Natural Cell-Mediated Immunity Against Tumors

Participants

Preface

Section I Natural Killer (NK) Cells and Related Cells

A Characteristics of NK and Related Cells

Characteristics of NK and Related Cells

Alloantisera Selectively Reactive with NK Cells: Characterization and Use in Defining NK Cell Classes

Asialo GMl and Thy 1 as Cell Surface Markers of Murine NK Cells

Characteristics of Natural Cytostatic Effector Cells

Characterization of the NK Cell in Man and Rodents

Characteristics of Murine NK Cells in Relation to T Lymphocytes and K Cells

Characteristics of NK Cells

Antigenic Phenotype of Mouse Natural Killer Cells

Natural Cytotoxicity of Macrophage Precursor Cells and of Mature MacrophageS

Centrifugal Elutriation Allows Enrichment of Natural Killing and Separates Xenogeneic and Allogeneic Reactivity

Effects of Alloantisera on Murine K and NK Cell Activity

Characteristics of Human Natural Killer Cells

Phenotypic Characteristics of NK Cells in the Mouse

Morphology and Surface Properties of Human NK Cells

Natural Cytotoxic (NC) Cells against Solid Tumors in Mice: General Characteristics and Comparison to Natural Killer (NK) Cells

Ontogeny and Other Age-Related Effects of Natural Cytotoxic (NC) Cells in Mice

Biophysical and Serological Characterization of Murine NK Cells

Analysis of Recognition Patterns of NK Cells through Use of Varying Combinations of Mouse Strains and Tumor Targets

FACS Analysis and Enrichment of NK Effector Cells

B Mechanism of Cytotoxicity by NK Cells and Their Relationship to K Cells

Summary: Characteristics of NK and Related Cells

Mechanism of Cytotoxicity by NK Cells and Their Relationship to K Cells

Quantitation of Human Natural and Antibody-Dependent Cytotoxicity

The Relationship between Natural and Antibody-Dependent Cell-Mediated Cytotoxicity

Differential Effects of Immune Complexes on Human Natural and Antibody-Dependent Cell-Mediated Cytotoxicity

Natural Killing and Antibody-Dependent Cellular Cytotoxicity: Independent Mechanisms Mediated by Overlapping Cell

Are Spontaneous and Antibody-Dependent Lysis Two Different Mechanisms of Cytotoxicity Mediated by the Same Cell?

A Comparative Analysis of the NK Cytolytic Mechanism and Regulatory Genes

Summary: Mechanism of Cytotoxicity by NK Cells and Their Relationship to K Cells

C1 Immunogenetic Regulation of NK Activity

Immunogenetics of Natural Immunity

Augmentation of Natural Killer Cell Activity of Beige Mice by Interferon and Interferon Inducers

Mutations That Influence Natural Cell-Mediated Cytotoxicity in Rodents

Genetic Influences Affecting Natural Cytotoxic (NC) Cells in Mice

Summary: Immunogenetic Regulation of NK Activity

C2 Development of NK Activity during in Vitro Culture

Development of NK Activity during in Vitro Culture

In Vitro Development of Human NK Cells: Characteristics of Precursors and Effector Cells and Possible Cell Lineage

MLC-Induced Cytotoxicity against NK-Sensitive Targets

Summary: Development of NK Activity during in Vitro Culture

C3 Augmentation of NK Activity

Interferon and NK Cells in Resistance to Persistently Virus-Infected Cells and Tumors

Interferon-Independent Activation of Murine Natural Killer Cell Activity

Enhancement of Human NK Activity by Interferon. In Vivo and in Vitro Studies

Regulatory Factors in Human Natural and Antibody-Dependent Cell-Mediated Cytotoxicity

Spontaneous Cell-Mediated Cytotoxicity (SCMC) and Short-Term Mixed Leukocyte Culture (MLC): Role of Soluble Factors and of Cellular Interactions

Augmentation of Human NK and ADCC by Interferon

Factors Controlling the Augmentation of Natural Killer Cells

Characteristics of Augmentation by Interferon of Cell-Mediated Cytotoxicity

Spontaneous Cell-Mediated Cytotoxicity (SCMC): Enhancement by Interferons and Corynebacterium Parvum-Induced T-Cell Factor(s) Lacking Antiviral Activity

Modulation of Natural Cytotoxicity in Man by BCG and Fibroblast Interferon

Regulation of Human Natural Killer Activity by Interferon

Spontaneous Cell-Mediated Cytotoxicity: Modulation by Interferon

Activated Natural Killer Cells Induced during the Lymphocytic Choriomeningitis Virus Infection in Mice

Augmentation of Human Natural Killer Cell Activity by Purified Interferon and Polyribonucleotides

Summary: Augmentation of NK Activity

C4 Suppression or Inhibition of NK Activity

Prostaglandin-Mediated Inhibition of Murine Natural Killer Cell Activity

C. Parvum-Mediated Suppression of the Phenomenon of Natural Killing and Its Analysis

Inhibition As Well As Augmentation of Mouse NK Activity by Pyran Copolymer and Adriamycin

The Effect of 17/3-Estradiol on Natural Killing in the Mouse

Summary: Suppression or Inhibition of NK Activity

D Specificity of Cytotoxicity by NK Cells and Nature of Recognition Structures on Effector and Target Cells

Comparison of Natural Immunity to MTV and Natural Killer Reactivity

The Use of Lymphoma Cell Variants Differing in Their Susceptibility to NK Cell-Mediated Lysis to Analyse NK Cell- Target Cell Interactions

Kinetic Analysis of Specificity in Human Natural Cell-Mediated Cytotoxicity

Human Natural Cell-Mediated Cytotoxicity: A Polyspecific System

Interaction between NK Cells and Normal Tissue: Definition of a NK-Sensitive Thymocyte Population

Specificity of NK Cells

Heterogeneity in Natural Killing

Are Natural Killer Cells Germ-Line V-Gene-Encoded Prothymocytes Specific for Self and Nonself Histocompatibility Antigens?

Natural and Activated Lymphocyte Killers which Affect Tumor Cells

Murine Retrovirus—Specific Natural Killer Cell Activity

The Specificity of NK Cells at the Level of Target Antigens and Recognition Receptors

Natural Cytotoxic (NC) Cells against Solid Tumors in Mice: Some Target Cell Characteristics and Blocking of Cytotoxicity by D-Mannose

Modification of Target Susceptibility to Activated Mouse NK Cells by Interferon and Virus Infections

Summary: Specificity of Cytotoxicity by NK Cells and Nature of Recognition Structures on Effector and Target Cells

E NK Aactivity during Carcinogenesis and Tumor Growth and Its Expression within Tumors

Intratumor NK Reactivity

Cytotoxicity and Cytostasis Mediated by Splenocytes of Mice Subjected to Chemical Carcinogens and of Mice-Bearing

NK Cell Activity in the Blood, Tumor-Draining Lymph Nodes, and Primary Tumors of Women with Mammary Carcinoma

Natural Cell-Mediated Cytotoxicity in Human Tumor Patients

Systemic and in Situ Natural Killer Activity in Tumor-Bearing Mice and Patients with Cancer

Natural Killer Cells in Tumor-Bearing Patients

Natural Cytotoxic (NC) Cells in Tumor-Bearing Mice

Natural Killers in Human Cancer: Activity of Tumor-Infiltrating and Draining Node Lymphocytes

Summary: NK Activity during Carcinogenesis and Tumor Growth and Its Expression within Tumors

F In Vivo Role of NK Cells in Host Defense

In Vivo Activity of Murine NK Cells

Analogy between Rejection of Hemopoietic Transplants and Natural Killing

Role of NK Cells in Rapid in Vivo Clearance of Radiolabeled Tumor Cells

Summary: In Vivo Role of NK Cells in Host Defense

G Natural Immunity and Resistance Against Microbial Agents

Natural Resistance of Mice toward Orthomyxoviruses

Natural Macrophage Cytotoxicity against Protozoa

Natural Killer Cell Activity against Virus-Infected Cells

Summary: Natural Immunity and Resistance against Microbial Agents

Section II Natural Lymphokine Production

Interferon Production in Murine Spleen Cell Cultures

Natural Production of Macrophage-Migration Inhibitory Factor and Human-Leukocyte Inhibitory Factor

Interferon Production in Lymphocytes Cultured with Tumor-Derived Cells

Summary: Natural Lymphokine Production

Section III Natural Macrophage Cytotoxicity

Regulatory Capacities of Mononuclear Phagocytes with Particular Reference to Natural Immunity against Tumors

Natural Cytotoxicity on Tumor Cells of Human Monocytes and Macrophages

Summary: Natural Macrophage Cytotoxicity

Section IV Natural Granulocyte Cytotoxicity

The Role of Granulocytes in Host Defense against Tumors

Summary: Natural Granulocyte Cytotoxicity

Index