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Metabolic Conjugation and Metabolic Hydrolysis
1st Edition - January 1, 1970
Editor: William Fishman
Hardback ISBN:9780122576027
9 7 8 - 0 - 1 2 - 2 5 7 6 0 2 - 7
eBook ISBN:9780323143080
9 7 8 - 0 - 3 2 3 - 1 4 3 0 8 - 0
Metabolic Conjugation and Metabolic Hydrolysis, Volume II, provides an extension and further development of the themes introduced in Volume I in which the subject matter dealt… Read more
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Metabolic Conjugation and Metabolic Hydrolysis, Volume II, provides an extension and further development of the themes introduced in Volume I in which the subject matter dealt either separately or in combination with the compound undergoing conjugation, the conjugate itself, the conjugating radical, and enzymic hydrolysis of the conjugate. Increased attention is also given to systems in which metabolic conjugation and metabolic hydrolysis interdigitate with each other. The book begins with studies on the role of conjugation in the biliary excretion of organic compounds; cholic acid and its conjugation; biliary secretion and intestinal metabolism and absorption; and the metabolic conjugation and hydrolysis of steroids and their conjugates, as observed in the fetoplacental unit of human pregnancy. Subsequent chapters cover the fabrication through physiological metabolic conjugation of macromolecules of glycoproteins and mucopolysaccharides; the biosynthesis of glycolipids (sphingolipids); the metabolic hydrolysis of hexosaminide linkages; ß-glucuronidases; the hydrolysis of sphingolipids; and mercapturic acid formation.
List of Contributors
Preface
Contents of Volume I
Factors in the Biliary Excretion of Organic Compounds
I. Introduction
II. Chemical Factors
III. Biological Factors
References
Bile Acid Conjugation
I. Introduction
II. Biosynthesis of Bile Acid Conjugates
III. Determination of Bile Acid Conjugate Synthesis
IV. Factors Influencing Bile Acid Conjugation
V. Physiological Role of Bile Acid Conjugates
VI. Bile Acid Conjugation in Diseases Affecting the Liver
VII. Concluding Remarks
References
Metabolic Conjugation and Hydrolysis of Estrogens and Progesterone in the Enterohepatic Circulation
I. Introduction
II. Variations in Biliary Excretion and Enterohepatic Circulation of Steroids
III. Nature of Steroid Conjugates Formed in the Liver and Excreted in the Bile
IV. Hydrolysis of Steroid Conjugates in the Intestine
V. Conjugation and Absorption in the Intestine
VI. Concluding Remarks
References
Metabolic Conjugation and Hydrolysis of Steroid Hormones in the Fetoplacental Unit
I. Introduction
II. Nomenclature and Abbreviations
III. Biosynthesis, Transformation, and Hydrolysis of Steroid Conjugates in the Fetoplacental Unit
IV. Isolation of Steroid Conjugates in the Different Fetal and Placental Tissues
V. Transfer of Steroid Conjugates between the Fetus and the Placenta and between the Placenta and the Mother
VI. Production of Free and Conjugated Steroids during Pregnancy as Compared to Normal Adults and Transformation of Steroid Conjugates during Pregnancy
VII. Steroid Conjugates and Their Transformation in Newborns
VIII. Localization of Sulfuryl- and Glucuronyltransferase and Other Enzymic Systems in the Fetus Compared to Adults and Control of the Production of Steroid Conjugates in Fetal Life
IX. Physiological Significance of Steroid Conjugates during Fetal Life
X. Concluding Remarks
References
Biochemistry of Mercapturic Acid Formation
I. Introduction
II. Scope of Mercapturic Acid Formation
III. Nutritional Aspects of Mercapturic Acid Formation
IV. Premercapturic Acids
V. Determination of Mercapturic Acids
VI. Mechanism of Mercapturic Acid Formation
VII. Metabolic Degradation of Mercapturic Acids
References
Metabolic Hydrolysis of Collagen
I. Introduction
II. Structure of Collagen
III. Soluble Collagen Chemistry
IV. Biosynthesis of Collagen
V. Degradation of Collagen
VI. Summary
References
Biosynthesis of Acidic Glycosaminoglycans (Mucopolysaccharides)
I. Introduction
II. Chemical Structure
III. Biosynthesis of Precursors
IV. Biosynthesis of Chondroitin Sulfate: A Model for the Assembly of Polysaccharide Chains
V. Biosynthesis of Other Glycosaminoglycans
VI. Regulation of Glycosaminoglycan Synthesis
References
The Metabolic Hydrolysis of Hexosaminide Linkages
I. Introduction
II. Biological Materials Containing Hexosamine Moieties
III. Enzymes Known to Bring About the Hydrolysis of Hexosaminide Linkages
IV. Enzymic Hydrolysis of Hexosaminide Linkages
V. Concluding Remarks
References
β-Glucuronidases in Metabolic Hydrolysis
I. Introduction
II. History of ß-Glucuronidase
III. Distribution
IV. Factors Which Alter ß-Glucuronidase in Tissues
V. Intracellular Redistribution of ß-Glucuronidase Activity
VI. Factors Which Influence β-Glucuronidase in Body Fluids
VII. Relation of β-Glucuronidase to Diseases
VIII. Genetics
IX. Purification of β-Glucuronidase
X. Properties
XI. Discussion
XII. Summary
References
Biosynthesis and Hydrolysis of Sphingolipids
I. Introduction
II. Sphingosine
III. Ceramide
IV. Ceramide Galactoside
V. Cerebroside Sulfate (Ceramide Galactoside 4-Sulfate, Sulfatide)
VI. Ceramide Glucoside
VII. Ceramide Lactoside
VIII. Ceramide Trihexoside
IX. Asialo Tay-Sachs Ganglioside (Aminoglycolipid)