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Elsevier

Books in Life sciences

  • Handbook of Biological Control

    Principles and Applications of Biological Control
    • 1st Edition
    • T. W. Fisher + 5 more
    • English
    For many years the use of chemical agents such as pesticides and herbicides has been effective in controlling the many varieties of pests that infest both agricultural crops and backyard gardens. However, these pests are gradually becoming resistant to these agents, because the agents themselves are acting as selective factors making the pests better and better able to resist and persist. As a result, the use of biological controlling agents is increasing. This book is a comprehensive and authoritative handbook of biological control.

  • Parasitology and Vector Biology

    • 2nd Edition
    • William H. Marquardt + 2 more
    • English
    Parasitology and Vector Biology, Second Edition, is a comprehensive introduction to human and animal parasitology. It provides basic information on the biologies of such agents as protists, worms, and arthropods, but it also emphasizes how control programs can be structured in a sociological, political, and economic milieu. Students and researchers alike will appreciate the added coverage of the molecular aspects of parasitology in this new edition.

  • Advances in Genetics

    • 1st Edition
    • Volume 41
    • English
    Advances in Genetics has established itself as an outstanding vehicle for the dissemination of research results in genetics. Once again, authoritative papers are presented here, beginning with a review by Rai and Black highlighting the salient features of mosquito genomes and their evolution. The recent progress which has been made by the cloning and characterization of two cooperating partners of the Neurospora blue light signal transduction chain is presented by Linden, Balario, Arpaia, and Macino. The emergence of the concept of X-linked mental retardation (XLMR) is discussed by Neri and Chiurazzi, as well as epidemiologic data and XLMR gene updates. In chapter 4, Mahato, Smith, and Rolland provide insights into the potentials of plasmid-based gene therapy and critical evaluation of gene delivery sciences and clinical applications of gene medicines. Kathleen Triman completes the volume with an outline of the genetic strategies designed to improve our understanding of the structure and function of 23S ribosomal RNA in E. coli.

  • Encyclopedia of Violence, Peace, and Conflict

    • 1st Edition
    • Lester R. Kurtz
    • English
    The Encyclopedia of Violence, Peace, and Conflict, a three-volume set written by more than 200 eminent contributors from around the world, takes advantage of increasing, worldwide awareness in the public, private, commercial, and academic sectors about manifestations of violence in all segments of society. While the contributors do not use these volumes to make specific arguments, they do describe and clarify the developments in thought that have led to current theories about and positions on violence and peace. Our reviewers consistently note that while many in-depth studies of war, peace, and aggression exist, the attendant specialization keeps scholars from learning about related fields. No publication competing with the Encyclopedia of Violence, Peace, and Conflict can satisfy their need for a vast introductory work to such a diverse and socially-important field. This major work includes more than 190 multidisciplinary articles with over 1,000 cross-references and more than 2,000 bibliography entries for further reading which are arranged alphabetically for easy access.

  • The Dictionary of Cell and Molecular Biology

    • 3rd Edition
    • John M. Lackie
    • English
    The Dictionary of Cell and Molecular Biology provides straightforward definitions for over 7,000 terms in the exciting and fast moving fields of modern cell and molecular biology. It is aimed at students and professional biologists who encounter new terms in this expanding area.

  • Encyclopedia of Virology

    • 2nd Edition
    • Allan Granoff + 1 more
    • English
    In recent years, progress in the field of virology has advanced at an unprecedented rate. Issues such as AIDS have brought the subject firmly into the public domain and its study is no longer confined solely to specialist groups.The Encyclopedia of Virology is the largest single reference source of current virological knowledge. It is also the first to bring together all aspects of the subject for a wide variety of readers. Unique in its use of concise 'mini-review' articles, the material covers biological, molecular, and medical topics concerning viruses in animals, plants, bacteria, and insects. More general articles focus on the effects of viruses on the immune system, the role of viruses in disease, oncology, gene therapy, and evolution, plus a wide range of related topics. Drawing on the latest research, the editors have produced the definitive source for both specialist and general readers. Easy-to-use and meticulously organized, the Encyclopedia of Virology clarifies and illuminates one of the most complex areas of contemporary study. It will prove an invaluable addition to libraries, universities, medical and nursing schools, and research institutions around the world. The Second Edition has been thoroughly updated with approximately 40 new articles. This edition includes more illustrations and color plates in each volume.

  • Expression of Recombinant Genes in Eukaryotic Systems

    • 1st Edition
    • Volume 306
    • English
    The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.

  • Advances in Clinical Chemistry

    Cumulative Subject and Author Indexes and Tables of Contents for Volumes 1-33
    • 1st Edition
    • Volume 34
    • English
    For more than thirty years, this serial has broadened the technical scope and expanded the scientific base of clinical chemistry. These volumes clarify the areas of molecular biology, informatics, and the monitoring of physiological parameters in critical situations as they pertain to clinical chemistry. Each volume of Advances in Clinical Chemistry contains an index, and each chapter includes references.

  • Computational Neuroscience

    Trends in Research 1999
    • 1st Edition
    • J.M. Bower
    • English
    This volume includes papers originally presented at the 7th annual Computational Neuroscience Meeting (CNS'98) held in July of 1998 at the Fess Parker Doubletree Inn in Santa Barbara, California. The CNS meetings bring together computational neuroscientists representing many different fields and backgrounds as well as many different experimental preparations and theoretical approaches. The papers published here range from pure experimental neurobiology, to neuro-ethology, mathematics, physics, and engineering. In all cases the research described is focused on understanding how nervous systems compute. The actual subjects of the research include a highly diverse number of preparations, modeling approaches, and analysis techniques. Accordingly, this volume reflects the breadth and depth of current research in computational neuroscience taking place throughout the world.

  • Biology of Brassica Coenospecies

    • 1st Edition
    • Volume 4
    • C. Gomez-Campo
    • English
    Brassica crop species and their allies (Raphanus, Sinapis, Eruca, etc.) are important sources of edible roots, stems, leaves, buds and inflorescences, as well as of edible or industrial oils, condiments and forage. Many well known names of plants or plant products, such as kale, cabbage, brocolli, cauliflower, Brussels sprouts, kohl-rabi, Chinese cabbage, turnip, rape, rutabaga, swede, colza or rapeseed, canola, mustard, rocket, etc. are directly associated to this botanical group.The scientific interest for this botanical group has run parallel to its economical importance, and research achievements in our days would have certainly appeared unimaginable only two decades ago. As the end of the millenium approaches, entirely new fields (transformation, somatic fusion, etc.) have been added to the classical ones. Thus, nobody can doubt the opportuneness of this book, which combines and presents both the basic and applied biological aspects of the Brassica species.

  • Potato Production, Processing and Technology

    • 1st Edition
    • WA Gould
    • English
    This compilation focuses on the events of growing, processing, quality control, color, as well as freezing, canning, chip, and dried production. This potato processing operations book, written in terms the nonprofessional plant worker will understand, is a must reference for all food processors, technologists, executives, students etc. as well as a valuable addition to the company technical reference library. Included are figures, tables and charts throughout the book.

  • Nonviral Vectors for Gene Therapy

    • 1st Edition
    • Mien-Chie Hung + 2 more
    • English
    Gene transfer within humans has been an obstacle until about 10 years ago. At that time, it was found that viral vectors were effective carriers of "healthy genes" into patients' cells. The problem, however, was that viral vectors proved unnecessarily harmful to humans: subjects experienced inflamatory activity and negative immunological responses to the genes. Viral vectors were also unable to meet the needs of the pharmaceutical community: they were not reproducible in large-scale proportions in cost-effective ways.Thus, research was undertaken to find a safer way to transfer genes to patients without jeopardizing the safety of the patient. And so non-viral vectors were discovered. This volume presents the various non-viral vectors currently under development. Although not methodologically oriented, it will provide the necessary details behind the development of the vectors. This information will prove useful to both researchers and clinicians.

  • Proteases of Infectious Agents

    • 1st Edition
    • Ben Dunn
    • English
    Proteases are enzymes that essentially "eat" protein. Without proteases, infectious organisms cannot properly mount an attack against a host. It is for this reason that proteases have become popular targets for drug discovery. Research has shown that if you can inhibit the protease, you can defend against the invading microbe. The defense against HIV, the virus that causes AIDS, is the best-documented case of the efficacy of protease inhibitors. Researchers are now trying to deploy this strategy against several infectious agents. This book gives information that is useful in that search.Proteases of Infectious Agents collects reviews from leading experts describing the latest information on the properties of key enzymes from a variety of viruses, fungi, and parasites. Each chapter provides the critical facts needed to initiate a drug discovery effort in that particular area.

  • Origin and Evolution of Viruses

    • 1st Edition
    • Esteban Domingo + 2 more
    • English
    Are infectious diseases caused by novel entities, viruses that have rapidly evolved into more pathogenic forms, or viruses that have crossed species divides and become more virulent in their alternative host? These questions and how new diseases such as AIDS emerged have prompted renewed interest in the ways viruses originated and co-evolved with their hosts.Origin and Evolution of Viruses presents a full and clear description of general viral concepts and specific viral systems, and provides an excellent foundation to our understanding of how viruses emerged.This unique and comprehensive work is essential reading for all researchers in virology, molecular biology and related areas, as well as evolutionary biologists interested in phylogenetic approaches to molecular evolution. The reader is taken on an illumination journey--in time and concepts--from the first primitive replicons to their present-day complex viral counterparts. Apart from the obvious interest, as humans are potential hosts for these viruses, there is also a great deal of academic interest in the evolutionary aspects of this simple group of organisms, since information can be gained about the origin of stains/species and evolutionary patterns that might be applicable to higher species.

  • Advances in Immunology

    • 1st Edition
    • Volume 73
    • English
    Advances in Immunology presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research.

  • Advances in Virus Research

    • 1st Edition
    • Volume 52
    • English

  • Osteoporosis in Men

    The Effects of Gender on Skeletal Health
    • 1st Edition
    • Eric S. Orwoll
    • English
    Osteoporosis in men is an important clinical problem that has received little attention, both in the medical arena and from the general public. Although the condition affects a higher percentage of women, it is estimated that two million men in the U.S. have osteoporosis, and three million more are at risk. The lack of awareness by doctors and their patients puts men at a higher risk that the condition may go undiagnosed and untreated.Osteoporos... in Men is the first book to explore this issue in depth. This groundbreaking text brings together eminent investigators and clinicians who interpret developments in this emerging field, and describe state-of-the-art research as well as practical approaches to diagnosis, prevention and therapy. It is an essential reference for researchers, students, and clinicians in bone-related disciplines.

  • Iron-Sulfur Proteins

    • 1st Edition
    • Volume 47
    • English
    Advances in Inorganic Chemistry presents timely and informative summaries of the current progress in a variety of subject areas within inorganic chemistry, ranging from bioinorganic to solid state. This acclaimed serial features reviews written by experts in the area and is an indispensable reference to advanced researchers. Each volume of Advances in Inorganic Chemistry contains an index, and each chapter is fully referenced.

  • Molecular Structure Description

    The Electrotopological State
    • 1st Edition
    • Lemont B. Kier + 1 more
    • English
    The entire thrust of industrial drug research is now directed toward the use of predictive methods and strategies to reduce the number of compounds made and tested. Furthermore, these theoretical/computat... methods are increasingly part of a general approach to chemical problems. Among non-empirical structure indices, the electrotopological state of atoms in a molecule is a new paradigm, providing a descriptor of intermolecular interactions at submolecular sights that is easy to calculate and information-rich. One of the authors (Hall) has included the E-state in his widely used MOLCONN computer program. Tripos has incorporated this index as an optional module for structure-activity analyses using a new Web-based tool called CHEMenlighten.

  • Caribbean Amphibians and Reptiles

    • 1st Edition
    • Brian I. Crother
    • English
    Amphibians and reptiles are the most numerous, diverse, and frequently encountered animals on the Caribbean islands. This book provides a variety of perspectives on this amazing group of organisms. Caribbean Amphibians and Reptiles, compiled by an international team of zoologists, takes a fresh and detailed look at the complex biological puzzle of the Caribbean. The first true overview of the islands, it includes a historical examination of the people who have studied the Caribbean amphibians and reptiles. The book reviews the ecology, evolutionary history, and biogeographic explanations for the origins and diversity of the region's fauna with island-by-island coverage. It puts the Caribbean in perspective by comparing the islands to Central America and its amphibian reptile diversity. Additionally, the book includes figures, tables, and color plates which bring to life some of the region's most spectacular creatures.

  • Harvested Forages

    • 1st Edition
    • Rodney Dwain Horrocks + 1 more
    • English
    Harvested Forages deals with the subject of food for domestic animal feeding. Such food is called "forage" and includes things like alfalfa and other plants usually referred to as "hay." Topics include the ways that this forage is produced, how it is harvested, and ways that it should be stored. Other issues that are dealt with include various criteria and measurement procedures for assessing forage nutritive quality, potential health hazards associated with particular plants and plant toxins, and various issues of plant growth, pest control, and soil fertility--among other topics. This book is essential for any institution with a strong program in range sciences, animal sciences, animal feeding and nutrition, and related programs.

  • Advances in Immunology

    • 1st Edition
    • Volume 72
    • English
    Advances in Immunology presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research.

  • Handbook of Animal Models of Infection

    Experimental Models in Antimicrobial Chemotherapy
    • 1st Edition
    • Merle A. Sande
    • Oto Zak
    • English
    Handbook of Animal Models of Infection is a complete revision of a three-volume text that was published in 1986. It incorporates the major advances in the field during the past decade, in particular those concerning molecular biological procedures and new models that have been developed. It focuses on both methods and techniques, which makes it an essential and comprehensive reference as well as a benchtop manual. The Handbook will help investigators save time and effort in formulating an approach to test a new potential therapeutic agent or combination of agents for in vivo efficacy and to position the therapy for specific infections where it may have therapeutic promise. The book is divided into five sections; the first covering the general methodologies, followed by sections describing experimental bacterial, mycotic, parasitic, and viral infections.

  • Genetic Methods for Diverse Prokaryotes

    • 1st Edition
    • Volume 29
    • English
    This new volume presents overviews of the very latest genetic approaches in a diverse range of prokaryotes. Divided into three sections, the topics include essential techniques for genetic analysis, case studies in which genetic methods in carefully chosen genera are described and approaches are used in the elucidation of specific phenomena.

  • Chromatin

    • 1st Edition
    • Volume 304
    • English
    This volume of Methods in Enzymology includes up-to-date procedures used for the assembly of nucleosomes, chromatin, and nuclei, extending the classical procedures described nearly ten years ago in Volume 170 (Nucleosomes) of this series, and should assist in the further investigation of the ways in which the structural dynamics of chromatin contribute to geh regulation of transcription, replication, recombination, and repair. Also described in this volume are assay for the structure and function of in vitro reconstituted chromatin and for defining the organization and characteristics of natural chromosomal material from yeast (Saccharomyces cerevisae), flies (Drosophila melanogaster), and frogs (Xenopus laevis), as well as from mammalian tissues. The purification and assay procedures for various chromatin remodeling activities, including histone acetyltransferases, histone deacetylases, and SWI/SNF ATPases are detailed.The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.

  • Preservation of Foods with Pulsed Electric Fields

    • 1st Edition
    • English
    Preservation of Foods with Pulsed Electric Fields discusses the basics of high voltage PEF as a low temperature food processing method, and the application of this technology in food preservation. This technology is attracting a great deal of interest around the world because it is more cost effective than conventional systems due to the conservative nature of PEF. This book thoroughly covers the electrical and food engineering aspects, as well as the food science components (i.e. food microbiology, enzyme inactivation kinetics, and sensory evaluation).

  • cDNA Preparation and Characterization

    • 1st Edition
    • Volume 303
    • John N. Abelson + 1 more
    • English
    Genomic sequences, now emerging at a rapid rate, are greatly expediting certain aspects of molecular biology. However, in more complex organisms, predicting mRNA structure from genomic sequences can often be difficult. Alternative splicing, the use of alternative promoters, and orphan genes without known analogues can call present difficulties in the predictions of the structure of mRNAs or even in gene detection. Both computational and experimental methods remain useful for recognizing genes and transcript templates, even in sequenced DNA. Methods for producing full-length cDNAs are important for determining the structures of the proteins the mRNA encodes, the positions of promoters, and the considerable regulatory information for translation that may be encoded in the 5' untranslated regions of the mRNA.Methods for studying levels of mRNA and their changes in different physiological circumstances are rapidly evolving, and the information from this area will rival the superabundance of information derived from genomic sequences. In particular, cDNAs can be prepared even from single cells, and this approach has already yielded valuable information in several areas. To the extent that reliable and reproducible information, both quantitative and qualitative, can be generated from very small numbers of cells, there are rather remarkable possibilities for complementing functional and genetic analysis of developmental patterns with descriptions of changes in mRNAs. Dense array analysis promises to be particularly valuable for the rapid expression pattern of known genes, while other methods such as gel display approaches offer the opportunity of discovering unidentified genes or for investigating species whose cDNAs or genomes have not been studied intensively.Knowledg... of mRNA structure, genomic location, and patterns of expression must be converted into information of the function of the encoded proteins. Each gene can be the subject of years of intensive study. Nevertheless, a number of methods are being developed that use cDNA to predict properties or permit the selective isolation of cDNAs encoding proteins with certain general properties such as selective isolation of cDNAs encoding proteins with certain general properties such as subcellular location. This volume presents an update of a number of approaches relevant to the areas referred to above. The technology in this field is rapidly evolving and these contributions represent a "snapshot in time" of the number of currently available and useful approaches to the problems referred to above.The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.

  • Biomembrane Transport

    • 1st Edition
    • Lon J. Van Winkle
    • English
    Biomembrane Transport covers the fundamental principles of biomembrane transport proteins, including thermodynamics and kinetics, structure and catalytic mechanism, and regulation and integration classification. The book considers recent advances in transport protein structure and function, along with established concepts. The importance of biomembrane transport to regulation and interorgan nutrient flows and metabolism is covered, as well as classical and modern techniques for characterizing transport. The book also contains a classification scheme for all known transport proteins according to their functions and amino acid residue sequence similarities.

  • Advances in Agronomy

    • 1st Edition
    • Volume 67
    • English
    Advances in Agronomy continues to be recognized as a leading reference and a first-rate source of the latest and best research in agronomy. As always, the topics covered are varied and exemplary of the panoply of subject matter dealt with by this long-running serial.Volume 67 contains four comprehensive and timely reviews on topics in the crop and soil sciences. Chapter 1 addresses one of the most active areas in agronomic research--precision agriculture. Chapter 2 is a thoughtful review on surface charge and solute interactions in soils. Chapter 3 thoroughly covers advances in the use of molecular genetics to enhance abiotic/edaphic stress resistance in turfgrass. Chapter 4 is a useful review on a topic that is of great interest to agronomists--allelop...

  • Biohydrometallurgy and the Environment Toward the Mining of the 21st Century

    • 1st Edition
    • Volume 9A
    • Ricardo Amils + 1 more
    • English
    The major theme of the International Biohydrometallurgy Symposium IBS-99 'Biohydrometallurgy and the Environment toward the mining of the 21st Century', held in El Escorial (Spain) from 20-23 June 1999, is biohydrometallurgy and the environment since it is predicted that in the coming century biotechnology will make its greatest contribution in this area. From the papers in these volumes it is clear that environmental issues are already of great interest to the biohydrometallurgica... community.Although all the classical biohydrometallurgica... topics - e.g. bioleaching, microbiology, molecular biology, biosorption, bioremediation - are addressed, the continued emphasis is on the environmentally friendly aspects of the biotechnologies used.Given the interdisciplinary nature of the field, biologists, hydrometallurgists, geologists, chemists, physicists and engineers should be interested in this collection of papers which discuss the future trends in biohydrometallurgy.

  • International Review of Cytology

    A Survey of Cell Biology
    • 1st Edition
    • Volume 191
    • English
    International Review of Cytology presents current advances and comprehensive reviews in cell biology-both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research.

  • Membrane Permeability: 100 Years Since Ernest Overton

    • 1st Edition
    • Volume 48
    • English
    Membrane permeability is fundamental to all cell biology and subcellular biology. The cell exists as a closed unit. Import and export depend upon a number of sophisticated mechanisms, such as active transport, endocytosis, exocytosis, and passive diffusion. These systems are critical for the normal housekeeping physiological functions. However, access to the cell is also taken advantage of by toxic microbes (such as cholera or ptomaine) and when designing drugs. Ernest Overton, one of the pioneers in lipid membrane research, put forward the first comprehensive theory of lipid membrane structure. His most quoted paper on the osmotic properties of cells laid the foundation for the modern concepts of membrane function, most notably important in anesthesia. This book is designed to celebrate the centennial anniversary (in the first chapter) of Overton's work. Subsequent chapters present readers with up-to-date concepts of membrane structure and function and the challenge they pose for new explorations.

  • Progress in Medicinal Chemistry

    • 1st Edition
    • Volume 36
    • English

  • Biochemistry and Molecular Biology of Plant Hormones

    • 1st Edition
    • Volume 33
    • P.J.J. Hooykaas + 2 more
    • English
    This book provides up-to-date coverage at an advanced level of a range of topics in the biochemistry and molecular biology of plant hormones, with particular emphasis on biosynthesis, metabolism and mechanisms of action. Each contribution is written by acknowledged experts in the field, providing definitive coverage of the field.No other modern book covers this subject matter at such an advanced level so comprehensively. It will be invaluable to university libraries and scientists in the plant biotechnology industries.

  • Tropical Mexico

    The Ecotravellers' Wildlife Guide
    • 1st Edition
    • Les Beletsky
    • English
    Most Ecotravellers to southern Mexico-Cancún and the Yucatán Peninsula, Oaxaca, Chiapas, and Tabasco--want to experience tropical forests and other stunning habitats, as well as catch a glimpse of exotic wildlife, including toucans, parrots, hummingbirds, hawks, monkeys, anteaters, frogs, toads, crocodiles and snakes. In this book is all the information you need to find, identify and learn about this region's magnificent animal life. The author visited national parks and nature reserves, discussed wildlife with local and international experts as well as veteran tour leaders, and then selected for color illustrations more than 500 of the most common fish, amphibians, reptiles, birds and mammals--the species you are most likely to see. In one easy-to-carry, entertainingly written, beautifully illustrated book, you will have a constant companion on your journey.

  • Ex Vivo Cell Therapy

    • 1st Edition
    • Klaus Schindhelm + 1 more
    • English
    Over the last two decades advances in the understanding of disease at a cellular and molecular level has led to innovative therapies that are based on the administration of cells which have been modified outside of the body. Ex vivo cell therapy is in essence gene therapy delivered by transfer of therapeutic genes to cells in culture, which are then given to the patient to treat fatal infections such as AIDS, or other conditions such as cancer or genetic diseases. These manipulations include the purification and culture of therapeutic cell subtypes, as well as elimination of cells which cause disease (cancer cells or immune cells reacting to the body itself). Gene therapy can be delivered by transfer of therapeutic genes to cells in culture, which are then given to the patient to treat fatal infections such as AIDS, cancer or genetic diseases. For small-scale laboratory methods to become clinically applicable processes, these new therapies require efficient technologies for cell separation, cell production in culture and gene transfer. This book integrates the recent advances in biological and clinical research with developments in cell-based technologies to provide a comprehensive review for clinicians, researchers, biotechnologists and biomedical engineers working in this rapidly developing area. The biotechnology and pharmaceutical industry requires a broad perspective for development of future technologies, and this text will provide then with an excellent overview of this rapidly evolving field.

  • Advances in Pharmacology

    • 1st Edition
    • Volume 46
    • English
    Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular bases of drug action, both applied and experimental.

  • Current Topics in Developmental Biology

    • 1st Edition
    • Volume 45
    • English
    Current Topics in Developmental Biology, Volume 45 surveys the major issues at the forefront of developmental biology. This volume, like others in the serial, is valuable to researchers in the fields of animal and plant development, and to students and other professionals who want an introduction to current topics in cellular and molecular approaches to developmental biology. Chapters on the nervous system, reproductive system, and flowering introduce new models and concepts for understanding these processes.

  • Advances in Genetics

    • 1st Edition
    • Volume 39
    • English
    Advances in Genetics increases its focus on modern human genetics and its relation to medicine with the merger of this long-standing serial with Molecular Genetic Medicine. This merger affirms the Academic Press commitment to publish important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines. Volume 39 of Advances in Genetics completes the trilogy of volumes authored by Dr. Igor Zhimulev of the Institute of Cytology and Genetics in Novosibirsk, Russia. This set comprises what is perhaps the most comprehensive collection of volumes dedicated to the study of polytene chromosomes. Volume 39 picks up where the previous two volumes, 34 and 37, left off. It covers the organization of genetic material in the morphological structures of the interphase chromosome, the chromomeres and the interchromomeric regions, and the structural changes occurring during the activation of the chomomeres, the puffs.

  • Amiloride-Sensitive Sodium Channels: Physiology and Functional Diversity

    • 1st Edition
    • Volume 47
    • English
    Sodium reabsorbing epithelia play a major role in whole-body sodium homeostasis. Some examples of sodium regulating tissues include kidney, colon, lung, and sweat ducts. Sodium transport across these membranes is a two-step process: entry through an amiloride-sensitive sodium channel and exit via the ouabain-sensitive sodium/potassium ATPase. The sodium entry channels are the rate-limiting determinant for transport and are regulated by several different hormones. The sodium channels also play a significant role in a number of disease states, like hypertension, edema, drug-induced hyperkalemia, and cystic fibrosis. Amiloride-Sensitive Sodium Channels: Physiology and Functional Diversity provides the first in-depth exchange of ideas concerning these sodium channels, their regulation and involvement in normal and pathophysiological situations.

  • Potassium Ion Channels: Molecular Structure, Function, and Diseases

    • 1st Edition
    • Volume 46
    • English
    This book is the first to focus on potassium ion channels and covers the recent remarkable progress made in research on these proteins. Many diseases are caused by the abnormalities of potassium ion channels. They include diabetes mellitus, life-threatening hereditary cardiac arrhythmia, epilepsy, neural degeneration, and renal hypertension. Written by leading scientists in the field, this volume offers readers a comprehensive update of this field in the understanding of the genes, molecular structure, function and diseases of potassium ion channels.

  • PCR Applications

    Protocols for Functional Genomics
    • 1st Edition
    • Michael A. Innis + 2 more
    • English
    PCR is the most powerful technique currently used in molecular biology. It enables the scientist to quickly replicate DNA and RNA on the benchtop. From its discovery in the early 80's, PCR has blossomed into a method that enables everything from ready mutation of DNA/RNA to speedy analysis of tens of thousands of nucleotide sequences daily.PCR Applications examines the latest developments in this field. It is the third book in the series, building on the previous publications PCR Protocols and PCR Strategies. The manual discusses techniques that focus on gene discovery, genomics, and DNA array technology, which are contributing factors to the now-occurring bioinformatics boom.

  • Coronary Angiogenesis

    • 1st Edition
    • Volume 7
    • K. Rakusan
    • English
    This volume surveys the progress that has been made in the study of coronary angiogenesis and provides the reader with a general coverage of the advances in the core knowledge in the field. It is clear that as we gain a deeper understanding of mechanisms underlying stimulation (and inhibition) of coronary angiogenisis, it might become possible to develop novel therapies for increasing the growth and formation of collateral vessels in the ischemic heart. Although research in the domain of angiogenesis is steadily approaching its golden age, the study of coronary angiogenesis is still in its infancy.

  • Neuromuscular Junctions in Drosophila

    • 1st Edition
    • Volume 43
    • English
    Neuromuscular Junctions in Drosophila gathers the main contributions that research using the fruit fly Drosophila melanogaster has made in the area of synapse development, synapse physiology, and excitability of muscles and nerve cells. The chapters in this book represent a synthesis of major advances in our understanding of neuronal development and synaptic physiology, which have been obtained using the above approach.This book is directed to the general neuroscience audience: researchers, instructors, graduate students, and advanced undergraduates who are interested in the mechanisms of synapse development and physiology. However, the book will also be a valuable resource for those that use the fruit fly as a model system in their laboratories.

  • PCR Applications

    Protocols for Functional Genomics
    • 1st Edition
    • John J. Sninsky
    • Michael A. Innis
    • English
    PCR is the most powerful technique currently used in molecular biology. It enables the scientist to quickly replicate DNA and RNA on the benchtop. From its discovery in the early 80's, PCR has blossomed into a method that enables everything from ready mutation of DNA/RNA to speedy analysis of tens of thousands of nucleotide sequences daily.PCR Applications examines the latest developments in this field. It is the third book in the series, building on the previous publications PCR Protocols and PCR Strategies. The manual discusses techniques that focus on gene discovery, genomics, and DNA array technology, which are contributing factors to the now-occurring bioinformatics boom.

  • Protein, Volume 2

    • 1st Edition
    • G. Allen
    • English
    In the first volume of this series, the structures of protein molecules were described, together with computational methods linking sequence data to folded structure and function. The determination of protein structure by nuclear magnetic resonance spectroscopy was also presented. Volume 2 begins by continuing the theme of protein structure with an outline of methods of crystallographic structure determination. Subsequent chapters describe various strucure-related properties of proteins. This book provides a valuable contribution to those new to the field of protein science as well as to those already expert in the field.

  • International Review of Cytology

    A Survey of Cell Biology
    • 1st Edition
    • Volume 189
    • English
    International Review of Cytology presents current advances and comprehensive reviews in cell biology-both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research.

  • Fluorescent and Luminescent Probes for Biological Activity

    A Practical Guide to Technology for Quantitative Real-Time Analysis
    • 2nd Edition
    • W. T. Mason
    • English
    The use of fluorescent and luminescent probes to measure biological function has increased dramatically since publication of the First Edition due to their improved speed, safety, and power of analytical approach. This eagerly awaited Second Edition, also edited by Bill Mason, contains 19 new chapters and over two thirds new material, and is a must for all life scientists using optical probes.The contents include discussion of new optical methodologies for detection of proteins, DNA and other molecules, as well as probes for ions, receptors, cellular components, and gene expression. Emerging and advanced technologies for probe detection such as confocal laser scanning microscopy are also covered. This book will be essential for those embarking on work in the field or using new methods to enhance their research.

  • The Biology of the Pancreatic Cell

    • 1st Edition
    • Volume 29
    • S.L. Howell
    • English
    As a result of the key advances made more than 30 years ago, specifically the ability to isolate islets of Langerhans from the pancreas, the ability to measure insulin accurately by immunoasay, and the development of microchemical techniques for studying cells and their components, many research volumes, symposium reports, and original papers have been produced. This explosion of interest has probably had at least three stimuli: 1. the inherent scientific interest in understanding secretion of the pancreatic ß-cell2. the ß-cells relevance to a very common disease3. the availability of funding from specific sources related to diabetes research, for instance, Juvenile Diabetes Foundation International and the British Diabetic Association. As a result of all this activity, detailed scientific literature including research reviews are readily available. Surprisingly enough, there are relatively few attempts to summarize this great bulk of knowledge in a way that is accessible to the newcomer to this field and this book is intended to bridge this gap.

  • Green Fluorescent Protein

    • 1st Edition
    • Volume 302
    • John N. Abelson + 1 more
    • English
    One of the most important recent discoveries in science is the green fluorescent protein, isolated from a bioluminescent jellyfish. The gene that codes for this protein is active in any type of cell, from microbes to humans, producing a "day-glo" dye visible as a bright green light in the microscope. The power of the gene is that by using recombinant DNA technology. GFP can be spliced to any protein, essentially painting that protein green. When such a spliced protein is inside a cell. Further, time-lapse microscopy can be used to examine how that protein and the cellular components that it is part of move within the cell during the cell's life cycle.This Methods in Enzymology volume deals with the utility of green fluorescent protein (GFP). The OVID database (including MEDLINE, Current Contents, and other sources) lists nine references to GFP for the ten-year period 1985-1994. In contrast, in less than four years thereafter, over 500 references are listed, a testament to the rapid growth of interest in this probe.This volume documents many diverse uses for this interesting molecule in disciplines that broadly span biology. The methods presented include shortcuts and conveniences not included in previously published sources. The techniques are described in a context that allows comparisons to other related methodologies-such comparisons are valuable to readers who must adapt existing procedures to new systems. Also, so far as possible, methodologies have been presented in a manner that stresses their general applicability and potential limitations. The volume provides a substantial and current overview of the extant methodology in the field and a view of its rapid development.The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.

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