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Elsevier

Books in Neuroscience

Elsevier's Neuroscience collection empowers educators, researchers, and students with actionable knowledge to drive collaborative research and advancements in the field. Content covers the nervous system's intricate workings, covering branches like Affective, Behavioral, and Cognitive neuroscience to investigate the neural basis of emotions, behavior, and cognitive functions. Spanning from Molecular and Cellular Neuroscience to Developmental Neuroscience, content provides insights into brain function in health and disease.

  • Pain Syndromes in Neurology

    Butterworths International Medical Reviews
    • 1st Edition
    • Howard L. Fields
    • English
    Pain Syndromes in Neurology deals with the diagnosis and treatment of painful conditions associated with dysfunction of the peripheral or central nervous system. It discusses advances in three areas: first, the normal anatomy and physiology of pain; second, the pathophysiology of damaged sensory neurons; and third, the diagnosis and treatment of patients with neuropathic pain. The book begins with a discussion of neural mechanisms relevant to pain perception along with a brief review of neuropathic pain. This is followed by separate chapters on hyperalgesia following cutaneous injury; the importance of peripheral processes in the etiology of neuropathic and radiculopathic pain; and mechanisms by which sympathetic efferent fibers contribute to the occurrence of pain. Subsequent chapters cover the diagnosis and treatment of reflex sympathetic dystrophy; pain in generalized neuropathies; surgical treatment of pain; clinical features and management of postherpetic neuralgia; diagnosis of cancer pain syndromes; and drugs in the management of chronic pain.

  • Neuro-psychopharmacology

    Proceedings of the Tenth Congress of the Collegium Internationale Neuro-Psychopharmacologicum Québec, July 4-9, 1976
    • 1st Edition
    • P. Deniker + 2 more
    • English

  • Visual and Oculomotor Functions

    Advances in Eye Movement Research
    • 1st Edition
    • Volume 5
    • G. d'Ydewalle + 1 more
    • English
    A collection of contemporary work in various areas of eye-movement research with an emphasis on physiological aspects is presented in this book. The contributions are divided into six sections: I. saccadic eye movements; II. smooth pursuit and motion perception; III. eye movements in pathology and clinical settings; IV. neurophysiology of eye movements; V. optokinetic nystagmus; and VI. methods. This volume provides updated information on the most recent research on eye movements carried out mainly in Europe.

  • Topical Reviews in Neurosurgery

    Volume 1
    • 1st Edition
    • J. M. Rice Edwards
    • English
    Topical Reviews in Neurosurgery, Volume 1 focuses on neurosurgery, a medical specialty concerned with the prevention, diagnosis, treatment, and rehabilitation of disorders that affect any portion of the nervous system. This book discusses the advances in computed tomography, vascular surgery in neurological disorders, and carotid endarterectomy. The extracranial-intracr... anastomosis, etiology of chronic subdural hematoma, radical surgery in the treatment of craniopharyngiomas, and syringomyelia are also covered. Other topics include the sensory neural deafness; aneurysmal hemorrhage; detection of carotid stenosis; bypass procedures; and completed stroke in the carotid territory. This publication likewise considers the middle cerebral aneurysms; cell kinetics of glioma; and pathophysiology of enlargement of chronic subdural hematomas. This publication is a good source for neurosurgeons and medical students interested in neurosurgery.

  • Biochemistry of Brain

    • 1st Edition
    • Sudhir Kumar
    • English
    Biochemistry of Brain is a collection of articles dealing with the developments in the biochemistry of the brain. This book gives a comprehensive and critical discussion of important developments in studies concerning the above subject. This text discusses the structure, function, and metabolism of glycosphingolipids, which are related to the study of sphingolipid storage diseases. Inborn defects of metabolism are found in Gaucher's and Fabry's disease, which are characterized by lipid accumulation in the brain. Another paper reviews the chemical and genetics of critically lysosomal hydrolase deficiencies that can cause the storage of sphingolipids. This book then explains the role of myelin basic protein in lipids in vivo that the weak bonding of the protein is not a major component of myelin stability. Another paper discusses the procedures for isolating subfractions of myelin and myelin-related membranes, with some attention given on the alterations in the subfractionation of myelin in pathological hypomyelinating and demyelinating conditions. Another article discusses the biochemical and enzymatic composition of lysosomes and the biosynthesis, intracellular transport, storage, and the degradation of lysosomal constituents. This collection of papers will benefit scientists doing research in microbiology, microchemistry, molecular genetics, and neurochemistry.

  • Catecholamines: Basic and Clinical Frontiers

    Proceedings of the Fourth International Catecholamine Symposium, Pacific Grove, California, September 17-22, 1978
    • 1st Edition
    • Earl Usdin + 2 more
    • English

  • Neuropeptide Analogs, Conjugates, and Fragments

    Methods in Neurosciences, Vol. 13
    • 1st Edition
    • P. Michael Conn
    • English
    Methods in Neurosciences, Volume 13: Neuropeptide Analogs, Conjugates, and Fragments covers the synthesis and characterization of peptide analogs, conjugates, and fragments, their use as ligands for receptors, and their role in the development and use of antisera. The book discusses techniques such as novel synthetic approaches; biotinylation; purification and characterization; radioligand techniques and assay development; use of agonists and antagonists; distinguishing receptor subtypes; conjugation to carrier proteins; antiidiotypic antibody development; and radiolabeling. Neuroscientists, biochemists, neurochemists, and pharmacologists will find the book useful.

  • Trophic Regulation of the Basal Ganglia

    Focus on Dopamine Neurons
    • 1st Edition
    • K. Fuxe + 2 more
    • English
    Trophic Regulation of the Basal Ganglia: Focus on Dopamine Neurons examines neurotransmitters. The book first discusses the role of fibroblast growth factor-2 (FGF-2) and ganglioside GM1 and the trophic regulation of the basal ganglia. Biochemical and histochemical studies on the cellular localization of FGF-2; mapping of FGF-2 and its receptors in the basal ganglia postnatally and adulthood; and mapping of the ganglioside GM1 distribution in the basal ganglia are presented. The text also explains glucocorticoid and estrogen effects on the nigrostriatal and mesolimbic dopaminergic systems; factors associated to dopaminergic cell death in Parkinson's disease; and compensatory mechanisms at dopamine D-2 receptors. The book also describes the effects of brain-derived neurotrophic factor on injured dopaminergic neurons; role of gangliosides and trophic factors in brain repair; and features of the trophic action of polyamines. The text also underscores the presence of interleukin-1 in the central nervous system; neuropeptides synthesis in astrocytes; and astrocytic kynurenines as modulators of dopaminergic function in the rat basal ganglia. The selection is a good source of information for readers wanting to study neurotransmitters.

  • Contributions to Contemporary Neurology

    A Tribute to Joseph Michael Foley
    • 1st Edition
    • Robert B. Daroff + 1 more
    • English
    Contributions to Contemporary Neurology features articles presented at the scientific meeting at the March 1986 gala evening affair held in Cleveland, Ohio in honor of neurologist Joseph Michael Foley's seventieth birthday and his impending transition to Professor Emeritus at Case Western University. This book is organized into 20 chapters written by 41 contributors. It starts with the biography of Foley and ends with his curriculum vitae. In between the biographies and curriculum vitae are basic and clinical articles written by professionals closely associated with Foley throughout his illustrious career. This book will be of interest to those interested in learning about the life and career of neurologist Joseph Michael Foley.

  • Neurosciences Research

    Volume 4
    • 1st Edition
    • S Ehrenpreis + 1 more
    • English
    Neuroscience Research, Volume 4 covers papers on a varied group of studies, ranging from synaptic transmission and local anesthetic action to the immobility reflex ("animal hypnosis") and control of food intake. The book presents papers on the mechanisms of synaptic transmission; the acetylcholine system and neural development; and the site of action and active form of local anesthetics. The text also includes papers on biological rhythms and their control in neurobehavioral perspective; neurophysiologic studies of the immobility reflex ("animal hypnosis" and the hepatic receptors and the neurophysiological mechanisms controlling feeding behavior. Neuroscientists, physiologists, and psychiatrists will find the book useful.

  • Methods in Neurotransmitter and Neuropeptide Research

    • 1st Edition
    • Volume 11
    • S.H. Parvez + 2 more
    • English
    This two-part book provides the most advanced biochemical and histochemical analytical methods on neurotransmitters, neuromodulators, and neuropeptides described by international specialists. The biochemical methods include liquid chromatography/elect... liquid chromatography/fluor... and chemiluminescence detection, gas chromatography or liquid chromatography with mass spectrometry, and immunoassays.Morphol... and physiological methods are also described, including immunohistochemistry... in situ hybridization, in vivo microdialysis, electrophysiological analysis, microwave irradiation, electrophysiological analysis, micro-anatomical dissection, peptide sequence analysis, quantitative autoradiographic analysis, and isolated CNS preparations. The neurotransmitters and neuropeptides include catecholamines, indoleamines, histamine, polyamines, and various neuropeptides, and their related enzymes. The book is the most comprehensive, advanced and versatile volume on the biochemical, morphological and physiological analysis of neurotransmitters and neuropeptides.

  • Comparative Neurochemistry

    Proceedings of the Fifth International Neurochemical Symposium
    • 1st Edition
    • Derek Richter
    • English
    Comparative Neurochemistry, a collection of papers presented at the Fifth International Symposium of Comparative Neurochemistry, held at St. Wolfgang, Austria in 1962, deals with variations in neurochemical mechanisms in different animal species. The book integrates the data derived from comparative studies in different disciplines and assesses their significance in relation to the understanding of nervous mechanisms in animals, including human. The papers are grouped into sections, which cover general topics on functional organization in different species; lipids, proteins, and ribonucleic acid; amino acids in different species; energy metabolism and function; neurosecretory mechanisms; and comparative neuropharmacology. The text will be of interest to biologists, zoologists, pharmacologists, chemists, neurologists, and researchers in the pharmaceutical and chemical industries.

  • Microsurgery

    Applied to Neurosurgery
    • 1st Edition
    • M. G. Yaşargil
    • English
    Microsurgery Applied to Neurosurgery focuses on microsurgical approaches to cerebrospinal lesions, including plastic surgery, suturing techniques, instruments for microsurgery, and microsurgical operations. The manuscript first offers information on the history of microsurgery and the operating microscope. Discussions focus on bipolar electric coagulation, plastic surgery, peripheral nerves, clinical application, binocular diploscope, automatic microscope stand, sterile covering of the microscope, and magnification. The text also elaborates on the instruments for microsurgery and suturing techniques. The publication takes a look at experimental microsurgical operations in animals and reconstructive and constructive surgery of the cerebral arteries in man. The manuscript also ponders on intracranial tumors and transnasal-transsphe... approach to the pituitary gland. Topics include transsphenoidal approach, suboccipital transmeatal approach, spinal tumors, and preoperative radiological study. The manuscript is a dependable reference for health professionals and readers interested in microsurgery.

  • Clinical Neuroendocrinology

    • 1st Edition
    • G. M. Besser + 1 more
    • English
    Clinical Neuroendocrinology, Volume II discusses neuroendocrine science and its application to the analysis of human physiology and behavior. This book stresses the importance of the interrelationships between central and peripheral signals, neurotransmitters and neuromodulators, and target glands and peripheral tissues to ensure coordination of somatic and behavioral development and function. The ""centralist"" concepts of the importance of brain hormones are revised in this text, emphasizing that neurohumoral factors isolated from brain tissues, and initially considered to be primarily involved in the central nervous system regulation of the endocrine system, also exist outside the brain and spinal cord. This volume is valuable to neuroendocrinologist... but is also a good source for those involved in basic and clinical research and patient management.

  • Neurological Emergencies

    • 1st Edition
    • S.D. Shorvon
    • English
    Neurological Emergencies presents a comprehensive guide on the initial assessment and early treatment of patients with neurological emergencies. It discusses the diagnosis, emergency investigations, and handling of coma patients. It addresses the management of focal supratentorial lesion. Some of the topics covered in the book are the diffuse neurological or systemic disturbance; emergency resuscitation; diagnosis and treatment of transtentorial herniation; diagnosis and treatment of acute viral encephalitis; raised intracranial pressure; diagnosis and treatment of non-viral infective encephalitis; viral meningitis; meningovascular syphilis; diagnosis and treatment of cerebral abscess; diagnosis and treatment of intracranial subdural empyema; and diagnosis and treatment of cerebral venous thrombosis. The diagnosis and treatment ofstroke is fully covered. An in-depth account of the difference between haemorrhage and infarction is provided. The diagnosis of subarachnoid haemorrhage is completely presented. A chapter is devoted to the prevention of more cranial bleeding.

  • Receptors in the Human Nervous System

    • 1st Edition
    • F. A. O. Mendelsohn + 1 more
    • English
    Receptors in the Human Nervous System is a synthesis of the results of receptor mapping by leaders in the field. In addition to a comprehensive discussion of the distribution and possible interactions of the receptors of different neuroactive substances, this book also contains an abundance of pictorial representations of receptor distributions. High-quality photographs of one receptor are often juxtaposed with photographs of the distribution of a different receptor or receptor subtype for the consideration of possible interactions between different systems. The book surveys the distribution of receptor subtypes for the classical monoamine transmitters (acetylcholine, adrenaline, noradrenaline and serotonin) as well as the distribution of receptors for the excitatory and inhibitory amino acids, (glutamate, GABA and benzodiazepines) as well as the opioid peptides, angiotensen and other neuropeptides. The distribution of multiple types of serotonin receptors is given in detail, and the codistribution of receptors in the cortex is discussed. The book is directed toward researchers in the field of chemical neuroanatomy, as well as pharmacologists, neurophysiologists, and neuroscientists.

  • Diagnostic Reference Index of Clinical Neurology

    • 2nd Edition
    • Pasquale F. Finelli
    • English
    Diagnostic Reference Index of Clinical Neurology aims to give the busy clinician a fast, easy-to-use guide to the core neurological literature published from 1980 to 1986. This book is divided into two sections, key words and references. The keywords section consists of neuroscience terms and each main entry is followed by reference citation numbers and corresponding references. This index, unlike the usual computerized systems for literature retrieval, is structured around clinical problems and uses the approach and terminology of a practicing neurologist. The contents were sources from the full text of articles that were published in critical core of fourteen major international English-language journals in medicine and neurology. This book will be of interest to neurology students and to practicing clinical neurologists.

  • Presynaptic Receptors and Neuronal Transporters

    Official Satellite Symposium to the IUPHAR 1990 Congress Held in Rouen, France, on 26–29 June 1990
    • 1st Edition
    • S.Z. Langer + 2 more
    • English
    Advances in the Biosciences, Volume 82: Presynaptic Receptors and Neuronal Transporters documents the proceedings of the Official Satellite Symposium to the IUPHAR 1990 Congress held in Rouen, France on June 26-29, 1990. The first part of this book deals with the extensive and still increasing list of presynaptic release-modulating auto and heteroreceptors, emphasizing the various subtypes of presynaptic receptors that are characterized by functional studies, both in vitro and in vivo, using a number of experimental approaches. The next chapters are devoted to the molecular pharmacology of presynaptic receptors, of which can interfere with G proteins and modify the activity of adenylate cyclase, guanylate cyclase, or protein kinase C. The purification and molecular biology of transporter systems, including cloning and sequencing of the neuronal sodium-ion coupled GABA transporter are also discussed. This compilation concludes with insights on the function of presynaptic receptors and neuronal transporters both in the periphery and in the CNS, as well as their ubiquitous locations and physiological roles. This publication is a good reference for students and individuals researching on the presynaptic autoreceptors and neurotransmitters.

  • Neurobiology of Steroids

    • 1st Edition
    • Volume 22
    • P. Michael Conn + 1 more
    • English
    Steroid hormones are unique compounds in that they are active at the interface of peripheral endocrine events and neural mechanisms. Thus their effects present an important peripheral signaling system to alter brain function. This volume presents state-of-the-art and classical techniques for the study of steroid hormones and their receptors and their effects and actions.

  • Neural Modeling and Neural Networks

    • 1st Edition
    • F. Ventriglia
    • English
    Research in neural modeling and neural networks has escalated dramatically in the last decade, acquiring along the way terms and concepts, such as learning, memory, perception, recognition, which are the basis of neuropsychology. Nevertheless, for many, neural modeling remains controversial in its purported ability to describe brain activity. The difficulties in "modeling" are various, but arise principally in identifying those elements that are fundamental for the expression (and description) of superior neural activity. This is complicated by our incomplete knowledge of neural structures and functions, at the cellular and population levels. The first step towards enhanced appreciation of the value of neural modeling and neural networks is to be aware of what has been achieved in this multidisciplinary field of research. This book sets out to create such awareness. Leading experts develop in twelve chapters the key topics of neural structures and functions, dynamics of single neurons, oscillations in groups of neurons, randomness and chaos in neural activity, (statistical) dynamics of neural networks, learning, memory and pattern recognition.

  • The Molecular Biology of Neurological Disease

    Butterworths International Medical Reviews
    • 1st Edition
    • Roger N. Rosenberg + 1 more
    • English
    The Molecular Biology of Neurological Disease reviews advances that have been made in understanding the molecular mechanisms of neurological disorders as well as immediate and future applications of molecular biological techniques to clinical practice. This book explores the molecular genetics of neurological disease such as muscular dystrophy, Joseph disease, and Huntington's disease, along with the mitochondrial genes implicated in such conditions. This text is comprised of 18 chapters and begins by introducing the reader to the basic principles and methods of molecular genetic techniques used in the diagnosis of neurological disease. Attention then turns to several aspects of genetic expression in the brain, including the extent to which the genome is expressed in the brain. The next chapter focuses on the visualization of polyadenylated messenger RNAs in individual cells in mammalian brain using in situ hybridization techniques, combined with immunohistochemical localization of specific proteins and neuropeptides implicated in diseases such as Alzheimer dementia. This book also discusses the molecular biology of chemical synaptic neurotransmission; proteins involved in the regulation of nervous system development; and gene expression in skeletal muscle. This text then concludes with a summary of the ""neurological gene map"" as it stands in the latter part of 1987. This book is intended for physicians who grapple with the problems of neurological disorders on a daily basis, including neurologists, neurologists in training, and those in related fields such as neurosurgery, internal medicine, psychiatry, and rehabilitation medicine.

  • Neural Models of Plasticity

    Experimental and Theoretical Approaches
    • 1st Edition
    • John H. Byrne + 1 more
    • English
    Neural Models of Plasticity: Experimental and Theoretical Approaches is an outgrowth of a conference that was held at Woods Hole, Massachusetts, in the spring of 1987. The purpose of that conference was to review recent developments in both areas and to foster communication between those researchers pursuing theoretical approaches and those pursuing more empirical approaches. Contributions have been solicited from individuals who represent both ends of the spectrum of approaches as well as those using a combination of the two. These indicate that our knowledge of the plastic capabilities of the nervous system is accelerating rapidly due to rapid advances in the understanding of basic subcellular and molecular mechanisms of plasticity, and because of the computational capabilities and plastic properties that emerge from neural networks and assemblies. The book contains 19 chapters and opens with a study on the role of the neuromodulator in associative learning of the marine mollusk Hermissend. Subsequent chapters examine topics such as learning and memory in Aplysia; the Hebb rule for synaptic plasticity; olfactory processing and associative memory in the mollusk Limax maximus; simulation of a classically conditioned response; and the neural substrates of memory, focusing on the role of the hippocampus.

  • Atlas of the Prenatal Mouse Brain

    • 1st Edition
    • Uta B. Schambra + 1 more
    • English
    The Atlas of the Prenatal Mouse Brain is the latest addition to Academic Press' list of atlases for neuroscientists and neuroscience students. It fills an urgent need for a comprehensive atlas of the developing mouse brain for use in studies of both normal and abnormal development. High-quality photomicrographs of brain sections are depicted in sagittal, coronal, and horizontal planes for four gestational age groups. Each photomicrograph is accompanied by a fully labeled, precision-drawn diagram for easy identification of brain structures. Researchers and students using normal, transgenic, or mutant mouse preparations in developmental neurobiology, neurotoxicology, and biotechnology will welcome this meticulously assembled and accessible guide.

  • The Neuropsychology of Consciousness

    • 1st Edition
    • A. D. Milner + 1 more
    • English
    The Neuropsychology of Consciousness is based on a symposium entitled “Consciousness and Cognition: Neuropsychological Perspectives” held at the University of St Andrews, September 1990. The intention was to assemble a group of the major researchers at the forefront of this field. The starting point for the symposium and for the book was the widespread realization that in several areas of human cognition (e.g. visual perception, memory, language comprehension, and attention), the severe and profound impairments due to brain damage that have been described over the past 150 years are often not absolute. In particular, the use of indirect methods of testing may reveal unsuspected preservation of capacities that are undetected by more traditional direct methods. The book opens with a discussion of the epidemic of dissociations and how well the phenomena within either neuropsychology or within normal human experimental psychology map onto each other. This is followed by separate chapters on topics such as blindsight, covert visual processing in patients, face recognition and awareness following brain injury, and the relationship between the study of attention and the understanding of consciousness.

  • Biological Markers in Psychiatry and Neurology

    Proceedings of a Conference Held at the Ochsner Clinic, New Orleans, on May 8-10, 1981
    • 1st Edition
    • Earl Usdin + 1 more
    • English
    Biological Markers in Psychiatry and Neurology is a collection of papers that details the advancement in the understanding of the biological markers that stems from psychiatric and neurological pathologies. The text first covers topics about various biological markers, such as neurochemical, enzymatic, membrane, receptors, endocrine, and physiological. Next, the selection examines the relationship between alcohol abuse and biological papers. The next part covers the genetic aspects of biological markers. The text also deals with use of tomography and modeling theory. The book will be of great use to students, researchers, and practitioners of neurology and psychiatry. Psychologists will also benefit from the text.

  • An Introduction to the Study of the Nervous System

    • 2nd Edition
    • E. E. Hewer + 1 more
    • English
    An Introduction to the Study of the Nervous System covers topics about the minute structure and functions of the nervous system. The book discusses the minute and gross anatomy of the various parts of the nervous system; the degenerative and regenerative changes following section of the nerves; and the descending and ascending tracts of the spinal cord. The text then describes the cerebellar connections; the deep connections of the cranial nerves; and the microscopic structure of the cortex of the cerebellum and of the cerebrum. The distribution, source, circulation and absorption, pressure, and normal composition of the cerebrospinal fluid and the parts and functions of the autonomic nervous system are also considered. The book further tackles the normal physiology of the sensory and motor paths; the results of interference with the general sensory path at various levels; and the visual path and interference therewith. The text also discusses the cochlear and olfactory paths and the interference therewith and the levels of integration and mechanism of coordinated muscular movement. Students taking courses related to neurology will find the book useful.

  • Methods in Behavioral Pharmacology

    • 1st Edition
    • Volume 10
    • F. van Haaren
    • English
    Methods in Behavioral Pharmacology is unique in offering a complete description and critical evaluation of most, if not all, methods available to study the effects of drugs on behavior. It stands apart in that it is not limited to the analysis of a particular class of pharmacological agents in a limited number of paradigms. Methods in Behavioral Pharmacology covers all paradigms without reference to specific pharmacological compounds.The book provides a comprehensive overview of the methodology used to study the behavioral effects of legal and illegal drugs. It also provides an in-depth presentation of dependent variables, their quantification and a critical evaluation of their advantages and disadvantages. An excellent work, contributed to by well-known experts in the different fields of behavioral pharmacology.

  • Neurotrauma

    Treatment, Rehabilitation, and Related Issues
    • 1st Edition
    • Michael E. Miner + 1 more
    • English
    Neurotrauma features the papers presented at the Second Houston Conference on Neurotrauma in Texas held in May 1985. These papers cover discussions on patients who have both brain and spinal cord injuries and acute care treatment and investigations of brain injury, as well as rehabilitation strategies and approaches. This second edition is organized into four parts. The first part deals with the treatment of less-than-severe head injury, barbiturate-induced coma, closed head injuries, and severely brain-injured patients. The second part focuses on the evaluation of physiological and anatomical recovery of brain injury patients, while the third part discusses the management of patients with combined head and spinal cord injury. The final part focuses on rehabilitation issues that include nonpharmacological management, the impact of traumatic brain injury on sexuality, and ethical aspects of lifesaving therapeutic strategies. This book may be of interest to persons dealing with studies on the treatment of brain and spinal cord injuries.

  • Neurobiology of Motor Programme Selection

    New Approaches to the Study of Behavioural Choice
    • 1st Edition
    • J. Kien + 2 more
    • English
    The traditional view of motor systems as a linear chain of elements switched on and off by command neurons has become increasingly difficult to maintain in the face of accumulating evidence against the existence of command elements. So far, however, the general formulation of an alternative approach has been lacking. This book, by summarising the evidence against the linear approach to motor systems, argues forcefully against it. Analyses are presented of motor systems ranging from the lobster stomatogastric system through molluscan systems, leech movement, insect singing and locomotion, fish and amphibian behaviour, to goal-directed a movements in primates and volitional movements in humans. Comparison of these motor systems reveal the existence of some general principles underlying motor control and behavioural choice such that motor systems appear generally to be parallel, distributed processing networks. By discussing the treatment of motor systems in terms of parallel distributed processing systems, this book presents in concentrated form an alternative to the earlier view of motor systems. As such, the book is a must for all neuroscientists interested in the organisation of motor systems and the neuronal substrates of behavioural choice.

  • Interleukin-1 in the Brain

    • 1st Edition
    • Nancy J. Rothwell
    • English
    Interest in interleukin-1 (IL-1) has increased dramatically over the last decade, but has been largely restricted to immunologists, cell biologists and those studying inflammation and cancer. However, it has recently been recognized that the brain directly controls or modulates many aspects of immune function, while molecules classically associated with the immune system, such as interleukin-1, are synthesised within the brain and act directly on the central nervous system to modify local and systemic functions. Thus, this topic is relatively new to neurobiologists, and this book is the first comprehensive description of current knowledge on interleukin-1 in the brain, including its location, synthesis and receptors, actions on behaviour, fever, metabolism, neuroendocrine function, electrical activity of the brain, nerve growth factor, and relationship to clinical indications. The book is organised into three sections. The first reviews the data available on the neural localisation of IL-1 and the nature of its central receptors. The main part of the book examines the different neural effects of IL-1 and the mechanisms which are involved in these actions, comparing IL-1 where possible to other inflammatory cytokines which also have neurotrophic effects. The final section evaluates the possible role of IL-1 in neural plasticity and neuronal degeneration.

  • Antipsychotic Drugs and Their Side-Effects

    • 1st Edition
    • Thomas R.E. Barnes
    • English
    In line with other volumes in the Neuroscience Perspectives Series, this volume covers the background, pharmacology, molecular biology, and biochemistry of antipsychotic drugs, together with an overview assessment of the therapeutic considerations. Over the past 40 years, the effectiveness of conventional neuroleptic agents for psychotic illness has been offset by a wide range of adverse side-effects, including motor side-effects like parkinsonism. Studies show that lowering doses may still produce the antipsychotic effect while lessening the risk of side-effects. As all available antispychotic drugs are able to block dopamine, specifically D2 receptors, doses below the threshold level for producing acute motor disorder can still be therapeutically effective. With the identification and characterization of multiple dopamine receptors, the possibility of more selective drugs with better side-effect potential has arisen. Other novel antipsychotic agents include D1 receptor blockers, partial dopamine agonists and non-dopamine drugs such as 5-HT receptor blockers, sigma receptor antagonists and NMDA receptor agonists. This volume reviews both the basic science of the conventional and atypical neuroleptics and their present and potential therapeutic use.

  • Neurotrauma

    Treatment, Rehabilitation, and Related Issues
    • 1st Edition
    • Michael E. Miner + 1 more
    • English
    Neurotrauma: Treatment, Rehabilitation, and Related Issues discusses the issues pertinent to central nervous system trauma. This book is organized into three parts encompassing 17 chapters that tackle the study and management of head injury, including the range of treatment, rehabilitation, and reintegration into the community. Some of the topics covered in the book are the demography of head injury in the United States; cardiopulmonary changes after head injury; management of intracranial hypertension; mechanisms and management of posttraumatic epilepsy; metabolic responses to severe head damage; and evoked responses monitoring in the intensive care unit. Other chapters deal with the auditory assessment of neural trauma, the issues in the evaluation of rehabilitation effects, and the sociological parameters affecting comparisons of long-term outcome. A chapter is devoted to the sensory evoked responses in the diagnosis of brain death. The final chapter focuses on the outcome and recovery of children after experiencing head injury. The book can provide useful information to doctors, neurologists, students, and researchers.

  • Progress in Behavior Modification

    Volume 3
    • 1st Edition
    • Michel Hersen + 2 more
    • English
    Progress in Behavior Modification, Volume 3, is a multidisciplinary serial publication that encompasses the contributions of psychology, psychiatry, social work, speech therapy, education, and rehabilitation. This serial aims to meet the need for a review publication that undertakes to present yearly in-depth evaluations that include a scholarly examination of theoretical underpinnings, a careful survey of research findings, and a comparative analysis of existing techniques and methodologies. The discussions center on a wide spectrum of child and adult disorders. The present volume opens with a chapter on behavior modification and hypnosis. This is followed by separate chapters on applications of behavior modification procedures in classroom settings; smoking behavior modification; and psychotherapy outcome research. Subsequent chapters deal with the behavioral approach to teaching learning disabled children; evaluation of animal analogues of behavioral treatment; therapy for sexual dysfunction; and research in the area of transfer of training of operant treatment effects with children.

  • The Catecholamines in Psychiatric and Neurologic Disorders

    • 1st Edition
    • C. Raymond Lake + 1 more
    • English
    The Catecholamines in Psychiatric and Neurologic Disorders focuses on the contributions of catecholamines (CA) in the modulation of blood pressure, stress and exercise, body movements, memory, learning, emotions, thought processing, appetite, and mediation of psychotropic drug action. The selection first elaborates on the techniques for the assessment and interpretation of catecholamine measurements in neuropsychiatric patients and catecholaminergic response to stress and exercise. Discussions focus on noradrenergic response to isometric exercise, isotonic exercise, effect of acceleration on sympathetic activity, techniques for sympathetic nervous system evaluation, and measurements of CA and their metabolites in cerebrospinal fluid. The text then takes a look at urinary CA in behavioral research on stress; CA in anxiety disorders and mitral valve prolapse; and interaction with neurotransmitters in normal subjects and in patients with selected neurologic diseases. The selection examines noradrenergic responses in postural hypotension, norepinephrine, alcohol, and alcoholism, and catecholamine metabolism in anorexia nervosa. Topics include cerebral catecholamine metabolism in anorexia nervosa; central nervous system norepinephrine and voluntary alcohol drinking; and overview of norepinephrine in selected pediatric disorders. The book is a dependable reference for neuropsychiatrists and readers interested in the contributions of catecholamines on psychiatric disorders.

  • Progress in Behavior Modification

    Volume 5
    • 1st Edition
    • Michel Hersen + 2 more
    • English
    Progress in Behavior Modification, Volume 5, is a multidisciplinary serial publication that encompasses the contributions of psychology, psychiatry, social work, speech therapy, education, and rehabilitation. This serial aims to meet the need for a review publication that undertakes to present yearly in-depth evaluations that include a scholarly examination of theoretical underpinnings, a careful survey of research findings, and a comparative analysis of existing techniques and methodologies. The discussions center on a wide spectrum of child and adult disorders. The book opens with a chapter on the assessment and treatment of minimal dating behavior in college students. This is followed by separate chapters on methods of behavioral control of excessive drinking; behavioral analysis and treatment of child noncompliance to parental requests; and behavioral group therapy. Subsequent chapters deal with the conceptual underpinnings of research in children's self-management and treatment strategies; the assessment and therapeutic functions of self-monitoring; and behavioral treatment in homosexuality.

  • International Review of Neurobiology

    Supplement 1
    • 1st Edition
    • Carl C. Pfeiffer
    • English
    International Review of Neurobiology, Supplement 1: Neurobiology of the Trace Metals Zinc and Copper represents a first report in the study of the neurobiology of zinc and copper. Topics covered by this supplementary volume include the effects of zinc deficiency; the link between acute stress and trace element metabolism; the effects of trace elements on behavior; the pathophysiology of zinc; and the role of copper in schizophrenia. This book consists of seven chapters and begins with a historical overview of zinc deficiency syndrome in humans, followed by a discussion on the metabolism of zinc, effects of its deficiency, and its biochemical functions. Gross congenital malformations in zinc-deficient rats are highlighted. The reader is then introduced to the effect of acute stress on the metabolism of a trace element; the importance of trace elements to development and behavior; and the biological effect(s) of zinc. The next chapter is devoted to idiopathic hypogeusia with dysgeusia, hyposmia, and dysosmia, its symptoms, clinical pathology, and treatment. This monograph will be of value to neurobiologists, biochemists, and nutritionists.

  • Selected Topics from Neurochemistry

    • 1st Edition
    • Neville N. Osborne
    • English
    This book contains up-dated versions of articles which proved very popular when first published in Neurochemistry International. The articles draw attention to developments in a specific field perhaps unfamiliar to the reader, collating observations from a wide area which seem to point in a new direction, giving the author's personal view on a controversial topic, or directing soundly based criticism at some widely held dogma or widely used technique in the neurosciences.

  • Cell Culture

    • 1st Edition
    • P. Michael Conn
    • English
    Methods in Neurosciences, Volume 3: Quantitative and Qualitative Microscopy is a collection of papers that deals with microscopic techniques in statistical measures. This volume describes microscopy using sophisticated stains and dyes to advance observation of tests and experiments. Section I describes autoradiography including micro chemical methods, high-resolution autoradiography, and single- or double-label quantitative autoradiography for use in imaging of brain activity patterns or determining cerebral physiology. Section II discusses the quantification of structures through statistical and computational methods including dynamic video imaging technology. Section III explains the use of tracers, toxins, or dyes in tracing neuronal connections. One paper addresses the use of small injections of axonally transported fluorescent tracers. Section IV explains staining technology such as using the silver impregnation method for frozen sections of human nervous tissue that are gathered from tissues preserved in formalin. Section V addresses freezing techniques and those using freeze-fracture methods in neurobiology. The text also discusses cryoprotection and other freezing methods to control ice crystals found in fixed or unfixed brain tissues. Section VI presents the combined and high-resolution methods in polarization microscopy and microscopic investigations. Cellular biologists, micro-chemists, and scientific researchers in the field of micro- and cellular biology will appreciate this book.

  • The Primary Care of Seizure Disorders

    A Practical Guide to the Evaluation and Comprehensive Management of Seizure Disorders
    • 1st Edition
    • Hugh B. McIntyre
    • English
    The Primary Care of Seizure Disorders: A Practical Guide to the Evaluation and Comprehensive Management of Seizure Disorders is designed to help physicians who in the course of clinical practice care for patients who have epileptic seizures. The intention is to provide a thorough but concise treatment of the subject which may serve as a basic text as well as a handy reference source for solving problems as they arise on a case-by-case basis. The book contains 10 chapters organized according to the sequence which clinical management often follows. These include differential diagnosis and genetic aspects of seizure disorders; the electroencephalograp... evaluation; medical therapy of seizure disorders, including first aid and the treatment of status epilepticus; psychiatric aspects of epilepsy; problems of noncompliance; medical-legal aspects of epilepsy; and finding ancillary, community resources for patients, including voluntary organizations and patient and lay education.

  • Pulsatility in Neuroendocrine Systems

    • 1st Edition
    • Volume 20
    • Jon E. Levine + 1 more
    • English
    Pulsatility is now recognized as a nearly ubiquitous functional feature of neuroendocrine systems. This volume presents a comprehensive guide to the established and emerging technologies being used to study the perplexing phenomenon of pulsatility. Molecular, cellular, physiological, and mathematical approaches are described in detail.

  • Applied Neurophysiology

    With Particular Reference to Anaesthesia
    • 1st Edition
    • J.A. Simpson + 1 more
    • English
    Applied Neurophysiology is intended to promote understanding of the structure and function of the human nervous system for anesthetists. For that reason this book presented concepts rather than critical discussions of experimental work. This book is organized into five parts. There are chapters intended for specialists such as those on vision, control of gaze, hearing and locomotion that were included in order to introduce concepts on brain stem automatisms and cortical function necessary to understand respiration and conscious awareness. There is also a chapter on autonomic nervous system which provides an account of the regulation of the cerebral circulation. The final sections of this volume also include quantitative data and references to original studies which were not thought necessary in other sections. This book will be of interest to anesthetists, clinicians, psychologists, speech pathologists and even neurologists in training.

  • Providing Pharmacological Access to the Brain

    Alternate Approaches
    • 1st Edition
    • Volume 21
    • P. Michael Conn + 1 more
    • English
    This volume focuses on contemporary approaches for delivering experimental and therapeutic agents into the brain. The contributions provide methodological details that are typically not available in the literature. Subtleties and shortcuts critical to each procedure are included to facilitate their use by both the experienced researcher and novice.

  • Neurologic Emergencies in Infancy and Childhood

    • 2nd Edition
    • John M Pellock + 1 more
    • English
    This second edition of Neurologic Emergencies in Infancy and Childhood is written in response to colleagues who have requested an updated version of the book because of numerous advances in child neurology and medicine in general since the first offering. The chapters were designed for easy use in emergency and general medical situations and all chapters have been revised, rewritten, or replaced. This book is organized into 21 chapters written by 31 contributors. A separate section on spinal cord disorders has greatly expanded the previous chapter on myelomeningocele and it includes a discussion on spinal cord trauma and other causes of paraplegia. A separate chapter on psychiatric emergencies possibly presenting with neurologic signs or symptoms has been added. The chapters also contain information concerning drug dosages and the use of newer agents, including antibiotics, antiepileptics and other drugs. This book will be of interest to persons dealing with studies on the management of neurologic emergencies.

  • Lipid Metabolism in Signaling Systems

    • 1st Edition
    • Volume 18
    • P. Michael Conn + 1 more
    • English
    Many of the phospholipases and even the receptor for inositol 1,4,5-trisphosphate have recently been cloned and sequenced and play an important role in neurotransmission. Methods developed in recent years for the study of the enzymes and intermediates involved in the regulation of neuronal signal transduction involving phospholipid turnover are presented in this volume.

  • Neurotoxins

    • 1st Edition
    • Volume 8
    • P. Michael Conn
    • English
    The exquisite simplicity and potency of toxins have made them valuable probes of neural systems. This book presents a comprehensive compilation of techniques used for the preparation, handling, and, particularly, for the use of neurotoxins. Model systems are described in which these neurotoxins have been extremely valuable in developing an understanding of the cellular and molecular basis of secretion and electrophysiological events leading to altered cell function.

  • Movement Disorders

    Neurology
    • 1st Edition
    • C. David Marsden + 1 more
    • English
    Neurology, Volume 2: Movement Disorders is a part of an international series of critical reviews of topics in neurology. This volume focuses on Parkinsonism and dyskinesia, a condition characterized by abnormal involuntary movements. Organized into 18 chapters, this book first elucidates the problems, causes, pathology, brain neurotransmitter changes and receptors, depression, dementia, fluctuations of disability, and treatment of Parkinson's disease. Subsequent chapters then explore the problems, controversies, and surgical approaches involved in certain dyskinesias. The role of dopamine receptors in movement disorders is also explored. This book will be valuable to neurologists-in-trai... as well as to those in research field or in practice in this field of interest. The book's clinical content will help in the management of patients with movement disorders.

  • Interlimb Coordination

    Neural, Dynamical, and Cognitive Constraints
    • 1st Edition
    • Stephan P. Swinnen + 3 more
    • English
    This comprehensive edited treatise discusses the neurological, physiological, and cognitive aspects of interlimb coordination. It is unique in promoting a multidisciplinary perspective through introductory chapter contributions from experts in the neurosciences, experimental and developmental psychology, and kinesiology. Beginning with chapters defining the neural basis of interlimb coordination in animals, the book progresses toward an understanding of human locomotor control and coordination and the underlying brain structures and nerves that make such control possible. Section two focuses on the dynamics of interlimb coordination and the physics of movement. The final section presents information on how practice and experience affect coordination, including general skill acquisition, learning to walk, and the process involved in rhythmic tapping.

  • Ion Channels of Excitable Cells

    • 1st Edition
    • Volume 19
    • Toshio Narahashi + 1 more
    • English
    Because of the highly significant and widely recognized roles of ion channels in physiology, pathophysiology, pharmacology, and toxicology, the term ion channel has now become a household word in the biomedical sciences. This volume covers preparations and techniques for the study of various ion channels. Both voltage-gated and ligand-gated ion channels of neurons, axons, and cardiac and smooth muscles are covered. It includes not only patch clamp techniques but molecular biology and imaging techniques as well.

  • Neurosciences Research

    Volume 3
    • 1st Edition
    • S Ehrenpreis + 1 more
    • English
    Neurosciences Research, Volume 3 covers research problems concerned with the central nervous system. The book discusses the transport processes at the brain cell; the life history of the microglial cell; and studies on the choroid plexus. The text also describes the role of the cerebral peduncle in movements, as well as the pathobiological aspects of the action of tetanal toxin in the nervous system and skeletal muscle. Neuroscientists, neurochemists, and neuropathologists will find book useful.

  • Neurobiology of Cytokines

    Methods in Neurosciences, Vol. 16
    • 1st Edition
    • Errol B. De Souza
    • English
    Neurobiology of Cytokines, Part A provides an overview of the effects of cytokines in the brain and in the endocrine system. The book discusses the general aspects of cytokines, including the endogenous agonists and antagonists, their receptors, their second messengers, and transport mechanisms for cytokines across the blood-brain barrier. The text also describes the anatomical localization of cytokines, cytokine receptors, and their respective mRNA in brain and in endocrine tissues. The methods for evaluating the in vivo as well as in vitro actions of cytokines on hormone secretion are also considered. The book further tackles the synthesis and release of cytokines and their central nervous system actions; and the methodology for studying the role of cytokines in human neuropathological conditions.

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