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Elsevier

Books in Neuroscience

Elsevier's Neuroscience collection empowers educators, researchers, and students with actionable knowledge to drive collaborative research and advancements in the field. Content covers the nervous system's intricate workings, covering branches like Affective, Behavioral, and Cognitive neuroscience to investigate the neural basis of emotions, behavior, and cognitive functions. Spanning from Molecular and Cellular Neuroscience to Developmental Neuroscience, content provides insights into brain function in health and disease.

  • Magnetoencephalography

    • 1st Edition
    • Volume 68
    • English
    Magnetoencephalograp... (MEG) is the only neuroimaging method that provides high spatial and temporal information of human brain activation. In addition, MEG is completely non-invasive and allows recordings with minimal preparation time. This makes it suitable to investigate even fetuses in utero. This volume in the International Review of Neurobiology series addresses the most relevant research areas and shows how MEG could be used for investigations over the whole life span in humans.

  • Neuroanatomy of the Oculomotor System

    • 1st Edition
    • Volume 151
    • Jean A. Büttner-Ennever
    • English
    This volume in the Progress in Brain Research series features reviews on the functional neuroanatomy and connectivity of the brain areas involved in controlling eye movements. Oculomotor control of the eyes is now the subject of many research projects and advances in this field are relevant to understanding motor control in general.

  • Neuroimaging Part A

    • 1st Edition
    • Volume 66
    • English
    Consisting of two separate volumes, Neuroimaging provides a state-of-the-art review of a broad range of neuroimaging techniques applied to both clinical and research settings. The breadth of the methods covered is matched by the depth of description of the theoretical background. Part A focuses on the cutting edge of research methodologies, providing a foundation for both established and evolving techniques. These include voxel-based morphometry using structural MRI, functional MRI, perfusion MRI, diffusion tensor imaging, near-infrared spectroscopy and the technique of combining EEG and fMRI studies. Two chapters are devoted to describing methods for studying brain responses and neural models, focusing on functional connectivity, effective connectivity, dynamic causal modeling, and large-scale neural models. The important role played by brain atlases in facilitating the study of normal and diseased brain populations is described in one chapter, and the concept of neuroimaging data bases as a future resource for scientific discovery is elucidated in another. The two parts of Neuroimaging complement each other providing in-depth information on a broad range of routine and cutting edge techniques that is not available in any other text. This book is superbly written and beautifully illustrated by contributors working at the top of their chosen specialty.

  • Basic Neurochemistry

    Molecular, Cellular and Medical Aspects
    • 7th Edition
    • Scott Brady + 5 more
    • English
    Basic Neurochemistry: Molecular, Cellular and Medical Aspects, a comprehensive text on neurochemistry, is now updated and revised in its Seventh Edition. This well-established text has been recognized worldwide as a resource for postgraduate trainees and teachers in neurology, psychiatry, and basic neuroscience, as well as for graduate and postgraduate students and instructors in the neurosciences. It is an excellent source of information on basic biochemical processes in brain function and disease for qualifying examinations and continuing medical education.

  • Handbook of Categorization in Cognitive Science

    • 1st Edition
    • Henri Cohen + 1 more
    • English
    Categorization, the basic cognitive process of arranging objects into categories, is a fundamental process in human and machine intelligence and is central to investigations and research in cognitive science. Until now, categorization has been approached from singular disciplinary perspectives with little overlap or communication between the disciplines involved (Linguistics, Psychology, Philosophy, Neuroscience, Computer Science, Cognitive Anthropology). Henri Cohen and Claire Lefebvre have gathered together a stellar collection of contributors in this unique, ambitious attempt to bring together converging disciplinary and conceptual perspectives on this topic."Categorizatio... is a key concept across the range of cognitive sciences, including linguistics and philosophy, yet hitherto it has been hard to find accounts that go beyond the concerns of one or two individual disciplines. The Handbook of Categorization in Cognitive Science provides just the sort of interdisciplinary approach that is necessary to synthesize knowledge from the different fields and provide the basis for future innovation." Professor Bernard Comrie, Department of Linguistics, Max Planck Institute for Evolutionary Anthropology, Germany"Anyone concerned with language, semantics, or categorization will want to have this encyclopedic collection."Professo... Eleanor Rosch, Dept of Psychology, University of California, Berkeley, USA

  • Neuroimaging Part B

    • 1st Edition
    • Volume 67
    • English
    Comprised of two separate volumes, Neuroimaging provides a state-of-the-art review of a broad range of neuroimaging techniques applied to both clinical and research settings. The breadth of the methods covered is matched by the depth of description of the theoretical background. Part B covers the application of neuroimaging in both research and clinical settings for the study of anxiety disorders, dementia, depression, schizophrenia, functional somatic syndromes, stroke, and multiple sclerosis using a range of neuroimaging modalities including CT, PET, SPECT, DTI, structural MRI and fMRI. One chapter is devoted to the study of brain development using structural MRI, and one chapter to the study of pediatric neurobehavioral disorders using fMRI. One of the most exciting recent applications of neuroimaging to the area of genetics is covered, and with the theory and application of neuroreceptor imaging in psychiatry, forms the final two chapters. The two parts of Neuroimaging complement each other providing in-depth information on a broad range of routine and cutting edge techniques that is not available in any other text. This book is superbly written and beautifully illustrated by contributors working at the top of their chosen specialty.

  • Autonomic Dysfunction After Spinal Cord Injury

    • 1st Edition
    • Volume 152
    • Lynne C. Weaver + 1 more
    • English
    Autonomic dysfunction is a major and poorly understood consequence of spinal cord injury. It is a cause of very serious disability and requires much more research. It should be a focus of treatment strategies. This book will be of interest to anyone involved in research and treatment of spinal cord injury since it helps to explain the tremendously negative impact on the body caused by cord injury that is not as obvious as paralysis and loss of sensation. It contains a compilation of what is known about bladder, cardiovascular, bowel and sexual dysfunction after spinal cord injury, as it relates to the changes within the autonomic nervous system control of these functions.The book begins with a description of the time course of autonomic dysfunctions and their ramifications from the first hours after a spinal cord injury to the more stable chronic states. The next section contains three chapters that address anatomical findings that may provide some of the foundation for autonomic dysfunctions in many of the systems. The system-specific chapters then follow in four sections. Each section begins with a chapter or two defining the clinical problems experienced by people with cord injury. The following chapters present research, basic and clinical, that address the autonomic dysfunctions.

  • Development of the Nervous System

    • 2nd Edition
    • Dan H. Sanes + 2 more
    • English
    Development of the Nervous System, Second Edition has been thoroughly revised and updated since the publication of the First Edition. It presents a broad outline of neural development principles as exemplified by key experiments and observations from past and recent times. The text is organized along a development pathway from the induction of the neural primordium to the emergence of behavior. It covers all the major topics including the patterning and growth of the nervous system, neuronal determination, axonal navigation and targeting, synapse formation and plasticity, and neuronal survival and death. This new text reflects the complete modernization of the field achieved through the use of model organisms and the intensive application of molecular and genetic approaches. The original, artist-rendered drawings from the First Edition have all been redone and colorized to so that the entire text is in full color. This new edition is an excellent textbook for undergraduate and graduate level students in courses such as Neuroscience, Medicine, Psychology, Biochemistry, Pharmacology, and Developmental Biology.

  • Atlas of Ambulatory EEG

    • 1st Edition
    • Steven C. Schachter + 2 more
    • English
    Atlas of Ambulatory EEG covers the areas of clinical neurophysiology, an atlas that comprehensively depicts normal, abnormal, and artifactual findings from actual ambulatory EEG recordings in a convenient and easily accessible format. As the use of ambulatory EEG has increased in recent years, the need for a concise atlas of ambulatory EEG has grown significantly, since ambulatory EEG tracings are subject to their own unique issues and artifacts, often not discussed in standard EEG atlases. This book begins with several chapters that introduce the history, technology, and clinical utility of ambulatory EEG. The bulk of the atlas consists of a page-by-page display of high-quality ambulatory EEG excerpts that are easy to review and come with short annotations describing the relevant findings. Atlas of Ambulatory EEG is a critical resource for anyone involved in the interpretation of ambulatory EEG studies.

  • International Review of Neurobiology

    • 1st Edition
    • Volume 65
    • Ronald J. Bradley + 2 more
    • English
    Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research.

  • Cortical Function: a View from the Thalamus

    • 1st Edition
    • Volume 149
    • V. A. Casagrande + 2 more
    • English
    Almost all of the messages that are received by the cerebral cortex from the environment or from the body's internal receptors come through the thalamus and much current thought about perceptual processing is based on sensory pathways that relay in the thalamus. This volume focuses on three major areas: the role of thalamocortical communication in cognition and attention; the role of the thalamus in communication between cortical areas; the hypothesis that much or all of the information relayed by thalamus, even to classical, pure "sensory" areas of cortex, represents a corollary message being sent simultaneously to motor centers. It presents a broad overview of important recent advances in these areas.

  • The Neuromodulators

    • 1st Edition
    • Volume 64
    • Ronald J. Bradley + 2 more
    • English
    Glutamate and GABA are the main information carrying neurotransmitters in the brain. Their action is modulated by a further series of small molecules called neuromodulators. The major neuromodulators in the brain are acetylcholine (both muscarinic and nicotinic), dopamine, norepinephrine, epinephrine and serotonin. These have an enormous range of functions in a wide variety of brain mechanisms. This book attempts to give a general overview of this field with a section devoted to each of these. Each section starts with anatomy, both structural and functional. The various types of receptors for these agents are described and then the effects of stimulating these receptors. These receptors trigger a variety of electrical reactions that generally involve potassium, sodium or calcium channels. Also reviewed are other receptors that trigger a wide variety of post-synaptic signaling cascades that influence a large number of neuronal functions including receptor sensitivity, synaptic plasticity and gene manipulation. Finally the relevance of these systems to disease states is detailed. There are many reviews of individual neuromodulators but this is the only book where one author attempts to cover the whole field.

  • Handbook of Stress and the Brain (Two-Volume Set)

    • 1st Edition
    • Thomas Steckler + 2 more
    • English
    The Handbook of Stress and the Brain focuses on the impact of stressful events on the functioning of the central nervous system; how stress affects molecular and cellular processes in the brain, and in turn, how these brain processes determine our perception of and reactivity to, stressful challenges - acutely and in the long-run. Written for a broad scientific audience, the Handbook comprehensively reviews key principles and facts to provide a clear overview of the interdisciplinary field of stress. The work aims to bring together the disciplines of neurobiology, physiology, immunology, psychology and psychiatry, to provide a reference source for both the non-clinical and clinical expert, as well as serving as an introductory text for novices in this field of scientific inquiry.Part 1 addresses basic aspects of the neurobiology of the stress response including the involvement of neuropeptide, neuroendocrine and neurotransmitter systems and its corollaries regarding gene expression and behavioural processes such as cognition, motivation and emotionality. Part 2 treats the complexity of short-term and long-term regulation of stress responsivity, the role of stress in psychiatric disorders as based on both preclinical and clinical evidence, and the current status with regard to new therapeutic strategies targetting stress-related disorders.

  • MRI Atlas of Human White Matter

    • 1st Edition
    • Susumu Mori + 3 more
    • English
    Recent advances in modern imaging techniques that can be used non-invasively for the visualization of the human brain have greatly enhanced the knowledge of brain anatomy and the understanding of its relationship to brain function. A unique new MRI modality, called diffusion tensor imaging (DTI) allows the three-dimensional study of the large white matter (WM) fiber bundles at macroscopic resolution (millimeter scale). MRI Atlas of Human White Matter provides a three-dimensional and two-dimensional in vivo atlas of various white matter tracts in the human brain. The images are based on diffusion tensor imaging and various tracts are reconstructed three-dimensionally from the data. Following an introduction and description of the methodology (Chapters 1 and 2), the 3D anatomy of individual tracts is delineated in Chapter 3. Chapter 4 consists of a series of color-coded orientation maps to delineate white matter anatomy in a slice-by-slice manner, in which the structures are extensively annotated. This richly illustrated Atlas is a valuable resource for students studying white matter anatomy and researchers working in brain research and radiology. This book also provides the structural assignment, which will assist neuroradiologists when interpreting diffusion tensor images in routine clinical studies.

  • Multiple Sclerosis As A Neuronal Disease

    • 1st Edition
    • Stephen Waxman
    • English
    This book examines the role of neurons in multiple sclerosis (MS) and the changes that occur in neurons as a result of MS. It places MS in a new and important perspective that not only explains the basis for symptom production, remission, and progress in MS, but also promises to open up new therapeutic possibilities.

  • International Review of Neurobiology

    • 1st Edition
    • Volume 63
    • Ronald J. Bradley + 2 more
    • English
    Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research.

  • Neurobiology of Attention

    • 1st Edition
    • Laurent Itti + 2 more
    • English
    A key property of neural processing in higher mammals is the ability to focus resources by selectively directing attention to relevant perceptions, thoughts or actions. Research into attention has grown rapidly over the past two decades, as new techniques have become available to study higher brain function in humans, non-human primates, and other mammals. Neurobiology of Attention is the first encyclopedic volume to summarize the latest developments in attention research.An authoritative collection of over 100 chapters organized into thematic sections provides both broad coverage and access to focused, up-to-date research findings. This book presents a state-of-the-art multidisciplinary perspective on psychological, physiological and computational approaches to understanding the neurobiology of attention. Ideal for students, as a reference handbook or for rapid browsing, the book has a wide appeal to anybody interested in attention research.

  • Handbook of Stress and the Brain Part 1: The Neurobiology of Stress

    • 1st Edition
    • Volume 15
    • Thomas Steckler + 2 more
    • English
    The Handbook of Stress and the Brain focuses on the impact of stressful events on the functioning of the central nervous system; how stress affects molecular and cellular processes in the brain, and in turn, how these brain processes determine our perception of and reactivity to, stressful challenges - acutely and in the long-run. Written for a broad scientific audience, the Handbook comprehensively reviews key principles and facts to provide a clear overview of the interdisciplinary field of stress. The work aims to bring together the disciplines of neurobiology, physiology, immunology, psychology and psychiatry, to provide a reference source for both the non-clinical and clinical expert, as well as serving as an introductory text for novices in this field of scientific inquiry.Part 1 addresses basic aspects of the neurobiology of the stress response including the involvement of neuropeptide, neuroendocrine and neurotransmitter systems and its corollaries regarding gene expression and behavioural processes such as cognition, motivation and emotionality.

  • Handbook of Stress and the Brain Part 2: Stress: Integrative and Clinical Aspects

    • 1st Edition
    • Volume 15
    • Thomas Steckler + 2 more
    • English
    The Handbook of Stress and the Brain focuses on the impact of stressful events on the functioning of the central nervous system; how stress affects molecular and cellular processes in the brain, and in turn, how these brain processes determine our perception of and reactivity to, stressful challenges - acutely and in the long-run. Written for a broad scientific audience, the Handbook comprehensively reviews key principles and facts to provide a clear overview of the interdisciplinary field of stress. The work aims to bring together the disciplines of neurobiology, physiology, immunology, psychology and psychiatry, to provide a reference source for both the non-clinical and clinical expert, as well as serving as an introductory text for novices in this field of scientific inquiry.Part 2 treats the complexity of short-term and long-term regulation of stress responsivity, the role of stress in psychiatric disorders as based on both preclinical and clinical evidence, and the current status with regard to new therapeutic strategies targetting stress-related disorders.

  • Movement Disorders

    Genetics and Models
    • 1st Edition
    • Mark S. LeDoux
    • English
    The use of animal models is a key aspect of scientific research in numerous fields of medicine. This book vigorously examines the important contributions and application of animal models to the understanding of human movement disorders and will serve as an essential resource for basic neuroscientists engaged in movement disorders research. Academic clinicians, translational researchers and basic scientists are brought together to connect experimental findings made in different animal models to the clinical features, pathophysiology and treatment of human movement disorders. A vital feature of this book is an accompanying DVD with video clips of human movement disorders and their corresponding animal models. The book is divided into sections on Parkinson disease, Huntington disease, dystonia, tremor, paroxysmal movement disorders, ataxia, myoclonus, restless legs syndrome, drug-induced movement disorders, multiple system atrophy, progressive supranuclear palsy/corticobasal degeneration and spasticity. This book serves as an essential resource for both clinicians interested in the science being generated with animal models and basic scientists studying the pathogenesis of particular movement disorders.

  • Dopamine

    • 1st Edition
    • Volume 21
    • S.B. Dunnett + 3 more
    • English
    Dopamine is a major neurotransmitter of the brain involved in the control of movement, emotion, and cognition; disturbance in dopamine function is associated with disorders like Parkinson’s disease, schizophrenia and attention deficit hyperactivity disorder. This volume of the Handbook of Chemical Neuroanatomy provides a series of in depth critical reviews of our present understanding of the most important aspects of dopamine’s organisation and disturbed function in the animal and human brain.

  • Magnetic Resonance in Epilepsy

    Neuroimaging Techniques, Second Edition
    • 2nd Edition
    • Ruben Kuzniecky + 1 more
    • English
    Remarkable advances in imaging have increased the importance of MRI for diagnostic, treatment and management of epilepsy. Neuroimaging of patients with epilepsy no longer simply deals with the technology and interpretation of images but also with issues of brain metabolism, energetics, cognition and brain dysfunction. The first edition of Magnetic Resonance in Epilepsy came into clinical practice in 1995 with a revolutionary idea; that is, MR is as important as EEG in the clinical management of patients with epilepsy. The second edition of Magnetic Resonance in Epilepsy, the only comprehensive text in the field of epilepsy neuroimaging, reviews fundamental concepts and new advances in MR technology, computerized analysis, MR spectroscopy, DWI and other neuroimaging techniques such as PET, SPECT and MEG application to the study of patients with epileptic disorders.

  • The Psychology of Learning and Motivation

    Advances in Research and Theory
    • 1st Edition
    • Volume 45
    • English
    The Psychology of Learning and Motivation publishes empirical and theoretical contributions in cognitive and experimental psychology, ranging from classical and instrumental conditioning to complex learning and problem solving. Each chapter provides a thoughtful integration of a body of work.

  • Advances in the Study of Behavior

    • 1st Edition
    • Volume 34
    • Peter J.B. Slater + 5 more
    • English
    The aim of Advances in the Study of Behavior is to serve scientists engaged in the study of animal behavior, including psychologists, neuroscientists, biologists, ethologists, pharmacologists, endocrinologists, ecologists, and geneticists. Articles in the series present critical reviews of significant research programs with theoretical syntheses, reformulation of persistent problems, and/or highlighting new and exciting research concepts. Volume 34 is purely eclectic and illustrates the breadth of behavior research. Contents include sexual conflict among insects, the evolution of sexual cannibalism, odor processing and activity patterns in honeybees, hormone secretion in vertebrates, bird song organization, food transfer in primates, game theory approaches to mutualism, as well as neural mechanisms of learning and memory and how these change during infant development.

  • Human Brain Proteome

    • 1st Edition
    • Volume 61
    • English
    Proteomics is a systematic approach for studying the identity and function of all proteins expressed in a cell, tissue or organ. New drug targets for diseases are often identified by comparing the proteome of the disease state to the normal state. As a result, proteomics has become increasingly important in the pharmaceutical and biotechnology industries as well as academics. This book contains five sections encompassing the research aspects of proteomics on the brain including the most recent advances in the technology and informatics. It discusses advances in high-throughput proteomic technologies and their application to studying neurological disorders such as Alzheimer’s disease, alcoholism, trauma/stroke, Huntington's disease, and Parkinson's disease. With numerous illustrations to explain the concepts, it provides a comprehensive review on the topic.

  • Creating Coordination in the Cerebellum

    • 1st Edition
    • Volume 148
    • Chris I. De Zeeuw + 1 more
    • English
    Creating Coordination in the Cerebellum provides a multidisciplinary collection of chapters on the cerebellum with topics covering the entire spectrum from development and molecular neurobiology, cell physiology and plasticity to motor control, system physiology, functional imaging and pathology. The book not only presents novel discoveries obtained with recently developed technologies, but also gives new general concepts in global issues of cerebellar development and functions. By doing so it sets the standard for cerebellar research of the 21st century.

  • Emission Tomography

    The Fundamentals of PET and SPECT
    • 1st Edition
    • Miles N. Wernick + 1 more
    • English
    PET and SPECT are two of today’s most important medical-imaging methods, providing images that reveal subtle information about physiological processes in humans and animals. Emission Tomography: The Fundamentals of PET and SPECT explains the physics and engineering principles of these important functional-imaging methods. The technology of emission tomography is covered in detail, including historical origins, scientific and mathematical foundations, imaging systems and their components, image reconstruction and analysis, simulation techniques, and clinical and laboratory applications. The book describes the state of the art of emission tomography, including all facets of conventional SPECT and PET, as well as contemporary topics such as iterative image reconstruction, small-animal imaging, and PET/CT systems. This book is intended as a textbook and reference resource for graduate students, researchers, medical physicists, biomedical engineers, and professional engineers and physicists in the medical-imaging industry. Thorough tutorials of fundamental and advanced topics are presented by dozens of the leading researchers in PET and SPECT. SPECT has long been a mainstay of clinical imaging, and PET is now one of the world’s fastest growing medical imaging techniques, owing to its dramatic contributions to cancer imaging and other applications. Emission Tomography: The Fundamentals of PET and SPECT is an essential resource for understanding the technology of SPECT and PET, the most widely used forms of molecular imaging.

  • The Rat Brain in Stereotaxic Coordinates - The New Coronal Set

    • 5th Edition
    • George Paxinos + 1 more
    • English
    The preceding editions made The Rat Brain in Stereotaxic Coordinates the second most cited book in science. This Fifth Edition is the result of years of research providing the user with the drawings of the completely new set of coronal sections, now from one rat, and with significantly improved resolution by adding a third additional section level as compared to earlier editions. Numerous new nuclei and structures also have been identified. The drawings are presented in two color, providing a much better contrast for use. The Fifth Edition continues the legacy of this major neuroscience publication and is a guide for all students and scientists who study the rat brain.

  • Development, Dynamics and Pathology of Neuronal Networks: From Molecules to Functional Circuits

    • 1st Edition
    • Volume 147
    • J. van Pelt + 5 more
    • English
    This book is about neuronal networks within the brain. With roughly 100 billion nerve cells the human brain contains about 3.2 million kilometers of 'wires' to make a million billion of connections between these nerve cells. Nerve cells exchange electrical and chemical signals through these connections and the dynamical patterns of electrical/chemical signals are the basis of all our thinking, memories, consciousness, and control of our behaviour. How do these networks develop their specific connectivity, what are the patterns of electrical activity that serve such a fundamental role in our cognitive abilities, how can it go wrong in these networks resulting in different types of brain pathologies, such as mental retardation, Alzheimer’s disease, epilepsy or schizophrenia? These questions are among the most fundamental ones in neuroscience and are addressed in this volume. The chapters in this book cover both state-of-the-art broad reviews and in-depth studies of topics selected in order to bridge different levels of neurobiological organization, from the molecular, cellular, neural network to the cognitive level. An excellent example of such a 'red thread' is given by the chapters devoted to the visual system, illustrating the advanced state of understanding of network development, plasticity and functioning of the visual system. Other chapters illustrate how scientific advances are driven by technical developments as shown for multi-electrode recording and life imaging techniques that enable the study of electrical activity simultaneously in many nerve cells.

  • International Review of Neurobiology

    • 1st Edition
    • Volume 62
    • Ronald J. Bradley + 2 more
    • English
    Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research.

  • From Neuroscience to Neurology

    Neuroscience, Molecular Medicine, and the Therapeutic Transformation of Neurology
    • 1st Edition
    • Stephen Waxman
    • English
    The field of neurology is being transformed, from a therapeutically nihilistic discipline with few effective treatments, to a therapeutic specialty which offers new, effective treatments for disorders of the brain and spinal cord. This remarkable transformation has bridged neuroscience, molecular medicine, and clinical investigation, and represents a major triumph for biomedical research. This book, which contains chapters by more than 29 internationally recognized authorities who have made major contributions to neurotherapeutics, tells the stories of how new treatments for disabling disorders of the nervous system, such as stroke, multiple sclerosis, Parkinson’s disease, and migraine, were developed, and explores evolving themes and technologies that offer hope for even more effective treatments and ultimately cures for currently untreatable disorders of the brain and spinal cord. The first part of this book reviews the development of new therapies in neurology, from their inception in terms of basic science to their introduction into the clinical world. It also explores evolving themes and new technologies. This book will be of interest to everyone – clinicians and basic scientists alike – interested in diseases of the brain and spinal cord, and in the quest for new treatments for these disorders.

  • DNA Arrays in Neurobiology

    • 1st Edition
    • Volume 60
    • English
    DNA array technology is a technique for studying gene expression by comparing samples of different genes. The result is an enormous amount of data that must be carefully analyzed in order for it to be useful and meaningful. This book examines both data analysis and techniques for ensuring optimal experimental conditions. The array approach has applications in a number of model systems, including development, learning and drug abuse. In addition, the technique has applications in a number of neurological disorders such as Alzheimer's disease, schizophrenia, multiple sclerosis, and neurological cancers.

  • Principles of Hormone/Behavior Relations

    • 1st Edition
    • Donald W. Pfaff + 2 more
    • English
    This text introduces underlying principles of the endocrine regulation of behavior in animals and humans. Every chapter begins by stating a principle, followed by specific examples of hormone actions derived from scientific experiments and clinical observations, and concludes with a few challenging unanswered questions. The reference source Hormones, Brain & Behavior identified this field as rapidly expanding within neurobiology and endocrinology. Now, this well-illustrated and referenced text will serve students from undergraduate school to medical school as they learn this new discipline.

  • Introduction to Psychoneuroimmunology

    • 1st Edition
    • Jorge H. Daruna
    • English
    Psychoneuroimmunolog... investigates the relationships between behavior, psychosocial factors, the nervous, endocrine, and immune systems, and disease. Each system affects the others, enhancing and/or inhibiting processes elsewhere in the body. Research in this field has grown tremendously in recent years as science better understands the checks and balances of these interdisciplinary systems and processes. Introduction to Psychoneuroimmunolog... provides the first introductory text for this complex field.Beginning with a discussion of immune system basics, Introduction to Psychoneuroimmunolog... explores endocrine-immune modulation, neuro-immune modulation, the relationship between stress, contextual change, and disease, as well as infection, allergy, immune activity and psychopathology, and immune function enhancement. This text provides a sound introduction to the field and will serve as a valuable overview to what is otherwise a complex interdisciplinary subject at the junction of molecular biology, genetics, the neurosciences, immunology, cell biology, endocrinology, pharmacology, biochemistry, and the behavioral sciences.

  • The Neuroendocrine Immune Network in Ageing

    • 1st Edition
    • Volume 4
    • R.H. Straub + 1 more
    • English
    The book describes the mechanisms involved in the maintenance of neuroendocrine-immun... interactions in ageing. The lack of this maintenance leads to the appearance of age-related diseases (cancer, infections, dementia) and subsequent disability. The capacity of some hormones or nutritional factors in restoring and remodelling the neuroendocrine-immun... response during ageing is reported presenting possible new anti-ageing strategies in order to reach healthy ageing and longevity.

  • Representation in Mind

    New Approaches to Mental Representation
    • 1st Edition
    • Volume 1
    • Hugh Clapin + 2 more
    • English
    'Representation in Mind' is the first book in the new series 'Perspectives on Cognitive Science' and includes well known contributors in the areas of philosophy of mind, psychology and cognitive science.The papers in this volume offer new ideas, fresh approaches and new criticisms of old ideas. The papers deal in new ways with fundamental questions concerning the problem of mental representation that one contributor, Robert Cummins, has described as "THE problem in philosophy of mind for some time now". The editors' introductory overview considers the problem for which mental representation has been seen as an answer, sketching an influential framework, outlining some of the issues addressed and then providing an overview of the papers. Issues include: the relation between mental representation and public, non-mental representation; misrepresentation; the role of mental representations in intelligent action; the relation between representation and consciousness; the relation between folk psychology and explanations invoking mental representations

  • Neuromimetic Semantics

    Coordination, quantification, and collective predicates
    • 1st Edition
    • Harry Howard
    • English
    This book attempts to marry truth-conditional semantics with cognitive linguistics in the church of computational neuroscience. To this end, it examines the truth-conditional meanings of coordinators, quantifiers, and collective predicates as neurophysiological phenomena that are amenable to a neurocomputational analysis. Drawing inspiration from work on visual processing, and especially the simple/complex cell distinction in early vision (V1), we claim that a similar two-layer architecture is sufficient to learn the truth-conditional meanings of the logical coordinators and logical quantifiers. As a prerequisite, much discussion is given over to what a neurologically plausible representation of the meanings of these items would look like. We eventually settle on a representation in terms of correlation, so that, for instance, the semantic input to the universal operators (e.g. and, all)is represented as maximally correlated, while the semantic input to the universal negative operators (e.g. nor, no)is represented as maximally anticorrelated. On the basis this representation, the hypothesis can be offered that the function of the logical operators is to extract an invariant feature from natural situations, that of degree of correlation between parts of the situation. This result sets up an elegant formal analogy to recent models of visual processing, which argue that the function of early vision is to reduce the redundancy inherent in natural images. Computational simulations are designed in which the logical operators are learned by associating their phonological form with some degree of correlation in the inputs, so that the overall function of the system is as a simple kind of pattern recognition. Several learning rules are assayed, especially those of the Hebbian sort, which are the ones with the most neurological support. Learning vector quantization (LVQ) is shown to be a perspicuous and efficient means of learning the patterns that are of interest. We draw a formal parallelism between the initial, competitive layer of LVQ and the simple cell layer in V1, and between the final, linear layer of LVQ and the complex cell layer in V1, in that the initial layers are both selective, while the final layers both generalize. It is also shown how the representations argued for can be used to draw the traditionally-recogn... inferences arising from coordination and quantification, and why the inference of subalternacy breaks down for collective predicates. Finally, the analogies between early vision and the logical operators allow us to advance the claim of cognitive linguistics that language is not processed by proprietary algorithms, but rather by algorithms that are general to the entire brain. Thus in the debate between objectivist and experiential metaphysics, this book falls squarely into the camp of the latter. Yet it does so by means of a rigorous formal, mathematical, and neurological exposition – in contradiction of the experiential claim that formal analysis has no place in the understanding of cognition. To make our own counter-claim as explicit as possible, we present a sketch of the LVQ structure in terms of mereotopology, in which the initial layer of the network performs topological operations, while the final layer performs mereological operations. The book is meant to be self-contained, in the sense that it does not assume any prior knowledge of any of the many areas that are touched upon. It therefore contains mini-summaries of biological visual processing, especially the retinocortical and ventral /what?/ parvocellular pathways; computational models of neural signaling, and in particular the reduction of the Hodgkin-Huxley equations to the connectionist and integrate-and-fire neurons; Hebbian learning rules and the elaboration of learning vector quantization; the linguistic pathway in the left hemisphere; memory and the hippocampus; truth-conditional vs. image-schematic semantics; objectivist vs. experiential metaphysics; and mereotopology. All of the simulations are implemented in MATLAB, and the code is available from the book’s website.

  • Time-to-Contact

    • 1st Edition
    • Volume 135
    • Heiko Hecht + 1 more
    • English
    Time-to-contact is the visual information that observers use in fundamental tasks such as landing an airplane or hitting a ball. Time-to-contact has been a hot topic in perception and action for many years and although many articles have been published on this topic, a comprehensive overview or assessment of the theory does not yet exist. This book fills an important gap and will have appeal to the perception and action community. The book is divided into four sections. Section one covers the foundation of time-to-contact, Section two covers different behavioral approaches to time-to-contact estimation, Section three focuses on time-to-contact as perception and strategy, and Section four covers time-to-contact and action regulation.

  • Primer on the Autonomic Nervous System

    • 2nd Edition
    • Phillip A. Low
    • English
    The Primer on the Autonomic Nervous System presents, in a readable and accessible format, key information about how the autonomic nervous system controls the body, particularly in response to stress. It represents the largest collection of world-wide autonomic nervous system authorities ever assembled in one book. It is especially suitable for students, scientists and physicians seeking key information about all aspects of autonomic physiology and pathology in one convenient source. Providing up-to-date knowledge about basic and clinical autonomic neuroscience in a format designed to make learning easy and fun, this book is a must-have for any neuroscientist’s bookshelf!

  • The Rat Nervous System

    • 3rd Edition
    • George Paxinos
    • English
    This third edition of the standard reference on the nervous system of the rat is a complete and updated revision of the 1994 second edition. All chapters have been extensively updated, and new chapters added covering early segmentation, growth factors, and glia. The book is now aligned with the data available in the Rat Brain in Stereotaxic Coordinates, making it an excellent companion to this bestselling atlas. Physiological data, functional concepts, and correlates to human anatomy and function round out the new edition.

  • Disorders of Synaptic Plasticity and Schizophrenia

    • 1st Edition
    • Volume 59
    • English
    Schizophrenia is a severe brain disorder that affects 1% of the population. Its cause is due to the interaction of a number of abnormal genes with environmental factors. This book summarizes new advances schizophrenia research that focus on the field of neural and synaptic plasticity. Synapses in the brain in schizophrenia show a wide range of disorders, both structural and functional. This volume covers the most active and promising of these new developments, and opens up new avenues for the treatment of schizophrenia.

  • Human Brain Function

    • 2nd Edition
    • Richard S.J. Frackowiak + 7 more
    • English
    This updated second edition provides the state of the art perspective of the theory, practice and application of modern non-invasive imaging methods employed in exploring the structural and functional architecture of the normal and diseased human brain. Like the successful first edition, it is written by members of the Functional Imaging Laboratory - the Wellcome Trust funded London lab that has contributed much to the development of brain imaging methods and their application in the last decade. This book should excite and intrigue anyone interested in the new facts about the brain gained from neuroimaging and also those who wish to participate in this area of brain science.

  • Human Hypothalamus: Basic and Clinical Aspects, Part II

    • 1st Edition
    • Volume 80
    • Dick F. Swaab
    • English
    This volume provides a comprehensive understanding of the human hypothalamus, an extremely complex structure that consists of a large number of very different functional units. It approaches the subject in a way that has not historically existed in standard neuropathological investigations of the human brain. As the hypothalamus was traditionally considered to be a neuroendocrine structure, and hence of little interest to neurologists, this volume explores new findings in the field and the value they bring to the field of neurology. New understandings of the role the hypothalamus plays in memory and attention deficits in the dementias, along with greater evidence that the hypothalamus is related to symptoms and signs in both neurological and psychological disorders provide users in the fields of neuroscience, endocrinology, pediatrics, and psychology with a comprehensive resource on which to base new research and exploration.

  • The Human Nervous System

    • 2nd Edition
    • George Paxinos + 1 more
    • English
    This long-awaited update of the classic, The Human Nervous System, stands as an impressive survey of our knowledge of the brain, spinal cord, and peripheral nervous system. The book has been completely redone and brought up-to-date. An impressive and respected cast of international authors have contributed 37 chapters on topics ranging from Brain Evolution, all phases of Brain Development, to all areas of the adult brain and peripheral pathways, along with careful descriptions of the spinal cord and peripheral nervous system, brainstem and cerebellum. The Human Nervous System, Second Edition will again serve as the gold standard, providing a one-stop source of up-to-date information about our knowledge of the human nervous system.

  • Myelin Biology and Disorders, Two-Volume Set

    • 1st Edition
    • Robert Lazzarini
    • English
    With the completion of the "Human Genome Project" and the cloning and complete molecular description of the known myelin genes, the stage has been set for a detailed understanding of the biology of myelin, the disease processes affecting myelin and the potential for myelin repair and regeneration. Myelin Biology and Disorders brings together in one place, the recent advances in molecular and cellular biology along with visual data from MRI, confocal microscopy and high voltage EM techniques to provide new insights into disease mechanisms. This book represents a unique research reference on myelin biology and will serve as the definitive resource for both the professional clinical and basic scientist.

  • International Review of Neurobiology

    • 1st Edition
    • Volume 57
    • Ronald J. Bradley + 2 more
    • English
    International Review of Neurobiology is a well-respected series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research. This volume is a cumulative subject index of volumes 1-25.

  • Advances in the Study of Behavior

    • 1st Edition
    • Volume 33
    • Peter J.B. Slater + 4 more
    • English
    The aim of Advances in the Study of Behavior remains as it has been since the series began: to serve the increasing number of scientists who are engaged in the study of animal behavior by presenting their theoretical ideas and research to their colleagues and to those in neighboring fields. We hope that the series will continue its "contribution to the development of the field", as its intended role was phrased in the Preface to the first volume in 1965. Since that time, traditional areas of animal behavior have achieved new vigor by the links they have formed with related fields and by the closer relationship that now exists between those studying animal and human subjects.

  • International Review of Neurobiology

    • 1st Edition
    • Volume 58
    • Ronald J. Bradley + 2 more
    • English
    International Review of Neurobiology is a well-respected series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research. This volume is a cumulative subject index of volumes 26-50.

  • Human Hypothalamus: Basic and Clinical Aspects, Part I

    • 1st Edition
    • Volume 79
    • Dick F. Swaab
    • English
    As the human hypothalamus has traditionally been considered part of the neuroendocrine system, it has been of little interest to neurologists. This volume creates renewed interest in the subject, highlighting groundbreaking research that links this complex part of the human brain to a variety of neurological and psychological disorders. Clinicians, researchers, and practitioners from a variety of medical fields will find this to be a comprehensive presentation of new research that applies to a variety of disorders, including their origin, diagnosis, and treatment. From groundbreaking discussions that link the human hypothalamus to attention deficits in the dementias, to its role in disorders such as narcolepsy and certain epilepsies, users will find this volume to be an invaluable resource for research and patient care. Specific information on topics including depression, eating disorders, aggression, and mental retardation are included, giving those in the field of neurology, psychiatry, endocrinology, and pediatrics a comprehensive understanding on how the human hypothalamus is related to patient disorders in these fields.

  • International Review of Neurobiology

    • 1st Edition
    • Volume 56
    • Ronald J. Bradley + 2 more
    • English
    Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research. This volume is a collection of articles covering recent advances in the field of neurobiology. Topics covered include behavioral mechanisms and the neurobiology of conditioned sexual responding; NMDA receptors in alcoholism; processing and representation of species-specific communication calls in the auditory system of bats; central nervous system control of micturition; the structure and physiology of the rat auditory system; and neurobiology of cat and human sexual behavior.

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