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Receptors For Extracellular Matrix
- 1st Edition - December 2, 2012
- Editor: John Mcdonald
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 4 1 2 2 1 0 - 9
- eBook ISBN:9 7 8 - 0 - 3 2 3 - 1 4 1 2 3 - 9
Receptors for Extracellular Matrix covers the major receptor families and their potential biological functions. Composed of eight chapters, the book first discusses the structure… Read more
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Request a sales quoteReceptors for Extracellular Matrix covers the major receptor families and their potential biological functions. Composed of eight chapters, the book first discusses the structure and function of membrane-associated proteoglycans, focusing on two classes of integral membrane molecules: syndecan and CD44. It then examines the important area of mechanisms of signal transduction from integrin receptors that must mediate the effects of extracellular matrices and other ligands on cell behavior. Multidomain proteins of the extracellular matrix and their role in controlling cellular growth are also considered. This book also discusses the significant research developments in NCAM, the most abundant and widespread of the known vertebrate cell-cell adhesion. The discussion particularly emphasizes the role of posttranslational glycosylation with polysialic acid in the function of the NCAM molecule that undergoes unusual and highly characteristic differences in glycosylation during development. Other chapters deal with the regulation of neural development by the extracellular matrix and the molecular basis of cell adhesion. This book includes discussions on the interaction of adhesion receptors with well-characterized cellular recognition sites and extracellular ligands and cell migration occurring during embryogenesis, gastrulation, neural crest cell migration, neurite extension, lymphocyte migration, and wound healing. The concluding chapters address the wide array of integrin associations, their physiologic relevance and structural aspects, as well as the anchorin CII, a collagen-binding protein of the calpactin-lipocortin family. This book is of great value to cell biologists and researchers.
ContributorsPrefaceBinding of Extracellular Effector Molecules by Cell Surface Proteoglycans I. Introduction II. Syndecan, a Mediator of Morphogenesis III. CD44/Hermes, a Multifunctional Molecule IV. Phosphatidyl Inositol-Linked Cell Surface Proteoglycans V. Binding of Effector Molecules to Other Cell Surface Proteoglycans VI. A Regulatory Role for Cell Surface Proteoglycans in the Binding of Effector Molecules References Macrophage and Inflammatory Cell Matrix Receptors LFA-1, Mac-1, pl50,95 Family I. Introduction II. LeuCAM Structure III. Leukocyte Adherence Deficiency IV. Β2 Integrins in Leukocyte Adhesion to Endothelium V. Unique Functions of Members of the LeuCAM Family VI. LeuCAM Function VII. Other Leukocyte Integrins References Multidomain Proteins of the Extracellular Matrix and Cellular Growth I. Introduction II. Promotion of Growth and Differentiation by the Extracellular Matrix III. Promotion of Growth and Differentiation by Individual ECM Components IV. Synergic Actions of ECM Components and Growth Factors V. Growth Factors Bound and Presented by the ECM VI. Domains with Growth Factor Activity VII. Other Functional Sites and Their Possible Involvement in Growth Promotion VIII. Principles of Growth Factor Action and Growth Control IX. Receptors for Growth Factor and the Mode of Transmembrane Signal Transduction X. Second Messengers in the Mitogenic Cascade XI. Which Receptors Are Involved in Mitogenic Stimulation by ECM Proteins? XII. Mitogenic Activity of Domains as Integral Parts of Large Structures in Comparison to That of Small Growth Factors References Neural Cell Adhesion Molecule and Polysialic Acid I. The Biochemistry of NCAM II. Genetics and Evolution of NCAM III. NCAM and PSA Expression in Tissues IV. Biological Function V. Conclusion References Regulation of Neural Development by the Extracellular Matrix I. Regulation of Cell Migration and Axon Guidance II. Regulation of Synaptogenesis III. Regulation of Cell Proliferation and Differentiation IV. Regulation of Cell Survival and Differentiation V. Neural ECM Receptors VI. Additional ECM Receptors in the Nervous System VII. Potential Mechanisms of Action References Matrix Receptors in Cell Migration I. Concepts and Hypotheses: Functions of the Extracellular Matrix in Cell Migration II. The Molecular Basis of Cell Adhesion III. Embryonic Cell Migration IV. Wound Healing V. Tumor Cell Biology VI. Future Perspectives ReferencesStructures and Functions of VLA Proteins and Related Integrins I. Introduction II. Discovery and Early Studies of VLA Proteins and Other Integrins III. VLA Proteins as Part of the Integrin Family IV. Physiological Relevance of Integrins V. Structural Aspects of Integrin α Subunits VI. Structural Aspects of Integrin β Subunits VII. Integrin Heterodimers VIII. Functional Aspects of Integrins/VLA Proteins IX. Conclusion ReferencesAnchorin CII, A Collagen-Binding Protein of the Calpactin-Lipocortin Family I. Introduction II. Isolation of Anchorin CII III. Binding to Collagen In Vitro IV. Role of Anchorin in Cell-Collagen Interactions V. Structural Analysis of Anchorin II: Homology to Calpactin and Lipocortin VI. Biosynthesis, Secretion, and Localization of Anchorin CII on the Cell Surface VII. Distribution of Anchorin in Tissues VIII. Role of Anchorin CII in Development IX. Other Possible Functions of Anchorin CII X. Endonexin II, the Mammalian Homolog to Anchorin CII with Anticoagulatory and Collagen-Binding Activities References Index
- No. of pages: 344
- Language: English
- Edition: 1
- Published: December 2, 2012
- Imprint: Academic Press
- Paperback ISBN: 9780124122109
- eBook ISBN: 9780323141239
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