biosynthesis and metabolism, cellular and humoral factors in bone resorption, electrical properties of bone, circulation in relation to bone growth and metabolism, and dentin and bone formation. Organized into 12 chapters, this edition begins with an overview of noncalcifying matrix and its conversion to calcifiable matrix, impregnation of collagen, and extraskeletal calcification. The remaining chapters focus on the effects of pyrophosphate and diphosphonates on calcium metabolism and skeletal turnover, calcium kinetics in plasma, the method matrix vesicles use in initiating calcification, the chemistry of parathyroid biosynthesis and metabolism, and mammalian osteopetrosis as a model for investigating cellular and humoral factors involved in bone resorption. It also discusses the use of electron spin resonance spectrometry in studying mineralized tissues, electrical response in flexed wet bone, bone blood volume and flow, and origin and fate of bone cells. The book concludes with a chapter on the biogenesis of matrix and mineral components of dentin and bone tissues. This book is highly recommended to biochemists, cell biologists, physiologists, anatomists, orthopedists, pathologists, clinicians, biomedical engineers, graduate students, professors, and others interested in the calcification and physiology of bone.

  • The Use Of Radioautography in Investigating Protein Synthesis

    • 1st Edition
    • C Leblond
    • English
    The Use of Radioautography in Investigating Protein Synthesis represents the 1965 Symposium on The Use of Radioautography in Investigating Protein Synthesis, supported by the International Society for Cell Biology. This book is composed of four parts encompassing 18 chapters. The opening part deals first with the basic aspects and mode of operation of the radioautography technique. This part also examines the advantages and potentials of this technique compared to other cytological techniques. The next parts are devoted to the experimental methods of protein synthesis in nucleus and in cells of various types, as revealed by the electron microscope radioautography. The concluding part discusses the secretion and synthesis of protein enzymes by the acinar cells in rat pancreas and fibroblasts in wound healing. This part also considers the application of radioautography to determining the sites of synthesis of proteins. This book is of great value to cell biologists, biochemists, cytologists, histologists, and pathologists.

  • Regulatory Mechanisms in Lymphocyte Activation

    • 1st Edition
    • David Lucas
    • English
    Regulatory Mechanisms in Lymphocyte Activation covers the proceedings of the 11th Leukocyte Culture Conference, held at the Arizona Medical Center, University of Arizona on September 19-23, 1976. The contributors cover the various aspects of the conference theme ""Regulatory Mechanisms in Lymphocyte Activation."" This book is organized into 15 parts encompassing 160 chapters. The three symposium parts discuss the parameters of lymphocyte activation, positive regulation, and suppression. Considerable sections explore the membrane determinants and receptors; major histocompatibility complex; lymphocyte response; and kinetics of DNA synthesis and cell proliferation in lymphocyte activation. Other general topics covered include subpopulations of immune reactive cells, leukocyte separation techniques, cell interactions, and ontogeny of lymphocytes. The remaining parts consider the leukocyte regulatory mechanisms and issues in lymphocytotoxicity. Immunologists and cell biologists will find this book invaluable.

  • Proteins and Nucleic Acids

    • 1st Edition
    • Isidore Gersh
    • English
    Submicroscopic Cytochemistry, Volume I: Proteins and Nucleic Acids presents laboratory findings and theoretical aspects involved or derived from submicroscopic cytochemistry study of proteins and nucleic acids. It is a two-volume book, encompassing 14 chapters covering three major topics: the pattern of distribution of nucleic acids at the molecular level in various cells and states of activity and in relation to protein synthesis; the molecular and macromolecular organization of cellular membranes; and the origin and distribution of the major macromolecular aggregates of connective tissue. After a brief introduction to the aspects of submicroscopic cytochemistry, the book discusses morphology, with emphasis on the distribution of cell components and their organization in cells at the macromolecular level. It then presents developed methods to preserve and selectively identify proteins, nucleic acids, lipids, acid mucopolysaccharides, and molecular aggregates very nearly in the position they occupied in the living state. Chapters 8 to 12 describe DNA molecular patterns during cell differentiation and cell maturation, and the alteration of these patterns in certain mouse cells. A discussion on DNA molecular patterns during metaplasia of stratified squamous mouse epithelium and of spinal ganglion cells during regeneration is provided. The concluding chapters examine DNA organization during mitotic cycle in Drosophila eggs and the persistence of chromosome individuality during interphase. This book is a valuable source of information for cytochemists, cell biologists, cell researchers, and protein nucleic acid enthusiasts who wish to expand their knowledge on comprehensive cytochemistry laboratory study.

  • Diseases of Sugarcane

    Major Diseases
    • 1st Edition
    • C. Ricaud + 3 more
    • English
    An extensive volume of Sugarcane Diseases and their World Distribution (Vol. I) was published by Elsevier under the auspices of the International Society of Sugar Cane Technologists in 1961. The present volume was intended to be a new edition of the book, but so many changes were required that a new book was needed. Only three chapters have been kept with slight amendments. The other chapters have been completely re-written. In fact with changes in importance of major diseases, four diseases previously treated have been left out; on the other hand, three new topics have been included in the new book, two new diseases and a chapter on sugarcane quarantine.The first chapter gives a brief account of the anatomy, morphology and physiology of the sugarcane plant to facilitate terminology and especially for a better appreciation of the effect of disease on the growth of the crop. Diseases are extensively treated as in Volume I, with a very good description of their symptoms and variation under different conditions and severity, all well illustrated by black and white figures and in a set of colour plates at the end of the book which will prove of valuable help for identification. The causal agents of the diseases are described giving synonyms, cultural characteristics, isolation methods and present knowledge on race variation, an aspect on which there has been quite an advance in knowledge since Volume I was published. New techniques of diagnosis are also given. Advances in research on the diseases over the last 25 years are well covered and supported by an extensive bibliography at the end of each chapter.The book has been edited by people having first hand experience in the field and in research on these diseases. Authors have been selected from among the most knowledgeable all over the sugar cane world, especially with due regard to the importance of the different diseases in their countries.The book should prove of immense value to those concerned with practical aspects of plant disease control in the field: pathologists, agronomists and crop specialists, including consultants, to those concerned with quarantine of the crop, for university lectures and students, and research scientists.In a pre-publication review D.J. Heinz and S.A. Ferreira of the Hawaiian Sugar Planters' Association stated: ``Much has changed and new information generated since the original version of this book was published in 1961. This new edition incorporates most of it, providing both the laboratory and field sugarcane pathologist a complete and authoritative guide to the major sugarcane diseases of the world. It is the best single book available on sugarcane diseases.''

  • Neuronal Information Transfer

    • 1st Edition
    • Arthur Karlin
    • English
    Neuronal Information Transfer contains the proceedings of the symposium on Neuronal Information Transfer, held in Columbia University in June 1977. The symposium focuses on the molecular, ultrastructural, and morphological study of a number of systems showing defined receptor-effector interactions. The collection of papers presented in the symposium provides insights into the understanding of nervous information transfer. The book includes findings and studies on the biogenic amine systems, cholinergic system, amino acid systems, and brain peptides and opiate system. Treatises that covered cyclic nucleotides and the neuronal structure and development are also presented. Neuroscientists, neurologists, researchers, educators, and students in neuroscience will benefit from this book.

  • Glycoconjugate Research

    Proceedings of the Interior Symposium on Glycoconjugates
    • 1st Edition
    • John Gregory
    • English
    Glycoconjugate Research, Volume II contains the proceedings of the Fourth International Symposium on Glycoconjugates held in Woods Hole, Massachusetts in 1977. The papers explore the biosynthesis and regulation of glycoconjugates, particularly those of cell membranes, and glycolipid storage diseases. This volume is comprised of 95 chapters divided into three sections. After reviewing the regulatory mechanisms underlying glycoprotein synthesis, it turns to enzymic modifications of sialic acids in the course of glycoconjugate biosynthesis. The following chapters focus on the biosynthesis and characterization of lipid-linked sugars in the outer membrane of liver mitochondria; effect of bacitracin on the biosynthesis of dolichol derivatives in calf pancreas microsomes; secretion of proteoglycans by chondrocytes; and heterogeneity of arterial proteoglycans. The biosynthesis of elastin by chondroblasts in monolayer cultures is also considered, along with the phosphorylation of proteoglycans in human articular cartilage. The final chapter describes a double-antibody radioimmunoassay for soluble and cell-surface blood group Ii antigens. This book will be a useful resource for biochemists.

  • Interferons

    • 1st Edition
    • Thomas Merigan
    • English
    Interferons documents the proceedings of a major international conference on Chemistry and Biology of Interferons: Relationship to Therapeutics held at Squaw Valley, California, in March 1982. The meeting was one of the 1982 UCLA Symposia on Molecular and Cellular Biology organized through the Molecular Biology Institute of the University of California at Los Angeles. The book is organized into four parts. Part I presents papers on recombinant DNA production of interferon. It includes studies on the synthesis of human immune interferon in E. coli and monkey cells; the expression of human β interferon gene in heterologous cells; and the molecular activities of recombinant and hybrid leukocyte interferons. Part II deals with the biology of interferons, covering topics such as interferon production control process; the effect of interferon on cellular enzymes; and human amniotic interferon. Part III examines the factors relevant to clinical application of interferons, including structure-function studies with human interferon-gamma and on human alpha interferon. Part IV presents clinical studies of interferon, such as interferon α trials in human tumor diseases and interferon in renal transplant recipients.

  • Human Milk and Infant Formula

    • 1st Edition
    • Vernal Packard
    • English
    Human Milk and Infant Formula focuses on human milk and infant formula as the major sources of infant food. This book discusses the basic composition of human milk and explains the significant causes of variations in vitamins, minerals, and macronutrients. Comprised of nine chapters, this monograph starts with an overview of the benefits of breast-feeding with emphasis on the disease-fighting potential of mother's milk. This text then proceeds with a discussion of breast infections, contaminants of breast milk, allergic responses, and issues of drug use. Other chapters explore the formulation and processing of infant formula. This book discusses as well the emergence of milk banks that observe precautions in obtaining, storing, and pasteurizing human milk. The final chapter deals with the inability to digest lactose properly, which is commonly known as lactose intolerance. This monograph is a valuable resource for pediatricians, nutritionists, immunologists, as well as food technologists and chemists.

  • Fire and Ecosystems

    • 1st Edition
    • T.T. Kozlowski
    • English
    Fire and Ecosystems focuses on a number of aspects of fire ecology. This book deals separately with both harmful and beneficial effects of fire on soils, soil organisms, animals, and plants. This reference material elucidates the effects of fire on grasslands and considers the role of fire in temperate forests and related ecosystems. Four chapters are presented on a regional basis to highlight variations in responses, especially plant succession, to fire. The use of fire in land management is also explored. This book will serve as an invaluable reference material to researchers, teachers, and land managers.

  • Human Chromosome Methodology

    • 2nd Edition
    • Jorge J. Yunis
    • English
    Human Chromosome Methodology serves as an authoritative guide to cytogenetic techniques. This book presents each phase of laboratory work from preparation of materials for the X and Y bodies to application of other laboratory techniques including chromosome identification, autoradiography, and dermatoglyphics. The text also describes the structure and molecular organization of chromosomes and the advances in the automation of chromosome analysis. It provides a thorough review of the clinical manifestations of chromosome disorders. Organized into 13 chapters, the book presents the illustrated and diagrammatic examples and discussions of the subject matter and detailed tables and charts for learning efficiency. It also provides outlined presentation of cytogenetic procedures and notes and comments for each procedure that will assist readers in erroneous work phases. Moreover, it gives thorough lists of references in each chapter for further reading. This reference will be useful for research professionals, lecturers, genetics and molecular biology students, and members of the medical profession involved in genetics.

  • Germination Control. Metabolism, and Pathology

    • 1st Edition
    • T.T. Kozlowski
    • English
    Seed Biology, Volume II: Germination Control, Metabolism, and Pathology is a part of a three-volume treatise, which aims to bring together a large body of important information on seed biology. Organized into five chapters, this book begins with a discussion on environmental control of germination and its biological significance. Separate chapters follow that discuss physiology and metabolism of seeds with specific dormancy and anomalous storage history, as well as those germinated under abnormal conditions. This work will be useful to various groups of research biologists and teachers, including agronomists, plant anatomists, biochemists, ecologists, entomologists, foresters, horticulturists, plant pathologists, and plant physiologists.

  • Integument, Pigments, and Hormonal Processes

    Volume 9: Integument, Pigments and Hormonal Processes
    • 1st Edition
    • Dorothy E. Bliss
    • English
    The Biology of Crustacea is a comprehensive treatise, which should become the standard reference in its field. Incorporating the contributions of a distinguished international group of scientists, it encompasses the significant findings - including methods - in three general areas of crustacean research: systematics, morphology, evolution, and the fossil record; physiology, ecology, and behaviour; applied biology, including fisheries, mariculture, and pathology.The state-of-the-art presentations provide both background information and vital perspective. The complete set, and the individual volumes, will be of value to zoologists, marine biologists, fisheries biologists, physiologists, ecologists, environmentalists, endocrinologists, anatomists, neurobiologists, and paleontologists.

  • The Role of Membranes in Metabolic Regulation

    • 1st Edition
    • Myron Mehlman
    • English
    The Role of Membranes in Metabolic Regulation is the second volume in a series of in-depth reviews of specific areas of metabolic regulation. This volume is based on the 1972 symposium on The Role of Membranes in Metabolic Regulation held at the University of Nebraska Medical School. Separating 20 manuscripts into chapters, this book emphasizes membrane structure and function as well as utilization of affinity chromatography for purification of biologically important cellular components, called membrane receptors. It also discusses the role of phospholipids in hormone sensitive enzyme systems, with an emphasis on adenylate cyclase system. Other chapters describe the induction of steroidogenesis by corticotrophin and its synthetic analogues coupled by an azo linkage in free adrenal cells and the interaction between the mammary epithelial cells and insulin-sepharose systems. Topics on erythrocyte as a system for studying the properties of adenylate cyclase and the ionic effects in the sugar transport regulation in muscle are discussed in the concluding chapters of the book. Biochemists, physiologists, pharmacologists, physicians, researchers, and all others interested in the concepts about metabolic regulation will find this series of great value.

  • Methods in Mycoplasmology V2

    Diagnostic Mycoplasmology
    • 1st Edition
    • Joseph Tully
    • English
    Methods in Mycoplasmology, Volume II: Diagnostic Mycoplasmology is the second of a two-volume series that resulted from cumulative efforts to meet the need for standardized techniques in mycoplasmology. The book is organized into five sections. Section A discusses techniques for isolating mycoplasmas from humans. These include the recovery of mycoplasmas from the respiratory and genitourinary tracts, from blood and special tissues, and serological Identification of mycoplasmas from humans. Section B focuses on techniques for isolating mycoplasmas from animals, including the recovery and identification of avian, bovine, caprine, ovine, canine, and feline mycoplasmas. Section C presents techniques for isolating mycoplasmas from cell cultures. These include agar and broth techniques, the use of indicator cell lines, and DNA fluorochrome staining. Section D discusses techniques for isolating mycoplasmas from plants and insects. Section E describes some of the techniques that are useful in evaluating the pathogenicity of mycoplasmas, ureaplasmas, and spiroplasmas. Section F defines some of the techniques useful in virus detection by electron microscopy and presents methods for isolating and characterizing viruses from both mycoplasmas and spiroplasmas.

  • population genetics and ecology

    • 1st Edition
    • Samuel Karlin
    • English
    Population Genetics and Ecology is a collection of papers presented at a 1975 conference-workshop held in Israel and is devoted to topics in population genetics and ecology. Contributors discuss topics related to population genetics and ecology, including the determinants of genetic variation in natural populations; experimental design and analysis of field and laboratory data; and theory and applications of mathematical models in population genetics. The book describes a number of field and laboratory studies that focus on a variety of spatial and temporal character and enzyme frequency patterns in natural populations, along with possible associations between these patterns and ecological parameters. This volume is organized into three sections encompassing 31 chapters and begins by summarizing the results of field and laboratory research that investigated gene frequency patterns in space and time of animal and plant populations. This book then explains the origin of new taxa; animal and plant domestication; variation in heritability related to parental age; and problems in the genetics of certain haplo-diploid populations. The next section offers a combination of data analyses and interpretations of related models, with some papers devoted to the origin of race formation and the interaction between sexual selection and natural selection. Among the theoretical studies presented are facets of selection migration interaction; stochastic selection effects; properties of density and frequency dependent selection; concepts and measures of genetic distance and speciation; aspects of altruism; and kin selection. This book will be of interest to naturalists, experimentalists, theoreticians, statisticians, and mathematicians.

  • Glycoconjugate Research

    • 1st Edition
    • John Gregory
    • English
    Glycoconjugate Research, Volume I contains the proceedings of the Fourth International Symposium on Glycoconjugates, held in Woods Hole, Massachusetts, in September 1977. Contributors focus on the state of knowledge in the field of glycoconjugates ranging from polysaccharides and glycoproteins to glycolipids, proteoglycans, and all their varieties in plants, animals, and microorganisms. This text is organized into three sections and consists of 87 chapters. After an introductory chapter where the use of glycosidases for the structural analysis of complex carbohydrates is described, the discussion turns to other methods used for elucidating the structure of complex carbohydrates. The chapters that follow focus on the primary structure and conformation of glycans that are N-glycosically linked to peptide chains; isolation of monofuco-disialogang... from human and bovine brains; and partial chemical characterization of activated peptides isolated from a single cell suspension of rat colonic secretory cells. The last two sections explore cartilage proteoglycans and the structure-function relationships of glycoconjugates, touching on topics such as link proteins; the biochemical aspects of malignancy in human chondrosarcomas; defensive response of plants to a microbial oligosaccharide with a pheromone-like activity; and the interaction of saccharides with ricin. This book is intended for students and practitioners of chemistry and biochemistry; biology and microbiology; and physiology.

  • Large-Scale Mammalian Cell Culture

    • 1st Edition
    • Joseph Feder
    • English
    Large-Scale Mammalian Cell Culture is composed of papers presented as part of a symposium sponsored by the American Chemical Society Division of Microbial and Biochemical Technology at the 188th American Chemical Society National Meeting, held at Philadelphia, Pa., on Aug. 27, 1984. A rapid development of large-scale mammalian cell culture technology for the production of biologically important molecules becomes apparent. This book looks into this technology, its potential for commercial application, and the regulatory concerns posed by its use for the production of human therapeutics.

  • Biological Approaches and Evolutionary Trends in Plants

    • 1st Edition
    • Shoichi Kawano
    • English
    Biological Approaches and Evolutionary Trends in Plants is a collection of papers presented at the Fourth International Symposium of Plant Biosystematics held on July 10-14, 1989 in Kyoto, Japan. Contributors, some are world's leading plant biologists, discuss the findings in evolutionary biology and issues in plant biosystematics in light of the evidence and ideas brought forward at various levels of biological organization, from molecule to cell, individual, population, species, and community levels. This volume is organized into four sections encompassing 22 chapters and begins with an overview of discoveries concerning parapatric differentiation of weed populations, including adaptive evolution in herbicide resistant biotypes and complex evolutionary patterns in weed-crop complexes of various groups. The next section explores molecular approaches in plant biosystematics, focusing on amino acid sequencing of proteins; restriction-site variations of cpDNA, mitDNA, rDNA, etc.; and chromosome-banding patterns revealed by differential staining. The discussion shifts to a wave of research in plant population biology and evolutionary ecology since the 1970s and its impact on biology and biosystematics. The book considers various aspects of reproductive biology and evolutionary changes in significant reproductive parameters and attempts to demographically quantify these parameters. The final chapter is devoted to the use of functional phylogenetic systematics for predictive ecology. This book will be of interest to plant biologists and scientists and researchers in fields such as biochemistry, botany, microbiology, ecology, and evolutionary biology.

  • The Kidney Morphology, Biochemistry, Physiology

    • 1st Edition
    • Charles Rouiller
    • English
    The Kidney: Morphology, Biochemistry, and Physiology, Volume IV covers the developments in the study of renal structure and function, particularly on the subcellular and molecular level. This book is composed of six chapters that consider the correlation of kidney's structure with function, as well as the participation of the kidney in metabolic systems and its relation to other organs. This text discusses topics such as experimental and renal transplantation, the structure and function of the juxtaglomerular apparatus, and the macula densa. Other chapters deal with the gaseous and substrate metabolism of the kidney and the role of this organ in the osmotic concentration and dilution of the urine. The remaining chapters explore hydrogen secretion, potassium and sodium excretion, and the correlation of the kidney with vitamins and parathyroid gland. This book is of value to morphologists, biochemists, physiologists, pathologists, pharmacologists, and clinicians.

  • Tracer Methods for in Vivo Kinetics

    Theory and Applications
    • 1st Edition
    • Reginald Shipley
    • English
    Tracer Methods for In Vivo Kinetics: Theory and Applications summarizes and evaluates the variety of working formulas in applying tracer methods for kinetic studies in vivo. This book discusses the basic concepts, derives the important equations, and evaluates each working formula to ensure its proper application within the set of experimental conditions available. Organized into 12 chapters, this book starts with an overview of tracers such as radioactive atoms. This text then discusses the errors inherent in treating a two-pool system as though it were one pool. Other chapters describe how, from curves of tracer content of the labeled pool or of the secondary pool, a definitive evaluation is made of rate constants and rate of interflow and outflow in the two-pool open system. This book discusses as well the limited usefulness of a curve of specific gravity when information is limited to such a curve obtained from the secondary pool. This book is intended for mathematicians, biomedical scientists, and graduate students.

  • Enzymatic Basis of Detoxication Volume 1

    • 1st Edition
    • William B. Jakoby
    • English
    Enzymatic Basis of Detoxication, Volume I focuses on the catalytic mechanisms and physiological expression of the enzymes that are involved in the detoxication of foreign compounds. The book explores foreign compound metabolism at the level of what specific enzymes can do. This book is organized into three sections and comprised of 17 chapters. The discussion begins with an overview of detoxication and covers both catalytic and non-catalytic removal of foreign substances, along with the general properties of the enzymes that are active in detoxication. The reader is then introduced to the physiological aspects of detoxication, paying particular attention to the kinetic aspects of metabolism and elimination of foreign compounds in animals, human genetic variation in detoxication enzymes, and how such enzymes are induced. The next section focuses on mixed function oxygenase systems and includes chapters on cytochrome P-450 and the detoxication reactions it catalyzes. The book also considers other oxidation-reduction systems, with reference to alcohol dehydrogenase, aldehyde reductase, aldehyde oxidizing enzymes, ketone reductases, xanthine oxidase and aldehyde oxidase, glutathione peroxidase, and superoxide dismutases. The final chapter is devoted to monoamine oxidase, its properties, substrate specificity, inhibitors, kinetics and mechanism, and multiple forms. Pharmacologists, toxicologists, and biochemists will find this book extremely helpful.

  • Growth, Nutrition, and Metabolism of Cells In Culture V2

    • 1st Edition
    • George Rothblat
    • English
    Growth, Nutrition, and Metabolism of Cells in Culture, Volume 2, summarizes the state of knowledge of the growth, nutrition, and metabolism of various types of cell cultures. The chapters are both detailed and comprehensive enough for the specialist and broad enough to provide a general background for the nonspecialist. The present volume deals with specialized mammalian, plant, and invertebrate cell systems and techniques. The book begins by tracing the history of the development of tissue culture. This is followed by separate chapters on the use of perfusion systems in cell and tissue culture; and the cultivation of muscle tissue, nerve tissue, and hematopoietic cells. Subsequent chapters discuss the use of cell culture to study mechanisms of hormone action; the cultivation of mammalian embryos; cultivation of cells from poikilothermie vertebrates; and the cultivation of arthropod cells and plant cells. This book will be valuable resource for investigators who routinely use cell culture techniques, as well as students and individuals in associated areas of cell and molecular biology.

  • Electron Microscopy of Plant Cells

    • 1st Edition
    • C Hawes
    • English
    Electron Microscopy of Plant Cells serves as manual or reference of major modern techniques used to prepare plant material for transmission and scanning electron microscopy. There have been other books that generally discuss electron microscope methodology. This book focuses on problem areas encountered through the presence of tough cell walls and large central vacuole. It details preparative techniques for botanical specimens. Each of the nine chapters of this book covers the basic principles, useful applications, and reliable procedures used on the method of electron microscopy. Other topics discussed in each chapter include the general preparation and straining of thin sections, quantitative morphological analysis, and enzyme cytochemistry. This book also explains the immunogold labelling, rapid-freezing methods, and ambient- and low-temperature scanning electron microscopy among others. This book will be invaluable to general scientists, biologists, botanists, and students specializing in plant anatomy.

  • The Pyridine Nucleotide Coenzymes

    • 1st Edition
    • Johannes Everse
    • English
    The Pyridine Nucleotide Coenzymes provides a comprehensive discussion of the evolution, properties, and reactions of pyridine nucleotide coenzymes. The pyridine nucleotide coenzymes, NAD and NADP, appear to be among the most versatile of molecules with respect to their biological functions. In addition to their well-documented roles in a large number of oxidation-reduction reactions, these coenzymes are involved in many aspects of metabolic regulation. The book begins by tracing the evolution of coenzymes and pyridine nucleotide coenzymes. This is followed by separate chapters that deal with the static and dynamic properties of the pyridine nucleotide coenzymes; chemistry and solution conformation of the pyridine coenzymes; pyridine nucleotide analogs; and the three-dimensional structures of pyridine nucleotide binding enzymes. Subsequent chapters cover the synthesis and characterization of immobilized coenzymes and derivatives and their applications in affinity chromatography and enzyme reactors; the pathways to quinolinate, a major precursor of pyridine nucleotides; the role of pyridine nucleotides in phagocytosis; and non-oxidation-reduct... reactions of pyridine nucleotides.

  • Metabolic Aspects of Food Safety

    • 1st Edition
    • Francis Roe
    • English
    Metabolic Aspects of Food Safety is based on the proceedings of the Second Food Safety Conference held in 1969. The first conference was held in April 1966 and was concerned solely with the Pathology of Small Laboratory Animals. The program of the second Conference was intended to be complementary to that of the first. In 1966, the animals used for tests were considered. The 1969 conference focused on the tests themselves and their interpretation in relation to the toxicity or safety of the constituents, including additives and contaminants, of man's food for man. The contributions made by researchers at the conference included studies on the need for more biochemical information in food safety evaluation; the physiology of gastrointestinal absorption; renal function tests in laboratory animals; significance of age of test animals in food additive evaluation; aspects of protein metabolism relevant to food safety evaluation; and significance of organ-weight changes in food safety evaluation.

  • Cell Biology and Immunology of Leukocyte Function

    • 1st Edition
    • Efraim Racker
    • English
    Cell Biology and Immunology of Leukocyte Function is a collection of papers presented at the 12th International Leukocyte Culture Conference, held in Beersheba, Israel on June 1978. This book is organized into seven parts encompassing 111 chapters. The contributors cover the different aspects of cell biology and immunology and the unique leukocyte function. Part I describes the mechanism of lymphocyte activation, the structure and function of the plasma membrane, and the macromolecular synthesis during lymphocyte activation. This part also deals with the interaction of lymphocytes with mitogenic lectins, the comparison of the mitogenic and nonmitogenic lectin binding, and the role of macrophages in the response of lymphocytes to lectins. Part II explores the thymic factors and the development of characteristic markers, antigens, and receptors. This part particularly emphasizes lymphocyte differentiation. Parts III and IV examine the genetic control and intercellular interactions involved in leukocyte function and the parameters of the immune response under in vitro conditions. Chapters on cytotoxicity, the mechanisms of phagocytic killing, autoimmunity, and the responses of leukocytes to tumor cells are included in these parts. Part V discusses the interactions of viruses and leukocytes and provides data on the physical mapping and analysis of sarcoma and leukemia viruses, while Part VI considers the application of leukocyte culture to problems of clinical medicine. Part VII involves the study of radiation effects, with an emphasis on the application of total lymphoid irradiation to the induction of transplantation tolerance. This part also looks into the role of the DNA repair process. Cell biologists, immunologists, and biomedical scientists and researchers will greatly benefit from this book.

  • Efferent Organization and The Integration of Behavior

    • 1st Edition
    • Jack Maser
    • English
    Efferent Organization and the Integration of Behavior is a nine-chapter text that discusses the hypotheses and alternative conceptualizations of efferent mechanisms, as well as the neural basis of patterned movement. The opening chapters examine several behavioral categories, the neural mediation of movement, and the distinction between efferent response and efferent motor processes. These chapters also present a revised theory of the role of the motor system in physiological regulation and neural-metabolic integration in energy production for behavior. These topics are followed by considerable chapters devoted to efferent organization of specific brain sections, including the motor cortex, pyramidal system, globus pallidus, substantia nigra, diencephalon, hippocampus, and neocortex. This text also deals with the instrumental conditioning based on alimentary or food reinforcements. A chapter discusses the constraints on theoretical interpretations of neuroanatomical circuitry functions of noradrenergic and cholinergic brain systems. The concluding chapter describes the relationship between the motor integration systems of extrapyramidal structures and the motivational systems of limbic structures. This chapter also looks into the anatomical organization of self-stimulation and the microelectrode data, which delineate the response of single neurons to stimulation at hypothalamic self-stimulation sites.

  • Data Analysis in Biochemistry and Biophysics

    • 1st Edition
    • Magar Mager
    • English
    Data Analysis in Biochemistry and Biophysics describes the techniques how to derive the most amount of quantitative and statistical information from data gathered in enzyme kinetics, protein-ligand equilibria, optical rotatory dispersion, chemical relaxation methods. This book focuses on the determination and analysis of parameters in different models that are used in biochemistry, biophysics, and molecular biology. The Michaelis-Menten equation can explain the process to obtain the maximum amount of information by determining the parameters of the model. This text also explains the fundamentals present in hypothesis testing, and the equation that represents the statistical aspects of a linear model occurring frequently in this field of testing. This book also analyzes the ultraviolet spectra of nucleic acids, particularly, to establish the composition of melting regions of nucleic acids. The investigator can use the matrix rank analysis to determine the spectra to substantiate systems whose functions are not known. This text also explains flow techniques and relaxation methods associated with rapid reactions to determine transient kinetic parameters. This book is suitable for molecular biologists, biophysicists, physiologists, biochemists, bio- mathematicians, statisticians, computer programmers, and investigators involved in related sciences

  • The Lectins

    Properties, Functions, and Applications in Biology and Medicine
    • 1st Edition
    • Irvin Liener
    • English
    The Lectins: Properties, Functions, and Applications in Biology and Medicine is a 10-chapter text that deals with the advances in research studies on the properties, functions, and applications of lectins in biology and medicine. The first two chapters consider the historical development, physicochemical properties, isolation, and remarkable specificity toward sugars of lectins. These topics are followed by a discussion on the molecular aspects of protein evolution, with a particular emphasis on lectins, which provide an excellent example of a family of homologous proteins. The following chapters explore the diverse biological activities of lectins and how these properties are utilized for the isolation and characterization of carbohydrate-contain... compounds in solution and on cells. A chapter focuses on the functions of lectins in their natural milieu. This text further covers the importance of lectins in nonplant systems as exemplified by lectins that occur in vertebrates, slime molds, and bacteria. The last chapter highlights the nutritional significance of the occurrence of lectins in plant foods such as legumes. This book is an ideal source for organic chemists, protein researchers, and workers in the fields of biology and medicine.

  • Molecular of Cloning of Recombinant Dna

    • 1st Edition
    • W.A. Scott
    • English
    Mobilization and Reassembly of Genetic Information documents the proceedings of the Miami Winter Symposium, sponsored by the Department of Biochemistry, University of Miami School of Medicine, Miami, Florida, January 1977. This volume is the 13th in the ""Miami Winter Symposia"" series. Topics for the Miami Winter Symposia focus on areas of biochemistry in which recent progress offers new insights into the molecular basis of biological phenomena. The manuscripts presented by researchers at the symposium cover a wide range of topics including DNA cloning and plasmid biology; yeast DNA expression in Escherichia coli; characterization of tetracycline and ampicillin resistant plasmid cloning vehicles; eukaryotic genome organization; bacterial plasmids containing silk gene sequences; DNA cloning in bacteria for the study of immunoglobulin genes; DNA degradation by rat intestinal nucleases; recombination between bacterial plasmids leading to the formation of plasmid multimers; general methods for inserting specific DNA sequences in cloning vehicles; and cloning and characterization of yeast DNA.

  • Seed Biology

    Importance, Development, and Germination
    • 1st Edition
    • T.T. Kozlowski
    • English
    Seed Biology, Volume I: Importance, Development, and Germination is a part of a three-volume treatise, which aims to bring together a large body of important information on seed biology. Organized into six chapters, this book begins with a discussion on the importance and characteristics of seeds. Separate chapters follow that discuss the development of gymnosperm and angiosperm seeds, as well as the anatomical mechanisms of seed dispersal. Other chapters focus on the morphogenetic events involved in the germination and the scientific basis for the concept of physiological predetermination or seedling vigor, including the potential application of this concept in agriculture, forestry, and management of natural resources. This work will be useful to various groups of research biologists and teachers, including plant anatomists, pathologists, and physiologists as well as agronomists, biochemists, ecologists, entomologists, foresters, and horticulturists.

  • Sex Selection of Children

    • 1st Edition
    • Neil G. Bennett
    • English
    Sex Selection of Children explores the strategies used to control the sex of children, the conditions under which a couple would employ a given technique, and the technology to achieve their desired family composition. It also considers the social consequences of sex-selection techniques, the legal factors that might impinge on the use of such a technology, and the ethical considerations associated with its use. Organized into 10 chapters, this book begins with an overview of some of the more humorous past approaches to sex selection. It then discusses the effects of sex selection on fertility, sex selection by means of amniocentesis and selective abortion, and the theorized link between the timing of fertilization and the sex ratio of offspring. A chapter considers a decision-making model that describes the use of sex-selection techniques by couples who wish to have a specific number of children over their entire childbearing period, while another chapter analyzes the economics of sex preference and selection. The remaining chapters address the parental preferences about the sexes of their offspring in different societies, the legal aspects of prenatal sex selection, a moral policy for sex choice, and the ethics and public policy on sex choice. This book is a valuable resource for specialists involved in fields ranging from sociology and economics to biology, public health, law, and ethics.

  • Brain Messengers and the Pituitary

    • 1st Edition
    • Eugenio Muller
    • English
    Brain Messengers and the Pituitary discusses the significant advances in neurotransmission and in understanding the physiology and pathophysiology of neuroendocrine control. This book is organized into seven chapters and begins with a discussion on the main biochemical and electrophysiological mechanisms underlying synaptic communication and the cotransmission and receptor plasticity. The following chapters describe the topographical localization and function of classical neurotransmitter and neuropeptide neurons. This book then presents the evidence on pituitary function control by the brain through specific hypophysiotropic regulatory hormones in relation to the secretion of adrenocorticotropic hormone and pro-opiomelanocortin... peptides, growth hormone, gonadotropins, prolactin, and thyroid-stimulating hormone. A chapter focuses on the neuroendocrine effects of an increasing number of neuropeptides. This text further deals with the role of pituitary gland as the target of central nervous system-derived and peripheral hormonal influences. The concluding chapters look into the experimental evidence linking brain neurotransmitters to the secretion of hypothalamic hormones and to anterior pituitary hormones or to neuroendocrine feedback regulation. These chapters also explore the evidence for neurotransmitter-neu... dysfunction as an etiology for specific neuroendocrine disorders and the potential of the neuropharmacologic approach to the diagnosis and therapy. Clinical neuroendocrinologist... and researchers and students in neuroendocrinology, neurobiology, neuropharmacology, neurophysiology, and psychiatry will find this book invaluable.

  • Drugs and the Cell Cycle

    • 1st Edition
    • A Zimmerman
    • English
    Drugs and the Cell Cycle provides an introduction to fundamental principles and studies on the mechanisms of drug action on proliferating cells. The book is intended to reduce the time lag between observation and practical application. Comprised of 10 chapters, the book describes the plant alkaloids, alkylating agents, mercurials, adrenergic agents, radiomimetics, narcotics, hallucinogens, mitogens, hepatotoxins, antiobiotics, and antimetabolites of various types. The text also emphasizes the drugs used in cancer chemotherapy, and the in vitro and in vivo cell systems of bacteria, protozoa, sea urchins, and mammals. The concepts are presented with comprehensive illustrations and tables to help readers obtain more efficient understanding and learning. The information and concepts presented in this volume will be of great interest to scientists and students in many disciplines, including physiology, pharmacology, and oncology, as well as cellular, molecular, and developmental biology. The book will also fill the gap between drug experimental observations and their potential relevance to man.

  • Visual Perception

    The Neurophysiological Foundations
    • 1st Edition
    • Lothar Spillmann + 1 more
    • English
    This book presents an interdisciplinary overview of the main facts and theories that guide contemporary research on visual perception. While the chapters cover virtually all areas of visual science, from philosophical foundations to computational algorithms, and from photoreceptor processes to neuronal networks, no attempt has been made to provide an exhaustive treatment of these topics. Rather, researchers from such diverse disciplines as psychology, neurophysiology, anatomy, and clinical vision sciences have worked together to review some of the most important correlations between perceptual phenomena and the underlying neurophysiological processes and mechanisms. The book is thus intended to serve as an advanced text for graduate students and as a guide for all vision researchers to understanding current progress outside their specialized fields of interest.

  • Chloride Transport in Biological Membranes

    • 1st Edition
    • Jose Zadunaisky
    • English
    Chloride Transport in Biological Membranes is a collection of papers that present advances and the state of knowledge in the transport of chloride and other anions across biological membranes. The book includes papers that discuss topics such as the anion transport protein; functional sites of the red cell anion exchange protein; and anion and proton transport through lipid bilayers. Also covered in the book are chloride transport in certain areas such as the renal tubule, the gastric mucosa, and the cornea; the role of sodium in anion transport; chloride reabsorption; and the hormonal control of chloride secretion. The text is recommended for biologists, biochemists, and practitioners in health science, especially those who would like to know more about the processes involved in chloride transport.

  • Psychopharmacological Agents V3

    • 1st Edition
    • Maxwell Gordon
    • English
    Psychopharmacologica... Agents, Volume III focuses on psychopharmacologica... agents used for the treatment of mental disorders such as depression and schizophrenia. The drugs considered include antipsychotic agents, butyrophenones, dephenylbutylpiperid... 1,4-benzodiazepines, and antidepressants. Comprised of seven chapters, this volume opens with an overview of the progress that has been made in the therapy of the mentally ill by means of psychopharmacologica... agents, with emphasis on indole derivatives and miscellaneous compounds such as mepiprazol, metoclopramide, benzothiazinone, and benzothienopyridine. The next chapter focuses on biological factors in the affective disorders and schizophrenia, followed by a discussion on tricyclic antipsychotic agents, butyrophenones and dephenylbutylpiperid... and antianxiety agents of the benzodiazepine class. Potential central nervous system drugs are also considered briefly, together with electroencephalogram applications in psychopharmacology. The final chapter is devoted to the chemistry, pharmacology, and clinical activity of antidepressant drugs. This book will be of interest to chemists, pharmacologists, psychiatrists, physicians, and other medical professionals.

  • Metabolic Conjugation and Metabolic Hydrolysis

    • 1st Edition
    • William Fishman
    • English
    Metabolic Conjugation and Metabolic Hydrolysis, Volume II, provides an extension and further development of the themes introduced in Volume I in which the subject matter dealt either separately or in combination with the compound undergoing conjugation, the conjugate itself, the conjugating radical, and enzymic hydrolysis of the conjugate. Increased attention is also given to systems in which metabolic conjugation and metabolic hydrolysis interdigitate with each other. The book begins with studies on the role of conjugation in the biliary excretion of organic compounds; cholic acid and its conjugation; biliary secretion and intestinal metabolism and absorption; and the metabolic conjugation and hydrolysis of steroids and their conjugates, as observed in the fetoplacental unit of human pregnancy. Subsequent chapters cover the fabrication through physiological metabolic conjugation of macromolecules of glycoproteins and mucopolysaccharides; the biosynthesis of glycolipids (sphingolipids); the metabolic hydrolysis of hexosaminide linkages; ß-glucuronidases; the hydrolysis of sphingolipids; and mercapturic acid formation.

  • Molecular Genetic Mechanisms in Development and Aging

    • 1st Edition
    • Morris Rockstein
    • English
    Molecular Genetic Mechanisms in Development and Aging discusses the mechanisms of aging at the level of the genome. This book explores the fundamental knowledge concerning the regulation and expression of gene, which is derived from investigations on microbial organisms. Organized into nine chapters, this book starts with an overview of the molecular genetic basis for the processes of aging. This text then explores the highly complex multicellular members of the class Insecta, which provide the researcher with many distinct and unique advantages for aging studies. Other chapters discuss the mechanisms of genetic control and organization during the development and aging of eukaryotes, which pose some challenging problems in cellular and developmental biology. The final chapter deals with the limitations of previous studies, including the lack of comparability due to differences in techniques, the measuring of free amino acid titers in hemolyph only, and differing diet and environmental variations. Biologists and students interested in developmental and molecular genetics will find this book useful.

  • Spore Research 1976 V1

    • 1st Edition
    • A.N. Barker
    • English
    Spore Research 1976, Volume I presents most of the papers reported at the meeting of British Spore Group held at the University of Leeds in December 1975. Divided into 25 chapters, this volume begins by explaining the metabolic control of sporulation. It then talks about the structure, form, and function of peptidoglycans; the biological significance of chelation; the initiation of sporulation; and the role of highly phosphorylated nucleotides in sporulation. Notably, various organisms are described with respect to their sporulation characteristics.

  • Handbook of Food and Beverage Stability

    • 1st Edition
    • Bozzano G Luisa
    • English
    FROM THE PREFACE: Fortunately, chemistry--the root of all life processes--is becoming better understood and more accessible. A strong synergism between the chemical, agricultural, and related sciences is highly desirable. This handbook attempts to provide in easily accessible detail up-to-date information relevant to the stability of foods and beverages. Highly qualified scientists have compiled an extraordinary amount of data on the chemical, biochemical, and microbiological stability, along with sensory aspects, of selected foods and beverages. These data have been distilled and are presented mostly in tabular form, with a minimum of commentary whenever possible.****A total of 17 chapters (10 on food, 7 on beverages) by renowned experts in their particular fields from the United States, Europe, and Japan present a wealth of food and beverage stability information in handbook format. In particular, the chapters on fish and shellfish, cheese, and meat are remarkable in presenting data not readily available in an easily digestible form.****This handbook, encompassing as it does aging, shelf life, and stability--in short, the knowledge necessary to ensure preservation of our food supply--should help to bring about the above-mentioned synergism between chemical, agricultural, and related sciences. It is expected to fill a need, especially through the convenience of its tabular presentations.

  • Arctic and Tropical Arboviruses

    • 1st Edition
    • Edouard Kurstak
    • English
    Arctic and Tropical Arboviruses contains the proceedings of the Second International Symposium on Arctic Arboviruses held at Mont Gabriel, Canada on May 26-28, 1977. This book contains a total of 20 chapters; a few of these chapters describe the diseases with arbovirus as a possible etiological agent, such as in the case of nephropatia epidemica, rapid diagnostic techniques for the detection of arboviruses, and in vitro culture methods for arboviruses using arthropod cells. Several other chapters are devoted to the investigations on arboviruses in the northern regions and on their vectors, mosquitoes, and ticks, as well as to the detection in the north of arboviruses originally isolated inthe south. Such bipolar distribution of arboviruses could be the result of the transport of arbovirus-infected ticks by migratory birds. This volume will provide a useful tool for all concerned with viral diseases, including virologists, epidemiologists, and ecologists.

  • Soybean Physiology, Agronomy, and Utilization

    • 1st Edition
    • A.G. Norman
    • English
    Soybean Physiology, Agronomy, and Utilization attempts to cover and treat in logical sequence the factors that contribute to the potential and versatility of soybeans. The soybean is a major crop plant in the United States. Based on the utilization of the bean, or products therefrom, a substantial soybean industry has also developed. Its uses, agricultural and industrial, primarily depend on the high content of both protein (ca. 40%) and oil (ca. 20%) in the bean. The book begins by discussing soybean production in the United States and worldwide; the uses and economics of soybean products; and the soybean in physiological research. It explains the growth and development of soybeans. It discusses the physiological processes responsible for assimilating the plant body from the environment, namely photosynthesis, nitrogen fixation, and nitrate reduction. Subsequent chapters examine the impact of environmental variables—such as light, temperature, water, wind, and pests—on soybean plant characteristics as well as soybean breeding, production, processing, and utilization.

  • The Genome of Drosophila Melanogaster

    • 1st Edition
    • Dan L. Lindsley + 1 more
    • English
    Dedicated to the memory of George Lefevre in recognition of his exhaustive cytogenetic analysis of the X chromosome, The Genome of Drosophila melanogaster is the complete compendium of what is known about the genes and chromosomes of this widely used model organism. The volume is an up-to-date revision of Lindsley and Grell's 1968 work, Genetic Variations of Drosophila melanogaster. The new edition contains complete descriptions of normal and mutant genes including phenotypic, cytological, molecular, and bibliographic information. In addition, it describes thousands of recorded chromosome rearrangements used in research on Drosophila. This handbook and its accompanying polytene chromosome maps, are sturdily bound into the book as foldouts and available as a separate set, are essential research tools for the Drosophila community.

  • The Initiation of DNA Replication

    • 1st Edition
    • Dan S Ray
    • English
    The Initiation of DNA Replication contains the proceedings of the 1981 ICN-UCLA Symposia on Structure and DNA-Protein Interactions of Replication Origins, held in Salt Lake City, Utah on March 8-13, 1981. The papers explore the initiation of DNA replication and address relevant topics such as whether there are specific protein recognition sites within an origin; how many proteins interact at an origin and whether they interact in a specific temporal sequence; or whether origins can be subdivided into distinct functional domains. The specific biochemical steps in DNA chain initiation and how they are catalyzed are also discussed. This book is organized into six sections and comprised of 41 chapters. The discussion begins by analyzing the replication origin region of the Escherichia coli chromosome and the precise location of the region carrying autonomous replicating function. A genetic map of the replication and incompatibility regions of the resistance plasmids R100 and R1 is described, and several gene products produced in vivo or in vitro from the replication region are considered. The sections that follow focus on the DNA initiation determinants of bacteriophage M13 and of chimeric derivatives carrying foreign replication determinants; suppressor loci in E. coli; and enzymes and proteins involved in initiation of phage and bacterial chromosomes. The final chapters examine the origins of eukaryotic replication. This book will be of interest to scientists, students, and researchers in fields ranging from microbiology and molecular biology to biochemistry, molecular genetics, and physiology.

  • Mutagenic Effects of Environmental Contaminants

    • 1st Edition
    • H.E. Sutton
    • English
    Mutagenic Effects of Environmental Contaminants investigates the mutagenic consequences of environmental contaminants, such as pesticides, industrials, food additives, drugs, and biologicals, as well as the possible relationships between mutagenesis and carcinogenesis. It describes the monitoring of chemical mutagens in the environment and the ways that genetic mutations cause disease in humans. Organized into 14 chapters, this volume begins with an overview of the current burden of human genetic disease and the biochemical mechanisms of mutation. It then discusses practical and feasible methods that use a variety of organisms to screen potential mutagenic agents, increased mutation rates in human populations, mutagens that are currently used commercially, and the interrelationships between mutagenicity, carcinogenicity, and teratogenicity. The reader is also introduced to genetic toxicology, detection of chemically induced mutations in experimental animals, and chromosome and somatic mutations in humans. This book is a valuable resource for scientists, policymakers, and administrators of environmental programs.

  • Human Cholinesterases and Anticholinesterases

    • 1st Edition
    • Hermona Soreq
    • English
    Human Cholinesterases and Anticholinesterases summarizes the many fundamental concepts of human cholinesterases (ChEs) and their inhibitors. This book is divided into three chapters that represent human cholinesterase research studies from different points of view. Chapter 1 deals with the biochemical and biological background of human ChEs. This chapter also examines the molecular polymorphism, genomic origin, genetic variants, and biological roles of these enzymes. Chapter 2 provides the molecular characterization of human ChE genes and their multileveled regulation, with a special emphasis on butyrylcholinesteras... Chapter 3 discusses the scientific, ecological, and clinical implications of the studies presented in the previous chapters. Protein scientists, engineers, and researchers will find this work invaluable.

  • Enzymatic Basis of Detoxication Volume 2

    • 1st Edition
    • William B. Jakoby
    • English
    Enzymatic Basis of Detoxication, Volume II, reviews the state of knowledge on foreign compound metabolism at the level of what specific enzymes can do. The book attempts to provide a holistic view of the information gleaned from work with specific, purified enzymes encompassing as many mammalian sources as have been studied. The book is organized into two parts. Part I on conjugation reactions and related systems includes studies on the properties of glucuronide formation; the physiological function, assay, and purificatgion of function of bilirubin-glucuronos... glucuronosyltransfer... the roles of N- and O-methylation reactions and glutathione transferases in detoxication; and amino acid conjugation. Part II presents studies on hydrolytic systems, covering the role of epoxide hydrolase, carboxylesterases, and amidases in detoxication and the regulatory effects of these enzymes. This book provides pharmacologists and toxicologists with the biochemical view of detoxication, and biochemists with the corresponding pharmacological and toxicological aspects.

Related subjects