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Lung Metabolism
Proteolysis and Antioproteolysis Biochemical Pharmacology Handling of Bioactive Substances
- 1st Edition - January 1, 1975
- Editor: Alain Junod
- Language: English
- Hardback ISBN:9 7 8 - 0 - 1 2 - 3 9 2 2 5 0 - 2
- Paperback ISBN:9 7 8 - 0 - 1 2 - 4 1 4 4 2 3 - 1
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 1 4 7 4 1 - 5
Lung Metabolism: Proteolysis and Antiproteolysis Biochemical Pharmacology Handling of Bioactive Substances focuses on studies on the response of the lung relative to the management… Read more
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Request a sales quoteLung Metabolism: Proteolysis and Antiproteolysis Biochemical Pharmacology Handling of Bioactive Substances focuses on studies on the response of the lung relative to the management of bioactive substances. Divided into three sections with 35 chapters, the book focuses first on proteolysis and antiproteolysis in the lung. Concerns include properties and role of antiproteases; role of leucoproteases in the development of emphysema; and the genetic and clinical considerations of alpha1-antitrypsin deficiencies. The second section focuses on biochemical pharmacology of the lung. Concerns include pulmonary drug-metabolizing enzymes; carrier for oxygen and carbon monoxide in the lung; and metabolism of drugs administered by aerosol. The last section looks at the handling of bioactive substances by the lung. Covered areas include the pharmacokinetic function of the lung; biosynthesis and metabolism of prostaglandins in the lung; and importance and nature of the mechanism of inactivation of prostaglandins in the lung. The book is a vital source of information for readers interested in studying the metabolism of the lung.
List of Contributors
Preface
Section I Proteolysis and Antiproteolysis in the Lung
Properties and Role of Antiproteases
Role of Leucoproteases in the Genesis of Emphysema
Bacterial Proteolytic Enzymes
Mycotic Proteolytic Enzymes
Genetic Considerations on Alpha1-Antitrypsin Deficiency
Clinical Spectrum of Alpha1-Antitrypsin Deficiency
The Antiproteolytic System of the Upper Respiratory Tract
Studies of Alphal-Antitrypsin in Amniotic Fluid, Meconium and Cord Serum of a Homozygote Newborn Infant
Influence of Intravenous Injection of D-Penicillamine and Trasylol® on the Serum Levels of Alpha1-Antitrypsin in Human Subjects
Section II Biochemical Pharmacology of the Lung
Pulmonary Drug-Metabolizing Enzymes
A Specific Carrier for Oxygen and Carbon Monoxide in the Lung
Pulmonary Metabolism of Inhaled Substances and Possible Relationship with Carcinogenicity and Toxicity
Metabolism of Drugs Administered by Aerosol
Mechanisms of Drug Accumulation in the Lung
Hormone Receptors in the Lung
Lung and Coagulation
Drug-Induced Pulmonary Changes
Paraquat Poisoning—Possible Therapeutic Approach
General Discussion
Section III Handling of Bioactive Substances by the Lung
The Pharmacokinetic Function of Lung
Biosynthesis and Metabolism of Prostaglandins in the Lung
Conditions of Release of Prostaglandins from the Lung
Importance and Nature of the Mechanism of Inactivation of Prostaglandins in the Lung
Dipeptidyl Carboxypeptidase in Lung and Blood Plasma
Bradykininase and Converting Enzyme in Lung
Measurement of Prostaglandins E1,E2, and Fα Histamine and Serotonin, Upstream and Downstream the Lung during Pulmonary Vasopressor Response to Hypoxia in Man. Effects of Prostaglandin Synthesis Inhibitors
Mechanism of Uptake of Biogenic Amines in the Pulmonary Circulation
Metabolic Activities of Plasma Membrane and Caveolae of Pulmonary Endothelial Cells, with a Note on Pulmonary Prostaglandin Synthetase
Several Plasma Proteins Demonstrated in Lung Tissue by Immunoelectron Microscopy using the Peroxidase Coupling Technique
Cardiopulmonary Bypass and Conversion of Angiotensin I in Man
Clinical Aspects of Hydrolysis of Vasoactive Peptides in the Pulmonary Circulation
Some Changes in the Lungs Associated with Cardiopulmonary Bypass
Serum Complement Studies during and following Cardiopulmonary Bypass
General Discussion
Concluding Remarks
Author Index
Subject Index
- No. of pages: 516
- Language: English
- Edition: 1
- Published: January 1, 1975
- Imprint: Academic Press
- Hardback ISBN: 9780123922502
- Paperback ISBN: 9780124144231
- eBook ISBN: 9780323147415
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