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Stem Cells of Renewing Cell Population

1st Edition - January 1, 1976

Editor: A.B. Cairnie

Hardback ISBN:

9 7 8 - 0 - 1 2 - 1 5 5 0 5 0 - 9

eBook ISBN:

9 7 8 - 0 - 3 2 3 - 1 5 1 8 4 - 9

Stem Cells of Renewing Cell Populations constitutes the proceedings of the ""Stem Cells in Various Tissues"" symposium, organized as a tribute to Charles P. Leblond on the… Read more

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Stem Cells of Renewing Cell Populations constitutes the proceedings of the ""Stem Cells in Various Tissues"" symposium, organized as a tribute to Charles P. Leblond on the occasion of his 65th birthday. The pioneering studies of Dr. Leblond on the kinetics of cell populations led him to the identification and analysis of the behavior of the ""stem cells,"" which are at the origin of each cell line. This book focuses on the study of stem cells in various organs, including intestine, epidermis, hematopoietic and lymphoid tissues, and testis, under normal steady state conditions. It examines the behavior of stem cell in these organs, such as cell cycle and differentiation and regulation using several distinct techniques. The concluding part discusses the behavior of hematopoietic stem cell during growth and aging, as well as its distribution and dynamics in tumor-bearing tissues. Workers from many disciplines, including biologists, stem cell biologists, and regenerative medicine researchers will greatly benefit from this book.

List of Contributors

CP. Leblond

Tribute to CP. Leblond-Y. Clermont

Preface

Chairman's Opening Address

Session I — Stem Cells in the Intestine

Identification of Stem Cells in the Small Intestine of the Mouse

Colony-Forming Units in the Intestine

Presence of Intestinal Chalones

Factors Involved in the Differentiation of the Epithelial Cells in the Adult Rat Small Intestine

Homeostasis in the Small Intestine

Small Intestinal Crypt Stem Cells

Discussion

Session II — Stem Cells in the Epidermis

Identification of Clonogenic Cells in the Epidermis and the Structural Arrangement of the Epidermal Proliferative Unit (EPU)

The Influence of Epidermal Chalone on Cell Proliferation

Discussion

Session III - Stem Cells in Hemopoietic and Lymphoid Tissue I

Regulation of Hemopoietic Stem Cells

Cell Cycle Characteristics of Haemopoietic Stem Cells

Stem Cell Reserve and Its Control

The Granulocytic and Monocytic Stem Cell

Discussion

Session IV — Stem Cells in Hemopoietic and Lymphoid Tissue II

Potentials of Bone Marrow Lymphocytes

Some Techniques for Analyzing B Lymphocyte Development

Hemopoietic Stem Cell Migration

Regulation of Stem Cells after Local Bone Marrow Injury: The Role of an Osseous Environment

Hemopoietic Inductive Microenvironments

Discussion

Session V - Stem Cells in the Testis

Spermatogonial Stem Cells and Their Behaviour in the Seminiferous Epithelium of Rats and Monkeys

Spermatogonial Stem Cell Renewal in the Mouse as Revealed by 3 H-Thymidine Labeling and Irradiation

A New Approach to Stem Cell Research in Spermatogenesis

Studies of the Genetic Implications of Abnormal Spermatozoa

Discussion

Session VI - Stem Cells in Growth, Aging and Neoplasia

Hemopoietic Stem Cells during Embryonic Development and Growth

Ageing of Haematopoietic Stem Cell Populations in the Mouse

Hemopoietic Stem Cells in Tumor Bearing Hosts

Teratocarcinoma: A Model of Stem Cell Differentiation

Discussion

Concluding Address -L F. Lamerton

Subject Index