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Elsevier

Books in Neuroscience

Elsevier's Neuroscience collection empowers educators, researchers, and students with actionable knowledge to drive collaborative research and advancements in the field. Content covers the nervous system's intricate workings, covering branches like Affective, Behavioral, and Cognitive neuroscience to investigate the neural basis of emotions, behavior, and cognitive functions. Spanning from Molecular and Cellular Neuroscience to Developmental Neuroscience, content provides insights into brain function in health and disease.

  • Lipid Metabolism in Signaling Systems

    • 1st Edition
    • Volume 18
    • P. Michael Conn + 1 more
    • English
    Many of the phospholipases and even the receptor for inositol 1,4,5-trisphosphate have recently been cloned and sequenced and play an important role in neurotransmission. Methods developed in recent years for the study of the enzymes and intermediates involved in the regulation of neuronal signal transduction involving phospholipid turnover are presented in this volume.

  • Neuropeptide Analogs, Conjugates, and Fragments

    Methods in Neurosciences, Vol. 13
    • 1st Edition
    • P. Michael Conn
    • English
    Methods in Neurosciences, Volume 13: Neuropeptide Analogs, Conjugates, and Fragments covers the synthesis and characterization of peptide analogs, conjugates, and fragments, their use as ligands for receptors, and their role in the development and use of antisera. The book discusses techniques such as novel synthetic approaches; biotinylation; purification and characterization; radioligand techniques and assay development; use of agonists and antagonists; distinguishing receptor subtypes; conjugation to carrier proteins; antiidiotypic antibody development; and radiolabeling. Neuroscientists, biochemists, neurochemists, and pharmacologists will find the book useful.

  • Neurochemistry of the Retina

    Proceedings of the International Symposium on the Neurochemistry of the Retina Held in Athens, Greece, August 28 - September 1, 1979
    • 1st Edition
    • Nicolas G. Bazan + 1 more
    • English
    Neurochemistry of the Retina covers the proceedings of the International Symposium on the Neurochemistry of the Retina held in Athens, Greece, on August 28 – September 1, 1979. This book mainly focuses on the retina and its neurochemistry. This text is divided into eight major parts. The first part discusses the composition, metabolism, and biogenesis of membrane components. This book then explains the biochemical approaches to the study of visual cells and their relationship with the pigment epithelium, photorector shedding, and circadian rhythm. Chemical transmission of nerve signals is also tackled. This text also looks into the biochemical aspects of photoreceptor structure and function; cyclic nucleotides; and biochemical and pharmacological approaches to study the entire retina. This book concludes by explaining the neurochemical studies in retinal diseases and future research and prospective of the subject. This publication will be invaluable to ophthalmologists and students of ophthalmology.

  • Aminopyridines and Similarly Acting Drugs: Effects on Nerves, Muscles and Synapses

    Proceedings of a IUPHAR Satellite Symposium in Conjunction with the 8th International Congress of Pharmacology, Paris, France, July 27-29, 1981
    • 1st Edition
    • P. Lechat + 2 more
    • English
    Aminopyridines and Similarly Acting Drugs: Effects on Nerves, Muscles and Synapses presents the proceedings of a IUPHAR Satellite Symposium in conjunction with the eighth International Congress of Pharmacology held in Paris, France on July 27-29, 1981. The book contains papers on the effects of aminopyridines on ionic currents in excitable membranes; the effects of aminopyridines on synaptic transmission; and the effects of aminopyridines on the release of chemical transmitters. The text also presents papers on some differences in the blockade of potassium permeabilities by apamin and the aminopyridines; the miscellaneous actions of aminopyridines and related compounds; and the effects of aminopyridines on the skeletal, smooth and cardiac muscle. The clinical applications of aminopyridines and further miscellaneous actions of aminopyridines and related compounds are also considered.

  • Progress in Behavior Modification

    Volume 2
    • 1st Edition
    • Michel Hersen + 2 more
    • English
    Progress in Behavior Modification, Volume 2 reviews issues and developments in the field of behavior modification, with emphasis on a wide spectrum of child and adult disorders. Topics covered range from behavioral assessment and treatment of alcoholism to sexual arousal in male sexual deviates, along with aversion therapy and research methods in behavior modification. Comprised of eight chapters, this volume begins with a discussion on the status and future trends in behavior assessment of alcoholism and behavior modification with alcoholics. The next chapter deals with therapy models, focusing on the domain of social learning, removal of fears, and assertive and social skill training. The discussion then turns to the measurement and generation of sexual arousal in male sexual deviates; applications of behavior modification in nursing practice; aversion therapy and its clinical effects; deceleration of aberrant behavior among retarded individuals; and research methods in behavior modification. The final chapter examines clinical issues regarding behavioral self-control. This book should be of value to theoreticians, researchers, or practitioners in the fields of psychiatry, psychology, and behavior therapy as well as social work, speech therapy, education, and rehabilitation.

  • Biochemistry of Brain

    • 1st Edition
    • Sudhir Kumar
    • English
    Biochemistry of Brain is a collection of articles dealing with the developments in the biochemistry of the brain. This book gives a comprehensive and critical discussion of important developments in studies concerning the above subject. This text discusses the structure, function, and metabolism of glycosphingolipids, which are related to the study of sphingolipid storage diseases. Inborn defects of metabolism are found in Gaucher's and Fabry's disease, which are characterized by lipid accumulation in the brain. Another paper reviews the chemical and genetics of critically lysosomal hydrolase deficiencies that can cause the storage of sphingolipids. This book then explains the role of myelin basic protein in lipids in vivo that the weak bonding of the protein is not a major component of myelin stability. Another paper discusses the procedures for isolating subfractions of myelin and myelin-related membranes, with some attention given on the alterations in the subfractionation of myelin in pathological hypomyelinating and demyelinating conditions. Another article discusses the biochemical and enzymatic composition of lysosomes and the biosynthesis, intracellular transport, storage, and the degradation of lysosomal constituents. This collection of papers will benefit scientists doing research in microbiology, microchemistry, molecular genetics, and neurochemistry.

  • Neuromuscular Function and Disorders

    • 1st Edition
    • Alan J. McComas
    • English
    Neuromuscular Function and Disorders focuses on the various processes underlying disordered neuromuscular function. Topics covered include the nature of membrane defects in myotonia and familial periodic paralysis; the disorder of neuromuscular transmission responsible for myasthenia gravis and the various pseudo-myasthenic syndromes; and the disorders of Schwann cell function which cause demyelination. This book is comprised of 28 chapters divided into two sections and begins with a discussion on the normal anatomy and physiology of peripheral nerve and muscle. Included in the first section are descriptions of the ionic mechanisms responsible for the resting and action potentials of nerve and muscle; the sequential stages in neuromuscular transmission; excitation-contracti... coupling; the sliding filament mechanism of myofibrillar shortening; and the morphological and functional properties of motor units. The neurophysiology of exercise and muscle fatigue is also considered, along with the nature of the trophic influences exerted by the motoneuron and muscle fiber upon each other. The second half of the book deals entirely with various diseases of peripheral nerve and muscle, together with diagnostic procedures and therapeutic management. A consistent theme in this section is the recognition of neural abnormalities in diseases hitherto considered as primary disorders of the muscle fiber. This monograph should be of value to neurologists, medical students, research workers, and students and research scientists in physiology, zoology, pharmacology, kinesiology, and physical education.

  • Receptors in the Human Nervous System

    • 1st Edition
    • F. A. O. Mendelsohn + 1 more
    • English
    Receptors in the Human Nervous System is a synthesis of the results of receptor mapping by leaders in the field. In addition to a comprehensive discussion of the distribution and possible interactions of the receptors of different neuroactive substances, this book also contains an abundance of pictorial representations of receptor distributions. High-quality photographs of one receptor are often juxtaposed with photographs of the distribution of a different receptor or receptor subtype for the consideration of possible interactions between different systems. The book surveys the distribution of receptor subtypes for the classical monoamine transmitters (acetylcholine, adrenaline, noradrenaline and serotonin) as well as the distribution of receptors for the excitatory and inhibitory amino acids, (glutamate, GABA and benzodiazepines) as well as the opioid peptides, angiotensen and other neuropeptides. The distribution of multiple types of serotonin receptors is given in detail, and the codistribution of receptors in the cortex is discussed. The book is directed toward researchers in the field of chemical neuroanatomy, as well as pharmacologists, neurophysiologists, and neuroscientists.

  • Biological Aspects of Affective Disorders

    • 1st Edition
    • Volume 1
    • R.W. Horton
    • English
    Biological research in the affective disorders has been an international growth industry for several years. Biological Aspects of Affective Disorders is a comprehensive introduction to the biochemical, pharmacological, and genetic aspects constituting the abnormalities that may underline the diseases of depression and mania, together with the current understanding of the clinical features and management of affected patients.It will be of great value especially to young researchers from all disciplines contributing to this area and to trainee psychiatrists.

  • Neural Models of Plasticity

    Experimental and Theoretical Approaches
    • 1st Edition
    • John H. Byrne + 1 more
    • English
    Neural Models of Plasticity: Experimental and Theoretical Approaches is an outgrowth of a conference that was held at Woods Hole, Massachusetts, in the spring of 1987. The purpose of that conference was to review recent developments in both areas and to foster communication between those researchers pursuing theoretical approaches and those pursuing more empirical approaches. Contributions have been solicited from individuals who represent both ends of the spectrum of approaches as well as those using a combination of the two. These indicate that our knowledge of the plastic capabilities of the nervous system is accelerating rapidly due to rapid advances in the understanding of basic subcellular and molecular mechanisms of plasticity, and because of the computational capabilities and plastic properties that emerge from neural networks and assemblies. The book contains 19 chapters and opens with a study on the role of the neuromodulator in associative learning of the marine mollusk Hermissend. Subsequent chapters examine topics such as learning and memory in Aplysia; the Hebb rule for synaptic plasticity; olfactory processing and associative memory in the mollusk Limax maximus; simulation of a classically conditioned response; and the neural substrates of memory, focusing on the role of the hippocampus.

  • Using Secondary Datasets to Understand Persons with Developmental Disabilities and their Families

    • 1st Edition
    • Volume 45
    • English
    International Review of Research in Developmental Disabilities is an ongoing scholarly look at research into the causes, effects, classification systems, syndromes, etc. of developmental disabilities. Contributors come from wide-ranging perspectives, including genetics, psychology, education, and other health and behavioral sciences.

  • Readings in Cognitive Science

    A Perspective from Psychology and Artificial Intelligence
    • 1st Edition
    • Allan Collins + 1 more
    • English
    Readings in Cognitive Science: A Perspective from Psychology and Artificial Intelligence brings together important studies that fall in the intersection between artificial intelligence and cognitive psychology. This book is composed of six chapters, and begins with the complex anatomy and physiology of the human brain. The next chapters deal with the components of cognitive science, such as the semantic memory, similarity and analogy, and learning. These chapters also consider the application of mental models, which represent the domain-specific knowledge needed to understand a dynamic system or natural physical phenomena. The remaining chapters discuss the concept of reasoning, problem solving, planning, vision, and imagery. This book is of value to psychologists, psychiatrists, neurologists, and researchers who are interested in cognition.

  • Tissue Engineering of the Peripheral Nerve: Biomaterials and Physical Therapy

    • 1st Edition
    • Volume 109
    • English
    This issue of International Review of Neurobiology brings together cutting-edge research on tissue engineering of the peripheral nerve. It reviews current knowledge and understanding, provides a starting point for researchers and practitioners entering the field, and builds a platform for further research and discovery.

  • Tissue Engineering of the Peripheral Nerve

    Stem Cells and Regeneration Promoting Factors
    • 1st Edition
    • Volume 108
    • English
    This issue of International Review of Neurobiology brings together cutting-edge research on tissue engineering of the peripheral nerve. It reviews current knowledge and understanding, provides a starting point for researchers and practitioners entering the field, and builds a platform for further research and discovery.

  • Hysteria and Related Mental Disorders

    An Approach to Psychological Medicine
    • 1st Edition
    • D. Wilfred Abse
    • English
    Hysteria and Related Mental Disorders: An Approach to Psychological Medicine deals with the problems of diagnosis and their bearing on management and treatment of hysteria and related hysteriform conditions. This book is composed of 16 chapters, and starts with a description of the etiology and psychopathology of hysteria. These topics are followed by intensive discussions on the clinical manifestations and diagnosis of hysteria and related mental disorders, including neurosis, psychosis, schizophrenia, and multiple personality. Other chapters consider the nature of dissociative phenomena from a structural and dynamic point of view, as well as its significance in understanding the etiology of ego disorders. This book also looks into some aspects of language development, the conversion process, and the features of hysteria as a communicative disorder. The last chapters present several medical cases illustrating the differences between conversion hysteria and psychophysiologic autonomic disorder. These chapters also deal with the types of psychotherapy for hysteria. This book is of great value to psychologists, neurologists, clinicians, and psychotherapists.

  • The Choroid Plexus in Health and Disease

    • 1st Edition
    • Martin G. Netsky + 1 more
    • English
    The Choroid Plexus in Health and Disease is a collection of data and information elucidating the normal structure and function, and the clinical disorders of the choroid plexus in relation to embryology, anatomy, chemistry, and physiology. The book contains articles that discuss topics on the origin of choroid plexus and ependyma; normal structure of choroid plexus; physiology of the choroid plexus; heterotopic choroid plexus and ependyma; traumatic disorders and their effect on choroid plexus and ependyma; and metastatic tumor in the choroid plexus. Physiologists, neurologists, anatomists, teachers, and students in the medical field will find the book invaluable.

  • Brain Preparations

    By Means of Defibrillation or Blunt Dissection: A Guide to the Macroscopic Study of the Brain
    • 1st Edition
    • J. Wilh. Hultkrantz
    • English
    Brain Preparations by means of Defibrillation or Blunt Dissection: A Guide to the Macroscopic Study of the Brain presents a critical review of anatomical facts and preparation of brain specimens. The book discusses the techniques and the principles of the defibrillation method, as well as the splitting properties of the hardened brain to show its structure. Some of the topics covered in the text are the preparation of a half-brain according to the defibrillation method; the outer form, soft membranes, nerves and vessels of the brain; and the description of the white substance of the cerebrum, association fibres, corpus callosum, and brain ventricles. The structure of the nucleus caudatus and thalamus; the preparation of the outer form of the rhombencephalon and ventricle; and the description of supplementary preparations on a half-brain are discussed. The book further presents the investigation made on the pallium, ventricles, and its structures; and the parts of the brain stem. A chapter is devoted to photographic illustrations of preparations made on the brain using defibrillation method. The book can provide useful information to neurosurgeons, doctors, students, and researchers.

  • Neuro-psychopharmacology

    Proceedings of the Tenth Congress of the Collegium Internationale Neuro-Psychopharmacologicum Québec, July 4-9, 1976
    • 1st Edition
    • P. Deniker
    • English
    Neuro-psychopharmaco...

  • The Fine Arts, Neurology, and Neuroscience

    Neuro-Historical Dimensions
    • 1st Edition
    • Volume 203
    • English
    This well-established international series examines major areas of basic and clinical research within neuroscience, as well as emerging and promising subfields. This volume explores the history and modern perspective on neurology and neuroscience.

  • The Fine Arts, Neurology, and Neuroscience

    New Discoveries and Changing Landscapes
    • 1st Edition
    • Volume 204
    • English
    This volume on neuroscience, neurology, and the fine arts brings several disciplines together. It presents current thoughts and modern examples about how science, medicine and the arts have interacted in the past and are still converging. This volume specifically explores the history and modern perspective on neurology and neuroscience.

  • Noise and the Brain

    Experience Dependent Developmental and Adult Plasticity
    • 1st Edition
    • Jos J. Eggermont
    • English
    In our industrialized world, we are surrounded by occupational, recreational, and environmental noise. Very loud noise damages the inner-ear receptors and results in hearing loss, subsequent problems with communication in the presence of background noise, and, potentially, social isolation. There is much less public knowledge about the noise exposure that produces only temporary hearing loss but that in the long term results in hearing problems due to the damage of high-threshold auditory nerve fibers. Early exposures of this kind, such as in neonatal intensive care units, manifest themselves at a later age, sometimes as hearing loss but more often as an auditory processing disorder. There is even less awareness about changes in the auditory brain caused by repetitive daily exposure to the same type of low-level occupational or musical sound. This low-level, but continuous, environmental noise exposure is well known to affect speech understanding, produce non-auditory problems ranging from annoyance and depression to hypertension, and to cause cognitive difficulties. Additionally, internal noise, such as tinnitus, has effects on the brain similar to low-level external noise.Noise and the Brain discusses and provides a synthesis of hte underlying brain mechanisms as well as potential ways to prvent or alleviate these aberrant brain changes caused by noise exposure.

  • Catecholamines: Basic and Clinical Frontiers

    Proceedings of the Fourth International Catecholamine Symposium, Pacific Grove, California, September 17-22, 1978
    • 1st Edition
    • Earl Usdin
    • English
    Catecholamines: Basic and Clinical Frontiers is a collection of papers that discusses clinical problems related to this series of compounds which includes dopamine, epinephrine, and norepinephrine. One paper discusses the role of biogenic amines in several mental disorders, such as senile dementia, schizophrenia, chronic alcoholism, and affective disorders. Another paper describes that in studies of mice, the number of neurotransmitter-spe... neurons is under a genetic control and can be a significant determinant of species-dependent variation in brain chemistry, nuclear organization, drug responses, and spontaneous behavior. One paper investigates if prostaglandins can directly alter the release or reuptake of catecholamines in the central nervous system, as well as their action upon the disposition of different metabolites of dopamine and norepinephrine in brain perfusate. The effects of several drugs on shock elicited fighting in rats show no significant aspects with amphetamine, apomorphine, phenoxybenzamine or phentolamine. The use of clonidine and propranolol shows a significant inhibition of fighting, while low doses of piperoxane exhibits a marked increase in fighting behavior. The collection can prove beneficial for pharmacologists, biochemists, micro-biologists, cellular researchers, and academicians involved in the study of physiology or neuroendocrinology.

  • Institutional Neurosis

    • 3rd Edition
    • Russell Barton
    • English
    Institutional Neurosis describes the clinical features of the disorder in mental hospitals, its differential diagnosis, etiology, treatment, and prevention. This book defines institutional neurosis as a disease characterized by apathy, lack of initiative, loss of interest in things and events not immediately personal or present, submissiveness, and sometimes no expression of feelings of resentment at harsh or unfair orders. The cause of institutional neurosis is uncertain, but it can be associated with many factors in the environment in which the patient lives. This text considers the factors associated with institutional neurosis such as loss of contact with the outside world; enforced idleness; brutality, browbeating and teasing; bossiness of staff; loss of personal friends, possessions and personal events; drugs; ward atmosphere; and loss of prospects outside the institution. This publication is a good reference for medical practitioners and students interested in the mental changes that may result from institutional life.

  • Minireviews of the Neurosciences

    Volume 13, 14, 15
    • 1st Edition
    • Bernard B. Brodie + 1 more
    • English
    Minireviews of the Neurosciences from Life Sciences discusses the regulation of tryptophan and tyrosine hydroxylase. This book also addresses the neurochemical correlations of synaptically active amino acids. This book deals first with the role of calcium in the central effects of biogenic amines; neuroendocrinology of human sleep; factors in central serotonergic synapse regulation; noradrenergic mediation of traumatic spinal cord; role of cyclic nucleotides in visual excitation; and function and organization of chromaffin vesicle. Other chapters consider the analysis of nerve growth factor, the sympathetic regulation of thyroid hormone secretion, and the mechanism if trans-synaptic enzyme induction. A study of the functions of the catecholamines and acetylcholine in endocrine regulation is presented. The final chapters examine the effects of brain monoamines in male sexual behavior and the behavior of L-dopa in Parkinson’s disease. The book can provide useful information to neurologists, students, and researchers.

  • Thalamic Networks for Relay and Modulation

    Pergamon Studies in Neuroscience
    • 1st Edition
    • Diego Minciacchi + 2 more
    • English
    Thalamic Networks for Relay and Modulation is the third in a series that springs from an idea of Giorgio Macchi who wished to establish periodical updates on thalamic research by bringing to Italy investigators who would engage in an international sharing of ideas and experiences. It reflects the renewed interest in the modulation of thalamic relay activity by intrinsic and extrinsic sources, while continuing to underscore the essential role of the thalamus as the gatekeeper of the cerebral cortex and of the pathways to perception. The papers that form the substance of this book were presented at a Symposium held at the Catholic University, Rome, Italy, in September 1992, as a Satellite to the 15th Annual Meeting of the European Neuroscience Association. The volume is organized into four parts. Part I is basically concerned with developmental and evolutionary approaches. Part II highlights relay functions of visual, motor, and somatosensory relay nuclei and relay functions of the intralaminar nuclei. Part III deals primarily with the pharmacology of thalamic neurons. Part IV emphasizes the mechanisms that underlie the functional assembly of thalamic cells into collectively acting ensembles, largely revealed in rhythmic oscillations, and on the behavioral manifestations that accompany them.

  • Neuroendocrinology

    Volume I
    • 1st Edition
    • Luciano Martini + 1 more
    • English
    Neuroendocrinology, Volume I, is the first in a two-volume treatise designed to provide a survey of all aspects of the rapidly expanding science of neuroendocrinology. Only in recent years have the relations between the nervous system and the endocrine system come under intensive scrutiny, but their interactions have already been shown to be multiple and diverse. This diversity is reflected in the range of subjects covered. There are chapters on neural control of endocrine function; the effects of hormones on the brain; brain-endocrine interrelations during various phases of development; and the comparative aspects of neuroendocrine integration. The relation of brain chemistry to endocrine function, the effect of drugs on neuroendocrine mechanisms, and the new discipline of clinical neuroendocrinology have also been considered. Not only neurophysiologists and endocrinologists, but pharmacologists, zoologists, biochemists, psychologists, and those in clinical medicine will find the treatise of interest. Parts of neuroendocrinology have been discussed in other works, but this is the first treatise in which an attempt has been made to cover all ramifications of neuroendocrinology. This book can be used both as a text for advanced students and as a reference source.

  • Cognitive Electrophysiology of Attention

    Signals of the Mind
    • 1st Edition
    • George R. Mangun
    • English
    Cognitive Electrophysiology of Attention explores the fundamental mechanisms of attention and related cognitive functions from cognitive neuroscience perspectives. Attention is an essential cognitive ability that enables humans to process and act upon relevant information while ignoring distracting information, and the capacity to focus attention is at the core of mental functioning. Understanding the neural bases of human attention remains a key challenge for neuroscientists and psychologists, and is essential for translational efforts to treat attentional deficits in a variety of neurological and psychiatric disorders. Cognitive electrophysiology is at the center of a multidisciplinary approach that involves the efforts of psychologists, neuroscientists, neuropsychologists, psychiatrists, and neurologists to identify basic brain mechanisms and develop translational approaches to improve mental health. This edited volume is authored by leading investigators in the field and discusses methods focused on electrophysiological recordings in humans, including electroencephalograp... (EEG) and event-related potential (ERP) methods, and also incorporates evidence from functional magnetic resonance imaging (fMRI). Cognitive Electrophysiology of Attention illuminates specific models about attentional mechanisms in vision, audition, multisensory integration, memory, and semantic processing in humans.

  • Global Clinical Trials for Alzheimer's Disease

    Design, Implementation, and Standardization
    • 1st Edition
    • Menghis Bairu + 1 more
    • English
    Global Clinical Trials for Alzheimer’s Disease is a handy one-stop reference for researchers and physicians planning and conducting global clinical trials in this area. This book addresses important considerations that may arise during the successful design and execution of these trials, including site selection, local regulatory issues, pharmacogenomics, ethical matters and much more. Given the saturation of traditional clinical trial markets and the worldwide progression of Alzheimer’s disease, there is a need to focus on clinical trials in emerging markets and developing countries. This book provides you with a practical approach to recognizing the opportunities and tackling the challenges that are present during the planning and execution of global clinical trials for Alzheimer’s disease.

  • Placebo and Pain

    From Bench to Bedside
    • 1st Edition
    • Luana Colloca + 2 more
    • English
    The placebo effect continues to fascinate scientists, scholars, and clinicians, resulting in an impressive amount of research, mainly in the field of pain. While recent experimental and clinical studies have unraveled salient aspects of the neurobiological substrates and clinical relevance of pain and placebo analgesia, an authoritative source remained lacking until now. By presenting and integrating a broad range of research, Placebo and Pain enhances readers’ knowledge about placebo and nocebo effects, reexamines the methodology of clinical trials, and improves the therapeutic approaches for patients suffering from pain. Review for Placebo and Pain:“This ambitious book is the first comprehensive and unified presentation of the placebo and nocebo phenomena in the area of pain. Written by the international leading experts in the field, the book provides an accurate up-to-date [work] on placebo and pain dealing with current perspectives and future challenging issues.”--Ted Kaptchuk, Associate Professor of Medicine, Harvard Medical School

  • Peripheral Nerve Disorders

    • 1st Edition
    • Volume 115
    • Gérard Said + 1 more
    • English
    Disorders of the peripheral nervous system (PNS) are the cause of prominent neurological symptoms including weakness, sensory loss, pain and autonomic dysfunction associated with deficits, morbidity and mortality. These disorders may be primary hereditary or cryptogenic neurologic disorders confined to the PNS or part of the pathology of both the central nervous system and the PNS. Most PNS disorders are secondary to other system disorders and may be responsive to treatment of the primary disease. Important advances have been obtained in several areas including molecular genetics, biochemistry, immunology, morphology and physiology that have enhanced our understanding of the causes and consequences of damage to peripheral nerve. Understanding of both these groups of PNS diseases has greatly expanded over recent years and has led to important advances of treatment both to protect and to repair damages of peripheral nerve. This volume provides an overview of the state-of-the-art of examination, diagnosis and treatment of these very diverse disorders and will be of interest to both the research and clinical neuroscience and neurology communities.

  • Mathematical Neuroscience

    • 1st Edition
    • Stanislaw Brzychczy + 1 more
    • English
    Mathematical Neuroscience is a book for mathematical biologists seeking to discover the complexities of brain dynamics in an integrative way. It is the first research monograph devoted exclusively to the theory and methods of nonlinear analysis of infinite systems based on functional analysis techniques arising in modern mathematics. Neural models that describe the spatio-temporal evolution of coarse-grained variables—such as synaptic or firing rate activity in populations of neurons —and often take the form of integro-differential equations would not normally reflect an integrative approach. This book examines the solvability of infinite systems of reaction diffusion type equations in partially ordered abstract spaces. It considers various methods and techniques of nonlinear analysis, including comparison theorems, monotone iterative techniques, a truncation method, and topological fixed point methods. Infinite systems of such equations play a crucial role in the integrative aspects of neuroscience modeling.

  • Novel Psychoactive Substances

    Classification, Pharmacology and Toxicology
    • 1st Edition
    • Paul I. Dargan + 1 more
    • English
    Novel Psychoactive Substances: Classification, Pharmacology and Toxicology provides readers with background on the classification, detection, supply and availability of novel psychoactive substances, otherwise known as "legal highs." This book also covers individual classes of novel psychoactive substances that have recently emerged onto the recreational drug scene and provides an overview of the pharmacology of the substance followed by a discussion of the acute and chronic harm or toxicity associated with the substance. Written by international experts in the field, this multi-authored book is a valuable reference for scientists, clinicians, academics, and regulatory and law enforcement professionals.

  • Introduction to Diffusion Tensor Imaging

    And Higher Order Models
    • 1st Edition
    • Susumu Mori + 1 more
    • English
    The concepts behind diffusion tensor imaging (DTI) are commonly difficult to grasp, even for magnetic resonance physicists. To make matters worse, a many more complex higher-order methods have been proposed over the last few years to overcome the now well-known deficiencies of DTI. In Introduction to Diffusion Tensor Imaging: And Higher Order Models, these concepts are explained through extensive use of illustrations rather than equations to help readers gain a more intuitive understanding of the inner workings of these techniques. Emphasis is placed on the interpretation of DTI images and tractography results, the design of experiments, and the types of application studies that can be undertaken. Diffusion MRI is a very active field of research, and theories and techniques are constantly evolving. To make sense of this constantly shifting landscape, there is a need for a textbook that explains the concepts behind how these techniques work in a way that is easy and intuitive to understand—Introduct... to Diffusion Tensor Imaging fills this gap.

  • Medical Imaging Technology

    • 1st Edition
    • Victor I. Mikla + 1 more
    • English
    Medical Imaging Technology reveals the physical and materials principles of medical imaging and image processing, from how images are obtained to how they are used. It covers all aspects of image formation in modern imaging modalities and addresses the techniques, instrumentation, and advanced materials used in this rapidly changing field. Covering conventional and modern medical imaging techniques, this book encompasses radiography, fluoroscopy, computed tomography, magnetic resonance imaging, ultrasound, and Raman spectroscopy in medicine. In addition to the physical principles of imaging techniques, the book also familiarizes you with the equipment and procedures used in diagnostic imaging.

  • Chronic Pain and Brain Abnormalities

    • 1st Edition
    • Carl Y. Saab
    • English
    It is only natural for someone in pain to attend to the body part that hurts. Yet this book tells the story of persistent pain having negative effects on brain function. The contributors, all leading experts in their respective fields of pain electrophysiology, brain imaging, and animal models of pain, strive to synthesize compelling and, in some ways, connected hypotheses with regard to pain-related changes in the brain. Together, they contribute their clinical, academic, and theoretical expertise in a comprehensive overview that attempts to define the broader philosophical context of pain (disentangling sensical from nonsensical claims), list the changes known to take place in the brains of individuals with chronic pain and animal models of pain, address the possible causes and mechanisms underlying these changes, and detail the techniques and analytical methods at our disposal to "visualize" and study these changes.

  • Invertebrate Learning and Memory

    • 1st Edition
    • Volume 22
    • Randolf Menzel + 1 more
    • English
    Understanding how memories are induced and maintained is one of the major outstanding questions in modern neuroscience. This is difficult to address in the mammalian brain due to its enormous complexity, and invertebrates offer major advantages for learning and memory studies because of their relative simplicity. Many important discoveries made in invertebrates have been found to be generally applicable to higher organisms, and the overarching theme of the proposed will be to integrate information from different levels of neural organization to help generate a complete account of learning and memory. Edited by two leaders in the field, Invertebrate Learning and Memory will offer a current and comprehensive review, with chapters authored by experts in each topic. The volume will take a multidisciplinary approach, exploring behavioral, cellular, genetic, molecular, and computational investigations of memory. Coverage will include comparative cognition at the behavioral and mechanistic level, developments in concepts and methodologies that will underlie future advancements, and mechanistic examples from the most important vertebrate systems (nematodes, molluscs, and insects). Neuroscience researchers and graduate students with an interest in the neural control of cognitive behavior will benefit, as will as will those in the field of invertebrate learning.

  • Intelligence and Human Progress

    The Story of What was Hidden in our Genes
    • 1st Edition
    • James Flynn
    • English
    Written by James R. Flynn of the "Flynn effect" (the sustained and substantial increase in intelligence test scores across the world over many decades), Intelligence and Human Progress examines genes and human achievement in all aspects, including what genes allow and forbid in terms of personal life history, the cognitive progress of humanity, the moral progress of humanity, and the cross-fertilization of the two. This book presents a new method for weighing family influences versus genes in the cognitive abilities of individuals, and counters the arguments of those who dismiss gains in IQ as true cognitive gains. It ranges over topics including: how family can handicap those taking the SAT; new IQ thresholds for occupations that show elite occupations are within reach of the average American; what Pol Pot did to the genetic potential of Cambodia; why dysgenics (the deterioration of human genes over the generations) is important, but no menace for the foreseeable future; and what might derail human intellectual progress. Researchers in developmental and cognitive psychology, educators, and professionals involved in intelligence testing or psychometrics will benefit from the perspectives offered here. But beyond that, anyone interested in the potential of the human mind will be engaged and challenged by one of the most important contemporary thinkers on the subject.

  • Rio-Hortega's Third Contribution to the Morphological Knowledge and Functional Interpretation of the Oligodendroglia

    • 1st Edition
    • Jose R. Iglesias-Rozas + 1 more
    • English
    Pío del Rio-Hortega, one of the pioneering neuroscientists and discoverer of microglia, has been recognized as one of the most important Spanish neurohistogists of the past century. His landmark research on oligodendroglia, originally published in Spanish in 1928, has been translated into English for the first time by Dr. José R. Iglesias-Rozas and Prof. Manuel Garrosa. The book establishes definitively the concept of oligodendroglia and describes in great detail its structure, varieties, function, origin and pathology, providing a thorough review. The entire 1928 writing is presented, including the 79 excellent drawings and photographs from the original publication. To complement the original book and provide historical context, the translators have also included an introduction to the research and a biography of Pío del Rio-Hortega. This book constitutes a milestone in the history of neuroscience, biology and medicine, and it will be valuable reading for researchers and practitioners in these fields.

  • Challenging Behavior

    • 1st Edition
    • Volume 44
    • English
    International Review of Research in Developmental Disabilities is an ongoing scholarly look at research into the causes, effects, classification systems, syndromes, etc. of developmental disabilities. Contributors come from wide-ranging perspectives, including genetics, psychology, education, and other health and behavioral sciences. Volume 44 of the series offers chapters on challenging behavior.

  • The Psychology of Learning and Motivation

    • 1st Edition
    • Volume 59
    • English
    Psychology of Learning and Motivation publishes empirical and theoretical contributions in cognitive and experimental psychology, ranging from classical and instrumental conditioning to complex learning and problem solving. Each chapter thoughtfully integrates the writings of leading contributors, who present and discuss significant bodies of research relevant to their discipline. Volume 59 includes chapters on such varied topics as pupillometric studies of face memory, self-organization of human interaction, and the role of relational competition in the comprehension of modifier-noun phrases and noun-noun compounds.

  • Cellular Migration and Formation of Neuronal Connections

    Comprehensive Developmental Neuroscience
    • 1st Edition
    • John Rubenstein + 1 more
    • English
    The genetic, molecular, and cellular mechanisms of neural development are essential for understanding evolution and disorders of neural systems. Recent advances in genetic, molecular, and cell biological methods have generated a massive increase in new information, but there is a paucity of comprehensive and up-to-date syntheses, references, and historical perspectives on this important subject. The Comprehensive Developmental Neuroscience series is designed to fill this gap, offering the most thorough coverage of this field on the market today and addressing all aspects of how the nervous system and its components develop. Particular attention is paid to the effects of abnormal development and on new psychiatric/neurolog... treatments being developed based on our increased understanding of developmental mechanisms. Each volume in the series consists of review style articles that average 15-20pp and feature numerous illustrations and full references. Volume 2 offers 56 high level articles devoted mainly to Formation of Axons and Dendrites, Migration, Synaptogenesis, Developmental Sequences in the Maturation of Intrinsic and Synapse Driven Patterns.

  • Patterning and Cell Type Specification in the Developing CNS and PNS

    Comprehensive Developmental Neuroscience
    • 1st Edition
    • John Rubenstein + 1 more
    • English
    The genetic, molecular, and cellular mechanisms of neural development are essential for understanding evolution and disorders of neural systems. Recent advances in genetic, molecular, and cell biological methods have generated a massive increase in new information, but there is a paucity of comprehensive and up-to-date syntheses, references, and historical perspectives on this important subject. The Comprehensive Developmental Neuroscience series is designed to fill this gap, offering the most thorough coverage of this field on the market today and addressing all aspects of how the nervous system and its components develop. Particular attention is paid to the effects of abnormal development and on new psychiatric/neurolog... treatments being developed based on our increased understanding of developmental mechanisms. Each volume in the series consists of review style articles that average 15-20pp and feature numerous illustrations and full references. Volume 1 offers 48 high level articles devoted mainly to patterning and cell type specification in the developing central and peripheral nervous systems.

  • Neural Circuit Development and Function in the Healthy and Diseased Brain

    Comprehensive Developmental Neuroscience
    • 1st Edition
    • John Rubenstein + 1 more
    • English
    The genetic, molecular, and cellular mechanisms of neural development are essential for understanding evolution and disorders of neural systems. Recent advances in genetic, molecular, and cell biological methods have generated a massive increase in new information, but there is a paucity of comprehensive and up-to-date syntheses, references, and historical perspectives on this important subject. The Comprehensive Developmental Neuroscience series is designed to fill this gap, offering the most thorough coverage of this field on the market today and addressing all aspects of how the nervous system and its components develop. Particular attention is paid to the effects of abnormal development and on new psychiatric/neurolog... treatments being developed based on our increased understanding of developmental mechanisms. Each volume in the series consists of review style articles that average 15-20pp and feature numerous illustrations and full references. Volume 3 offers 40 high level articles devoted mainly to anatomical and functional development of neural circuits and neural systems, as well as those that address neurodevelopmental disorders in humans and experimental organisms.

  • Pediatric Demyelinating Disease and its Mimics, An Issue of Neuroimaging Clinics

    • 1st Edition
    • Volume 23-2
    • Manohar Shroff
    • English
    This issue reviews the state of the art in pediatric demyelinating diseases. Articles cover topics on childhood transverse myelitis, neuromyelitis optica, multiple sclerosis, acute demyelinating encephalopathy, and more.

  • Pediatric Neurology, Part I

    • 1st Edition
    • Volume 111
    • Olivier Dulac + 2 more
    • English
    The child is neither an adult miniature nor an immature human being: at each age, it expresses specific abilities that optimize adaptation to its environment and development of new acquisitions. Diseases in children cover all specialties encountered in adulthood, and neurology involves a particularly large area, ranging from the brain to the striated muscle, the generation and functioning of which require half the genes of the whole genome and a majority of mitochondrial ones. Human being nervous system is sensitive to prenatal aggression, is particularly immature at birth and development may be affected by a whole range of age-dependent disorders distinct from those that occur in adults. Even diseases more often encountered in adulthood than childhood may have specific expression in the developing nervous system. The course of chronic neurological diseases beginning before adolescence remains distinct from that of adult pathology – not only from the cognitive but also motor perspective, right into adulthood, and a whole area is developing for adult neurologists to care for these children with persisting neurological diseases when they become adults. Just as pediatric neurology evolved as an identified specialty as the volume and complexity of data became too much for the general pediatician or the adult neurologist to master, the discipline has now continued to evolve into so many subspecialties, such as epilepsy, neuromuscular disease, stroke, malformations, neonatal neurology, metabolic diseases, etc., that the general pediatric neurologist no longer can reasonably possess in-depth expertise in all areas, particularly in dealing with complex cases. Subspecialty expertise thus is provided to some trainees through fellowship programmes following a general pediatric neurology residency and many of these fellowships include training in research. Since the infectious context, the genetic background and medical practice vary throughout the world, this diversity needs to be represented in a pediatric neurology textbook. Taken together, and although brain malformations (H. Sarnat & P. Curatolo, 2007) and oncology (W. Grisold & R. Soffietti) are covered in detail in other volumes of the same series and therefore only briefly addressed here, these considerations justify the number of volumes, and the number of authors who contributed from all over the world. Experts in the different subspecialties also contributed to design the general framework and contents of the book. Special emphasis is given to the developmental aspect, and normal development is reminded whenever needed – brain, muscle and the immune system. The course of chronic diseases into adulthood and ethical issues specific to the developing nervous system are also addressed.

  • Pediatric Neurology, Part III

    • 1st Edition
    • Volume 113
    • English
    The child is neither an adult miniature nor an immature human being: at each age, it expresses specific abilities that optimize adaptation to its environment and development of new acquisitions. Diseases in children cover all specialties encountered in adulthood, and neurology involves a particularly large area, ranging from the brain to the striated muscle, the generation and functioning of which require half the genes of the whole genome and a majority of mitochondrial ones. Human being nervous system is sensitive to prenatal aggression, is particularly immature at birth and development may be affected by a whole range of age-dependent disorders distinct from those that occur in adults. Even diseases more often encountered in adulthood than childhood may have specific expression in the developing nervous system. The course of chronic neurological diseases beginning before adolescence remains distinct from that of adult pathology – not only from the cognitive but also motor perspective, right into adulthood, and a whole area is developing for adult neurologists to care for these children with persisting neurological diseases when they become adults. Just as pediatric neurology evolved as an identified specialty as the volume and complexity of data became too much for the general pediatician or the adult neurologist to master, the discipline has now continued to evolve into so many subspecialties, such as epilepsy, neuromuscular disease, stroke, malformations, neonatal neurology, metabolic diseases, etc., that the general pediatric neurologist no longer can reasonably possess in-depth expertise in all areas, particularly in dealing with complex cases. Subspecialty expertise thus is provided to some trainees through fellowship programmes following a general pediatric neurology residency and many of these fellowships include training in research. Since the infectious context, the genetic background and medical practice vary throughout the world, this diversity needs to be represented in a pediatric neurology textbook. Taken together, and although brain malformations (H. Sarnat & P. Curatolo, 2007) and oncology (W. Grisold & R. Soffietti) are covered in detail in other volumes of the same series and therefore only briefly addressed here, these considerations justify the number of volumes, and the number of authors who contributed from all over the world. Experts in the different subspecialties also contributed to design the general framework and contents of the book. Special emphasis is given to the developmental aspect, and normal development is reminded whenever needed – brain, muscle and the immune system. The course of chronic diseases into adulthood and ethical issues specific to the developing nervous system are also addressed.

  • Pediatric Neurology, Part II

    • 1st Edition
    • Volume 112
    • Olivier Dulac + 2 more
    • English
    The child is neither an adult miniature nor an immature human being: at each age, it expresses specific abilities that optimize adaptation to its environment and development of new acquisitions. Diseases in children cover all specialties encountered in adulthood, and neurology involves a particularly large area, ranging from the brain to the striated muscle, the generation and functioning of which require half the genes of the whole genome and a majority of mitochondrial ones. Human being nervous system is sensitive to prenatal aggression, is particularly immature at birth and development may be affected by a whole range of age-dependent disorders distinct from those that occur in adults. Even diseases more often encountered in adulthood than childhood may have specific expression in the developing nervous system. The course of chronic neurological diseases beginning before adolescence remains distinct from that of adult pathology – not only from the cognitive but also motor perspective, right into adulthood, and a whole area is developing for adult neurologists to care for these children with persisting neurological diseases when they become adults. Just as pediatric neurology evolved as an identified specialty as the volume and complexity of data became too much for the general pediatician or the adult neurologist to master, the discipline has now continued to evolve into so many subspecialties, such as epilepsy, neuromuscular disease, stroke, malformations, neonatal neurology, metabolic diseases, etc., that the general pediatric neurologist no longer can reasonably possess in-depth expertise in all areas, particularly in dealing with complex cases. Subspecialty expertise thus is provided to some trainees through fellowship programmes following a general pediatric neurology residency and many of these fellowships include training in research. Since the infectious context, the genetic background and medical practice vary throughout the world, this diversity needs to be represented in a pediatric neurology textbook. Taken together, and although brain malformations (H. Sarnat & P. Curatolo, 2007) and oncology (W. Grisold & R. Soffietti) are covered in detail in other volumes of the same series and therefore only briefly addressed here, these considerations justify the number of volumes, and the number of authors who contributed from all over the world. Experts in the different subspecialties also contributed to design the general framework and contents of the book. Special emphasis is given to the developmental aspect, and normal development is reminded whenever needed – brain, muscle and the immune system. The course of chronic diseases into adulthood and ethical issues specific to the developing nervous system are also addressed.

  • Context Effects on Embodied Representation of Language Concepts

    • 1st Edition
    • Jie Yang
    • English
    Embodied theories claim that semantic representations are grounded in sensorimotor systems, but the contribution of sensorimotor brain areas in representing meaning is still controversial. One current debate is whether activity in sensorimotor areas during language comprehension is automatic. Numerous neuroimaging studies reveal activity in perception and action areas during semantic processing that is automatic and independent of context, but increasing findings show that involvement of sensorimotor areas and the connectivity between word-form areas and sensorimotor areas can be modulated by contextual information. Context Effects on Embodied Representation of Language Concepts focuses on these findings and discusses the influences from word, phrase, and sentential contexts that emphasize either dominant conceptual features or non-dominant conceptual features.

  • Memory Reconsolidation

    • 1st Edition
    • Cristina M. Alberini
    • English
    As little as 10 years ago, it was believed that memory went from short to long term via one consolidation practice that made that memory intractable. Since then, research has shown that long-term memories can be activated, modified, and reconsolidated in their new form. This research indicates that memories are more dynamic than once believed. And understanding how this process works and helping people to redefine established memories can be clinically useful if those memories lead to problems, as is the case in post-traumatic stress disorder. This book provides a comprehensive overview of research on memory reconsolidation; what this has to say about the formation, storage, and changeability of memory; and the potential applications of this research to treating clinical disorders.

  • The Psychology of Learning and Motivation

    • 1st Edition
    • Volume 58
    • English
    The Psychology of Learning and Motivation series publishes empirical and theoretical contributions in cognitive and experimental psychology, ranging from classical and instrumental conditioning to complex learning and problem solving.

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