Skip to main content
Elsevier

Books in Life sciences

  • Molecular Biology of RNA

    New Perspectives
    • 1st Edition
    • Masayori Inouye + 1 more
    • English
    Molecular Biology of RNA: New Perspectives provides an overview of the developments in RNA research as well as the approaches, strategies, and methodologies used. Most of the contributing authors in the present volume participated in the Fifth Stony Brook Symposium entitled "New Perspectives on the Molecular Biology of RNA" in May 1986. The text is organized into six parts. Part I contains papers dealing with RNA as an enzyme. Part II presents studies on RNA splicing. Part III examines RNA viruses while Part IV focuses on the role of RNA in DNA replication. Part V is devoted to the structure, function, and isolation of RNA. Finally, Part VI takes up the role of RNA in regulation and repression. This volume will help provide new direction and insight for those already working on the subject and will serve as a useful guide to those about to start research in the molecular biology of RNA.

  • Arthritis and Society

    The Impact of Musculoskeletal Diseases
    • 1st Edition
    • Nortin M. Hadler + 1 more
    • English
    Arthritis and Society examines the interaction between the structure of our society and the impact of rheumatic diseases on the lifestyle of those afflicted. It has drawn the distinction between the private and public experience of illness in order to produce a comprehensive analysis of the impact of musculoskeletal disease on society. This book is organized into three main sections. Section 1 analyzes the personal experience of pain of the groups frequently afflicted and discusses the epidemiology and scope of the systemic rheumatic diseases. Section 2 views the plight of those suffering from rheumatic disease from a different perspective. Section 3 highlights the importance of appropriate care and of establishing a more compassionate society which can help lessen the impact of the disease. It also considers the role of rehabilitation. This book will be of interest to people dealing with studies on arthritis and other rheumatic disease and also those interested in understanding the impact on societal structure on healthcare issues.

  • Foundations of Mathematical Biology

    Supercellular Systems
    • 1st Edition
    • Robert J. Rosen
    • English
    Foundations of Mathematical Biology, Volume III, is devoted to the treatment of behavior of whole organisms and groups of organisms. The viewpoint taken throughout the book is a holistic, phenomenological one. That is, the integrated behavior of these organisms and groups of organisms is not, in general, referred back to specific structural properties of interacting subunits (as in a reductionist scheme), but is rather treated on its own terms without invoking the properties of lower levels of organization. The book begins with an overview of organization and control in physiological systems, with emphasis on the mathematical techniques involved in more detailed investigations of specific physiological mechanisms. Separate chapters cover the cardiovascular system, with particular reference to blood flow; gross problems of organic form; a relational overview of physics, biology, and sociology; the automata theory in the context of the central nervous system; and populations of interacting organisms. The final chapter discusses the material presented in the entire work, some of its philosophical presuppositions and implications, and the possibility of constructing a unified theory of mathematical biology.

  • The Maternal Organism

    • 1st Edition
    • N. S. Assali
    • English
    Biology of Gestation, Volume I: The Maternal Organism, is the first of a two-volume treatise that aims to fill the void which exists among the various disciplines that deal with the process of gestation. This work brings together in a comprehensive form basic knowledge acquired through intensive research work carried out by many investigators in the various disciplines that deal directly or indirectly with the process of gestation. Hence, it should prove to be of great interest to the student, the research worker, and the academically oriented individual in the general field of reproduction and in the specific fields of obstetrics and pediatrics. The treatise should also provide a source of basic information to the clinician in obstetrics and pediatrics which should assist him in the interpretation and understanding of the underlying. The present book deals with the maternal organism and the changes that occur during gestation. It opens with a chapter on the mechanism of ovulation and its control. Subsequent chapters deal with the problems of gametogenesis, fertilization, migration, and implantation of the ovum; and various morphological and physiological aspects of the placenta. The final two chapters discuss the physiological and biochemical changes that occur in labor, the puerperium, and lactation; and the physiological processes that adjust the maternal organism to pregnancy.

  • Wildlife Feeding and Nutrition

    • 2nd Edition
    • Charles T. Robbins
    • Tony J. Cunha
    • English
    Wildlife Feeding and Nutrition fills a serious gap in the wildlife and animal nutrition literature by providing a discussion of the basic principles of nutrition and their application to the broader field of wildlife ecology. This book is based on lectures presented in an upper-level wildlife nutrition course taught at Washington State University. The book opens with an introductory chapter on wildlife nutrition. This is followed by separate chapters on general nutrient and energy requirements; protein, water, vitamin, and mineral requirements; impact of nutrition on reproductive characteristics; gastrointestinal anatomy and function; and digestion and nutrient metabolism. The text will be invaluable to wildlife biologists, to those who are interested in captive animal nutrition and management, and to those who are interested in improving the feed supply and nutrition of free-ranging wildlife. It should also be helpful to undergraduate and graduate students as well as teachers of biology and wildlife management. The book will be a useful reference for all who are interested and concerned with wildlife throughout the world.

  • The Evolution of the Metazoa

    International Series of Monographs on Pure and Applied Biology: Zoology, Vol. 16
    • 1st Edition
    • Jovan Hadži
    • G. A. Kerkut
    • English
    Zoology, Volume 16: The Evolution of the Metozoa presents the significant results of the Cnidaria research, their interpretations and implications in the field of zoology. This book is composed of four chapters, and begins with the establishment of the systematic position of the Spongiae, the position of Ctenophora in the animal classification, and Cnidaria as the only Coelenterata. The subsequent chapter deals with a critical survey of the interpretations of the origin and nature of Cnidaria, with emphasis on the morphologic proofs of its phylogeny. These topics are followed by an outline of the most probable reconstruction of the phylogeny of Cnidaria and the descriptions of the evolution of this metozoa. The final chapter considers the established classification of the animal world and the genealogical tree. This book will be of value to zoologists and researchers who are interested in evolution and classification of Cnidaria.

  • Inflammation, Advancing Age and Nutrition

    Research and Clinical Interventions
    • 1st Edition
    • Irfan Rahman + 1 more
    • English
    The book provides a comprehensive overview to understanding the integrated impact of the concepts of cellular and molecular aspects, models, environmental factors, and lifestyle involved in premature aging. Additionally, it examines how functional food, dietary nutraceuticals or pharmacological compounds can reverse inflammation and premature aging based on personalized medicine. This book is a valuable resource for health professionals, scientists and researchers, nutritionists, health practitioners, students and for all those who wish to broaden their knowledge in the allied field.

  • Synaptic Constituents in Health and Disease

    Proceedings of the Third Meeting of the European Society for Neurochemistry, Bled, August 31st to September 5th, 1980
    • 1st Edition
    • Miro Brzin + 2 more
    • English
    Synaptic Constituents in Health and Disease is a collection of papers from the Proceedings of the Third Meeting of the European Society for Neurochemistry held in Yugoslavia, on August 31-September 5, 1980. This collection deals with gene analysis, the diagnosis, and treatment of inherent errors in metabolism. One paper discusses the role of vesicles in cholinergic systems in terms of the vesicle hypothesis or the cytosol hypothesis. Another paper focuses on the molecular organization of chromaffin granulles—the catecholamine-storin... vesicles of the adrenal medulla. One author discusses the interaction between antibodies and receptors in receptors such as insulin, TSH, prolactin, or estrogens. Another paper examines the occurrence and postulated functions of trans-synaptic structures to find out whether some kind of structural continuity exists, beyond mere contact, between the plasma membranes of two synapsing neurons. One other paper shows that morphological evidences of damage on nerve cells in some brain areas are found after gerbils inhaling an industrial solvent, trichloroethylene (TCE), The paper also discusses general topics in neurochemistry such as the DNA turnover in rat cerebral cortex. This collection can prove invaluable for biologists, medical and chemical researchers, molecular scientists, and the neuro-chemist investigators.

  • Entropy for Biologists

    An Introduction to Thermodynamics
    • 1st Edition
    • Harold J. Morowitz
    • English
    Entropy for Biologists: An Introduction to Thermodynamics is an introductory book for people in the life sciences who wish to master the concepts of thermal physics without being forced to a degree and rate of symbol manipulation which is foreign to their patterns of thought. The book opens with a chapter on temperature, followed by separate chapters that discuss the concepts of energy, kinetic theory, total energy, the second law of thermodynamics, entropy, and probability and information theory. Subsequent chapters deal with statistical mechanics and its relation to thermodynamics, free-energy functions, applications of the Gibbs free energy and the Gibbs chemical potential, and measurement in thermal physics. The book is primarily directed at those graduate and advanced undergraduate students of biology and biochemistry who wish to develop a sense of confidence about their understanding of the thermal physics which will be useful in pursuing their work. It may also prove useful to professionals who wish to bolster their knowledge in this area.

  • Fish in Research

    A Symposium on The Use of Fish as an Experimental Animal in Basic Research
    • 1st Edition
    • Otto W. Neuhaus + 1 more
    • English
    Fish in Research comprised of papers presented at a symposium entitled ""Fish in Research"" sponsored by the University of South Dakota in Vermillion. The purpose of the symposium was to ask those directly involved in research on fish, ""What unique information of biochemical and physiological processes can be gained by using fish as experimental animals?"" The book presents the environment aspects of neoplasia in fishes; experimental fish neoplasia; and the comparative aspects of neoplasia in fish and other laboratory animals. The text also includes papers on the control of cholesterol synthesis in normal malignant tissue; the biochemical aspects of salt; and steroidogenesis in fish. Papers on the lipid catabolism in fish muscle; the contrasts between fish and warm blooded vertebrates in enzymes systems of intermediary metabolism; and quantitative inheritance and environmental response of rainbow trout are also considered. The book further tackles the blood groups in salmonid fishes; ontogeny of lactate dehydrogenase isozymes in trout; and amino acid and protein requirements of fish. The text also looks into the inorganic salt effects on growth; salt water adaption; and gill ATPase of pacific salmon. Zoologists and scientists involved in fisheries research will find the book invaluable.

  • The Biology of the Coleoptera

    • 1st Edition
    • R. A. Crowson
    • English
    The Biology of the Coleoptera covers the branches of modern biology of Coleoptera. The book discusses the biological study of beetles; some skeletal peculiarities and the internal structures of the adults. The text also describes some structural features of larvae and pupae; food, digestion and the alimentary canal; and blood, osmoregulation, reserves, excretion and endocrine organs. The locomotion, respiration and energetics; the senses; and the cuticular properties, appearance, color and luminosity are also considered. The book further tackles the adult and larval behavior; the development and life-cycles; and the cytology and genetics. The text also looks into water beetles; special habitats; predation and defence; and symbiotic and parasitic relations. The ecological triangle: beetles, fungi and trees; and herbivorous beetles are also looked into. The book also discusses the role of beetles as ecological indicators; and the evolutionary history of beetles. Entomologists, ecologists, and biologists will find the book useful.

  • New Protein Foods

    Animal Protein Supplies
    • 1st Edition
    • Aaron M. Altschul + 1 more
    • English
    New Protein Foods, Volume 4: Animal Protein Supplies, Part B covers the realities of the world food problems, with special emphasis on protein supply. The book discusses the upper limits of livestock production; the government policy and the production of animal protein; and the nutritional and metabolic impact of variable protein intake in human. The text also describes the developments in pork production; issues in poultry production; as well as the use of small ruminants as food producers. The role of lysine and methionine fortification in animal and human nutrition is also considered. The book further tackles the use of microorganisms as feed and food protein; noncompetitive sources of carbohydrates for animal feeding; and recycling of animal wastes by feeding. The text concludes by discussing issues of affluent society malnutrition as the counterpart to the problems of scarcity. Nutritionists, agriculturists, economists, and people involved in public health and animal research will find the book invaluable.

  • Methods of Animal Experimentation

    Volume VI
    • 1st Edition
    • William I. Gay
    • English
    Methods of Animal Experimentation, Volume VI is a compendium of papers that defines which animals will prove most useful in biological experiments using the best methods in an environment of complex technologies and therapies. One paper reviews the genetic methods in animal experimentation including tests of Mendelian ratios, chromosomes crossing-over, chromosome anomalies, and gene transfer that produces congenic strains. Another paper explains the concepts and methodologies used in animals in ophthalmic research, particularly in ocular pharmacology, aqueous humor dynamics, glaucoma, and animal models of non-infectious uveitis. One paper analyzes the neural mechanisms of pain in an intact nervous system following ethical and moral principles of human treatment. For example, the use of different stimuli to elicit pain is applied only in situations where the stimuli is more appropriate, whether in behavioral or physiological experiments. The paper provides a list of requirements for the ideal pain stimulus. Another paper describes the methods in using standard animal models when an unknown agent is to be given as a general or local anesthesia. This book can prove beneficial to researchers, scientists, and laboratory technicians dealing with animals in relation to pharmacological, biological, chemical, and physiological research.

  • Protides of the Biological Fluids

    Proceedings of the Twenty-Fifth Colloquium, Brugge, 1977
    • 1st Edition
    • H. Peeters
    • English
    Protides of the Biological Fluids: Proceedings of the 25th Colloquium, Brugge, 1977 focuses on the structure, metabolism, transformations, and reactions of protides of biological fluids. The selection first takes a look at the structure and metabolism of plasma lipoproteins, including phosphatidylinositol exchange protein from bovine brain; structural integrity of the mitochondrial adenine nucleotide carrier; and reassembly of the monosaccharide transport system of the human erythrocyte in black lipid membranes. The book then discusses species and dietary effects on lipoprotein apoprotein metabolism in vivo; transfer of surface and core lipids of a lipoprotein from plasma into aortic wall; and pathophysiological implications of hyperlipoproteinemia... The text focuses on lipoproteins of human peripheral lymph, portacaval shunt and lipid metabolism, and low density lipoprotein catabolism in the liver. The methods and results of experiments are presented. The book also discusses the effects of dietary cholesterol on serum lipoprotein in human; long-term effects of physical training on blood lipids and lipoproteins in primary hyperlipoproteinemia... and effects of clofibrate on plasma proteins in subjects with hypertriglyceridemia... The selection is a vital source of data for readers wanting to study the protides of biological fluids.

  • Cystoscopy and Urography

    • 2nd Edition
    • Jas. B. MacAlpine
    • English
    Cystoscopy and Urography, Second Edition presents the significant advances in instrumentation and application of cytoscopy and urography. This book is organized into two parts encompassing 27 chapters. This edition adds six additional chapters from the first edition; three of these concern urography. The three other chapters survey pelvic resorption, excretion urography, and pyeloscopy. Other chapters deal with fistula of the bladder, funnel-neck deformity of the bladder, and congenital abnormalities of the kidney and ureter. This book also covers the topics of renal tuberculosis, purpura, and a description of endoscopic prostatic surgery. This book is of value to surgeons and urologists.

  • Progress in Liver Diseases

    Volume 2
    • 1st Edition
    • Hans Popper + 1 more
    • English
    Progress in Liver Diseases, Volume II presents the progress made in the understanding of bilirubin metabolism and secretion. This book discusses the mechanisms underlying the transport of bilirubin in the liver, intestine, and kidney. Organized into 31 chapters, this volume begins with an overview of bilirubin metabolism and secretion from the point of view of transport within the liver cell. This text then discusses the relation of hematopoietic factors and coagulation mechanisms to hepatic function. Other chapters consider the etiology of viral hepatitis. This book discusses as well the appearance of genetic considerations in liver disease, as a reflection of progress in this discipline. The final chapter deals with the effects of closer relations with other nations and of migration from foreign lands and vice-versa, which have continued the interest in geographic pathology. This book is a valuable resource for pathologists, physicians, biochemists, physiologists, clinicians, and clinical researchers.

  • Antibiotics

    Origin, Nature and Properties
    • 1st Edition
    • Tadeusz Korzybski + 2 more
    • English
    Antibiotics: Origin, Nature and Properties, Volume I is a systematic coverage of the sources, varieties, and properties of the antibiotics. This book is organized into two main parts encompassing 13 chapters. This book considers the antibiotics according to their sources. It describes the antibiotics produced by bacteria, Actinomycetes,Fungi imperfecti, Basidiomycetes, algae, lichens and green plants, and those from animal sources. This group of antibiotics includes, streptomycin, the tetracyclines, chloromycetin, the macrolide family of compounds of which erythromycin, magnamycin and spiramycin are members, and the antifungal polyene compounds. The members of each group are arranged according to their chemical and biological similarity. Sections on each antibiotic present complete information, including the name, description of the producing strains, composition of the media, methods of culture, isolation and purification of the antibiotic principle, its physical and chemical properties, antibiotic spectrum, toxicity for laboratory animals, results of treatment of experimental infections, and possible clinical applications. This book is of value to researchers and workers in various medical fields.

  • Control of Mycotoxins

    Special Lectures Presented at the Symposium on the Control of Mycotoxins Held at Göteborg, Sweden, 21—22 August 1972
    • 1st Edition
    • P. Krogh
    • English
    Control of Mycotoxins provides information pertinent to the fundamental aspects of the control of mycotoxins. This book provides a review of the toxicology of aflatoxins in the food industry. Organized into 13 chapters, this book begins with an overview of the significant association between tumor-bearing and alpha-foetoprotein when a sensitive immunoautoradiograph... method was used. This text then examines the methodology of assay of aflatoxins in food and feed products, as well as their application to the control of mycotoxins. Other chapters review some areas of research at the Northern Regional Research Laboratory involving the effects of insecticide treatment of sterile and unsterile wheat on the formation of aflatoxin and ochratoxin. This book discusses as well the methods for the extraction and determination of aflatoxins from cereals. The final chapter deals with the toxicological study of Fusarium toxicoses. This book is a valuable resource for chemists, microbiologists, biologists, toxicologists, nutritionists, scientists, and veterinarians.

  • The Origins of Prebiological Systems and of Their Molecular Matrices

    Proceedings of a Conference Conducted at Wakulla Springs, Florida, on 27-30 October 1963 under the Auspices of the Institute for Space Biosciences, the Florida State University and the National Aeronautics and Space Administration
    • 1st Edition
    • Sidney W. Fox
    • English
    The Origins of Prebiological Systems and of their Molecular Matrices covers the proceedings of the conference conducted at Wakulla Springs, Florida on 27-30 October 1963 under the Auspices of the Institute for Space Biosciences, the Florida State University, and the National Aeronautics and Space Administration. The publication focuses on the processes, methodologies, and assumptions on the origin of life, as well as evolution, molecular matrices, geochemistry, and hydrogenation. The selection first offers information on random polymers as a matrix for chemical evolution, the folly of probability, and molecular matrices for living systems. Discussions focus on ultraviolet photoproduction of polymers, melanin as a random polymer, and random polymer on the primitive earth. The book then takes a look at the aspects of the geochemistry of amino acids; asymmetric hydrogenation of carbonyl compounds; and stages and mechanisms of prebiological organic synthesis. The publication tackles thermal synthesis of amino acids from a hypothetically primitive terrestrial atmosphere and primordial ultraviolet synthesis of nucleoside phosphates. The text also ponders on the probable synthesis of porphine-like substances during chemical evolution; thermal polycondensation of free amino acids with polyphosphoric acid; and random polycondensation of sugars. The selection is highly recommended for readers interested in the origins of prebiological systems.

  • The Spleen and Some of Its Diseases

    Being the Bradshaw Lecture of the Royal College of Surgeons of England, 1920
    • 1st Edition
    • Berkeley Moynihan
    • English
    The Spleen and Some of its Diseases provides information pertinent to the fundamental aspects of the spleen. This book discusses the role that spleen plays in the etiology of diseases whose most obvious symptoms are evoked by associated or consecutive affections of other organs. Organized into 14 chapters, this book begins with an overview of the anatomy of the spleen, which is entirely covered with peritoneum and is situated behind the fundus of the stomach. This text then describes the first recorded case of splenectomy. Other chapters consider the effect of splenectomy in man and animals upon the general health, upon the blood, and upon the various tissues. This book discusses as well the biochemical investigations upon the spleen and upon the metabolic activities of the body. The final chapter deals with the determination of the functional capacity of all the various organs. This book is a valuable resource for surgeons and physicians.

  • Workbook for Pharmacy Practice Today for the Pharmacy Technician

    Career Training for the Pharmacy Technician
    • 1st Edition
    • LiAnne C. Webster
    • English
    Reinforce your knowledge of the pharmacy technician role, and prepare for certification exams! Corresponding to the chapters in Pharmacy Practice for Today’s Pharmacy Technician: Career Training for the Pharmacy Technician, by LiAnne Webster, this practical workbook offers a wide variety of review questions relating to essential pharmacy technician tasks and skills. Critical thinking exercises help you apply what you’ve learned to real-life situations in pharmacy practice.

  • Practical Biology

    For Advanced Level, Medical and Intermediate Students
    • 5th Edition
    • C. J. Wallis
    • English
    Practical Biology for Advanced Level and Intermediate Students, Fifth Edition is an eight-part laboratory manual covering the syllabuses in biology of the advanced level students and other examinations of similar standard. The Introduction presents general instructions for practical work and for the keeping of practical notebooks and a list of apparatus and instruments required, as well as a summary of the characteristics of living organisms, the differences between plants and animals and the principles of plant classification. Part I describes first the features and uses of a microscope, followed by a presentation of guidelines for the preparation of microscopical slides. Parts II to IV are devoted to the evaluation of the form, structure, the microscopical structure of tissues and organs, and the very important aspect of their mode of functioning. Parts V to VIII explore the biochemical, embryological, and genetic aspects of life. These parts also consider other forms and modes of life, including insectivorous plants, fungi, bacteria, saprophytism, symbiosis, commensalism, and parasitism. This book is directed toward advanced and intermediate level botany teachers and students.

  • Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging

    Volume 2 - Role in General Diseases
    • 1st Edition
    • M. A. Hayat
    • English
    Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging is a complete, authoritative examination of the role of autophagy in health and disease. Understanding this phenomenon is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and forward thinking, this four-volume work offers a valuable guide to cellular processes while encouraging researchers to explore their potentially important connections. Understanding the role of autophagy is critical, considering its association with numerous biological processes, including cellular development and differentiation, cancer (both antitumor and protumor functions), immunity, infectious diseases, inflammation, maintenance of homeostasis, response to cellular stress, and degenerative diseases such as Alzheimer's, Parkinson's, Huntington's, amyotrophic lateral sclerosis, and prion diseases. Cell homeostasis is achieved by balancing biosynthesis and cellular turnover. In spite of the increasing importance of autophagy in various pathophysiological conditions mentioned above, this process remains underestimated and overlooked. As a consequence, its role in the initiation, stability, maintenance, and progression of these and other diseases (e.g., autoimmune disease) remains poorly understood. This work will broaden the knowledge base of academic and clinical professors, post-doctoral fellows, graduate and medical students regarding this vital biological process. Volumes in the Series Volume 1: Molecular Mechanisms. Elucidates autophagy’s association with numerous biological processes, including cellular development and differentiation, cancer, immunity, infectious diseases, inflammation, maintenance of homeostasis, response to cellular stress, and degenerative diseases such as Alzheimer’s, Parkinson's, Huntington's, amyotrophic lateral sclerosis, and prion diseases. Volume 2: Role in General Diseases. Describes the various aspects of the complex process of autophagy in a myriad of devastating human diseases, expanding from a discussion of essential autophagic functions into the role of autophagy in proteins, pathogens, immunity, and general diseases. Volume 3: Role in Specific Diseases. Explores the role of autophagy in specific diseases and developments, including: Crohn’s Disease, Gaucher Disease, Huntington’s Disease, HCV infection, osteoarthritis, and liver injury, with a full section devoted to in-depth exploration of autophagy in tumor development and cancer, as well as the relationship between autophagy and apoptosis.Volume 4: Mitophagy. Presents detailed information on the role of mitophagy, the selective autophagy of mitochondria, in health and disease, by delivering an in-depth treatment of the molecular mechanisms involved in mitophagy initiation and execution, as well as the role of mitophagy in Parkinson Disease, cardiac aging, and skeletal muscle atrophy. Volume 5: Role in Human Diseases. Comprehensively describes the role of autophagy in human diseases, delivering coverage of the antitumor and protumor roles of autophagy; the therapeutic inhibition of autophagy in cancer; and the duality of autophagy’s effects in various cardiovascular, metabolic, and neurodegenerative disorders.Volume 6: Regulation of Autophagy and Selective Autophagy. Provides coverage of the mechanisms of regulation of autophagy; intracellular pathogen use of the autophagy mechanism; the role of autophagy in host immunity; and selective autophagy. Volume 7: Role of Autophagy in Therapeutic Applications. Provides coverage of the latest developments in autophagosome biogenesis and regulation; the role of autophagy in protein quality control; the role of autophagy in apoptosis; autophagy in the cardiovascular system; and the relationships between autophagy and lifestyle. Volume 8: Autophagy and Human Diseases. Reviews recent advancements in the molecular mechanisms underlying a large number of genetic and epigenetic diseases and abnormalities, and introduces new, more effective therapeutic strategies, in the development of targeted drugs and programmed cell death, providing information that will aid on preventing detrimental inflammation.Volume 9: Necrosis and Inflammation in Human Diseases. Emphasizes the role of Autophagy in necrosis and inflammation, explaining in detail the molecular mechanism(s) underlying the formation of autophagosomes, including the progression of Omegasomes to autophagosomes.

  • Methods in Biomedical Informatics

    A Pragmatic Approach
    • 1st Edition
    • Indra Neil Sarkar
    • English
    Beginning with a survey of fundamental concepts associated with data integration, knowledge representation, and hypothesis generation from heterogeneous data sets, Methods in Biomedical Informatics provides a practical survey of methodologies used in biological, clinical, and public health contexts. These concepts provide the foundation for more advanced topics like information retrieval, natural language processing, Bayesian modeling, and learning classifier systems. The survey of topics then concludes with an exposition of essential methods associated with engineering, personalized medicine, and linking of genomic and clinical data. Within an overall context of the scientific method, Methods in Biomedical Informatics provides a practical coverage of topics that is specifically designed for: (1) domain experts seeking an understanding of biomedical informatics approaches for addressing specific methodological needs; or (2) biomedical informaticians seeking an approachable overview of methodologies that can be used in scenarios germane to biomedical research.

  • Laboratory Methods in Enzymology: DNA

    • 1st Edition
    • Volume 529
    • English
    Methods in Enzymology volumes provide an indispensable tool for the researcher. Each volume is carefully written and edited by experts to contain state-of-the-art reviews and step-by-step protocols. In this volume, we have brought together a number of core protocols concentrating on DNA, complementing the traditional content that is found in past, present and future Methods in Enzymology volumes.

  • Renal Disease in Cancer Patients

    • 1st Edition
    • Kevin W. Finkel + 1 more
    • English
    Renal Disease in Cancer Patients is a translational reference detailing the nephrological problems unique to patients with cancer in an organized and authoritative fashion. This book provides a common language for nephrologists, oncologists, hematologists, and other clinicians who treat cancer patients, to discuss the development of renal diseases in the context of cancer and options for their optimum diagnosis, management, and treatment. With the advent of better supportive care and the era of personalized medicine, patients with cancer are living longer, and oncologists and nephrologists now recognize the serious consequences of renal disease among these patients. Designed especially with this new need in mind, Renal Disease in Cancer Patients presents the various renal diseases affecting cancer patients in a single, authoritative volume. The book covers topics in radiation nephritis, obstructive nephropathy, drug nephropathy, graft-versus-host disease, and more.

  • Laboratory Animal Welfare

    • 1st Edition
    • Kathryn Bayne + 1 more
    • English
    Laboratory Animal Welfare provides a comprehensive, up-to-date look into the new science of animal welfare within laboratory research. Animals specifically considered include rodents, cats and dogs, nonhuman primates, agricultural animals, avian animals and aquatic animals. The book examines the impact of experiment design and environment on animal welfare, as well as emergency situations and euthanasia practices. Readers will benefit from a review of regulations and policy guidelines concerning lab animal use, as well as information on assessing animal welfare. With discussions of the history and ethics of animals in research, and a debate on contemporary and international issues, this book is a go-to resource for laboratory animal welfare.

  • Cognitive Electrophysiology of Attention

    Signals of the Mind
    • 1st Edition
    • George R. Mangun
    • English
    Cognitive Electrophysiology of Attention explores the fundamental mechanisms of attention and related cognitive functions from cognitive neuroscience perspectives. Attention is an essential cognitive ability that enables humans to process and act upon relevant information while ignoring distracting information, and the capacity to focus attention is at the core of mental functioning. Understanding the neural bases of human attention remains a key challenge for neuroscientists and psychologists, and is essential for translational efforts to treat attentional deficits in a variety of neurological and psychiatric disorders. Cognitive electrophysiology is at the center of a multidisciplinary approach that involves the efforts of psychologists, neuroscientists, neuropsychologists, psychiatrists, and neurologists to identify basic brain mechanisms and develop translational approaches to improve mental health. This edited volume is authored by leading investigators in the field and discusses methods focused on electrophysiological recordings in humans, including electroencephalograp... (EEG) and event-related potential (ERP) methods, and also incorporates evidence from functional magnetic resonance imaging (fMRI). Cognitive Electrophysiology of Attention illuminates specific models about attentional mechanisms in vision, audition, multisensory integration, memory, and semantic processing in humans.

  • Benign and Pathological Chromosomal Imbalances

    Microscopic and Submicroscopic Copy Number Variations (CNVs) in Genetics and Counseling
    • 1st Edition
    • Thomas Liehr
    • English
    Benign & Pathological Chromosomal Imbalances systematically clarifies the disease implications of cytogenetically visible copy number variants (CG-CNV) using cytogenetic assessment of heterochromatic or euchromatic DNA variants. While variants of several megabasepair can be present in the human genome without clinical consequence, visually distinguishing these benign areas from disease implications does not always occur to practitioners accustomed to costly molecular profiling methods such as FISH, aCGH, and NGS. As technology-driven approaches like FISH and aCGH have yet to achieve the promise of universal coverage or cost efficacy to sample investigated, deep chromosome analysis and molecular cytogenetics remains relevant for technology translation, study design, and therapeutic assessment. Knowledge of the rare but recurrent rearrangements unfamiliar to practitioners saves time and money for molecular cytogeneticists and genetics counselors, helping to distinguish benign from harmful CG-CNV. It also supports them in deciding which molecular cytogenetics tools to deploy.

  • From Plant Genomics to Plant Biotechnology

    • 1st Edition
    • Palmiro Poltronieri + 2 more
    • English
    With the appearance of methods for the sequencing of genomes and less expensive next generation sequencing methods, we face rapid advancements of the -omics technologies and plant biology studies: reverse and forward genetics, functional genomics, transcriptomics, proteomics, metabolomics, the movement at distance of effectors and structural biology. From plant genomics to plant biotechnology reviews the recent advancements in the post-genomic era, discussing how different varieties respond to abiotic and biotic stresses, understanding the epigenetic control and epigenetic memory, the roles of non-coding RNAs, applicative uses of RNA silencing and RNA interference in plant physiology and in experimental transgenics and plants modified to specific aims. In the forthcoming years these advancements will support the production of plant varieties better suited to resist biotic and abiotic stresses, for food and non-food applications.This book covers these issues, showing how such technologies are influencing the plant field in sectors such as the selection of plant varieties and plant breeding, selection of optimum agronomic traits, stress-resistant varieties, improvement of plant fitness, improving crop yield, and non-food applications in the knowledge based bio-economy.

  • Handbook of Food Powders

    Processes and Properties
    • 1st Edition
    • Bhesh Bhandari + 3 more
    • English
    Many food ingredients are supplied in powdered form, as reducing water content increases shelf life and aids ease of storage, handling and transport. Powder technology is therefore of great importance to the food industry. The Handbook of food powders explores a variety of processes that are involved in the production of food powders, the further processing of these powders and their functional properties.Part one introduces processing and handling technologies for food powders and includes chapters on spray, freeze and drum drying, powder mixing in the production of food powders and safety issues around food powder production processes. Part two focusses on powder properties including surface composition, rehydration and techniques to analyse the particle size of food powders. Finally, part three highlights speciality food powders and includes chapters on dairy powders, fruit and vegetable powders and coating foods with powders.The Handbook of food powders is a standard reference for professionals in the food powder production and handling industries, development and quality control professionals in the food industry using powders in foods, and researchers, scientists and academics interested in the field.

  • Essentials of Stem Cell Biology

    • 3rd Edition
    • Robert Lanza + 1 more
    • English
    First developed as an accessible abridgement of the successful Handbook of Stem Cells, Essentials of Stem Cell Biology serves the needs of the evolving population of scientists, researchers, practitioners, and students embracing the latest advances in stem cells. Representing the combined effort of 7 editors and more than 200 scholars and scientists whose pioneering work has defined our understanding of stem cells, this book combines the prerequisites for a general understanding of adult and embryonic stem cells with a presentation by the world's experts of the latest research information about specific organ systems. From basic biology/mechanisms, early development, ectoderm, mesoderm, endoderm, and methods to the application of stem cells to specific human diseases, regulation and ethics, and patient perspectives, no topic in the field of stem cells is left uncovered.

  • Global Clinical Trials for Alzheimer's Disease

    Design, Implementation, and Standardization
    • 1st Edition
    • Menghis Bairu + 1 more
    • English
    Global Clinical Trials for Alzheimer’s Disease is a handy one-stop reference for researchers and physicians planning and conducting global clinical trials in this area. This book addresses important considerations that may arise during the successful design and execution of these trials, including site selection, local regulatory issues, pharmacogenomics, ethical matters and much more. Given the saturation of traditional clinical trial markets and the worldwide progression of Alzheimer’s disease, there is a need to focus on clinical trials in emerging markets and developing countries. This book provides you with a practical approach to recognizing the opportunities and tackling the challenges that are present during the planning and execution of global clinical trials for Alzheimer’s disease.

  • Placebo and Pain

    From Bench to Bedside
    • 1st Edition
    • Luana Colloca + 2 more
    • English
    The placebo effect continues to fascinate scientists, scholars, and clinicians, resulting in an impressive amount of research, mainly in the field of pain. While recent experimental and clinical studies have unraveled salient aspects of the neurobiological substrates and clinical relevance of pain and placebo analgesia, an authoritative source remained lacking until now. By presenting and integrating a broad range of research, Placebo and Pain enhances readers’ knowledge about placebo and nocebo effects, reexamines the methodology of clinical trials, and improves the therapeutic approaches for patients suffering from pain. Review for Placebo and Pain:“This ambitious book is the first comprehensive and unified presentation of the placebo and nocebo phenomena in the area of pain. Written by the international leading experts in the field, the book provides an accurate up-to-date [work] on placebo and pain dealing with current perspectives and future challenging issues.”--Ted Kaptchuk, Associate Professor of Medicine, Harvard Medical School

  • Integrated Pest Management

    Current Concepts and Ecological Perspective
    • 1st Edition
    • Dharam P. Abrol
    • English
    Integrated Pest Management: Current Concepts and Ecological Perspective presents an overview of alternative measures to traditional pest management practices using biological control and biotechnology. The removal of some highly effective broad-spectrum chemicals, caused by concerns over environmental health and public safety, has resulted in the development of alternative, reduced risk crop protection products. These products, less toxic to the environment and easily integrated into biological control systems, target specific life stages or pest species. Predation — recognized as a suitable, long-term strategy — effectively suppresses pests in biotechnological control systems. Integrated Pest Management covers these topics and more. It explores the current ecological approaches in alternative solutions, such as biological control agents, parasites and predators, pathogenic microorganisms, pheromones and natural products as well as ecological approaches for managing invasive pests, rats, suppression of weeds, safety of pollinators, role of taxonomy and remote sensing in IPM and future projections of IPM. This book is a useful resource to entomologists, agronomists, horticulturists, and environmental scientists.

  • Gene Therapy of Cancer

    Translational Approaches from Preclinical Studies to Clinical Implementation
    • 3rd Edition
    • Edmund C. Lattime + 1 more
    • English
    Gene therapy as a treatment for cancer is at a critical point in its evolution. Exciting new developments in gene targeting and vector technology, coupled with results from the first generation of preclinical and clinical studies have led to the design and testing of new therapeutic approaches. The Third Edition of Gene Therapy of Cancer provides crucial updates on the basic and applied sciences of gene therapy. It offers a comprehensive assessment of the field including the areas of suicide gene therapy, oncogene and suppressor gene targeting, immunotherapy, drug resistance gene therapy, and the genetic modification of stem cells. Researchers at all levels of development, from basic laboratory investigators to clinical practitioners, will find this book to be instructive. Cancer gene therapy, like cancer therapy in general, is evolving rapidly, testing new concepts, targets and pathways, evoking new technologies, and passing new regulatory hurdles. Its essence, however, has not changed: the hope and challenges of returning altered genes to normal, using targeted gene expression to alter the function of both tumor and microenvironment, and in some cases normal cells, and delivering functionally important genes to specific cell types to increase sensitivity to killing or to protect normal cells from cancer therapies. In some instances, gene therapy for cancer forms a continuum from gene repair through the use of molecularly modified cells; the use of viral and non-viral vector based gene delivery to both tumor and tumor microenvironment; the use of viral and gene based vaccines; and development of new gene-based therapeutics. The unique mechanistically chosen vector platforms are at the heart of this technology because they allow for direct and selective cell death and transient to sustained delivery of vaccine molecules or molecules that affect the microenvironment, vasculature, or the immune response.

  • Advances in Planar Lipid Bilayers and Liposomes

    • 1st Edition
    • Volume 18
    • English
    Advances in Planar Lipid Bilayers and Liposomes cover a broad range of topics, including main arrangements of the reconstituted system, namely planar lipid bilayers as well as spherical liposomes. The invited authors present the latest results of their own research groups in this exciting, multidisciplinary field.

  • Genetic Steroid Disorders

    • 1st Edition
    • English
    This is a comprehensive book addressing steroid disorders from hormonal, genetic, psychological, and surgical perspectives. It is meant to educate adult and pediatric endocrinologists, clinical geneticists, genetic counselors, reproductive endocrinologists, neonatologists, urologists, and psychoendocrinologis... It will assist these specialists in the diagnosis and treatment of steroid disorders. The book is written for postgraduate and faculty-level physicians. The content consists of steroid disorders, genetic bases for the disorder and case presentations of each disorder.

  • Microtubules, in vitro

    • 2nd Edition
    • Volume 115
    • John J. Correia + 1 more
    • English
    There continues to be intense interest in the microtubule cytoskeleton; the assembly, structure and regulation of microtubules; and the numerous motors and accessory proteins that control cell cycle, dynamics, organization and transport. The field continues to grow and explore new aspects of these issues driven immensely by developments in optical imaging and tracking techniques. This Second Edition brings together current research and protocols in the field of microtubules in vitro and will serve as a valuable tool for cell biologists, biophysicists and pharmacologists who study the microtubule cytoskeleton, as well as for researchers in the biomedical and biotechnology communities with interest in developing drugs that target microtubules, MAPS and motors.

  • Developmental Timing

    • 1st Edition
    • Volume 105
    • English
    This new volume of Current Topics in Developmental Biology covers developmental timing, with contributions from an international board of authors. The chapters provide a comprehensive set of reviews covering such topics as the timing of developmental programs in Drosophila, temporal patterning of neural progenitors, and environmental modulation of developmental timing.

  • Peripheral Nerve Disorders

    • 1st Edition
    • Volume 115
    • Gérard Said + 1 more
    • English
    Disorders of the peripheral nervous system (PNS) are the cause of prominent neurological symptoms including weakness, sensory loss, pain and autonomic dysfunction associated with deficits, morbidity and mortality. These disorders may be primary hereditary or cryptogenic neurologic disorders confined to the PNS or part of the pathology of both the central nervous system and the PNS. Most PNS disorders are secondary to other system disorders and may be responsive to treatment of the primary disease. Important advances have been obtained in several areas including molecular genetics, biochemistry, immunology, morphology and physiology that have enhanced our understanding of the causes and consequences of damage to peripheral nerve. Understanding of both these groups of PNS diseases has greatly expanded over recent years and has led to important advances of treatment both to protect and to repair damages of peripheral nerve. This volume provides an overview of the state-of-the-art of examination, diagnosis and treatment of these very diverse disorders and will be of interest to both the research and clinical neuroscience and neurology communities.

  • Mathematical Neuroscience

    • 1st Edition
    • Stanislaw Brzychczy + 1 more
    • English
    Mathematical Neuroscience is a book for mathematical biologists seeking to discover the complexities of brain dynamics in an integrative way. It is the first research monograph devoted exclusively to the theory and methods of nonlinear analysis of infinite systems based on functional analysis techniques arising in modern mathematics. Neural models that describe the spatio-temporal evolution of coarse-grained variables—such as synaptic or firing rate activity in populations of neurons —and often take the form of integro-differential equations would not normally reflect an integrative approach. This book examines the solvability of infinite systems of reaction diffusion type equations in partially ordered abstract spaces. It considers various methods and techniques of nonlinear analysis, including comparison theorems, monotone iterative techniques, a truncation method, and topological fixed point methods. Infinite systems of such equations play a crucial role in the integrative aspects of neuroscience modeling.

  • Dynamics of Proteins and Nucleic Acids

    • 1st Edition
    • Volume 92
    • English
    Published continuously since 1944, Advances in Protein Chemistry and Structural Biology has been a continuous, essential resource for protein chemists. Covering reviews of methodology and research in all aspects of protein chemistry, including purification/express... proteomics, modeling and structural determination and design, each volume brings forth new information about protocols and analysis of proteins while presenting the most recent findings from leading experts in a broad range of protein-related topics.

  • Toxoplasma Gondii

    The Model Apicomplexan - Perspectives and Methods
    • 2nd Edition
    • Louis M. Weiss
    • English
    This 2e of Toxoplasma gondii reflects the significant advances in the field in the last 5 years, including new information on the genomics, epigenomics and proteomics of T. gondii as well as a new understanding of the population biology and genetic diversity of this organism. T. gondii remains the best model system for studying the entire Apicomplexa group of protozoans, which includes Malaria, making this new edition essential for a broad group of researchers and scientists. Toxoplasmosis is caused by a one-celled protozoan parasite known as T. gondii. The infection produces a wide range of clinical syndromes in humans, land and sea mammals, and various bird species. Most humans contract toxoplasmosis by eating contaminated, raw or undercooked meat (particularly pork), vegetables, or milk products; by coming into contact with the T. gondii eggs from cat feces; or by drinking contaminated water. The parasite damages the ocular and central nervous systems, causing behavioral and personality alterations as well as fatal necrotizing encephalitis. It is especially dangerous for the fetus of an infected pregnant woman and for individuals with compromised immune systems, such as HIV-infected patients.

  • Fundamentals of Weed Science

    • 4th Edition
    • Robert L Zimdahl
    • English
    This book addresses herbicides and their use as an important aspect of modern weed management and strives to place them in an ecological framework. Many weed scientists believe agriculture is a continuing struggle with weeds--without good weed control, good and profitable agriculture is impossible. Each agricultural discipline sees itself as central to agriculture's success and continued progress, and weed science is no exception. While not denying the importance of weed management to successful agriculture, this book places it in a larger ecological context. The roles of culture, economics, and politics in weed management are also discussed, enabling scientists and students to understand the larger effects on society.

  • Advances in Applied Microbiology

    • 1st Edition
    • Volume 85
    • English
    Published since 1959, Advances in Applied Microbiology continues to be one of the most widely read and authoritative review sources in microbiology. The series contains comprehensive reviews of the most current research in applied microbiology. Recent areas covered include bacterial diversity in the human gut, protozoan grazing of freshwater biofilms, metals in yeast fermentation processes and the interpretation of host-pathogen dialogue through microarrays. Eclectic volumes are supplemented by thematic volumes on various topics, including Archaea and sick building syndrome. Impact factor for 2011: 5.233.

  • Inhibitors of the Ras Superfamily G-proteins, Part A

    • 1st Edition
    • Volume 33
    • English
    This special volume of The Enzymes is targeted toward researchers in biochemistry, molecular and cell biology, pharmacology, and cancer. This thematic volume discusses inhibitors of the Ras superfamily G-proteins.

  • Advances in Molecular Toxicology

    • 1st Edition
    • Volume 7
    • English
    Advances in Molecular Toxicology features the latest advances in all of the subspecialties of the broad area of molecular toxicology. Toxicology is the study of poisons, and this series details the study of the molecular basis by which a vast array of agents encountered in the human environment and produced by the human body itself manifest themselves as toxins. Not strictly limited to documenting these examples, the series is also concerned with the complex web of chemical and biological events that give rise to toxin-induced symptoms and disease. The new technologies that are being harnessed to analyze and understand these events will also be reviewed by leading workers in the field. Advances in Molecular Toxicology will report progress in all aspects of these rapidly evolving molecular aspects of toxicology with a view toward detailed elucidation of progress on the molecular level and on advances in technological approaches employed.

  • Digital Microscopy

    • 4th Edition
    • Volume 114
    • Greenfield Sluder + 1 more
    • English
    The previous edition of this book marked the shift in technology from video to digital camera use with microscope use in biological science. This new edition presents some of the optical fundamentals needed to provide a quality image to the digital camera. Specifically, it covers the fundamental geometric optics of finite- and infinity-corrected microscopes, develops the concepts of physical optics and Abbe’s theory of image formation, presents the principles of Kohler illumination, and finally reviews the fundamentals of fluorescence and fluorescence microscopy. The second group of chapters deals with digital and video fundamentals: how digital and video cameras work, how to coordinate cameras with microscopes, how to deal with digital data, the fundamentals of image processing, and low light level cameras. The third group of chapters address some specialized areas of microscopy that allow sophisticated measurements of events in living cells that are below the optical limits of resolution.

  • Novel Psychoactive Substances

    Classification, Pharmacology and Toxicology
    • 1st Edition
    • Paul I. Dargan + 1 more
    • English
    Novel Psychoactive Substances: Classification, Pharmacology and Toxicology provides readers with background on the classification, detection, supply and availability of novel psychoactive substances, otherwise known as "legal highs." This book also covers individual classes of novel psychoactive substances that have recently emerged onto the recreational drug scene and provides an overview of the pharmacology of the substance followed by a discussion of the acute and chronic harm or toxicity associated with the substance. Written by international experts in the field, this multi-authored book is a valuable reference for scientists, clinicians, academics, and regulatory and law enforcement professionals.

Related subjects