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Elsevier

Books in Life sciences

  • Anticonvulsants

    • 1st Edition
    • Julius Vida
    • English
    Medicinal Chemistry: A Series of Monographs, Volume 15: Anticonvulsants discusses the laboratory evaluation, drug disposition, clinical evaluation, and synthesis and design of anticonvulsant drugs. This book is organized into eight chapters. Chapters 1 and 2 provide an overview and neuropharmacological background of anticonvulsants. The laboratory evaluation of compounds is described in Chapter 3, while drug disposition is treated in Chapter 4. The chemistry and biological activities of the various classes of anticonvulsant compounds, such as cyclic ureides, benzopyrans, heterocyclic drugs, and noncyclic anticonvulsants are presented in Chapters 5 to 8. This volume is written specifically for medicinal chemists, biochemists, neurologists, and pharmacologists.

  • Fermented Food Beverages in Nutrition

    • 1st Edition
    • Clifford Gastineau
    • English
    Fermented Food Beverages in Nutrition presents the proceedings of International Symposium on Fermented Food Beverages in Nutrition convened at the Mayo Clinic in Rochester, Minnesota. It focuses on the contributions of alcoholic beverages in nutrition. It discusses the effects of specific alcoholic beverages, such as wine, beer, and certain distilled spirits, in human health. Organized into seven parts, encompassing 31 chapters, the book starts by discussing the history of alcoholic beverages and their nutrient contributions. Part II focuses on fermentation process, its history, biochemistry, nutrient synthesis by yeast, wine fermentation and aging, and beer brewing. Part III discusses the production and consumption trends of beer and wine, with emphasis on the changing attitudes of Americans toward wine consumption. Metabolism and therapeutic application of alcoholic beverages are examined in part IV. Discussions include role of alcoholic beverages in gerontology and ketogenesis, and the effect of alcoholic beverage incorporation into therapeutic diets. Part V highlights the effects of misuse and abuse of alcoholic beverages in various human body systems, including gastrointestine, pancreas, liver, and cardiovascular and nervous systems, as well as in cancer development and offspring effects during prenatal alcohol exposure. Parts VI and VII discuss the use of miniature swine as model for the study of human alcoholism and socioeconomic aspects of alcohol abuse. With the aim of bringing together existing factual knowledge concerning nutrition and health contributions of alcoholic beverages, this book is ideal for food scientists, nutritionists, dieticians, and researchers.

  • Genetic and Genomic Resources of Grain Legume Improvement

    • 1st Edition
    • Mohar Singh + 2 more
    • English
    Grain legumes, including common-bean, chickpea, pigeonpea, pea, cowpea, lentil and others, form important constituents of global diets, both vegetarian and non-vegetarian. Despite this significant role, global production has increased only marginally in the past 50 years. The slow production growth, along with a rising human population and improved buying capacity has substantially reduced the per capita availability of food legumes. Changes in environmental climate have also had significant impact on production, creating a need to identify stable donors among genetic resources for environmentally robust genes and designing crops resilient to climate change. Genetic and Genomic Resources of Grain Legume Improvement is the first book to bring together the latest resources in plant genetics and genomics to facilitate the identification of specific germplasm, trait mapping and allele mining to more effectively develop biotic and abiotic-stress-resis... grains. This book will be an invaluable resource for researchers, crop biologists and students working with crop development.

  • Genomic Biomarkers for Pharmaceutical Development

    Advancing Personalized Health Care
    • 1st Edition
    • Yihong Yao + 2 more
    • English
    Genomic Biomarkers for Pharmaceutical Development: Advancing Personalized Health Care provides an in-depth review of the state of translational science across all stages of pharmaceutical development with a special focus on personalized health care. This book provides a complete picture of biomarker development and validation in a pharmaceutical setting while addressing the inherent challenges of targeting the appropriate indications, biomarker robustness, regulatory hurdles, commercialization and much more. It features case studies devoted to the applications of pharmacogenomics, toxicogenomics, and other genetic technologies as they support drug discovery and development. With chapters written by international authorities in industry and academia, this work is a truly unique presentation of the thoughts and approaches that lead to the development of personalized medicine. Intended for all those involved in clinical translational research, this book is the ideal resource for scientists searching for the applications, strategies and successful approaches of translational science in pharmaceutical development.

  • The Path from Biomarker Discovery to Regulatory Qualification

    • 1st Edition
    • Federico Goodsaid + 1 more
    • English
    The Path from Biomarker Discovery to Regulatory Qualification is a unique guide that focuses on biomarker qualification, its history and current regulatory settings in both the US and abroad. This multi-contributed book provides a detailed look at the next step to developing biomarkers for clinical use and covers overall concepts, challenges, strategies and solutions based on the experiences of regulatory authorities and scientists. Members of the regulatory, pharmaceutical and biomarker development communities will benefit the most from using this book—it is a complete and practical guide to biomarker qualification, providing valuable insight to an ever-evolving and important area of regulatory science. For complimentary access to chapter 13, 'Classic' Biomarkers of Liver Injury, by John R. Senior, Associate Director for Science, Food and Drug Administration, Silver Spring, Maryland, USA, please visit the following site: http://tinyurl.com/C...

  • Waterborne Pathogens

    Detection Methods and Applications
    • 1st Edition
    • Helen Bridle
    • English
    This book gives an overview of advanced emerging technologies for the detection of a range of waterborne pathogens. The book will present existing methodology and highlight where improvements can be made, as well as have a strong focus on applications and the ways in which new technology could be applied in water management. Additionally, it addresses issues of sample preparation (from sampling to concentration and enrichment), a key stage in any detection protocol.

  • Hydrogen Peroxide and Cell Signaling, Part C

    • 1st Edition
    • Volume 528
    • English
    This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This is the third of three volumes on hydrogen peroxide and cell signaling, and includes chapters on such topics as the biological chemistry of hydrogen peroxide, reactive oxygen species in the activation of MAP kinases, and investigating the role of reactive oxygen species in regulating autophagy.

  • Electrical Stimulation Research Techniques

    • 1st Edition
    • Michael Patterson
    • English
    Methods in Psychological Physiology, Volume 3: Electrical Stimulation Research Techniques is a compilation of papers that focus on the different theories and techniques of electrical stimulation and its applications to psychology. The first five chapters cover different kinds of electrical stimulation, their basic principles, and techniques involved. These include extracellular and intracellular stimulation, the microstimulation technique, and the stimulation of the brain. Chapters 6 to 9 discuss the beneficial effects and uses of these stimulation techniques, such as motivation and reinforcement, memory research, its relation to brain lesions, and the implications for electroconvulsive therapy. The last two chapters talk about the electrical stimulation of the peripheral nerve and the grid and peripheral shock stimulation. The book is recommended for psychotherapists who wish to learn more about the use of electrical stimulation techniques as treatment, and for neurologists who would like to further understand the effects of electrical stimulation.

  • Hibernation and Torpor in Mammals and Birds

    • 1st Edition
    • Charles P Lyman
    • English
    Hibernation and Torpor in Mammals and Birds explores the physiological factors that control hibernation and torpor in birds and mammals. This text covers topics ranging from metabolism in hibernation to the role of endocrines, respiration and acid-base state in hibernation, and theories of hibernation. This book is comprised of 14 chapters and begins with an overview of some clear-cut definitions and why mammals and birds hibernate. The reader is then introduced to the variations from euthermia that have been observed among birds and mammals. To give some structure to this listing, the approach is phylogenetic, starting with the birds and proceeding through the primitive to the more advanced mammals. Subsequent chapters explains the process of entering hibernation and the hibernating state, itself; capability of a species in natural hibernation to arouse from that state using self-generated heat; physiological changes at the start of a spontaneous arousal; and physiological mechanisms underlying the ability of hibernators to rewarm. Consideration is also given to intermediary metabolism in hibernation, cold adaptation of metabolism in hibernators, and the response of hibernators to various extrinsic influences such as neoplastic growth, radiation injury, and parasitism and symbionts. This book will be of interest to students and researchers in fields ranging from zoology to physiology and biophysics.

  • Molecular Biology

    • 2nd Edition
    • David P. Clark + 1 more
    • English
    Molecular Biology, Second Edition, introduces the basic concepts of molecular biology while incorporating primary literature from today’s leading researchers. This new edition reflects the massive surge in our understanding of the molecular foundations of genetics, thanks to major scientific revolutions in genetics and computer technology. It explains how living organisms function at a molecular level and how DNA, RNA, and proteins interact to provide the cell with genetic information. This volume goes far beyond the flowing text, annotation, and hyperlinking available in most ebooks. Unique features include interactive quizzes for enhanced student understanding and self-testing; narrated animations to clarify complex content; and study guides equipped with 62 full-text Cell Press journal articles, all in one downloadable package. Also new to this second edition are updated chapters on genomics and systems biology, proteomics, bacterial genetics, and molecular evolution and RNA. A fully revised art completes the updates made in this ebook. This book will be of interest to undergraduate students taking a course in Molecular Biology, as well as upper-level students studying Cell Biology, Microbiology, Genetics, Biology, Pharmacology, Biotechnology, Biochemistry and Agriculture.

  • Pharmacy Practice Today for the Pharmacy Technician

    Career Training for the Pharmacy Technician
    • 1st Edition
    • LiAnne C. Webster
    • English
    Covering everything from certification exam review to key skills, Pharmacy Practice for Today’s Pharmacy Technician: Career Training for the Pharmacy Technician covers all of the knowledge needed by pharmacy technicians to provide exemplary patient care and build a successful career. It describes the role of the pharmacy technician in different practice settings, including the key tasks and skills set required to work in a community pharmacy, institutional pharmacy, or home health and long-term care/hospice care, then adds a road map taking you through certification, the job search, interviewing, and continuing education. Written by pharmacy technician educator and expert LiAnne Webster, this comprehensive text prepares you to succeed in this rapidly growing field.

  • Protein Kinase Inhibitors in Research and Medicine

    • 1st Edition
    • Volume 548
    • English
    This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers protein kinase inhibitors in research and medicine, and includes chapters on such topics as fragment-based screening, broad kinome profiling of kinase inhibitors, and designing drug-resistant kinase alleles.

  • Quality Assurance

    Problem Solving and Training Strategies for Success in the Pharmaceutical and Life Science Industries
    • 1st Edition
    • G Welty
    • English
    Quality assurance is necessary to maintain quality and services in the pharmaceutical and life science industries. Quality assurance demonstrates that the logic and practice of problem solving can integrate both program efficacy and regulatory compliance. This title is divided into three parts; the first part discusses the process by which a problem in regulated industry is identified, for example a manufacturing deviation that leads to an adulterated drug product, and reviews the decision-making steps involved in remedying the problem. The second part delves into the staff training requirements of procedures that are thereby revised. The third part expands on this discussion by considering piloting the proposed training module, preparing assessments of trainee proficiency, evaluating the training module, including integrating rigorous evaluative designs with formative program improvement, and documenting the entire effort.

  • Hydrogen Peroxide and Cell Signaling, Part B

    • 1st Edition
    • Volume 527
    • English
    This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This is the second of three volumes on hydrogen peroxide and cell signaling, and includes chapters on such topics as the cellular steady-state of H2O2, evaluating peroxiredoxin sensitivity towards inactivation by peroxide substrates, and peroxiredoxins as preferential targets in H2O2-induced signaling.

  • Chronic Pain and Brain Abnormalities

    • 1st Edition
    • Carl Y. Saab
    • English
    It is only natural for someone in pain to attend to the body part that hurts. Yet this book tells the story of persistent pain having negative effects on brain function. The contributors, all leading experts in their respective fields of pain electrophysiology, brain imaging, and animal models of pain, strive to synthesize compelling and, in some ways, connected hypotheses with regard to pain-related changes in the brain. Together, they contribute their clinical, academic, and theoretical expertise in a comprehensive overview that attempts to define the broader philosophical context of pain (disentangling sensical from nonsensical claims), list the changes known to take place in the brains of individuals with chronic pain and animal models of pain, address the possible causes and mechanisms underlying these changes, and detail the techniques and analytical methods at our disposal to "visualize" and study these changes.

  • Nonclinical Development of Novel Biologics, Biosimilars, Vaccines and Specialty Biologics

    • 1st Edition
    • Lisa M. Plitnick + 1 more
    • English
    Nonclinical Development of Novel Biologics, Biosimilars, Vaccines and Specialty Biologics is a complete reference devoted to the nonclinical safety assessment of novel biopharmaceuticals, biosimilars, vaccines, cell and gene therapies and blood products. This book compares and contrasts these types of biologics with one another and with small molecule drugs, while incorporating the most current and essential international regulatory documents. Each section discusses a different type of biologic, as well as early characterization strategies, principles of study design, preclinical pharmacokinetics and pharmacodynamics and preclinical assays. An edited book that is authored by leading experts in the field, this comprehensive reference provides critical insights to all researchers involved in early through late stage biologics.

  • Fish Nutrition

    • 1st Edition
    • John Halver
    • English
    Fish Nutrition aims to present the state of knowledge of basic and applied nutritional requirements of fishes. Most of the information found in this book involves salmonids, their nutrition, and metabolism of nutrients. This is in view of the fact that more research has been done and completed with this fish. Although applied fish nutrition is a very broad field, this book focuses on some of its aspects. These include the classes of nutrients and requirements for several types of fishes. This book comprises of 11 chapters. The first few chapters deal with the general nutrient requirements of fishes. Then, other chapters discuss calorie and energy as well as micro- and macronutrient needs and requirements. The following chapters deal with the non-nutrient components of the diet, or those that influence the characteristics of food products including texture, odor, flavor, and color. Other topics covered are enzymes and systems of intermediary metabolism (Chapter 6); feed formulation and evaluation (Chapter 7); and salmonid husbandry techniques (Chapter 9). Nutritional fish diseases are also discussed in this book. Some of these diseases include thyroid tumor, gill disease, anemia, lipoid liver degeneration, and visceral granuloma. In Chapter 11, the relationship of nutrition and pathology is given emphasis. This chapter also tackles the diet and general fish husbandry. This topic is very important, because an adequate diet for fish husbandry is the foundation of fish farming.

  • Advances in Virus Research

    • 1st Edition
    • Volume 87
    • Karl Maramorosch + 1 more
    • English
    Published since 1953, Advances in Virus Research covers a diverse range of in-depth reviews, providing a valuable overview of the current field of virology.

  • Hormones and Breast Cancer

    • 1st Edition
    • Volume 93
    • English
    First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology and enzyme mechanisms. Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines. This volume focuses on hormones and breast cancer.

  • International Review of Cell and Molecular Biology

    • 1st Edition
    • Volume 304
    • Kwang W. Jeon
    • English
    International Review of Cell and Molecular Biology presents current advances and comprehensive reviews in cell biology--both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth.

  • Introduction to Food Engineering

    • 5th Edition
    • R. Paul Singh + 1 more
    • English
    Long recognized as the bestselling textbook for teaching food engineering to food science students, this 5e transitions with today’s students from traditional textbook learning to integrated presentation of the key concepts of food engineering. Using carefully selected examples, Singh and Heldman demonstrate the relationship of engineering to the chemistry, microbiology, nutrition and processing of foods in a uniquely practical blend. This approach facilitates comprehensive learning that has proven valuable beyond the classroom as a lifetime professional reference.

  • Advances in Agronomy

    • 1st Edition
    • Volume 121
    • English
    Advances in Agronomy continues to be recognized as a leading reference and a first-rate source for the latest research in agronomy. As always, the subjects covered are varied and exemplary of the myriad of subject matter dealt with by this long-running serial.

  • Protein-Nucleic Acids Interactions

    • 1st Edition
    • Volume 91
    • English
    Published continuously since 1944, the Advances in Protein Chemistry and Structural Biology serial has been a continuous, essential resource for protein chemists. Covering reviews of methodology and research in all aspects of protein chemistry, including purification/express... proteomics, modeling and structural determination and design, each volume brings forth new information about protocols and analysis of proteins while presenting the most recent findings from leading experts in a broad range of protein-related topics.

  • Hydrogen Peroxide and Cell Signaling, Part A

    • 1st Edition
    • Volume 526
    • English
    This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This is the first of three volumes on hydrogen peroxide and cell signaling, and includes chapters on such topics as photooxidation of amplex red to resorufin, boronate-based fluorescent probes, and visualization of intracellular hydrogen peroxide with HyPer.

  • Invertebrate Learning and Memory

    • 1st Edition
    • Volume 22
    • Randolf Menzel + 1 more
    • English
    Understanding how memories are induced and maintained is one of the major outstanding questions in modern neuroscience. This is difficult to address in the mammalian brain due to its enormous complexity, and invertebrates offer major advantages for learning and memory studies because of their relative simplicity. Many important discoveries made in invertebrates have been found to be generally applicable to higher organisms, and the overarching theme of the proposed will be to integrate information from different levels of neural organization to help generate a complete account of learning and memory. Edited by two leaders in the field, Invertebrate Learning and Memory will offer a current and comprehensive review, with chapters authored by experts in each topic. The volume will take a multidisciplinary approach, exploring behavioral, cellular, genetic, molecular, and computational investigations of memory. Coverage will include comparative cognition at the behavioral and mechanistic level, developments in concepts and methodologies that will underlie future advancements, and mechanistic examples from the most important vertebrate systems (nematodes, molluscs, and insects). Neuroscience researchers and graduate students with an interest in the neural control of cognitive behavior will benefit, as will as will those in the field of invertebrate learning.

  • Osteoporosis

    • 4th Edition
    • Robert Marcus + 3 more
    • English
    Now in its fourth edition, Osteoporosis is a classic reference on this disease, comprising a tremendous wealth of knowledge in a single source not found elsewhere. Written by renowned experts in the field, this two-volume work is a must-have for academic and medical libraries, physicians, researchers, and any company involved in osteoporosis research and development. This newest edition covers everything from basic anatomy and physiology to diagnosis, management and treatment in which direct care costs for osteoporotic fractures in the United States reach up to $18 billion each year. Worldwide, 200 million women ages 60 to 80 suffer from osteoporosis and have a lifetime risk of fracture between 30% and 40%, continuing to make osteoporosis a critical challenge in medicine.

  • Food Protected Designation of Origin

    Methodologies and Applications
    • 1st Edition
    • Volume 60
    • English
    Protected designation of origin (PDO) taken together with other geographical indicators, such as protected geographical indication (PGI) and traditional specialty guaranteed (TSG), offer the consumer additional guarantees on the quality and authentication of foods. They are important tools that protect the names of regional foods, such as wines, cheeses, hams, sausages and olives, so that only foods that genuinely originate in a particular region are allowed to be identified as such. The economic value of these regional foods, as well as the increased interest from consumers and the food industry about the traceability and origin of food, mean that it has become necessary to establish methods for PDO and PGI authentication based on the specific characteristics and chemical markers of these kinds of products. This book offers a complete guide of the methods available to authenticate food PDO, beginning with an explanation of the analytical and chemometric methods available for PDO authentication, before looking at the main foods covered, PGI labels and the social and legal framework for food PGIs. It will be of interest to people engaged in the fields of food production, commercialization and consumption, as well as policymakers and control laboratories.

  • Comparative Color Vision

    • 1st Edition
    • Gerald Jacobs
    • English
    Comparative Color Vision provides information about the means by which color vision has been studied in nonhuman animals and about the outcomes of these studies for a variety of representative species. Individuals who become interested in color vision in animals come from a variety of different educational backgrounds—from the traditional biological and behavioral sciences as well as from more applied fields. Accordingly, this book includes sufficient tutorial information about color vision so that a relative newcomer would be able to make sense out of this area without having to search out still more background material. To provide this, basic information about the psychophysics of color vision and about the methods used to study color vision in animals is presented; along with coverage of the broad range of biological mechanisms responsible for color vision. Subsequent chapters present systematic reviews of studies of color vision in a wide selection of vertebrate species. The final chapter is devoted to a discussion of two fascinating issues raised by studies of animal color vision: the evolutionary origins and the functional utility of color vision.

  • Nutritional Toxicology Volume 2

    • 1st Edition
    • John N. Hathcock
    • English
    Nutritional Toxicology, Volume II, discusses the various interactions between nutritional phenomena and toxicologic processes. It addresses particular subjects that have become substantially more important through the development of new knowledge, significant increases in knowledge, or increased awareness of potential effects on human health and well-being. The implications of such knowledge have impact on basic research, toxicity testing, public health, food, and agriculture programs, and food safety regulation. The book begins with a review of the role and importance of macro- and micronutrients on detoxification processes of foreign compounds after absorption. This is followed by separate chapters on mixed-function oxidation in the liver; the metabolic and nutritional effects of ethanol; the effects of malnutrition on drug metabolism; interaction of nutrient intake with DNA and chromatin; and how such interactions may affect the process of toxicogenesis in the nucleus. Subsequent chapters cover mutagens in cooked foods; food sensitivities; anatomical, cardiovascular, and behavioral effects of dietary caffeine; the toxicology of dietary tin, aluminum, and selenium; and the toxicology of pesticides in foods.

  • Advances in Cancer Research

    • 1st Edition
    • Volume 118
    • English
    Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. Here, once again, outstanding and original reviews are presented on a variety of topics.

  • Basic and Applied Bone Biology

    • 1st Edition
    • David B. Burr + 1 more
    • English
    This book provides an overview of skeletal biology from the molecular level to the organ level, including cellular control, interaction and response; adaptive responses to various external stimuli; the interaction of the skeletal system with other metabolic processes in the body; and the effect of various disease processes on the skeleton. The book also includes chapters that address how the skeleton can be evaluated through the use of various imaging technologies, biomechanical testing, histomorphometric analysis, and the use of genetically modified animal models.

  • Handbook of Farm, Dairy and Food Machinery Engineering

    • 2nd Edition
    • Myer Kutz
    • English
    Handbook of Farm, Dairy and Food Machinery Engineering is the essential reference for engineers who need to understand those aspects of the food industry from farm machinery to food storage facilities to the machinery that processes and packages our foods. The process of getting food from "farm to fork," as the saying goes, involves more than planting, harvesting, shipping, processing, packaging and distributing—though those are all key components. Effective and efficient food delivery systems are built around processes that maximize the effort while minimizing cost, time, and resource depletion. This comprehensive reference is for engineers who design and build machinery and processing equipment, shipping containers, and packaging and storage equipment. It includes cutting-edge coverage of microwave vacuum application in grain processing, cacao processing, fruit and vegetable processing, ohmic heating of meat, facility design, closures for glass containers, double seaming, and much more.

  • Advances in Marine Biology

    • 1st Edition
    • Volume 65
    • English
    Advances in Marine Biology has been providing in-depth and up-to-date reviews on all aspects of marine biology since 1963--over 40 years of outstanding coverage! The series is well known for its excellent reviews and editing. Now edited by Michael Lesser (University of New Hampshire, USA), with an internationally renowned Editorial Board, the serial publishes in-depth and up-to-date content on a wide range of topics that will appeal to postgraduates and researchers in marine biology, fisheries science, ecology, zoology, and biological oceanography.

  • The Molecular Biology of Arrestins

    • 1st Edition
    • Volume 118
    • English
    This special volume of Progress in Molecular Biology and Translational Science focuses on the molecular biology of arrestins, with contributions from leaders in the field. Arrestins have emerged as central players in the regulation of many facets of G protein-coupled receptor signaling. This volume covers a variety of topics with reviews written by experts in the field.

  • The School of Pharmacy, University of London

    Medicines, Science and Society, 1842-2012
    • 1st Edition
    • Briony Hudson + 1 more
    • English
    The School of Pharmacy, University of London: Medicines, Science and Society, 1842-2012 represents the rich history of the University of London School of Pharmacy through numerous color photographs, important advances in the pharmacy profession, cultural milestones, biographies and more. Written in an engaging and authoritative style, this book depicts the chronological history of the school from its establishment in 1842 to the present day with a nod toward its aspirations for the future. By highlighting key periods in the school’s history and showing their connection to the wider world, this book truly commemorates the heritage of the School of Pharmacy and its cutting-edge role in pharmacy innovation, research and education.

  • Food Process Engineering and Technology

    • 2nd Edition
    • Zeki Berk
    • English
    The past 30 years have seen the establishment of food engineering both as an academic discipline and as a profession. Combining scientific depth with practical usefulness, this book serves as a tool for graduate students as well as practicing food engineers, technologists and researchers looking for the latest information on transformation and preservation processes as well as process control and plant hygiene topics.

  • Chemometrics in Food Chemistry

    • 1st Edition
    • Volume 28
    • English
    The issues related to food science and authentication are of particular importance for researchers, consumers and regulatory entities. The need to guarantee quality foodstuff – where the word "quality" encompasses many different meanings, including e.g. nutritional value, safety of use, absence of alteration and adulterations, genuineness, typicalness, etc. – has led researchers to look for increasingly effective tools to investigate and deal with food chemistry problems. As even the simplest food is a complex matrix, the way to investigate its chemistry cannot be other than multivariate. Therefore, chemometrics is a necessary and powerful tool for the field of food analysis and control. For food science in general and food analysis and control in particular, there are several problems for which chemometrics are of utmost importance. Traceability, i.e. the possibility of verifying the animal/botanical, geographical and/or productive origin of a foodstuff, is, for instance, one area where the use of chemometric techniques is not only recommended but essential: indeed, at present no specific chemical and/or physico-chemical markers have been identified that can be univocally linked to the origin of a foodstuff and the only way of obtaining reliable traceability is by means of multivariate classification applied to experimental fingerprinting results. Another area where chemometrics is of particular importance is in building the bridge between consumer preferences, sensory attributes and molecular profiling of food: by identifying latent structures among the data tables, bilinear modeling techniques (such as PCA, MCR, PLS and its various evolutions) can provide an interpretable and reliable connection among these domains. Other problems include process control and monitoring, the possibility of using RGB or hyperspectral imaging techniques to nondestructively check food quality, calibration of multidimensional or hyphenated instruments etc.

  • Intelligence and Human Progress

    The Story of What was Hidden in our Genes
    • 1st Edition
    • James Flynn
    • English
    Written by James R. Flynn of the "Flynn effect" (the sustained and substantial increase in intelligence test scores across the world over many decades), Intelligence and Human Progress examines genes and human achievement in all aspects, including what genes allow and forbid in terms of personal life history, the cognitive progress of humanity, the moral progress of humanity, and the cross-fertilization of the two. This book presents a new method for weighing family influences versus genes in the cognitive abilities of individuals, and counters the arguments of those who dismiss gains in IQ as true cognitive gains. It ranges over topics including: how family can handicap those taking the SAT; new IQ thresholds for occupations that show elite occupations are within reach of the average American; what Pol Pot did to the genetic potential of Cambodia; why dysgenics (the deterioration of human genes over the generations) is important, but no menace for the foreseeable future; and what might derail human intellectual progress. Researchers in developmental and cognitive psychology, educators, and professionals involved in intelligence testing or psychometrics will benefit from the perspectives offered here. But beyond that, anyone interested in the potential of the human mind will be engaged and challenged by one of the most important contemporary thinkers on the subject.

  • Advances in Applied Microbiology

    • 1st Edition
    • Volume 84
    • English
    Published since 1959, Advances in Applied Microbiology continues to be one of the most widely read and authoritative review sources in microbiology. The series contains comprehensive reviews of the most current research in applied microbiology. Recent areas covered include bacterial diversity in the human gut, protozoan grazing of freshwater biofilms, metals in yeast fermentation processes and the interpretation of host-pathogen dialogue through microarrays. Eclectic volumes are supplemented by thematic volumes on various topics, including Archaea and sick building syndrome. Impact factor for 2011: 5.233

  • Computational Toxicology

    Methods and Applications for Risk Assessment
    • 1st Edition
    • Bruce A. Fowler
    • English
    Computational Toxicology: Methods and Applications for Risk Assessment is an essential reference on the translation of computational toxicology data into information that can be used for more informed risk assessment decision-making. This book is authored by leading international investigators who have real-world experience in relating computational toxicology methods to risk assessment. Key topics of interest include QSAR modeling, chemical mixtures, applications to metabolomic and metabonomic data sets, toxicogenomic analyses, applications to REACH informational strategies and much more. The examples provided in this book are based on cutting-edge technologies and set out to stimulate the further development of this promising field to offer rapid, better and more cost-effective answers to major public health concerns.

  • Cancer Immunotherapy

    Immune Suppression and Tumor Growth
    • 2nd Edition
    • George C. Prendergast + 1 more
    • English
    There has been major growth in understanding immune suppression mechanisms and its relationship to cancer progression and therapy. This book highlights emerging new principles of immune suppression that drive cancer, and it offers radically new ideas about how therapy can be improved by attacking these principles. Following work that firmly establishes immune escape as an essential trait of cancer, recent studies have now defined specific mechanisms of tumor immune suppression. It also demonstrates how attacking tumors with molecular targeted therapeutics or traditional chemotherapeutic drugs can produce potent anti-tumor effects in preclinical models. This book provides basic, translational, and clinical cancer researchers with an indispensable overview of immune escape as a critical trait in cancer and how applying specific combinations of immunotherapy and chemotherapy to attack this trait may radically improve the treatment of advanced disease.

  • Rio-Hortega's Third Contribution to the Morphological Knowledge and Functional Interpretation of the Oligodendroglia

    • 1st Edition
    • Jose R. Iglesias-Rozas + 1 more
    • English
    Pío del Rio-Hortega, one of the pioneering neuroscientists and discoverer of microglia, has been recognized as one of the most important Spanish neurohistogists of the past century. His landmark research on oligodendroglia, originally published in Spanish in 1928, has been translated into English for the first time by Dr. José R. Iglesias-Rozas and Prof. Manuel Garrosa. The book establishes definitively the concept of oligodendroglia and describes in great detail its structure, varieties, function, origin and pathology, providing a thorough review. The entire 1928 writing is presented, including the 79 excellent drawings and photographs from the original publication. To complement the original book and provide historical context, the translators have also included an introduction to the research and a biography of Pío del Rio-Hortega. This book constitutes a milestone in the history of neuroscience, biology and medicine, and it will be valuable reading for researchers and practitioners in these fields.

  • Advances in Applied Microbiology

    • 1st Edition
    • Volume 86
    • English
    Published since 1959, Advances in Applied Microbiology continues to be one of the most widely read and authoritative review sources in microbiology. The series contains comprehensive reviews of the most current research in applied microbiology. Recent areas covered include bacterial diversity in the human gut, protozoan grazing of freshwater biofilms, metals in yeast fermentation processes and the interpretation of host-pathogen dialogue through microarrays. Eclectic volumes are supplemented by thematic volumes on various topics, including Archaea and sick building syndrome. Impact factor for 2012: 4.974.

  • Advances in Clinical Chemistry

    • 1st Edition
    • Volume 61
    • English
    Volume 61 in the internationally acclaimed Advances in Clinical Chemistry contains chapters submitted from leading experts from academia and clinical laboratory science. Authors are from a diverse field of clinical chemistry disciplines and diagnostics, ranging from basic biochemical exploration to cutting-edge microarray technology.

  • Sea Urchins

    Biology and Ecology
    • 3rd Edition
    • Volume 38
    • John M. Lawrence
    • English
    This fully revised and expanded edition of Sea Urchins provides a wide-ranging understanding of the biology and ecology of this key component of the world's oceans. Coverage includes reproduction, metabolism, endocrinology, larval ecology, growth, digestion, carotenoids, disease and nutrition. Other chapters consider the ecology of individual species that are of major importance ecologically and economically, including species from Japan, New Zealand, Australia, Europe, North America, South America and Africa. In addition, six new contributions in areas such as immunology, digestive systems and community ecology inform readers on key recent developments and insights from the literature.Sea urchins are ecologically important and often greatly affect marine communities. Because they have an excellent fossil record, they are also of interest to paleontologists. Research on sea urchins has increased in recent years, stimulated first by recognition of their ecological importance and subsequently their economic importance. Scientists around the world are actively investigating their potential for aquaculture and fisheries, and their value as model systems for investigations in developmental biology continues to increase.

  • Joining and Assembly of Medical Materials and Devices

    • 1st Edition
    • Y N Zhou + 1 more
    • English
    As medical devices become more intricate, with an increasing number of components made from a wide range of materials, it is important that they meet stringent requirements to ensure that they are safe to be implanted and will not be rejected by the human body. Joining and assembly of medical materials and devices provides a comprehensive overview of joining techniques for a range of medical materials and applications.Part one provides an introduction to medical devices and joining methods with further specific chapters on microwelding methods in medical components and the effects of sterilization on medical materials and welded devices. Part two focuses on medical metals and includes chapters on the joining of shape memory alloys, platinum (Pt) alloys and stainless steel wires for implantable medical devices and evaluating the corrosion performance of metal medical device welds. Part three moves on to highlight the joining and assembly of medical plastics and discusses techniques including ultrasonic welding, transmission laser welding and radio frequency (RF)/dielectric welding. Finally, part four discusses the joining and assembly of biomaterial and tissue implants including metal-ceramic joining techniques for orthopaedic applications and tissue adhesives and sealants for surgical applications.Joining and assembly of medical materials and devices is a technical guide for engineers and researchers within the medical industry, professionals requiring an understanding of joining and assembly techniques in a medical setting, and academics interested in this field.

  • Human Motion Simulation

    Predictive Dynamics
    • 1st Edition
    • Karim Abdel-Malek + 1 more
    • English
    Simulate realistic human motion in a virtual world with an optimization-based approach to motion prediction. With this approach, motion is governed by human performance measures, such as speed and energy, which act as objective functions to be optimized. Constraints on joint torques and angles are imposed quite easily. Predicting motion in this way allows one to use avatars to study how and why humans move the way they do, given specific scenarios. It also enables avatars to react to infinitely many scenarios with substantial autonomy. With this approach it is possible to predict dynamic motion without having to integrate equations of motion -- rather than solving equations of motion, this approach solves for a continuous time-dependent curve characterizing joint variables (also called joint profiles) for every degree of freedom.

  • Animal Models for the Study of Human Disease

    • 1st Edition
    • P. Michael Conn
    • English
    Animal Models for the Study of Human Disease identifies important animal models and assesses the advantages and disadvantages of each model for the study of human disease. The first section addresses how to locate resources, animal alternatives, animal ethics and related issues, much needed information for researchers across the biological sciences and biomedicine.The next sections of the work offers models for disease-oriented topics, including cardiac and pulmonary diseases, aging, infectious diseases, obesity, diabetes, neurological diseases, joint diseases, visual disorders, cancer, hypertension, genetic diseases, and diseases of abuse.

  • Advances in Food and Nutrition Research

    • 1st Edition
    • Volume 70
    • English
    Advances in Food and Nutrition Research recognizes the integral relationship between the food and nutritional sciences and brings together outstanding and comprehensive reviews that highlight this relationship. Contributions detail scientific developments in the broad areas of food science and nutrition and are intended to provide those in academia and industry with the latest information on emerging research in these constantly evolving sciences.

  • Advances in Genetics

    • 1st Edition
    • Volume 82
    • English
    The field of genetics is rapidly evolving, and new medical breakthroughs are occurring as a result of advances in our knowledge of genetics. This series continually publishes important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines.

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