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Inorganic Controlled Release Technology
Materials and Concepts for Advanced Drug Formulation
- 1st Edition - August 24, 2015
- Authors: Xiang Zhang, Mark Cresswell
- Language: English
- Hardback ISBN:9 7 8 - 0 - 0 8 - 0 9 9 9 9 1 - 3
- eBook ISBN:9 7 8 - 0 - 0 8 - 1 0 0 0 0 6 - 9
Inorganic Controlled Release Technology: Materials and Concepts for Advanced Drug Formulation provides a practical guide to the use and applications of inorganic controlle… Read more
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Request a sales quoteInorganic Controlled Release Technology: Materials and Concepts for Advanced Drug Formulation provides a practical guide to the use and applications of inorganic controlled release technology (iCRT) for drug delivery and other healthcare applications, focusing on newly developed inorganic materials such as bioresorbable glasses and bioceramics. The use of these materials is introduced for a wide range of applications that cover inorganic drug delivery systems for new drug development and the reformulation of existing drugs. The book describes basic concepts, principles, and industrial practices by discussing materials chemistry, physics, nano/microstructure, formulation, materials processing, and case studies, as well as the evaluation and characterization of iCRT systems commonly investigated during industrial R&D.
- Provides the first book on inorganic controlled release technology (iCRT), covering key aspects from chemistry, physics, synthetic methods, formulation design, characterization and evaluation
- Includes several industry-related case studies to provide practical guidance on how to use iCRT as an alternative to organic polymers systems for both future drug developments and other active ingredient applications
- Demonstrates how iCRT offers an unmet business need for improved, controlled release of actives versus traditional CRT systems, which are known to have difficulty with the controlled delivery of both poorly and highly water soluble drug compounds
- About the Author
- Preface
- Acknowledgments
- Key Features
- Chapter 1: Materials for Inorganic Controlled Release Technology
- Abstract
- 1.1 Introduction
- 1.2 Comparison between Organic and Inorganic CRT
- 1.3 Materials Chemistry and Processing Technology
- 1.4 Materials Physics and Drug-Loaded Micro/Nanostructure
- Chapter 2: Materials Fundamentals of Drug Controlled Release
- Abstract
- 2.1 Introduction of Materials Nanostructure
- 2.2 API Distribution Within Inorganic Matrices
- 2.3 Basic Understanding of Potential Molecular Interactions
- 2.4 Theory and Practical Modelling of Drug Controlled Release Kinetics
- Chapter 3: Materials Characterization of Inorganic Controlled Release
- Abstract
- 3.1 Introduction
- 3.2 Chemical Analysis
- 3.3 Physical Property Analysis
- 3.4 Microscopy
- 3.5 Technology for Evaluation of API and Inorganic CRT Carrying System
- Chapter 4: Silica-Based Amorphous Drug Delivery Systems
- Abstract
- 4.1 Introduction
- 4.2 Sol-Gel Chemistry and Processing
- 4.3 Ordered Mesoporous Silica
- 4.4 Non-Ordered Porous Silica for Controlled Release
- 4.5 Porous Silica for Improved Efficacy and Tolerability of Topically Administered Active Compounds
- Chapter 5: Mesoporous Bioactive Glass-Based Controlled Release Systems
- Abstract
- 5.1 Introduction
- 5.2 General Synthesis Methods for Mesoporous Bioactive Glasses
- 5.3 Mesoporous Glass-Based 3D Scaffold Structures
- 5.4 The Role of MBG Surface Functionalization for Controlling Active Release
- 5.5 Case Studies
- 5.6 Conclusions and Future Context
- Chapter 6: Calcium Phosphate Materials for Controlled Release Systems
- Abstract
- 6.1 Calcium Phosphate Materials and Their Properties
- 6.2 Calcium Phosphate Cements
- 6.3 Calcium Phosphate Foams for Drug Delivery
- 6.4 Drug Release from Calcium Phosphate Coatings
- Chapter 7: Alternative Inorganic Systems for Controlled Release Applications
- Abstract
- 7.1 Introduction
- 7.2 Clays
- 7.3 Alternative Mesoporous Inorganic CRT Materials
- 7.4 Nanoparticle Delivery Systems
- Chapter 8: Future Development of iCRT
- Abstract
- 8.1 Overview
- 8.2 Design and Development of Inorganic CRT Systems
- 8.3 Regulation and Relevant Issues
- 8.4 Summary
- Index
- No. of pages: 264
- Language: English
- Edition: 1
- Published: August 24, 2015
- Imprint: Butterworth-Heinemann
- Hardback ISBN: 9780080999913
- eBook ISBN: 9780081000069
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Xiang Zhang
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