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Movement Disorders
Genetics and Models
- 1st Edition - January 25, 2005
- Editor: Mark S. LeDoux
- Language: English
- eBook ISBN:9 7 8 - 0 - 0 8 - 0 4 7 0 5 6 - 6
The use of animal models is a key aspect of scientific research in numerous fields of medicine. This book vigorously examines the important contributions and application of animal… Read more
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Request a sales quoteThe use of animal models is a key aspect of scientific research in numerous fields of medicine. This book vigorously examines the important contributions and application of animal models to the understanding of human movement disorders and will serve as an essential resource for basic neuroscientists engaged in movement disorders research. Academic clinicians, translational researchers and basic scientists are brought together to connect experimental findings made in different animal models to the clinical features, pathophysiology and treatment of human movement disorders. A vital feature of this book is an accompanying DVD with video clips of human movement disorders and their corresponding animal models. The book is divided into sections on Parkinson disease, Huntington disease, dystonia, tremor, paroxysmal movement disorders, ataxia, myoclonus, restless legs syndrome, drug-induced movement disorders, multiple system atrophy, progressive supranuclear palsy/corticobasal degeneration and spasticity. This book serves as an essential resource for both clinicians interested in the science being generated with animal models and basic scientists studying the pathogenesis of particular movement disorders.
* Provides a single comprehensive resource on animal models of movement disorders that academic clinicians, translational researchers, and basic neuroscientists can refer to
* Includes contributions by expert movement disorder clinicians and top-level researchers in the field
* Features a DVD containing over 170 video clips of human movement disorders and the corresponding animal models
* Includes contributions by expert movement disorder clinicians and top-level researchers in the field
* Features a DVD containing over 170 video clips of human movement disorders and the corresponding animal models
General neurologists, neurologists with subspecialty interest in movement disorders, neuroscientists, rehabilitation physicians, psychiatrists, and academic veterinarians with an interest in animal models.
Table of Contents
Preface
List of Contributors
Section A: Scientific Foundations
A1: Classification and Clinical Features of Movement Disorders
A2: Animal Models and the Science of Movement Disorders
A3: Generation of Transgenic and Gene-Targeted Mouse Models of Movement Disorders
A4: Genetics of Spontaneous Mutations in Mice
A5: Assessment of Movement Disorders in Rodents
A6: Response Dynamics: Measurement of the Force and Rhythm of Motor Responses in Laboratory Animals
A7: Behavior in Drosophila: Analysis and Control
A8: Use of C. elegans to Model Human Movement Disorders
Section B: Parkinson Disease
B1: The Phenotypic Spectrum of Parkinson Disease
B2: MPTP-Induced Nigrostriatal Injury in Nonhuman Primates
B3: From Man to Mouse: The MPTP Model of Parkinson Disease
B4: Rotenone Rat and Other Neurotoxin Models of Parkinson Disease
B5: Drosophila Models of Parkinson Disease
B6: Phenotypical Characterization of Genetic Mouse Models of Parkinson Disease
B7: Utility of 6-Hydroxydopamine Lesioned Rats in the Preclinical Screening of Novel Treatments for Parkinson Disease
B8: Motor Complications in Primate Models of Parkinson Disease
B9: C. elegans Models of Parkinson Disease
Section C: Dystonia
C1: Clinical Features and Classification of the Human Dystonias
C2: The Genetically Dystonic Rat
C3: Animal Models of Benign Essential Blepharospasm and Hemifacial Spasm
C4: Mouse Models of Dystonia
C5: The Owl Monkey Model of Focal Dystonia
C6: DYT1 Transgenic Mouse
C7: The hph-1 Mouse
Section D: Huntington Disease
D1: Clinical and Pathological Characteristics of Huntington Disease
D2: Transgenic Rodent Models of Huntington Disease
D3: Knock-in and Knock-out Models of Huntington Disease
D4: Drosophila Models of Huntington Disease
Section E: Tremor Disorders
E1: Neurophysiologic Characterization of Tremor
E2: Essential Tremor
E3: Harmaline Tremor
E4: GABAA Receptor a1 Subunit Knockout Mice: A Novel Model of Essential Tremor
E5: Production and Physiological Study of Holmes Tremor in Monkeys
E6: The Campus Syndrome in Pietrain Pig
Section F: Myoclonus
F1: Pathophysiology, Neurophysiology, and Pharmacology of Human Myoclonus
F2: Post-Hypoxic Myoclonus in Rodents
F3: Baboon Model of Myoclonus
Section G: Tic Disorders
G1: Tourette Syndrome
G2: Animal Models of Tourette Syndrome
Section H: Paroxysmal Movement Disorders
H1: Paroxysmal Dyskinesias in Humans
H2: The Genetically Dystonic Hamster: An Animal Model of Paroxysmal Dystonia
H3: Mouse Models of Hyperekplexia
H4: Bovine Hyperekplexia
H5: Movement Disorders in Drosophila Mutants of Potassium Channels and Biogenic Amine Pathways
Section I: Progressive Supranuclear Palsy and Corticobasal Ganglionic Degeneration
I1: Progressive Supranuclear Palsy and Corticobasal Degeneration
I2: Genetic Susceptibility and Animal Modeling of PSP
I3: Rodent Models of Tauopathies
Section J: Multiple System Atrophy
J1: Clinical Spectrum and Pathological Features of Multiple System Atrophy
J2: Double-Lesion Animal Models of Multiple System Atrophy
J3: A Mouse Model for Multiple System Atrophy
Section K: Ataxias
K1: Clinical and Pathological Features of Hereditary Ataxias
K2: Acquired Ataxias
K3: Animal Models of Spinocerebellar Ataxia Type 1 (SCA1)
K4: Spinocerebellar Ataxia Type 2 (SCA2)
K5: SCA7 Mouse Models
K6: Animal Models of Friedreich Ataxia
K7: Animal Oculomotor Data Illuminate Cerebellum-Related Eye Movement Disorders
Section L: Spasticity
L1: Spasticity
L2: Hereditary Spastic Paraplegia: Clinical Features and Animal Models
L3: The Spastic Rat with Sacral Spinal Cord Injury
L4: Rat Spinal Cord Contusion Model of Spasticity
Section M: Drug-induced Movement Disorders
M1: Drug-Induced Movement Disorders
M2: Neuroleptic-Induced Acute Dystonia and Tardive Dyskinesia in Primates
M3: Motor Effects of Typical and Atypical Antipsychotic Drugs in Rodents
M4: Animal Models of Drug-Induced Akathisia
Section N: Restless legs Syndrome
N1: Clinical Features and Animal Models of Restless Legs Syndrome and Periodic Limb Movement
Index
- No. of pages: 824
- Language: English
- Edition: 1
- Published: January 25, 2005
- Imprint: Academic Press
- eBook ISBN: 9780080470566
ML
Mark S. LeDoux
Mark S. LeDoux, MD, PhD is a physician-scientist at the University of Tennessee Health Science Center. At present he holds a joint appointment as Professor in the Departments of Neurology, and Anatomy and Neurobiology. He specializes in the neurological subspecialty of movement disorders and treats patients at the University of Tennessee Medical Group and Memphis VA hospital. As an active clinical researcher, Dr. LeDoux’s work has focused on the genetics and treatment of dystonia, Parkinson disease and Huntington disease. He has described Huntington disease in a nonagenarian and reported one of the world’s largest pedigrees with HDL2. In the laboratory, Dr. LeDoux has published extensively on the genetics and molecular biology of dystonia, mechanisms of cell death in Parkinson’s disease, animal models of dystonia and autism, and the neuroanatomy of motor systems. His work with the dt rat engendered paradigm shifts in dystonia and motor systems research. Dr. LeDoux’s lab showed that familial and sporadic adult-onset primary dystonia may be associated with rare sequence variants in THAP1 and CIZ1.
Affiliations and expertise
Department of Neurology, University of Tennessee Health Science Center, Memphis, TN, USA; Department of Anatomy & Neurobiology, University of Tennessee Health Science Center, Memphis, TN, USARead Movement Disorders on ScienceDirect