Enzymatic Basis of Detoxication Volume 2

List of ContributorsPrefaceContents of Volume IPart I. Conjugation Reactions and Related Systems Chapter 1 Glucuronidation I. Introduction II. Metabolic Glucuronidation III. Properties of Purified UDP-Glucuronosyltransferase IV. Evidence for Heterogeneity of UDP-Glucuronosyltransferase V. Relationship of UDP-Glucuronosyltransferase to Membrane Environment VI. Regulation of Transferase Activity VII. Measurement of UDP-Glucuronosyltransferase Activity VIII. Comments References Chapter 2 Dismutation of Bilirubin Monoglucuronide I. Scope of the Reaction in Detoxication II. Physiological Role III. Assay of Bilirubin Glucuronoside Glucuronosyltransferase IV. Purification of the Enzyme References Chapter 3 N- and O-Methylation I. Scope of N- and O-Methylation Reactions in Detoxication II. Enzymes Involved in N- and O-Methylation Reactions References Chapter 4 Glutathione Transferases I. Introduction II. Detoxication by Catalysis III. The Binding Function IV. Distribution, Induction, and Role References Chapter 5 Enzymes of Mercapturic Acid Formation I. Introduction II. γ-Glutamyl Transpeptidase III. Peptidases Active in Hydrolysis of Cysteinylglycine Peptides IV. N-Acetyltransferase V. Perspectives References Chapter 6 Cysteine Conjugate ß-Lyase I. Introduction II. Assay Method for the Enzyme Activity III. Purification and Properties IV. Distribution V. Implication of the Enzyme in the Methylthiolation of a Drug References Chapter 7 S-Methylation: Thio S-Methyltransferase I. Introduction II. The Enzyme III. Distribution IV. Detoxication of Hydrogen Sulfide References Chapter 8 Conjugation by Peptide Bond Formation I. Introduction II. Reactions and Enzymes Involved in Peptide Bond Formation III. Conjugation of Benzoates and Aryl Acetates with Glycine and L-Glutamine IV. Conjugation of Bile Acids with Glycine and Taurine V. Comments References Chapter 9 Acetylation I. Introduction II. Enzyme Purification and Properties III. Toxicology and Acetylation Polymorphism References Chapter 10 Arylhydroxamic Acid Acyltransferase I. N,O-Acyltransferase-Mediated Toxicity of Arylhydroxamic Acids II. Arylhydroxamic Acid Acyltransferase References Chapter 11 Sulfotransferases I. Introduction II. Activation of Sulfate III. The Sulfotransferases IV. Regulation of Conjugation with Sulfate V. Comments References Chapter 12 Thioltransferases I. Scope of the Reactions Catalyzed by Thioltransferases in Detoxication II. Thioltransferases References Chapter 13 Rhodanese and the Sulfane Pool I. Detoxication of Cyanide and Inorganic Sulfide II. Enzyme-Catalyzed Reactions That Use or Produce Sulfane Sulfur III. Conclusion—Toxicity of Sulfane Depletion References Chapter 14 Glyoxalase I I. Scope of the Reactions Catalyzed by Glyoxalase I in Detoxication II. Glyoxalase I ReferencesPart II. Hydrolytic Systems Chapter 15 Epoxide Hydrolase I. Introduction II. Scope of the Reaction in Detoxication III. Purification, Assay, and Properties of the Enzyme IV. Regulation of the Enzyme V. Comments References Chapter 16 Carboxylesterases and Amidases I. Role of Carboxylesterases/Amidases in Detoxication II. The Enzymes: B-Type Carboxylesterases/Amidases III. Regulatory Effects ReferencesIndex