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Elsevier

Books in Life sciences

  • Advances in Drug Research

    • 1st Edition
    • Volume 18
    • Bernard Testa
    • English
    Each volume in this distinguished series presents authoritative reviews, both generally, on topics of broad interest in drug research, and specifically, on novel and established therapeutic classes. Acknowledged experts contribute in areas such as drug design, clinical and molecular pharmacology, drug metabolism, and mechanisms of action. Reviewers have consistently praised Advances in Drug Research for its comprehensive and lucid summaries of up-to-date knowledge.

  • Essays in Toxicology

    Volume 5
    • 1st Edition
    • Wayland J. Hayes
    • English
    Essays in Toxicology, Volume 5 covers essays in toxicology. The book presents essays on nitrosamines; a laboratory model ecosystem to evaluate compounds producing biological magnification; and the metabolism of DDT in human. The text also includes essays on the toxins of Clostridium botulinum; the use of breath analysis in clinical toxicology; and the biochemical toxicology of methanol. Toxicologists, biochemists, microbiologists, pharmacologists, and people involved in the research of toxicology will find the book invaluable.

  • Diversity of Environmental Biogeochemistry

    • 1st Edition
    • Volume 6
    • J. Berthelin
    • W.S. Fyfe
    • English
    Biogeochemistry, still in its formative stage twenty years ago, is now a young, interdisciplinary subfield of earth sciences, life sciences and chemistry. An international scientific association (International Symposia on Environmental Biogeochemistry incorporated - ISEB) was founded to organize international symposia to bring together microbiologists, biologists, chemists, geochemists, soil scientists, oceanographers, ecologists and environmental engineers interested in the biogeochemistry of terrestrial, aquatic and atmospheric environments.After the 8th ISEB held in Nancy, France, this volume was compiled. These fifty selected contributions from specialists of varying backgrounds and interests show the diversity and the common framework of the direct or indirect interactions of living organisms and their abiotic environments.

  • Essays in Toxicology

    Volume 1
    • 1st Edition
    • Frank R. Blood
    • English
    Essays in Toxicology, Volume 1 covers essays in toxicology and related topics. The book presents essays on the use of poisons as tools in studying the nervous system as well as teratology. The text also includes essays on the significance of methemoglobinemia in toxicology and lead poisoning. Biochemists, plant and animal physiologists, pharmacologists, pathologists, microbiologists, entomologists, food technologist, and people involved in forensic medicine and industrial medicine.

  • International Review of General and Experimental Zoology

    Volume 2
    • 1st Edition
    • William J. L. Felts + 1 more
    • English
    International Review of General and Experimental Zoology, Volume 2 is a collection of world literature concerning developments in general and experimental zoology. This book is composed of six chapters, and begins with a survey of the biochemical and serological techniques and their application in experimental taxonomy. The succeeding chapters review the field of general and comparative endocrinology in lower vertebrates, as well as the problems of understanding the fine structure of the synaptic cleft of presumed chemically transmitting synapses. These topics are followed by discussions on structural and functional aspects of the avian lungs and air sacs; the metabolic aspect of heat transfer in biological systems; and the external energy transfer from the organism to the surrounding environment. The final chapter focuses on the experimental studies of neurocranium morphology and growth. This book will prove useful to zoologists and taxonomists.

  • Neuropeptide Technology

    Synthesis, Assay, Purification, and Processing
    • 1st Edition
    • P. Michael Conn
    • English
    Methods in Neurosciences, Volume 6: Neuropeptide Technology: Synthesis, Assay, Purification, and Processing describes procedures and tools of assay useful for the identification, purification, and quantification of neuropeptides and their receptors. This volume is divided into four sections— chemical synthesis and biosynthesis; measurement of neuropeptides; purification and characterization; and neuropeptide degrading and processing enzymes. In these sections, this book specifically discusses the synthesis of peptide substrates for protein kinase C; synthesis of glycosyl neuropeptides; and ultrastructural localization of peptides. The measurement of neurokinin B by radioimmunoassay; purification and characterization of neuroendocrine peptides from rat brain; and preparation of glia maturation factor ß are also elaborated. This text likewise covers the assays for arginine/lysine carboxypeptidases and enzymes that metabolize atrial natriuretic peptide. This publication is beneficial to neuroscientists and students researching on the synthesis, assay, purification, and processing of neuropeptides.

  • Cell Culture

    • 1st Edition
    • P. Michael Conn
    • English
    Methods in Neurosciences, Volume 3: Quantitative and Qualitative Microscopy is a collection of papers that deals with microscopic techniques in statistical measures. This volume describes microscopy using sophisticated stains and dyes to advance observation of tests and experiments. Section I describes autoradiography including micro chemical methods, high-resolution autoradiography, and single- or double-label quantitative autoradiography for use in imaging of brain activity patterns or determining cerebral physiology. Section II discusses the quantification of structures through statistical and computational methods including dynamic video imaging technology. Section III explains the use of tracers, toxins, or dyes in tracing neuronal connections. One paper addresses the use of small injections of axonally transported fluorescent tracers. Section IV explains staining technology such as using the silver impregnation method for frozen sections of human nervous tissue that are gathered from tissues preserved in formalin. Section V addresses freezing techniques and those using freeze-fracture methods in neurobiology. The text also discusses cryoprotection and other freezing methods to control ice crystals found in fixed or unfixed brain tissues. Section VI presents the combined and high-resolution methods in polarization microscopy and microscopic investigations. Cellular biologists, micro-chemists, and scientific researchers in the field of micro- and cellular biology will appreciate this book.

  • Structural and Functional Aspects of Phytochemistry

    Recent Advances in Phytochemistry, Vol. 5
    • 1st Edition
    • V. C. Runeckles + 1 more
    • English
    Recent Advances in Phytochemistry, Volume 5: Structural and Functional Aspects of Phytochemistry covers the proceedings of the 10th Symposium of the Phytochemical Society of North America held in Beltsville College Park, Maryland on October 6-9, 1970. The book discusses the energy conversion in both photooxidation and photophosphorylation reactions of photosynthesis; and advances in phytochrome studies, including the physiological and biochemical characterization of the pigment, the mechanism of action, and the regulation of phytochrome-mediated processes. The text also describes the structure, function, and photocontrolled synthesis of betalains; the chemistry of flavylium salts; and the histochemistry of plants in health and disease. The enzyme reaction to wound injury and parasites, and the evolution of the mechanisms of disease resistance are also considered. The book further tackles herbicide metabolism in plants; the chemistry of tea and tobacco; and the alkaloid biosynthesis of tobacco plants. Botanists, entomologists, and people involved in the study of plant chemistry will find the book invaluable.

  • Neuropeptide Technology

    Gene Expression and Neuropeptide Receptors
    • 1st Edition
    • P. Michael Conn
    • English
    Methods in Neurosciences, Volume 5: Neuropeptide Technology: Gene Expression and Neuropeptide Receptors discusses procedures and tools of assay useful for the identification, purification, and quantification of neuropeptides and their receptors. This volume is divided into two sections—neuropeptid... gene expression and neuropeptide receptors. In these sections, this book specifically discusses the assays for peptide products of somatostatin gene expression; molecular assays for rat thyrotropin-releasin... hormone gene; and structure, expression, and chromosomal localization of human gene. The gastrin-releasing peptide or mammalian bombesin; semiquantitative analysis of cellular somatostatin mRNA Levels; and atrial natriuretic factor receptor assays are also elaborated. This text likewise covers the receptors for opioid peptides in brain and autoradiography of somatostatin receptors in rat cerebellum. This publication is beneficial to neuroscientists and students intending to acquire knowledge of gene expression and neuropeptide receptors.

  • Progress in Chemical Toxicology

    Volume 5
    • 1st Edition
    • Abraham Stolman
    • English
    Progress in Chemical Toxicology, Volume 5 covers topics on the improved isolation and detection procedures and quantitation methods for volatile poisons, stimulants, hallucinogenic drugs, and marihuana. The book discusses the absorption, distribution, and excretion of drugs and poisons and their metabolites; the system for the toxicological analysis of drugs in biological specimens; and the isolation and analysis of phenothiazines. The text also describes the use of fluorescence in toxicology and the toxicology of new synthetic organic polymers used in containers for food, pharmaceutical compounds, and drinkable water. Some microcrystal tests for drugs and advances in polarography as applied to toxicological analysis are also considered. Biochemists, toxicologists, and scientists involved in the study of narcotics will find the book invaluable.

  • Essays in Toxicology

    Volume 2
    • 1st Edition
    • Frank R. Blood
    • English
    Essays in Toxicology, Volume 2 covers essays on toxicology and related topics. The book presents essays on fungal toxins, such as mycotoxin, aflatoxin, moldy corn toxicoses, alimentary toxic aleukia, ochratoxin, sporidesmin, zearalenone and other estrogenic compounds, pink rot dermatitis, and slaframine. The text also includes essays on hyperbilirubinemia and cholestasis induced by alpha-naphthylisothi... taurolithocholic acid, and 2-ethyl-2-phenyl butyramide, as different forms of liver injury produced in animals. The evolution of pesticide analyses is also encompassed. Biochemists, physiologists, pathologists, and microbiologists will find the book invaluable.

  • Progress in Biomass Conversion

    Volume 2
    • 1st Edition
    • Kyosti V. Sarkanen + 1 more
    • English
    Progress in Biomass Conversion, Volume 2, provides an overview of the state of knowledge and development in the biomass energy and chemicals field. The current cornerstone of biomass fuel utilization is wood. This form of biomass is storable ""on the stump"", and it can be harvested without any particular regard to season. Further, it is the basic raw material for the vast, essential forest products industry that produces lumber, plywood, pulp and paper, particleboard, and numerous other products. The book opens with an assessment of the energy potential of logging residue. This is followed by separate chapters on the use of genetics to improve forest trees for biomass production; total wood fuels consumption in 1978; and sugar stalk crops as potential sources of fuels and chemicals. Subsequent chapters deal with the organosolv delignification process for ""total biomass utilization""; environmental impact of wood fuel; and the sources and preparation of wood fuel.

  • Progress in Behavior Modification

    Volume 4
    • 1st Edition
    • Michel Hersen + 2 more
    • English
    Progress in Behavior Modification, Volume 4, is a multidisciplinary serial publication that encompasses the contributions of psychology, psychiatry, social work, speech therapy, education, and rehabilitation. This serial aims to meet the need for a review publication that undertakes to present yearly in-depth evaluations that include a scholarly examination of theoretical underpinnings, a careful survey of research findings, and a comparative analysis of existing techniques and methodologies. The discussions center on a wide spectrum of child and adult disorders. The present volume opens with a chapter on behavioral treatment for obesity. This is followed by separate chapters on applications of reinforcement techniques in the areas of pollution control and energy conservation, job performance and unemployment, community self-government, racial integration, and others; and behavior modification in community settings. Subsequent chapters deal with demand characteristics in behavior modification; the clinical utility of biofeedback procedures; and the technology of training parents in behavior therapy. The final chapter reviews the rationale and empirical support for the extinction approach of implosive (flooding) therapy.

  • Receptors

    Model Systems and Specific Receptors
    • 1st Edition
    • P. Michael Conn
    • English
    Methods in Neurosciences, Volume 11: Receptors: Model Systems and Specific Receptors is a compilation of papers that describes techniques and information that are important to the neurosciences. This volume discusses preferred receptor techniques, molecular techniques, and methods to determine receptor subclasses and localization in the ligand design. The first paper discusses the steroid receptor found in the central nervous system for steroid hormones that affects strongly the structure and function of both developed and immature nervous systems. Another paper describes how a glycoprotein of 79.5 kDa (transferrin) carries iron in the blood stream for delivery to different tissues, after the transferrin has bound with a specific receptor on the surface of the cell. This book also explains the binding sites of pituitary adenylate cyclase-activating polypeptide in the human brain, while one paper analyzes the neurotensin receptors during the primary culture of neurons. This volume then also analyzes the structure and function of the fast nerve growth factor receptor, particularly how a signal on the outside of a cell is transmitted to the cell's interior. This collection is helpful for microbiologists, cellular researchers, students, and professors in the discipline of neurosciences.

  • Computers and Computations in the Neurosciences

    • 1st Edition
    • P. Michael Conn
    • English
    Methods in Neurosciences, Volume 10: Computers and Computations in the Neurosciences discusses the use of computers in the neurosciences. The book deals with data collection, analysis, and modeling, with emphasis on the use of computers. Section I involves data collection using a personal microcomputer system. One paper presents a tutorial on using a PC-based motor control composed of an electronic circuit to adjust the motion of a light microscope stage through a software program. Other papers discuss computer methods in nuclei cartography and a computer-assisted quantitative receptor autoradiography in studying receptor density distribution. Section II deals with data analysis and some computer programs for kinetic modeling of gene expression in neurons. The book also discusses a computerized analysis of opioid receptor heterogeneity by ligand binding in test animals using computerized programs instead of employing manual or graphical methods. Computerized curve-fitting allows the researcher to utilize a more precise mathematical model to describe the binding of one ligand to one class of sites. Section III evaluates data modeling and simulations and describes the practicality of using computers to design model ion channels. Another paper discusses a graphical interaction program called MEMPOT to simulate an electrophysiological investigation of the properties of the membrane potential in stimulated cells. The book also presents a quantitative data gathered from computer simulation of the factors that affect neuronal density per measured sections. The book is suitable for microbiologists, biochemists, neuroscientists, and researchers in the field of medical research, as well as for advanced computer programmers in medical research work.

  • Lesions and Transplantation

    • 1st Edition
    • P. Michael Conn
    • English
    Methods in Neurosciences, Volume 7: Lesions and Transplantation describes the chemical and nonchemical production of lesions and preparation and development of transplants, implants, and grafts. This book consists of four sections—chemical and nonchemical lesioning; model systems utilizing lesioning; transplants, implants, and grafts; and assessment of lesions and transplants. In these sections, this volume discusses the excitotoxins as tools for producing brain lesions; use of acromelic acid for production of rat spinal lesions; and opioid and nonopioid antinociception as revealed by lesion studies. The endothelin-1-induced lesions in the brain as a new model of focal ischemia; fetal implants in the lesioned spinal cord of the rat; and hippocampal transplants in oculo are also elaborated. This book likewise covers the assessment of neurochemical function of brain transplants and in vitro electrophysiological analysis of in oculo. This publication is intended for neuroscientists, but is also beneficial to researchers conducting work on lesions and transplants.

  • Cultivating Edible Fungi

    International Symposium on Scientific and Technical Aspects of Cultivating Edible Fungi (IMS 86), July 15 - 17, 1986 Proceedings
    • 1st Edition
    • P.J. Wuest + 2 more
    • English
    Developments in Crop Science, 10: Cultivating Edible Fungi covers the proceedings of the International Symposium on Scientific and Technical Aspects of Cultivating Edible Fungi (IMS 86), held on July 15-17, 1986. The book focuses on the methodologies, processes, and technologies involved in the cultivation of edible fungi. The selection first offers information on antitumor activities of edible mushrooms by oral administration; variability of fluorescent Pseudomonas populations in composts and casing soils used for mushroom cultures; and influence of microorganisms and fungistasis on sporophore initiation in Agaricus brunnescens. The text then elaborates on the kratovirulence determinant of wood-decay fungi in transfer of mycelia to, and basidiocarp formation on, wooden raw substrates; spent compost as a carrier for bacterial inoculant production; and effects of growth regulator compounds on yield and size of Agaricus bisporus. The manuscript examines the effect of benomyl application and spawnmate supplementation on yield and size of selected genotypes of Pleurotus spp; changes in free amino acid content of the compost during growth and development of Agaricus bisporus; and basidiospore number variation in Agaricus. The book then takes a look at the integrated control of pests and diseases in mushroom cultivation; status of pests in the cultivated mushroom in India; and laboratory and cropping tests with cyromazine for mushroom sciarid control in mushroom compost. The selection is a dependable source of data for researchers interested in the cultivation of edible fungi.

  • Providing Pharmacological Access to the Brain

    Alternate Approaches
    • 1st Edition
    • Volume 21
    • Thomas R. Flanagan + 1 more
    • English
    This volume focuses on contemporary approaches for delivering experimental and therapeutic agents into the brain. The contributions provide methodological details that are typically not available in the literature. Subtleties and shortcuts critical to each procedure are included to facilitate their use by both the experienced researcher and novice.

  • The Common Agricultural Policy beyond the MacSharry Reform

    • 1st Edition
    • Volume 230
    • C. Folmer + 4 more
    • J. Tinbergen
    • English
    The reform of the Common Agricultural Policy (CAP) which is now being implemented, reduces the support for a selected number of agricultural products. This book uses welfare theory and applied general equilibrium analysis to assess the medium to long term consequences of this reform, if the new policies remain in place until the beginning of the next century. It analyses the implications of two alternative scenarios: a) a further trade liberalisation covering all commodities; and b) increased protectionism with high prices, constraints on production and export subsidies (financed by the farmers themselves). The study also investigates the implications of financial renationalisation, whereby the European Union member-states would cover the costs of their own support measures.

  • International Review of Forestry Research

    Volume 3
    • 1st Edition
    • John A. Romberger + 1 more
    • English
    International Review of Forestry Research, Volume 3 reviews some areas of forest science that are of growing importance. The book discusses the advances in poplar breeding; the economics of yield planning; and the mycorrhizal inoculation in afforestation. The text also describes the heart rots in living trees; and the biochemical approaches to forest genetics. People involved in forest research, silviculture, and populiculture will find the book invaluable.

  • Wheat Studies - Retrospect and Prospects

    • 1st Edition
    • Volume 3
    • H. Kihara
    • English
    This authoritative work has been written by a man whose career as an active wheat geneticist has spanned sixty years and has earned him a world-wide reputation. The book contains descriptions and much original data on genetical and cytogenetical findings concerning cultivated wheats and their relatives. It covers chromosomal analyses, genome analyses, ancestors of wheat, artificial synthesis of wheat, evidence of cytoplasmic inheritance and variations of wild species. The author explains how these facts and concepts have been discovered, points out the importance inherent in these discoveries, and shows how they can be utilized in genetical and breeding studies. Special emphasis is placed on the motives, processes and development of the studies.

  • Neurobiology of Cytokines

    Methods in Neurosciences, Vol. 16
    • 1st Edition
    • Errol B. De Souza
    • English
    Neurobiology of Cytokines, Part A provides an overview of the effects of cytokines in the brain and in the endocrine system. The book discusses the general aspects of cytokines, including the endogenous agonists and antagonists, their receptors, their second messengers, and transport mechanisms for cytokines across the blood-brain barrier. The text also describes the anatomical localization of cytokines, cytokine receptors, and their respective mRNA in brain and in endocrine tissues. The methods for evaluating the in vivo as well as in vitro actions of cytokines on hormone secretion are also considered. The book further tackles the synthesis and release of cytokines and their central nervous system actions; and the methodology for studying the role of cytokines in human neuropathological conditions.

  • Neurobiology of Cytokines, Part B

    • 1st Edition
    • Volume 17
    • P. Michael Conn + 1 more
    • English
    Recent data suggest a critical role for cytokines in the regulation of brain and endocrine function under normal physiological conditions. The aim of this volume and its companion Volume 16 is to provide an overview of the effects of cytokines in the brain and in the endocrine system.

  • International Review of Connective Tissue Research

    Volume 10
    • 1st Edition
    • David A. Hall + 1 more
    • English
    International Review of Connective Tissue Research is a compilation of scientific research mainly focuses on developments in special tissues. A detailed discussion of the lung and liver is included. Another topic of interest is the liver fibrosis development induced by parasitic infection or alcohol. The periodontal ligament is specialized tissue whose basic role is tooth support. This tissue is covered in detail. A section of the book provides an analysis of the elastin gene expression and regulation. Topics such as the microfibrillar components of connective tissue, the regulation of collagen genes, the complexity and the evolution of the collagen molecule, the invasiveness of malignant tumors, and the characteristics of fibroblast are fully explained. The text presents an exhaustive description of the connective tissue of the lung. This chapter includes a comprehensive description of the pulmonary system. The book will provide useful information to doctors, students, researchers and specialists in the field of human anatomy.

  • International Review of Connective Tissue Research

    Volume 9
    • 1st Edition
    • David A. Hall + 1 more
    • English
    International Review of Connective Tissue Research, Volume 9 provides information pertinent to the fundamental aspects of connective tissue research. This book reviews the methods involved in chromosome mapping of genes and their application to genes. Organized into six chapters, this volume begins with an overview of basement membranes updates. This text then examines the widespread use of the methods of immunofluorescence and immune electron microscopy. Other chapters consider the degradation of collagen in vivo that is of necessity under close biological control. This book discusses as well the nature and role of inhibitors of the collagenolytic enzymes in normal and pathological conditions. The final chapter emphasizes that in addition to the multiplicity of functions of connective tissue in various organs, the formation of this tissue is the major mechanism of the repair of damaged tissues in species that have lost the power of regeneration. This book is a valuable resource for biochemists.

  • International Review of Connective Tissue Research

    Volume 7
    • 1st Edition
    • David A. Hall + 1 more
    • English
    International Review of Connective Tissue Research, Volume 7 focuses on the structural aspects of the connective tissues and their compounds. This book reviews the data concerning the primary structure of collagen and explores the physical features of elastin. Organized into six chapters, this volume begins with an overview of the amino acid sequence of collagen. This text then examines the relationship of the structure and function of elastic tissues and reviews the usefulness of immunological methods when applied to structural studies. Other chapters consider the substantial progress in the elucidation of the antigen determinants of the collagen molecule. This book discusses as well the immunological properties of collagen that may have considerable bearing on the causes of some connective tissue diseases. The final chapter deals with the extensive investigations into glycoproteins in various connective tissues of various species at various ages. This book is a valuable resource for biochemists and physicians.

  • Agriculture, Growth and Redistribution of Income

    Policy Analysis with an Applied General Equilibrium Model in India
    • 1st Edition
    • Volume 190
    • N.S.S. Narayana + 2 more
    • J. Tinbergen
    • English
    This book presents an empirically estimated applied general equilibrium model for India and the analysis of a wide range of policy issues carried out using the model. The various chapters in the book deal with public distribution policies, foreign trade and aid policies, rural works programmes, terms of trade policies, fertilizer subsidy policies and irrigation development policies. These policies are analysed in terms of their immediate and medium term effects on production, consumption and prices of different commodities, on the growth of the economy as well as on the distribution of income among different groups in rural and urban areas and the incidence of poverty in the economy. Each chapter dealing with policy analysis describes the analytical issues involved, the historical context and experience of the policy concerned, results of the model scenarios and the policy insights that emerge.

  • Applied Mutation Breeding for Vegetatively Propagated Crops

    • 1st Edition
    • Volume 12
    • C. Broertjes + 1 more
    • English
    When the first edition of this book appeared in 1978, it was warmly received. Most readers and reviewers especially valued the extensive coverage of the literature in the chapters dealing with the different crops. ``... a valuable and timely addition to plant breeders and of outstanding value to breeders of ornamental plants. The book's special strength resides in the extensive review of literature ...'' (International Journal for Breeding Research). This is also reflected by the many times that the work has been referred to in other publications.This new edition provides plant breeders as well as scientists with an up-to-date overview of methods and results of the application of mutation breeding in order to genetically improve vegetatively propagated crops. General principles and background information about mutation breeding in general, methods of treatment, material to be treated and results are discussed in the introductory chapters, followed by a description of the specific situation in each of the vegetatively propagated crops ever used in a mutation breeding project.This volume brings together all the important and relevant literature in the field. It provides a complete account of mutation breeding of vegetatively produced crops, presenting conclusions about the value of the method, its possibilities, limitations and shortcomings and the possible difficulties of further application in various crops. The initial chapters deal with the interactions between mutagenic treatment and plant material, such as aspects of mutagenic treatment, post-irradiation behaviour of shoot apices and adventitious bud techniques. All available literature is then discussed crop by crop and critically evaluated. Almost 1700 references are covered and whenever possible suggestions for more efficient application of mutation breeding methods are given.

  • Neurotoxins

    • 1st Edition
    • Volume 8
    • P. Michael Conn
    • English
    The exquisite simplicity and potency of toxins have made them valuable probes of neural systems. This book presents a comprehensive compilation of techniques used for the preparation, handling, and, particularly, for the use of neurotoxins. Model systems are described in which these neurotoxins have been extremely valuable in developing an understanding of the cellular and molecular basis of secretion and electrophysiological events leading to altered cell function.

  • Visual and Oculomotor Functions

    Advances in Eye Movement Research
    • 1st Edition
    • Volume 5
    • G. d'Ydewalle + 1 more
    • English
    A collection of contemporary work in various areas of eye-movement research with an emphasis on physiological aspects is presented in this book. The contributions are divided into six sections: I. saccadic eye movements; II. smooth pursuit and motion perception; III. eye movements in pathology and clinical settings; IV. neurophysiology of eye movements; V. optokinetic nystagmus; and VI. methods. This volume provides updated information on the most recent research on eye movements carried out mainly in Europe.

  • Neglected Factors in Pharmacology and Neuroscience Research

    Biopharmaceutics, Animal Characteristics, Maintenance, Testing Conditions
    • 1st Edition
    • V. Claassen
    • J.P. Huston
    • English
    Techniques in the Behavioral and Neural Sciences, Volume 12: Neglected Factors in Pharmacology and Neuroscience Research: Biopharmaceutics, Animal Characteristics, Maintenance, Testing Conditions can be used as reference in the improvement of test designs for biochemists and physiologists in the control of test conditions. The book is divided into five sections. The introduction deals with the uncertainty of animal characteristics and test conditions as hindrances to the development of general insight into biological regulatory mechanism. The first section discusses biopharmaceutics — the interaction of drugs when interacting with molecules or enzymes in sufficient concentration at a specific site of action. The second section reviews animal characteristics in terms of strain differences, sex differences, and changes during development and aging of the subject. The third section discusses the maintenance of experimental animals such as housing conditions, food composition, and water intake as these kinds of environmental factors may shape the phenotype and responsiveness of the experimental animal. The fourth section explains the testing conditions such as metabolic effects and drug interactions, anesthesia, stress, and even the effects on circadian rhythms. The last section is a discussion on the importance of experimental results. This section covers internal and external validities and statistical inference. The author concludes that the design of any experiment should include a power analysis so that reliable and valuable conclusions can follow. Biochemists, physiologists, pharmacokineticists, toxicologists, chemical researchers, and others for whom drugs are their main focus of study will find this book valuable.

  • Off-Flavors in Foods and Beverages

    • 1st Edition
    • Volume 28
    • G. Charalambous
    • English
    This book, volume 28 in the Developments in Food Science Series, reviews thelatest information and up-to-date concepts concerning a great number ofaspects of flavor quality. Particular attention has been afforded to providea balance between food and beverage chemistry, biochemistry, microbiology,nutriti... processing, packaging, storage, computer applications, andchemometrics.Twen... six specialists were invited to discuss the present state of knowledgein their particular fields. Together with their co-workers (totalling oversixty well known researchers) the authors were drawn from the internationalspectru... of academia, government institutes, and industry. Their presentationsinclude... original research results, background reviews, and comprehensivebibliog... informative and well documented book goes a long way to improving thecurrent knowledge in a complex area and certainly increase understanding of taste and odor, flavors and off-flavors of high quality foods and beverages.

  • Essays in Toxicology

    Volume 4
    • 1st Edition
    • Wayland J. Hayes
    • English
    Essays in Toxicology, Volume 4 covers three essays on habituating drugs, on the kinetics of the active-site-directed irreversible inhibition, and the hidden effects of trace elements. The first essay examines certain dependence-producing drugs; the mechanism of tolerance to barbiturates by changes in drugs metabolism; the distribution of barbiturates to the central nervous system; and the urinary excretion of barbiturates. The formation of morphine from heroin and codeine, and the dealkylation to form normorphine and to reduce naloxone to another compound is also considered in the first essay. The second essay discusses the time-course of enzyme inhibition at single-inhibitor concentrations and the effect of various inhibitor concentrations on the rate constants governing inhibition. The third essay is about the recondite toxicity of trace elements, taking into consideration the effects of these trace elements on body weight, survival, and longevity, clues to mechanisms of toxicity, and the production of chronic diseases simulating human disorders. Toxicologists, oncologists, biochemists, and pharmacologists will find the book invaluable.

  • Lipid Metabolism in Signaling Systems

    • 1st Edition
    • Volume 18
    • John N. Fain + 1 more
    • English
    Many of the phospholipases and even the receptor for inositol 1,4,5-trisphosphate have recently been cloned and sequenced and play an important role in neurotransmission. Methods developed in recent years for the study of the enzymes and intermediates involved in the regulation of neuronal signal transduction involving phospholipid turnover are presented in this volume.

  • Pharma's Prescription

    How the Right Technology Can Save the Pharmaceutical Business
    • 1st Edition
    • Kamal Biswas
    • English
    The pharmaceutical industry needs a shot in the arm – and not a moment too soon. The executive suite is mired in a bygone era, a time when extensive, well-funded pharmaceutical R&D produced blockbuster drugs, kept everything in-house and reaped the financial rewards. But that way of working needs to change. Executives now need to know what the technologists in their companies are doing in order to survive the next decade. Written for those new to industry, as well as for experienced professionals or specialists looking to expand their knowledge, this book is a must-read for business executives and information technologists alike. Pharma’s Prescription bridges the knowledge gap between current business practices and the most valuable technologies today. This book is filled with practical, real-life examples from industry and is a straightforward guide for all pharmaceutical and information technology executives who need to improve their businesses.

  • Catalytic RNA

    • 1st Edition
    • Volume 120
    • English
    This special volume of Progress in Molecular Biology and Translational Science focuses on catalytic RNA. Written by experts in the field, the reviews cover a range of topics, from hammerhead ribozymes to spliceosome catalysis to Varkud satellite and hairpin ribozymes.

  • Biomaterials for Cancer Therapeutics

    Diagnosis, Prevention and Therapy
    • 1st Edition
    • Kinam Park
    • English
    Cancer can affect people of all ages, and approximately one in three people are estimated to be diagnosed with cancer during their lifetime. Extensive research is being undertaken by many different institutions to explore potential new therapeutics, and biomaterials technology is now being developed to target, treat and prevent cancer. This unique book discusses the role and potential of biomaterials in treating this prevalent disease.The first part of the book discusses the fundamentals of biomaterials for cancer therapeutics. Chapters in part two discuss synthetic vaccines, proteins and polymers for cancer therapeutics. Part three focusses on theranosis and drug delivery systems, whilst the final set of chapters look at biomaterial therapies and cancer cell interaction.This extensive book provides a complete overview of the latest research into the potential of biomaterials for the diagnosis, therapy and prevention of cancer. Biomaterials for cancer therapeutics is an essential text for academics, scientists and researchers within the biomedical industry, and will also be of interest to clinicians with a research interest in cancer therapies and biomaterials.

  • From Academia to Entrepreneur

    Lessons from the Real World
    • 1st Edition
    • Eugene Khor
    • English
    From Academia to Entrepreneur: Lessons from the Real World provides practical advice on entrepreneurship, interspersed with insights the author gained from starting up his own business and in associations with other ventures. These same insights can be applied to bringing a technology concept from academia to an enterprise. A few of the questions From Academia to Entrepreneur: Lessons from the Real World answers: How do I pragmatically appraise business opportunities? What traits should I look for in an enterprise? What can and should I do with my concept while in academia, before entering such an endeavor? How do I overcome risk aversion? And most importantly, why should I be the one to build this business?

  • Receptor-Receptor Interactions

    • 1st Edition
    • Volume 117
    • P. Michael Conn
    • English
    This new volume of Methods in Cell Biology looks at receptor-receptor interactions, with sections on allosteric and effector interactions, crystallization and modeling, measuring receptor-receptor interactions and oligomerization in individual classes. With cutting-edge material, this comprehensive collection is intended to guide researchers of receptor-receptor interactions for years to come.

  • Principles of Tissue Engineering

    • 4th Edition
    • Robert Lanza + 2 more
    • English
    Now in its fourth edition, Principles of Tissue Engineering has been the definite resource in the field of tissue engineering for more than a decade. The fourth edition provides an update on this rapidly progressing field, combining the prerequisites for a general understanding of tissue growth and development, the tools and theoretical information needed to design tissues and organs, as well as a presentation by the world’s experts of what is currently known about each specific organ system. As in previous editions, this book creates a comprehensive work that strikes a balance among the diversity of subjects that are related to tissue engineering, including biology, chemistry, material science, and engineering, among others, while also emphasizing those research areas that are likely to be of clinical value in the future. This edition includes greatly expanded focus on stem cells, including induced pluripotent stem (iPS) cells, stem cell niches, and blood components from stem cells. This research has already produced applications in disease modeling, toxicity testing, drug development, and clinical therapies. This up-to-date coverage of stem cell biology and other emerging technologies –such as brain-machine interfaces for controlling bionics and neuroprostheses– is complemented by a series of new and updated chapters on recent clinical experience in applying tissue engineering, as well as a new section on the application of tissue-engineering techniques for food production. The result is a comprehensive textbook that will be useful to students and experts alike.

  • Quest for the Cure

    Reflections on the Evolution of Breast Cancer Treatment
    • 1st Edition
    • George R. Blumenschein
    • English
    This original fourteen chapter book is a brief, slightly autobiographic tale of medical oncologists, surgeons, radiation oncologists, and breast cancer patients in a well-established cancer center in Texas, who pursued the goal of cure for breast cancer. The evolution of improved outcomes in the treatment of microscopic metastatic breast cancer is also the story of the development of adjuvant chemotherapy for post-operative breast disease. The adjuvant therapy of breast cancer came about with the realization that this malignancy, when diagnosed in most patients, had spread beyond the confines of the primary cancer.

  • The HDL Handbook

    Biological Functions and Clinical Implications
    • 2nd Edition
    • Tsugikazu Komoda
    • English
    The HDL Handbook: Biological Functions to Clinical Implications brings laboratory research in HDL from bench to bedside in this needed resource for researchers and clinicians studying cholesterol, lipids, epidemiology, biochemistry, molecular medicine, and pathophysiology of cardiovascular diseases. In addition, researchers and clinicians working with an aging population, corporate researchers, post-doctorates; medical students and graduate students will find this publication useful because the scope of coverage includes basic science, genetics, epidemiology, and treatment of HDL cholesterol as well as potential targets to modify HDL cholesterol.

  • De Indiae utriusque re naturali et medica libri quatuordecim

    • 1st Edition
    • Willem Piso
    • English

  • Biology of the Rhizobiaceae

    International Review of Cytology, Vol. 13
    • 1st Edition
    • Kenneth L. Giles + 1 more
    • English
    Biology of the Rhizobiaceae covers the genetics, molecular biology, agricultural, and morphological aspects of the rhizobia. The book discusses the taxonomy and identification of the Rhizobiaceae; the biology of Agrobacterium tumefaciens and the specific events in the disease cycle of crown gall; and the agricultural control of Agrobacterium tumefaciens. The text also describes the growth potential of crown gall tumors and crown gall teratoma; plasmid studies in crown gall tumorigenesis; and the biology and microbiology of Agrobacterium rhizogenes. The recognition in rhizobium-legume symbioses; the rhizobium bacteroid state; and the exchange of metabolites and energy between legume and rhizobium are also considered. The book further tackles the mutants of rhizobium that are altered in legume interaction and nitrogen fixation; as well as the significance and application of Rhizobium in agriculture. Botanists, agriculturists, geneticists, molecular biologists, microbiologists, plant pathologists, and agronomists will find the book invaluable.

  • Plant Protoplasts

    International Review of Cytology, Vol. 16
    • 1st Edition
    • Kenneth L. Giles
    • English
    Plant Protoplasts covers the techniques involved with, and uses of, protoplast technology. The book discusses isolation, fusion, and culture of higher plant protoplasts, lower plant protoplasts, and blue-green algal protoplast. The text also describes the production of haploid protoplasts from developing pollen grains; the use of protoplasts in mutant selection schemes, and the development of protoplast systems for use with monocotyledonous plants. The book will be invaluable to plant technologists, botanists, biochemists, research workers as well as advanced students interested in gaining a background knowledge of the field.

  • Membrane Research: Classic Origins and Current Concepts

    • 1st Edition
    • A. L. Muggleton-Harris
    • English
    Membrane Research: Classic Origins and Current Concepts is a special volume of the International Review of Cytology dedicated to Dr. Danielli on the occasion of his retirement from official duties. The central theme of the volume is membranes. The diversity of topics ranges from the biogenesis of membranes and their components, to the use of optical and lectin probes as a means to study the structure, physiology, and interactions of cell components and organelles in plant and animal systems. The book begins with a study on the cell surface of the mammalian embryo and the events associated with the formation of the differentiated blastocyst. This is followed by separate chapters on the structural associations between the inner and outer bacterial membrane; the interactions of cell wall and membrane in plant cells; the morphological and functional aspects of membranes; and methods for studying the physiology of cell and organelles at the membrane level. Subsequent chapters deal with the synthesis of cellular proteins and glycoproteins; techniques for fixing and preserving the ultrastructure of the membrane; the synthesis of artificial organelles; and the effects of drugs and chemicals on membrane transport utilizing kidney tissue and vesicles. This book provides an outstanding reference source for all scientific researchers and teachers.

  • Using Secondary Datasets to Understand Persons with Developmental Disabilities and their Families

    • 1st Edition
    • Volume 45
    • English
    International Review of Research in Developmental Disabilities is an ongoing scholarly look at research into the causes, effects, classification systems, syndromes, etc. of developmental disabilities. Contributors come from wide-ranging perspectives, including genetics, psychology, education, and other health and behavioral sciences.

  • Pharmaceutics

    Basic Principles and Application to Pharmacy Practice
    • 1st Edition
    • Alekha Dash + 1 more
    • English
    Pharmaceutics: Basic Principles and Application to Pharmacy Practice is an engaging textbook that covers all aspects of pharmaceutics with emphasis on the basic science and its application to pharmacy practice. Based on curricular guidelines mandated by the American Council for Pharmacy Education (ACPE), this book incorporates laboratory skills by identifying portions of each principle that can be used in a clinical setting. In this way, instructors are able to demonstrate their adherence to ACPE standards and objectives, simply by using this book. Written in a straightforward and student-friendly manner, Pharmaceutics enables students to gain the scientific foundation to understand drug physicochemical properties, practical aspects of dosage forms and drug delivery systems, and the biological applications of drug administration. Key ideas are illustrated and reinforced through chapter objectives and chapter summaries. A companion website features resources for students and instructors, including videos illustrating difficult processes and procedures as well as practice questions and answers. Instructor resources include Powerpoint slides and a full-color image bank. This book is intended for students in pharmaceutical science programs taking pharmaceutics or biopharmaceutics courses at the undergraduate, graduate and doctoral level.

  • A History of Modern Immunology

    The Path Toward Understanding
    • 1st Edition
    • Zoltan A. Nagy
    • English
    A History of Modern Immunology: A Path Toward Understanding describes, analyzes, and conceptualizes several seminal events and discoveries in immunology in the last third of the 20th century, the era when most questions about the biology of the immune system were raised and also found their answers. Written by an eyewitness to this history, the book gives insight into personal aspects of the important figures in the discipline, and its data driven emphasis on understanding will benefit both young and experienced scientists. This book provides a concise introduction to topics including immunological specificity, antibody diversity, monoclonal antibodies, major histocompatibility complex, antigen presentation, T cell biology, immunological tolerance, and autoimmune disease. This broad background of the discipline of immunology is a valuable companion for students of immunology, research and clinical immunologists, and research managers in the pharmaceutical and biotechnology industries.

  • Regenerative Medicine Applications in Organ Transplantation

    • 1st Edition
    • Giuseppe Orlando
    • English
    Regenerative Medicine Applications in Organ Transplantation illustrates exactly how these two fields are coming together and can benefit one another. It discusses technologies being developed, methods being implemented, and which of these are the most promising. The text encompasses tissue engineering, biomaterial sciences, stem cell biology, and developmental biology, all from a transplant perspective. Organ systems considered include liver, renal, intestinal, pancreatic, and more. Leaders from both fields have contributed chapters, clearly illustrating that regenerative medicine and solid organ transplantation speak the same language and that both aim for similar medical outcomes. The overall theme of the book is to provide insight into the synergy between organ transplantation and regenerative medicine. Recent groundbreaking achievements in regenerative medicine have received unprecedented coverage by the media, fueling interest and enthusiasm in transplant clinicians and researchers. Regenerative medicine is changing the premise of solid organ transplantation, requiring transplantation investigators to become familiar with regenerative medicine investigations that can be extremely relevant to their work. Similarly, regenerative medicine investigators need to be aware of the needs of the transplant field to bring these two fields together for greater results.

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