Neuronal Information Transfer
- 1st Edition - January 1, 1978
- Imprint: Academic Press
- Editor: Arthur Karlin
- Language: English
- Hardback ISBN:9 7 8 - 0 - 1 2 - 3 9 8 4 5 0 - 0
- Paperback ISBN:9 7 8 - 0 - 1 2 - 4 1 4 5 6 3 - 4
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 1 4 8 8 2 - 5
Neuronal Information Transfer contains the proceedings of the symposium on Neuronal Information Transfer, held in Columbia University in June 1977. The symposium focuses on the… Read more
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Request a sales quoteNeuronal Information Transfer contains the proceedings of the symposium on Neuronal Information Transfer, held in Columbia University in June 1977. The symposium focuses on the molecular, ultrastructural, and morphological study of a number of systems showing defined receptor-effector interactions. The collection of papers presented in the symposium provides insights into the understanding of nervous information transfer. The book includes findings and studies on the biogenic amine systems, cholinergic system, amino acid systems, and brain peptides and opiate system. Treatises that covered cyclic nucleotides and the neuronal structure and development are also presented. Neuroscientists, neurologists, researchers, educators, and students in neuroscience will benefit from this book.
List of Participants
Preface
Opening Address
Text
References
Part I Biogenic Amine Systems
Genetic, Structural, and Molecular Mechanisms Governing the Long-Term Regulation of Tyrosine Hydroxylase, a Neurotransmitter Synthesizing Enzyme in the Brain
Neurotransmitter Synthesizing Enzymes in the Brain
Long-Term Regulation of Brain Tyrosine Hydroxylase
Summary
References
Regulations of Activity of the Nigrostriatal Dopaminergic Systems
Introduction
Influences of Substance P and GABAergic Neurons on the Activity of the Nigrostriatal Dopaminergic Pathway
Imbalance between the Activity of the Two Nigrostriatal Dopaminergic Pathways
The Release of Dopamine from Dopaminergic Dendrites
Role of the Dendritic Release of Dopamine in the Control of the Activity of the Nigrostriatal Dopaminergic Neurons
Concluding Remarks
References
Regulation of Sensitivity to ß-Adrenergic Stimulation in the Rat Pineal
Introduction
Variation in Sensitivity of Induction
Receptors and Adenylate Cyclase
Cyclic AMP and Phosphodiesterase
Protein Kinase
References
Molecular Properties and Regulation of Alpha- and Beta-Adrenergic Receptors
Introduction
Identification of α- and ß-Adrenergic Receptors by Radioligand Binding
Desensitization of Adrenergic Receptors
Receptor Supersensitivity
Summary and Conclusions
References
Biochemical Characterization of Neurotransmitter Receptors in the Brain
Introduction
Methodological Principles
The Dopamine Receptor
Evidence for a Two-State Model of Neurotransmitter Receptors
References
Part II Cholinergic System
The Cholinergic Electromotor System of Torpedo: Recent Biochemical and Morphological Findings
Introduction
Developmental Studies
Tissue Fractionation
Studies of Synaptic Vesicle Dynamics
Conclusions
References
Studies on the Mechanism of Acetylcholine Release in Mammalian Tissues
Introduction
Amount of ACh in a Vesicle and in a Quantum
Specificity of ACh Release and Storage
Turnover of ACh in Nerve Terminal Pools
Tissue Differences in ACh Storage and Release or Their Control
References
Nerve Excitability: From Descriptive Phenomenology to Molecular Interpretation
Introduction: Early Theories of Axonal Conduction and Synaptic Transmission
Alternative Interpretation of the Function of ACh in Excitable Membranes as a Result of Biochemical and Physiochemical Analyses
A Model Integrating Biochemical, Biophysical, and Thermodynamic Data
The Role of ACh at Synaptic Junctions
References
Acetylcholine Receptor-Mediated Ion Flux in Electroplax Membrane Microsacs
Text
References
Acetylcholine Receptor: Accelerated Dissociation of Receptor-Ligand Complexes
Introduction
Methods
Results
Discussion
References
Elementary Chemical Reactions of Acetylcholine with Receptor and Esterase: Relationship to Neuronal Information Transfer
Introduction
Localization of Acetylcholine Receptor and Acetylcholinesterase
Do Receptor and Esterase Compete for Acetylcholine?
Kinetic Analyses
Acetylcholinesterase
Acetylcholine Receptor
Comparisons between Competitive and Sequential Reactions of Acetylcho-line at the Synapse
References
Part III Amino Acid Systems
Roles of GABA in Neurons in Information Processing in the Vertebrate CNS
Introduction
Disinhibition as a Major Organizing Principle
GABA Neurons and Problems of Functional Coordination in the Nervous System
Identifying GABA-Releasing Neurons in Regions of the Vertebrate CNS
Cerebellum
Spinal Cord
Olfactory Bulb
Basal Ganglia
Interactions among Neurotransmitter Systems
"Wet" Neurobiology and Cybernetics
References
An Evaluation of the Proposed Transmitter Role of Glutamate and Taurine
Introduction
Excitatory Amino Acids
Taurine
Conclusion
References
Part IV Brain Peptides and Opiate System
Biologically Active Peptides in the Brain
Introduction
Biologically Active Peptides
Mapping Biologically Active Peptides in the Brain
Biosynthesis and Degradation of Peptides
Concluding Remarks
References
Opioid Peptides
Introduction
Pharmacological Activity of Opioid Peptides
Multiple Opiate Receptors
Enkephalins as Neurotransmitters
Biogenesis of Enkephalins
Concluding Remarks
References
On the Physiologic Role of Endorphins
Introduction
Endorphin Pharmacology
Functional Effects of Naloxone
Endorphin Steady-State Levels and Turnover
Induced Changes in Pituitary Endorphin Levels
References
Discovery and Function of the Endorphins
Introduction
Endorphins and Morphine—Chemical Comparisons
Multiple Endorphin Systems
Receptors for Opioid Alkaloids and for Opioid Peptides
Endorphins and Opiates—Actions Other than Analgesia
Summary
References
Recent Studies on Opiate Receptors and Analogs of Enkephalin
Introduction
Effects of N-Terminus and C-Terminus Alterations of Enkephalin
Evidence for Location of Opiate Receptors in Organotypic Cultures
References
Part V Cyclic Nucleotides
Regulation of Cyclic AMP Metabolism by Neural Hormones in Brain
Introduction
Role of Cyclic AMP in the Nervous System
Regulation of Neural Cyclic AMP Metabolism
Concluding Remarks
References
Electrophysiological Assessment of Mononucleotides and Nucleosides as First and Second Messengers in the Nervous System
Introduction
First Messenger Criteria
Second Messenger Criteria
Central Norepinephrine as a First Messenger for Cyclic AMP Second Messages
Dopamine as a First Messenger for Cyclic AMP
Cyclic GMP as a Second Messenger in the CNS
Central Purines as First Messengers for Cyclic AMP Second Messages
Mononucleotide Effects in Cultured Sympathetic Ganglia
Conclusions and Speculations
References
Part VI Neuronal Structure and Development
Development of Peripheral Monoaminergic Neurons
Introduction
Development of Adrenergic Ganglia and the Adrenal Medulla
3H-Thymidine Incorporation by Developing Adrenergic Ganglion Cells
Development of the Monoaminergic Innervation of the Gut
Conclusions
References
Characterization, Distribution, and Appearance of Surface Carbohydrates on Growing Neurites
Introduction
Topographic Distribution of Surface Carbohydrates on Growing Neurons
Appearance and Movement of Plasmalemmal Lectin Receptors during Membrane Growth
Surface Carbohydrate Composition of Growth Cones from Different Neuron Types
Summary and Conclusions
References
Selective Synapse Suppression as a Mechanism Contributing to Specificity of Connections in the Nervous System
Text
References
The Functional Motor Innervation of Supernumerary Hind Limbs in the Chick Embryo
Introduction
Results
Discussion
References
Cerebellar Maturation after Perinatal Alterations in Connectivity—Evidence for Intrinsic Determinism
Introduction
Methods
Results
Discussion
References
Index
- Edition: 1
- Published: January 1, 1978
- No. of pages (eBook): 480
- Imprint: Academic Press
- Language: English
- Hardback ISBN: 9780123984500
- Paperback ISBN: 9780124145634
- eBook ISBN: 9780323148825
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