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Elsevier

Books in Chemistry

Chemistry topic areas include: physical and theoretical, computational, organic, organometallic and inorganic, pharmaceutical and medicinal, analytical and bioanalytical, nuclear, general, nanochemistry, geochemistry, materials and polymer, as well as environmental, green and sustainable chemistry.

  • Progress in Heterocyclic Chemistry

    A Critical Review of the 1988 Literature Preceded by Three Chapters on Current Heterocyclic Topics
    • 1st Edition
    • Volume 1
    • E. F. V. AAA
    • H. Suschitzky
    • English
    The International Society of Heterocyclic Chemistry in collaboration with Pergamon Press is pleased to announce a new annual publication, Progress in Heterocyclic Chemistry. The first volume contains chapters on three new developing topics with the remainder of the volume being devoted to highlights of the 1988 heterocyclic chemistry literature. These highlights are novel and unusual chemistry and not a condensed summary of the literature. Subsequent volumes will review other topics of current interest to heterocyclic chemists as well as covering the previous year's literature. All contributors will be acknowledged authorities in their fields.

  • Sulfur

    Its Significance for Chemistry, for the Geo-, Bio-, and Cosmosphere and Technology
    • 1st Edition
    • Volume 5
    • A. Müller + 1 more
    • English
    Sulfur: Its Significance for Chemistry, for the Geo-, Bio- and Cosmosphere and Technology focuses on the significance of sulfur for chemistry, geosphere, biosphere, cosmosphere, and technology. Topics covered range from the geochemistry and natural cycle of sulfur to the role of sulfur in "black powder". Organometallic sulfur compounds, thiolates, and the spectroscopic effects of sulfur chemistry are also discussed. Comprised of 21 chapters, this volume begins with an introduction to elemental sulfur and related homocyclic compounds and ions, focusing on their preparation, molecular and crystal structures, molecular spectra, and thermodynamic properties. Subsequent chapters deal with the origin and natural cycle of sulfur in the earth's crust; the role of sulfur in the reactions of exploding gunpowder; the use of sulfur in artwork; and developments in the field of organic sulfur chemistry. The catalytic properties of metal complexes of sulfur and sulfur-nitrogen compounds are also examined, along with the synthetic aspects of sulfido-complexes of molybdenum and tungsten. The final section is devoted to the role of sulfur in microbiology, biochemistry, and medicine. This monograph will be useful to students, practitioners, and researchers in the field of inorganic chemistry, as well as those who are interested in sulfur and its compounds.

  • Principles of X-Ray Diagnosis of the Skull

    • 2nd Edition
    • G. H. du Boulay
    • English
    Principles of X-Ray Diagnosis of the Skull, Second Edition focuses on the process of examining skull radiographs. This book discusses the traditional method of neuroradiology that describes in turn the vault, the sella, and the base, followed by any intracranial calcification that may be present. The radiology of ears, nose, throat and eyes that have much more common ground with neuroradiology are also considered. The radiology of the ear is found in the chapters devoted to the skull base, but the nose, nasopharynx, sinuses, and orbits are treated in a different chapter. The mandible and teeth have little connection with neuroradiology and are not covered. This publication is intended for students of radiology, before and after their diploma examination, and for clinicians to whom the head is of special concern.

  • Advances in Heterocyclic Chemistry

    • 1st Edition
    • Volume 118
    • English
    Advances in Heterocyclic Chemistry is the definitive series in the field—one of great importance to organic chemists, polymer chemists, and many biological scientists. Because biology and organic chemistry increasingly intersect, the associated nomenclature also is being used more frequently in explanations. Written by established authorities in the field from around the world, this comprehensive review combines descriptive synthetic chemistry and mechanistic insight to yield an understanding of how chemistry drives the preparation and useful properties of heterocyclic compounds.

  • The Chemistry of Manganese, Technetium and Rhenium

    Pergamon Texts in Inorganic Chemistry
    • 1st Edition
    • R. D. W. Kemmitt + 1 more
    • J. C. Bailar + 2 more
    • English
    The Chemistry of Manganese, Technetium and Rhenium is a three-chapter book that discusses the composition, structure, properties, and change of manganese, technetium, and rhenium. The first chapter in this particular book is the 37th chapter of the volume of a series, which focuses on manganese. The history, occurrence, metallurgy, uses, and chemistry of manganese are specifically discussed in this chapter. The compounds of manganese are also presented. This chapter is followed by a chapter on the chemistry of technetium, including its discovery, isolation, and compounds. The last chapter is devoted to rhenium, discussing its discovery, isolation, compounds, and physical and chemical properties. This book will be invaluable to chemistry students and practitioners, especially those interested in the elements featured in this release.

  • Affinity Chromatography

    Biospecific Sorption — The First Extensive Compendium on Affinity Chromatography as Applied to Biochemistry and Immunochemistry
    • 1st Edition
    • O. Hoffmann-Ostenhof + 2 more
    • English
    Affinity Chromatography is a collection of papers that presents the advancement in various areas of affinity chromatography. The title particularly covers the development in affinity chromatography in the context of biochemistry and immunochemistry. The text first details gel matrices, coupling methods, and charge transfer chromatography. Next, the selection tackles the affinity chromatography of enzymes and hydrophobic interaction chromatography. The text also discusses matrix-bound antigens and antibodies, along with matrix-bound lectins and affinity chromatography of cells. Part VI deals with affinity chromatography of hormone receptors, while part vii talks about affinity techniques in the isolation Of DNA, RNA, and polysomes. The book will be of great use to students, researchers, and practitioners of biochemistry.

  • Chemical Analysis

    River Pollution
    • 1st Edition
    • Louis Klein
    • English
    River Pollution 1: Chemical Analysis discusses methods of detecting and determining the various forms of pollution and the interpretation of results. It aims to provide a chemical background for, and supplement to, the information on analytical methods, and to review critically other methods which may be useful in certain circumstances for research, control work, and field tests. The book begins with a description of river surveys, and physical and chemical methods for determining river pollution. Separate chapters cover methods to determine the presence of dissolved oxygen, combined nitrogen, sulfur compounds, carbon dioxide, free chlorine, metallic contaminants, and carbon compounds. Subsequent chapters discuss the estimation of less important substances which may sometimes be encountered in pollution problems; and the significance of chemical and physical tests and the interpretation of the results of an analysis. This book is intended for those interested in chemical analysis as applied to river pollution problems, sewage, and trade wastes.

  • Copper, Silver, Gold & Zinc, Cadmium, Mercury Oxides & Hydroxides

    • 1st Edition
    • Volume 23
    • T. P. Dirkse
    • English
    Interest in the title compounds has fallen into three phases: initial study of their solution chemistry, study of their role in the electrode reactions of alkaline batteries during and since World War II, and present concern over the mechanisms by which these elements can enter the environment through dissolution processes, sometimes with toxic results. This volume provides a complete compilation of solubility data published up to 1984, including all pertinent articles, together with critical evaluations of the data. Almost all the measurements relate to aqueous systems.

  • Chemical Binding and Structure

    • 1st Edition
    • J. E. Spice
    • J. E. Spice
    • English
    Chemical Binding and Structure describes the chemical binding and structure in terms of current chemical theory. This book is composed of 13 chapters, and starts with a presentation of the principles of the old and modified quantum theory and its application. The next chapters cover some basic topics related to chemical binding and structure, including electrons, the periodic table, the electrovalent and covalent bonds, and molecular geometry. These topics are followed by discussions on the nature of the bond in transition metal complexes; electronic and crystal structure; crystallinity; and other states of matter. The concluding chapters are devoted to some analytical techniques for structure determination, such as diffraction and spectroscopic methods. This book is of value to high school and college chemistry teachers and students.

  • Macromolecular Microsymposium — 16

    Main Lectures Presented at the Sixteenth Microsymposium on Macromolecules (Advances in Scattering Methods), Prague, 12 - 16 July 1976
    • 1st Edition
    • B. Sedláček
    • English
    Macromolecular Microsymposia – 16 (Prague, 1976) is a collection of lectures presented at the 16th Microsymposium on Macromolecules (Advances in Scattering Methods), held in Prague on July 12-16, 1976. This book contains four chapters and begins with a survey of density fluctuations in amorphous and semicrystalline polymers. The next chapter provides experimental procedures for studying light scattering from polymer films. This chapter also describes the theory for scattering from spherulites and the procedures for correction for multiple scattering, truncation, and disorder, and illustrated for studies n polyethylene terephthalate films. These topics are followed by a discussion of the classical light scattering from polymer solutions. The last chapter considers the progress of techniques and instruments of light-scattering spectroscopy, with emphasis on advances made in photon correlation. This book will be of value to analytical and organic chemists and researchers.

  • Photochemistry – 6

    Plenary Lectures Presented at the Sixth International Symposium on Photochemistry, Aix-En-Provence, France, 19-23 July, 1976
    • 1st Edition
    • A. Gilbert
    • English
    Photochemistry — 6 is a collection of plenary lectures presented at the Sixth International Symposium on Photochemistry held in Aix-en-Provence, France, on July 19-23, 1976. Contributors focus on the photochemistry of a variety of compounds and substances, including bichromophoric compounds, heterocycles, and metal carbonyls. The results of photochemical studies of visual pigments are also presented. This book is comprised of 14 chapters and opens with a review of the state of the art of ab initio quantum-mechanical calculations for polyatomic molecules, with particular reference to predictions of interest to photochemists. The major areas discussed are spectral predictions, substituent effects on energy gaps, and potential energy surfaces. The following chapters explore energy transfer and molecular mobility in polymer photochemistry; the photochemistry of polyenes and aromatic-N-ylides; cis-trans isomerization in the photochemistry of vision; and aromatic aldehyde-leuco dye photoxidation. The electrochemical boundaries for the photochemistry of spectrally sensitized silver halide emulsions are also examined, along with the photochemistry of organic chromophores incorporated into fatty acid monolayers. This monograph will be of interest to chemists in general and photochemists in particular.

  • History of Analytical Chemistry

    International Series of Monographs in Analytical Chemistry
    • 1st Edition
    • Ferenc Szabadváry
    • R. Belcher + 1 more
    • English
    History of Analytical Chemistry is a systematic account of the historical development of analytical chemistry spanning about 4,000 years. Many scientists who have helped to develop the methods of analytical chemistry are mentioned. Various methods of analysis are discussed, including electrogravimetry, optical methods, electrometric analysis, radiochemical analysis, and chromatography. This volume is comprised of 14 chapters and begins with an overview of analytical chemistry in ancient Greece, the origin of chemistry, and the earliest knowledge of analysis. The next chapter focuses on analytical chemistry during the Middle Ages, with emphasis on alchemy. Analytical knowledge during the period of iatrochemistry and the development of analytical chemistry during the phlogiston period are then examined. Subsequent chapters deal with the development of the fundamental laws of chemistry, including the principle of the indestructibility of matter; analytical chemistry during the period of Berzelius; and developments in qualitative and gravimetric analysis. Elementary organic analysis is also considered, along with the development of the theory of analytical chemistry. This book will be helpful to chemists as well as students and researchers in the field of analytical chemistry.

  • Chemical Kinetics of Gas Reactions

    • 1st Edition
    • V. N. Kondrat'Ev
    • English
    Chemical Kinetics of Gas Reactions explores the advances in gas kinetics and thermal, photochemical, electrical discharge, and radiation chemical reactions. This book is composed of 10 chapters, and begins with the presentation of general kinetic rules for simple and complex chemical reactions. The next chapters deal with the experimental methods for evaluating chemical reaction mechanisms and some theories of elementary chemical processes. These topics are followed by discussions on certain class of chemical reactions, including unimolecular, bimolecular, and termolecular reactions. The remaining chapters examine gas reactions, such as molecular collisions, photochemical reactions, chemical reactions in electrical discharge, chain reactions, and combustion. This book will be of value to reaction kinetics engineers and researchers.

  • Gases in Molten Salts

    • 1st Edition
    • Volume 45
    • R.P.T. Tomkins + 1 more
    • English
    This volume contains tabulated collections and critical evaluations of original data for the solubility of gases in molten salts, gathered from chemical literature through to the end of 1989. Within the volume, material is arranged according to the individual gas. The gases include hydrogen halides, inert gases, oxygen, nitrogen, hydrogen, carbon dioxide, water vapor and halogens. The molten salts consist of single salts, binary mixtures and multicomponent systems. Included also, is a special section on the solubility of gases in molten silicate systems, focussing on slags and fluxes.

  • A Physician's Handbook on Orthomolecular Medicine

    • 1st Edition
    • Roger J. Williams + 1 more
    • English
    A Physician's Handbook on Orthomolecular Medicine is a collection of articles that covers the advancement in the field of orthomolecular medicine. The title presents papers that discuss the methodology and technology involved in the adjustment of the natural chemical constituents of our bodies, along with related concerns. The book aims to further promote orthomolecular medicine by discussing its effectiveness and efficiency as a form of medical treatment. The coverage of the text includes orthomolecular medicine’s application in treating mental disorders and regulating disease. The book will be of great use to students, researchers, and practitioners of health sciences.

  • Advanced Mass Spectrometry

    Applications in Organic and Analytical Chemistry
    • 1st Edition
    • Urs P. Schlunegger
    • English
    Advanced Mass Spectrometry: Applications in Organic and Analytical Chemistry discusses the concepts that are essential in the effective utilization of mass spectrometry. The title particularly covers the fundamentals of the modern techniques, along with the technological concerns of mass spectrometry. The opening chapter of the selection introduces mass spectrometry, while the subsequent chapters cover the fundamentals and hardware. The next chapters talk about the analytical chemistry consequences and the ion-genetic relationships. The remaining chapter covers the application of mass spectrometry, which includes structural, mechanistic, chemical, and biochemical applications. The book will be of great use to organic and analytical chemists. Chemists from other branch of chemistry, along with practitioners of related fields such as chemical engineering will also benefit from the text.

  • Basic Molecular Spectroscopy

    • 1st Edition
    • P.A. Gorry
    • English
    BASIC Molecular Spectroscopy discusses the utilization of the Beginner's All-purpose Symbolic Instruction Code (BASIC) programming language in molecular spectroscopy. The book is comprised of five chapters that provide an introduction to molecular spectroscopy through programs written in BASIC. The coverage of the text includes rotational spectra, vibrational spectra, and Raman and electronic spectra. The book will be of great use to students who are currently taking a course in molecular spectroscopy.

  • Prostaglandins and Thromboxanes

    Butterworths Monographs in Chemistry
    • 1st Edition
    • Roger F. Newton + 1 more
    • English
    Prostaglandins and Thromboxanes explores the two members of the prostanoid class of fatty acid. This book attempts to thoroughly discuss the topic after collecting enough information through research in physical and biological sciences. As the title suggests, the book revolves around prostaglandins and thromboxanes. The book's first chapter contains a discussion on the subject's history, stating the year of discovery and crediting the scientist who coined the names. The chapter ends talking about the possible uses of prostaglandins and thromboxanes in the clinic. The chapters that follow discuss the two lipids' basic and advanced synthesis, pharmacology, biosynthesis, biological activity, chemical interconversions, and metabolism, along with its subtopics. The book will serve as an excellent reference for undergraduate and graduate students in the related field.

  • Energetic Nanomaterials

    Synthesis, Characterization, and Application
    • 1st Edition
    • Vladimir E Zarko + 1 more
    • English
    Energetic Nanomaterials: Synthesis, Characterization, and Application provides researchers in academia and industry the most novel and meaningful knowledge on nanoenergetic materials, covering the fundamental chemical aspects from synthesis to application. This valuable resource fills the current gap in book publications on nanoenergetics, the energetic nanomaterials that are applied in explosives, gun and rocket propellants, and pyrotechnic devices, which are expected to yield improved properties, such as a lower vulnerability towards shock initiation, enhanced blast, and environmentally friendly replacements of currently used materials. The current lack of a systematic and easily available book in this field has resulted in an underestimation of the input of nanoenergetic materials to modern technologies. This book is an indispensable resource for researchers in academia, industry, and research institutes dealing with the production and characterization of energetic materials all over the world.

  • Luminescence and the Light Emitting Diode

    The Basics and Technology of LEDS and the Luminescence Properties of the Materials
    • 1st Edition
    • E. W. Williams + 1 more
    • B.R. Pamplin
    • English
    Luminescence and the Light Emitting Diode: The Basics and Technology of LEDS and the Luminescence Properties of the Materials focuses on the basic physics and technology of light emitting diodes (LEDS) and pn junction lasers as well as their luminescence properties. Optical processes in semiconductors and the useful devices which can be made are discussed. Comprised of 10 chapters, this book begins with an introduction to the crystal structure and growth, as well as the optical and electrical properties of LED materials. The detailed fabrication of the LED is then considered, along with the luminescence of the material and the diode light emission. Subsequent chapters explore solid-state lasers made from LED materials; the equipment used to measure luminescence, cathodoluminescence, and diode electro-optic characteristics; and luminescence in gallium arsenide, GaAs1-xPx, and gallium phosphide. Other LED materials such as silicon carbide and ternary semiconducting compounds are also surveyed. The text concludes with a brief chapter that describes some of the applications of LEDs and LED products. This monograph will be of value to students and non-graduate engineers with an interest in LEDs.

  • Advances in Mathematical Chemistry and Applications: Volume 2

    • 1st Edition
    • Subhash C. Basak + 2 more
    • English
    Advances in Mathematical Chemistry and Applications highlights the recent progress in the emerging discipline of discrete mathematical chemistry. Editors Subhash C. Basak, Guillermo Restrepo, and Jose Luis Villaveces have brought together 27 chapters written by 68 internationally renowned experts in these two volumes. Each volume comprises a wise integration of mathematical and chemical concepts and covers numerous applications in the field of drug discovery, bioinformatics, chemoinformatics, computational biology, mathematical proteomics, and ecotoxicology. Volume 2 explores deeper the topics introduced in Volume 1, with numerous additional topics such as topological approaches for classifying fullerene isomers; chemical reaction networks; discrimination of small molecules using topological molecular descriptors; GRANCH methods for the mathematical characterization of DNA, RNA and protein sequences; linear regression methods and Bayesian techniques; in silico toxicity prediction methods; drug design; integration of bioinformatics and systems biology, molecular docking, and molecular dynamics; metalloenzyme models; protein folding models; molecular periodicity; generalized topologies and their applications; and many more.

  • Advances in Mathematical Chemistry and Applications: Volume 1

    • 1st Edition
    • Subhash C. Basak + 2 more
    • English
    Advances in Mathematical Chemistry and Applications highlights the recent progress in the emerging discipline of discrete mathematical chemistry. Editors Subhash C. Basak, Guillermo Restrepo, and Jose Luis Villaveces have brought together 27 chapters written by 68 internationally renowned experts in these two volumes. Each volume comprises a wise integration of mathematical and chemical concepts and covers numerous applications in the field of drug discovery, bioinformatics, chemoinformatics, computational biology, mathematical proteomics, and ecotoxicology. Volume 1 includes chapters on mathematical structural descriptors of molecules and biomolecules, applications of partially ordered sets (posets) in chemistry, optimal characterization of molecular complexity using graph theory, different connectivity matrices and their polynomials, use of 2D fingerprints in similarity-based virtual screening, mathematical approaches to molecular structure generation, comparability graphs, applications of molecular topology in drug design, density functional theory of chemical reactivity, application of mathematical descriptors in the quantification of drug-likeness, utility of pharmacophores in drug design, and much more.

  • Concepts of Mathematical Physics in Chemistry: A Tribute to Frank E. Harris - Part B

    • 1st Edition
    • Volume 72
    • English
    Concepts of Mathematical Physics in Chemistry: A Tribute to Frank E. Harris - Part B, presents a series of articles concerning important topics in quantum chemistry, including surveys of current topics in this rapidly-developing field that has emerged at the cross section of the historically established areas of mathematics, physics, chemistry, and biology.

  • Calorimetry

    • 1st Edition
    • Volume 567
    • English
    Calorimetry, the latest volume in the Methods in Enzymology series continues the legacy of this premier serial with quality chapters authored by leaders in the field. Calorimetry is a highly technical experiment and it is easy for new practioners to get fooled into interpreting artifacts as real experimental results. This volume will guide readers to get the most out of their precious biological samples and includes topics on specific protocols for the types of studies being conducted as well as tips to improve the data collection. Most importantly, the chapters will also help to identify pitfalls that need to be avoided to ensure that the highest quality results are obtained.

  • The Chemistry of Cationic Polymerization

    • 1st Edition
    • P. H. Plesch
    • English
    The Chemistry of Cationic Polymerization covers the fundamental aspects of organic chemistry that provide significant insights into the many facets of cationic polymerization processes and products. Each chapter deals with individual and groups of monomers. Considerable chapters examine the chemistry of oxygen compounds. Other chapters describe the techniques for cationic polymer analysis and detection. This text also considers sulfur compounds, particularly their polymerizations by radical and anionic mechanisms. The remaining chapters explore the polymerization and products of carbonium ions, related organic reactions and comparison with radical and anionic polymerizations, as well as the conspectus of kinetics and mechanism. This book is of great value to organic and polymer chemists.

  • Lithium Needs and Resources

    Proceedings of a Symposium Held in Corning, New York, 12-14 October 1977
    • 1st Edition
    • S. S. Penner
    • English
    Lithium: Needs and Resources focuses on the applications, reactions, and increasing demand for lithium, as well as the exploration methods used in the extraction of this element. The selection first offers information on the lithium industry, including markets for lithium metal and lithium compounds and lithium reserves. The text then surveys past and future development of the market for lithium in the global aluminum industry. Topics include effects of lithium carbonate, demand for aluminum, development of US demand, and survey of aluminum plants. The compilation takes a look at lithium ore in Brazil and lithium-bearing rocks in Clark County, Nevada, USA, including geology of lithium districts, future perspectives, and mineralogy and distribution of lithium. The text also discusses hydrogen-mineral reactions and their application to the removal of iron from spodumene. Considerations include iron removal process, crystal chemistry of spodumene, and hydrogen-mineral reactions. The publication surveys the deposits of lithium in the United Kingdom; exploration methods in the Tanco mine area in Manitoba, Canada; and the role of the U.S. Geological Survey in the lithium industry. The selection is a vital source of information for readers interested in studying the sources and applications of lithium.

  • Insights from Imaging in Bioinorganic Chemistry

    • 1st Edition
    • Volume 68
    • English
    Insights from Imaging in Bioinorganic Chemistry continues a long-running series that describes recent advances in scientific research, in particular, in the field of inorganic chemistry. Several highly regarded experts, mostly from academe, contribute on specific topics. The series editor chooses a sub-field within inorganic chemistry as the theme and focus of the volume, extending invitations to experts for their contributions; the current theme is insights from metal ion imaging in bioinorganic and medicinal chemistry.

  • The Alkaloids

    • 1st Edition
    • Volume 75
    • English
    For more than 60 years, The Alkaloids has been the leading book series in the field of alkaloid chemistry. In more than 70 volumes all aspects of alkaloids, including chemistry, biology and pharmacology, have been covered in high-quality timeless reviews written by renowned experts in the field.

  • Synthesis of Best-Seller Drugs

    • 1st Edition
    • Ruben Vardanyan + 1 more
    • English
    Synthesis of Best-Seller Drugs is a key reference guide for all those involved with the design, development, and use of the best-selling drugs. Designed for ease of use, this book provides detailed information on the most popular drugs, using a practical layout arranged according to drug type. Each chapter reviews the main drugs in each of nearly 40 key therapeutic areas, also examining their classification, novel structural features, models of action, and synthesis. Of high interest to all those who work in the captivating areas of biologically active compounds and medicinal drug synthesis, in particular medicinal chemists, biochemists, and pharmacologists, the book aims to support current research efforts, while also encouraging future developments in this important field.

  • Annual Reports on NMR Spectroscopy

    • 1st Edition
    • Volume 87
    • English
    Annual Reports on NMR Spectroscopy provides a thorough and in-depth accounting of the progress made in nuclear magnetic resonance (NMR) spectroscopy and its many applications. Nuclear magnetic resonance (NMR) is an analytical tool used by chemists and physicists to study the structure and dynamics of molecules. In recent years, no other technique has gained as much significance as NMR spectroscopy. It is used in all branches of science in which precise structural determination is required, and in which the nature of interactions and reactions in solution is being studied. Annual Reports on NMR Spectroscopy has established itself as a premier resource for both specialists and non-specialists alike who want to become familiar with the new techniques and applications of NMR spectroscopy.

  • Drug-Like Properties

    Concepts, Structure Design and Methods from ADME to Toxicity Optimization
    • 2nd Edition
    • Li Di + 1 more
    • English
    Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, only a fraction have sufficient ADME (absorption, distribution, metabolism, elimination) properties, and acceptable toxicology properties, to become a drug product that will successfully complete human Phase I clinical trials. Drug-Like Properties: Concepts, Structure Design and Methods from ADME to Toxicity Optimization, Second Edition, provides scientists and students the background and tools to understand, discover, and develop optimal clinical candidates. This valuable resource explores physiochemical properties, including solubility and permeability, before exploring how compounds are absorbed, distributed, and metabolized safely and stably. Review chapters provide context and underscore the importance of key concepts such as pharmacokinetics, toxicity, the blood-brain barrier, diagnosing drug limitations, prodrugs, and formulation. Building on those foundations, this thoroughly updated revision covers a wide variety of current methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties for process and product improvement. From conducting key assays for interpretation and structural analysis, the reader learns to implement modification methods and improve each ADME property. Through valuable case studies, structure-property relationship descriptions, and structure modification strategies, Drug-Like Properties, Second Edition, offers tools and methods for ADME/Tox scientists through all aspects of drug research, discovery, design, development, and optimization.

  • Introduction to Protein Mass Spectrometry

    • 1st Edition
    • Pradip K. Ghosh
    • English
    Introduction to Protein Mass Spectrometry provides a comprehensive overview of this increasingly important, yet complex, analytical technique. Unlike many other methods which automatically yield an absolutely unique protein name as output, protein mass spectrometry generally requires a deduction of protein identity from determination of peptide fragmentation products. This book enables readers to both understand, and appreciate, how determinations about protein identity from mass spectrometric data are made. Coverage begins with the technical basics, including preparations, instruments, and spectrometric analysis of peptides and proteins, before exploring applied use in biological applications, bioinformatics, database, and software resources. Citing the most recent and relevant work in the field of biological mass spectrometry, the book is written for researchers and scientists new to the field, but is also an ideal resource for those hoping to hone their analytical abilities.

  • In situ Spectroscopic Techniques at High Pressure

    • 1st Edition
    • Volume 7
    • Andreas Braeuer
    • English
    In situ Spectroscopic Techniques at High Pressure provides a comprehensive treatment of in-situ applications of spectroscopic techniques at high pressure and their working principles, allowing the reader to develop a deep understanding of which measurements are accessible with each technique, what their limitations are, and for which application each technique is best suited. Coverage is also given to the instrumental requirements for these applications, with respect to the high pressure instrumentation and the spectroscopic components of the equipment. The pedagogical style of the book is supplemented by the inclusion of "study questions" which aim to make it useful for graduate-level courses.

  • Semiconductor Heterojunctions

    • 1st Edition
    • B. L. Sharma + 1 more
    • B. R. Pamplin
    • English
    Semiconductor Heterojunctions investigates various aspects of semiconductor heterojunctions. Topics covered include the theory of heterojunctions and their energy band profiles, electrical and optoelectronic properties, and methods of preparation. A number of heterojunction devices are also considered, from photovoltaic converters to photodiodes, transistors, and injection lasers. Comprised of eight chapters, this volume begins with an overview of the theory of heterojunctions and a discussion on abrupt isotype and anisotype heterojunctions, along with graded heterojunctions. The reader is then introduced to the energy band profiles of isotype and anisotype heterojunctions, the practical aspects of their fabrication and characterization, and their electronic and optoelectronic properties. Some methods used in the preparation of heterojunctions are also described, including the chemical method, solution growth method, alloying method, and sputtering method. The remaining chapters focus on the characterization of the grown layers, examples of heterojunction devices, and experimental work on heterojunctions. This monograph is intended for research workers and graduate students.

  • The Encyclopedia of Mass Spectrometry

    Volume 9: Historical Perspectives, Part A: The Development of Mass Spectrometry
    • 1st Edition
    • English
    Volume 9: Historical Perspectives, Part A: The Development of Mass Spectrometry of The Encyclopedia of Mass Spectrometry describes and analyzes the development of many aspects of Mass Spectrometry. Beginning with the earliest types of Mass Analyzers, Historical Perspectives explores the development of many different forms of analytical processes and methods. The work follows various instruments and interfaces, to the current state of detectors and computerization. It traces the use of Mass Spectrometry across many different disciplines, including Organic Chemistry, Biochemistry, and Proteomics; Environmental Mass Spectrometry; Forensic Science; Imaging; Medical Monitoring and Diagnosis; Earth and Planetary Sciences; and Nuclear Science.Finally, the book covers the history of manufacturers and societies as well as the professionals who form the Mass Spectrometry community. Also available: Volume 9: Historical Perspectives, Part B: Notable People in Mass Spectrometry briefly reviews the lives and works of many of the major people who carried out this development.

  • Combustion Calorimetry

    Experimental Chemical Thermodynamics
    • 1st Edition
    • Stig Sunner + 1 more
    • English
    Combustion Calorimetry deals with expertise knowledge concerning the calorimetry of combustion reactions of an element or compound. After defining the use of units and physical constants, the book discusses the basic principles of combustion calorimetry and the various instruments and calorimeters used in the experiments to measure operations concerning temperatures and its time variations. One paper discusses the theory and design criteria of combustion calorimeter calibration. Another paper discusses the results obtained from a combustion calorimeter after it has measured the energy or enthalpy of combustion of an element or compound. The book then presents the need to define accurately the exact process in which a measured energy or enthalpy change is acknowledged. One paper then presents how to find an assessment of uncertainty for any experimentally determined value through analysis of random errors and the propagation of errors. Several papers discuss the combustion calorimetry of metals, of organometallic compounds, and of fluorine. One paper presents the technological applications of heat reaction especially in the design of a chemical production plant where a reactor volume should desirably be least expensive. The book then discusses the trends in combustion calorimetry such as the prevalence of a miniaturized bomb combustion calorimetry. This volume will be beneficial to researches, technicians, and scientists in the field of catalysis, biochemistry, synthetic chemistry, and medicine.

  • The Analytical Chemistry of Cannabis

    Quality Assessment, Assurance, and Regulation of Medicinal Marijuana and Cannabinoid Preparations
    • 1st Edition
    • Brian F. Thomas + 1 more
    • English
    A volume in the Emerging Issues in Analytical Chemistry series, The Analytical Chemistry of Cannabis: Quality Assessment, Assurance, and Regulation of Medicinal Marijuana and Cannabinoid Preparations provides analytical chemistry methods that address the latest issues surrounding cannabis-based products. The plethora of marketed strains of cannabis and cannabinoid-containi... products, combined with the lack of industry standards and labelling requirements, adds to the general perception of poor quality control and limited product oversight. The methods described in this leading-edge volume help to support the manufacturing, labelling, and distribution of safe and consistent products with known chemical content and demonstrated performance characteristics. It treats analytical chemistry within the context of the diverse issues surrounding medicinal and recreational cannabis in a manner designed to foster understanding and rational perspective in non-scientist stakeholders as well as scientists who are concerned with bringing a necessary degree of order to a field now characterized by confusion and contradiction.

  • Forced-Flow Layer Chromatography

    • 1st Edition
    • Erno Tyihak
    • English
    Forced-Flow Layer Chromatography takes a close look at the specifics of forced-flow layer chromatography techniques, from their evolution to the nuances of using these techniques in a variety of applications where traditional thin-layer chromatography (TLC) and high-performance thin-layer chromatography (HPTLC) are not as effective. This book presents a number of variations of TLC techniques, with special emphasis on the overpressured-layer chromatography (OPLC) technique and newer developments such as the BioArena System for biomedical analysis. The versatility of these forced-flow techniques opens up new avenues for the analysis of a large number of samples for high-throughput screening and for the analysis of very complex matrices, while the development of BioArena extends the use of these techniques to challenging new areas of bioanalysis.

  • Advances in Catalysis

    • 1st Edition
    • Volume 58
    • English
    Advances in Catalysis fills the gap between the journal papers and textbooks across the diverse areas of catalysis research. For more than 60 years, this series has been dedicated to recording progress in the field of catalysis, providing the scientific community with comprehensive and authoritative reviews. This series is an invaluable and comprehensive resource for chemical engineers and chemists working in the field of catalysis in both academia and industry.

  • Annual Reports in Computational Chemistry

    • 1st Edition
    • Volume 11
    • English
    Annual Reports in Computational Chemistry provides timely and critical reviews of important topics in computational chemistry as applied to all chemical disciplines. Topics covered include quantum chemistry, molecular mechanics, force fields, chemical education, and applications in academic and industrial settings. Focusing on the most recent literature and advances in the field, each article covers a specific topic of importance to computational chemists.

  • Frontiers in Computational Chemistry: Volume 1

    Computer Applications for Drug Design and Biomolecular Systems
    • 1st Edition
    • Zaheer Ul-Haq + 1 more
    • English
    Frontiers in Computational Chemistry, originally published by Bentham and now distributed by Elsevier, presents the latest research findings and methods in the diverse field of computational chemistry, focusing on molecular modeling techniques used in drug discovery and the drug development process. This includes computer-aided molecular design, drug discovery and development, lead generation, lead optimization, database management, computer and molecular graphics, and the development of new computational methods or efficient algorithms for the simulation of chemical phenomena including analyses of biological activity. In Volume 1, the leading researchers in the field have collected eight different perspectives in the application of computational methods towards drug design to provide an up-to-date rendering of the current field. This volume covers a variety of topics from G protein-coupled receptors, to the use of cheminformatics and bioinformatics, computational tools such as Molecular Mechanics Poisson-Boltzmann Surface Area, protein-protein interactions, the use of computational methods on large biological data sets, various computational methods used to identify pharmaceutically relevant targets, and more.

  • Frontiers in Computational Chemistry: Volume 2

    Computer Applications for Drug Design and Biomolecular Systems
    • 1st Edition
    • Zaheer Ul-Haq + 1 more
    • English
    Frontiers in Computational Chemistry, originally published by Bentham and now distributed by Elsevier, presents the latest research findings and methods in the diverse field of computational chemistry, focusing on molecular modeling techniques used in drug discovery and the drug development process. This includes computer-aided molecular design, drug discovery and development, lead generation, lead optimization, database management, computer and molecular graphics, and the development of new computational methods or efficient algorithms for the simulation of chemical phenomena including analyses of biological activity. In Volume 2, the authors continue the compendium with nine additional perspectives in the application of computational methods towards drug design. This volume covers an array of subjects from modern hardware advances that accelerate new antibacterial peptide identification, electronic structure methods that explain how singlet oxygen damages DNA, to QSAR model validation, the application of DFT and DFRT methods on understanding the action of nitrogen mustards, the design of novel prodrugs using molecular mechanics and molecular orbital methods, computational simulations of lipid bilayers, high throughput screening methods, and more.

  • Applications of NMR Spectroscopy: Volume 3

    • 1st Edition
    • Atta-ur Rahman + 1 more
    • English
    Applications of NMR Spectroscopy, Volume 3 presents the latest developments in the field of NMR spectroscopy, including the analysis of the structure-property relationship of polyphenols, breast cancer diagnosis, drug discovery and formulation, protein confirmation analysis using Fluorine NMR, and enaminone studies. The well-illustrated chapters contain comprehensive references to the recent literature. The content is ideal for readers who are seeking reviews and updates, as it consolidates scientific articles of a diverse nature into a single volume. The book is organized into sections based on disciplines such as food science and medical diagnostics, with each chapter written by eminent experts in the field. The applications presented cover a wide range of the field, such as drug development, medical imaging and diagnostics, food science, mining, petrochemical, process control, materials science, and chemical engineering, making this resource a multi-disciplinary reference.

  • Applications of NMR Spectroscopy: Volume 2

    • 1st Edition
    • Atta-ur Rahman + 1 more
    • English
    Applications of NMR Spectroscopy, Volume 2, originally published by Bentham and now distributed by Elsevier, presents the latest developments in the field of NMR spectroscopy, including the analysis of plant polyphenols, the role of NMR spectroscopy in neuroradiology, NMR–based sensors, studies on protein and nucleic acid structure and function, and mathematical formations for NMR spectroscopy in structural biology. The fully illustrated chapters contain comprehensive references to the recent literature. The applications presented cover a wide range of the field, such as drug development, medical imaging and diagnostics, food science, mining, petrochemical, process control, materials science, and chemical engineering, making this resource a multi-disciplinary reference with broad applications. The content is ideal for readers who are seeking reviews and updates, as it consolidates scientific articles of a diverse nature into a single volume. Sections are organized based on disciplines, such as food science and medical diagnostics. Each chapter is written by eminent experts in the field.

  • Applications of NMR Spectroscopy: Volume 1

    • 1st Edition
    • Atta-ur Rahman + 1 more
    • English
    Applications of NMR Spectroscopy, Volume 1, originally published by Bentham and now distributed by Elsevier, presents the latest developments in the field of NMR spectroscopy, including the analysis of edible oils and lipid content in foods, the role of NMR spectroscopy in the human metabolomics and the diagnosis of autism-related disorders, protein-protein interactions, and NMR spectroscopy of chiral molecules. The fully illustrated chapters contain comprehensive references to the recent literature. The applications presented cover a wide range of the field, such as drug development, medical imaging and diagnostics, food science, mining, petrochemical, process control, materials science, and chemical engineering, making this resource a multi-disciplinary reference with broad applications. The content is ideal for readers who are seeking reviews and updates, as it consolidates scientific articles of a diverse nature into a single volume. Sections are organized based on disciplines, such as food science and medical diagnostics. Each chapter is written by eminent experts in the field.

  • Advances in Heterocyclic Chemistry

    • 1st Edition
    • Volume 117
    • English
    Advances in Heterocyclic Chemistry is the definitive series in the field—one of great importance to organic chemists, polymer chemists, and many biological scientists. Because biology and organic chemistry increasingly intersect, the associated nomenclature also is being used more frequently in explanations. Written by established authorities in the field from around the world, this comprehensive review combines descriptive synthetic chemistry and mechanistic insight to yield an understanding of how chemistry drives the preparation and useful properties of heterocyclic compounds.

  • Advances in Physical Organic Chemistry

    • 1st Edition
    • Volume 49
    • English
    Advances in Physical Organic Chemistry series of volumes is the definitive resource for authoritative reviews of work in physical organic chemistry. It aims to provide a valuable source of information not only for physical organic chemists applying their expertise to both novel and traditional problems but also for non-specialists across diverse areas who identify a physical organic component in their approach to research. Its hallmark is quantitative, molecular level understanding of phenomena across a diverse range of disciplines.

  • Advances in Carbohydrate Chemistry and Biochemistry

    • 1st Edition
    • Volume 72
    • English
    Advances in Carbohydrate Chemistry and Biochemistry, part of a long running serial that began in 1945, provides critical and informative articles written by research specialists that integrate the industrial, analytical, and technological aspects of biochemistry, organic chemistry, and instrumentation methodology in the study of carbohydrates. Each article provides a definitive interpretation of the current status and future trends in carbohydrate chemistry and biochemistry.

  • Practical NMR Spectroscopy Laboratory Guide: Using Bruker Spectrometers

    • 1st Edition
    • John S. Harwood + 1 more
    • English
    Practical NMR Spectroscopy Laboratory Guide is designed to provide non-expert NMR users, typically graduate students in chemistry, an introduction to various facets of practical solution-state NMR spectroscopy. Each chapter offers a series of hands-on exercises, introducing various NMR concepts and experiments and guiding the reader in running these experiments using an NMR spectrometer. The book is written for use with a Bruker NMR spectrometer running TopSpin software versions 1 or 2. This practical resource functions both as a text for instructors of a practical NMR course and also as a reference for spectrometer administrators or NMR facility directors when doing user training. This guide serves as serve as excellent, practical resource on its own or as a companion book to Timothy Claridge’s High-Resolution NMR Techniques in Organic Chemistry, 2nd Edition (Elsevier, 2009).

  • Essentials of Coordination Chemistry

    A Simplified Approach with 3D Visuals
    • 1st Edition
    • Vasishta Bhatt
    • English
    Essentials of Coordination Chemistry: A Simplified Approach with 3D Visuals provides an accessible overview of this key, foundational topic in inorganic chemistry. Thoroughly illustrated within the book and supplemented by online 3D images and videos in full color, this valuable resource covers basic fundamentals before exploring more advanced topics of interest. The work begins with an introduction to the structure, properties, and syntheses of ligands with metal centers, before discussing the variety of isomerism exhibited by coordination compounds, such as structural, geometrical and optical isomerism. As thermodynamics and kinetics provide a gateway to synthesis and reactivity of coordination compounds, the book then describes the determination of stability constants and composition of complexes. Building upon those principles, the resource then explains a wide variety of nucleophilic substitution reactions exhibited by both octahedral and square planar complexes. Finally, the book discusses metal carbonyls and nitrosyls, special classes of compounds that can stabilize zero or even negative formal oxidation states of metal ions. Highlighting preparations, properties, and structures, the text explores the unique type of Metal-Ligand bonding which enable many interesting applications of these compounds. Thoughtfully organized for academic use, Essentials of Coordination Chemistry: A Simplified Approach with 3D Visuals encourages interactive learning. Advanced undergraduate and graduate students, as well as researchers requiring a full overview and visual understanding of coordination chemistry, will find this book invaluable.

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