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Quest for the Cure

Reflections on the Evolution of Breast Cancer Treatment

  • 1st Edition - October 16, 2013
  • Latest edition
  • Author: George R. Blumenschein
  • Language: English

This original fourteen chapter book is a brief, slightly autobiographic tale of medical oncologists, surgeons, radiation oncologists, and breast cancer patients in a we… Read more

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Description

This original fourteen chapter book is a brief, slightly autobiographic tale of medical oncologists, surgeons, radiation oncologists, and breast cancer patients in a well-established cancer center in Texas, who pursued the goal of cure for breast cancer. The evolution of improved outcomes in the treatment of microscopic metastatic breast cancer is also the story of the development of adjuvant chemotherapy for post-operative breast disease. The adjuvant therapy of breast cancer came about with the realization that this malignancy, when diagnosed in most patients, had spread beyond the confines of the primary cancer.

Key features

  • Patient histories in the form of Case Studies are used to illustrate certain issues
  • Devoted to the development of the chemotherapeutic regimens that currently are used to treat patients with advanced breast cancer

Readership

Cancer researchers, oncologists, and cancer patient advocates

Table of contents

Chapter 1. Anatomy of an Oncologist

  • 1.1 Next Stop—MDA
  • 1.2 Early Experience with 5-Fluorouracil, Adriamycin, and Cyclophosphamide
  • 1.3 Monday Night Confrontation

Chapter 2. Milestones Along the Road to the Cure

  • 2.1 The Importance of Patient Education
  • 2.2 Pioneers of Adjuvant Therapy
  • 2.3 Early Studies
  • 2.4 M.D. Anderson: A Pioneer in Radiation Therapy
  • 2.5 Lessons from Basic Science

Chapter 3. The Evolving Goal of Cure and Inflammatory Breast Cancer

  • 3.1 Understanding Treatment Strategy and the Perils of Prognostication
  • 3.2 Inflammatory Breast Cancer
  • 3.3 The Search for New Drugs to Cure IBC
  • 3.4 MCCFUD and FUMEP for IBC
  • 3.5 Taxanes
  • 3.6 Combination Chemotherapy versus Monotherapy for Consolidation Regimens

Chapter 4. Adjuvant Therapy Advances

  • 4.1 Prepared Minds Take on Breast Cancer
  • 4.2 Minimizing Adriamycin Cardiac Toxicity: The Most Significant Under-Utilized Clinical Observation
  • 4.3 Clinical Measurements: Predicting Prognosis
  • 4.4 Refining FAC
  • 4.5 Cisplatin Late Consolidation

Chapter 5. Marching Forward

  • 5.1 CALGB Study 8081
  • 5.2 Backstepping on FAC: FAC-lite
  • 5.3 Taxanes Revisited
  • 5.4 The Dose-Dense Option
  • 5.5 Slow Adoption of Consolidation Therapy
  • 5.6 The Impact of Statistical Dogmatism

Chapter 6. Concluding Thoughts — Where Do We Stand in the Quest for the Cure?

  • 6.1 Chemotherapeutic Principles that have Emerged
  • 6.2 Patients have an Important Role

Appendix1. Milestones in Adjuvant Therapy2. Breast Cancer Stages3. Abbreviation Glossary

Review quotes

"In Texas, and perhaps in all the world, there are few cancer specialists as widely regarded as Dr. George Blumenschein. Dr. Blumenschein worked tirelessly to save my sister, Suzy, from this devastating disease. He brought the same dedication to my breast cancer treatment several years later. His book is important reading for anyone interested in understanding the sea of change in breast cancer treatment over the past few decades, made possible in part by one doctor’s vision and advocacy for people with this disease."—Nancy G. Brinker, Founder, Susan G. Komen

"An authoritative, accurate, entertaining, and up-to-date summary of the battle against breast cancer, from a leader in the development of our current ability to control the disease. While Dr. Blumenschein is able to present the clinical science, in an understandable way, he maintains the human element with patient anecdotes, which he presents alongside the science."—Emil J Freireich, M.D., D.Sc.(Hon.), Distinguished Teaching Professor, Director, Special Medical Education Programs Director, Adult Leukemia Research Program, The University of Texas M. D. Anderson Cancer Center

Product details

  • Edition: 1
  • Latest edition
  • Published: October 16, 2013
  • Language: English

About the author

GB

George R. Blumenschein

George R. Blumenschein, M.D. led a team of brilliant young researchers at the M.D. Anderson Cancer Center who established Adriamycin as a mainstay of contemporary breast cancer treatment regimens. This book is intended to empower interested individuals by chronicling the development and explaining the rationale underlying contemporary multimodal breast cancer therapy and by providing illustrative patient histories.
Affiliations and expertise
Professor Emeritus, Oncology and Internal Medicine, MD Anderson Cancer Center, University of Texas, Houston, TX, USA

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