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Elsevier

Books in Life sciences

  • Effective Approaches to Global Health Issues

    • 1st Edition
    • Manoj Sharma + 1 more
    • English
    Effective Approaches to Global Health Issues is a comprehensive, interdisciplinary book that explores diverse topics in global health. It serves as a valuable resource for understanding the complexities and challenges associated with global health from various perspectives. The book delves into historical contexts, health indicators, cultural influences, behavioral factors, communicable and non-communicable diseases, malnutrition, nutritional deficiencies, obesity, environmental health, population issues, women's and children's health, mental well-being, global health systems, and emerging issues in the field. It goes beyond a mere recitation of topics and provides an engaging narrative that examines the interconnectedness of global health issues.This is an essential reference for students, researchers, and professionals involved in public health, international development, and related disciplines. By providing a comprehensive understanding of global health issues and potential solutions, this book equips readers with the knowledge and tools to address the complex challenges of global health in their respective fields.

  • Advances in Marine Biology

    • 1st Edition
    • Volume 97
    • English
    Advances in Marine Biology, Volume 97, the latest release in this serial that highlights new advances in the field, including comprehensive chapters written by an international board of authors.

  • Agroecology of Edible Weeds and Non-Crop Plants

    Ecology and Socioeconomic Potential of the Associated Plant Biodiversity
    • 1st Edition
    • Roland Ebel + 1 more
    • English
    Agroecology of Edible Weeds and Non-Crops: Ecology and Socio-Economic Potential of Plant Biodiversity is the first book to move beyond the ethnobotanical aspect of under-utilized non crops to explore how to optimize their potential. With case studies of edible weeds and non-crop plants from around the world, including Europe and North America, in urban as well as rural settings, the book highlights the global opportunities provided by these plants. The book includes much needed information for identifying, maintaining, and benefitting from these plant species. It is ideal for agricultural professionals, educators, researchers, and students.Those interested in increasing the diversity of the farming landscape and food systems by means of edible non-crop plants have access to a plethora of information on the ethnobotany of these species. Yet little to no information exists on the agroecological requirements and potential benefits of underutilized edible non-crop plants in the context of sustainable farming systems. This book fills that knowledge gap from identifying edible weeds and non-crop plants, to exploring the ways these plants can be used to economically improve nutrition.

  • Integrative Omics in Parkinson's Disease

    • 1st Edition
    • Joanne Trinh
    • English
    Integrative Omics in Parkinson’s Disease provides a comprehensive understanding of the current literature on high-throughput technologies relating to discoveries for Parkinson's disease etiology. This emerging field uses large omics datasets to investigate the etiology of Parkinson’s disease and other forms of parkinsonism. The book traces the evolution of omics technologies from the discovery of monogenic Parkinson's disease forms. Chapters delve into genomics, transcriptomics, epigenomics, artificial intelligence, and gene-environment interactions. Furthermore, it examines the potential therapeutic applications of these advancements and provides insights into the future of omics research in Parkinson's disease.

  • Planning, Writing and Reviewing Medical Device Clinical and Performance Evaluation Reports (CERs/PERs)

    A Practical Guide for the European Union and Other Countries
    • 1st Edition
    • Joy Frestedt
    • English
    A Practical Guide to Planning, Writing, and Reviewing Medical Device Clinical Evaluation Reports guides readers through clinical data evaluation of medical devices that is in compliance with the EU MDR requirements and other similar regulatory requirements throughout the world. This book brings together knowledge learned as the author constructed hundreds of CERs and taught thousands of learners on how to conduct clinical data evaluations. This book will support training for clinical engineers, clinical evaluation scientists, and experts reviewing medical device CERs, and will help individual writers, teams and companies to develop stronger, more robust CERs.

  • Neonatal Intensive Care for Extremely Preterm Infants

    Japanese NICU Practices to Prevent Mortality and Morbidities
    • 1st Edition
    • Satoshi Kusuda + 2 more
    • English
    Neonatal Intensive Care for Extremely Preterm Infants: Japanese NICU Practices to Prevent Mortality and Morbidities presents the latest updates from top Japanese researchers at top Japanese institutions who come together to share their knowledge and implementation strategies globally. Utilizing the same drugs and devices found in NICUs worldwide, this title reviews how Japanese NICUs use them most effectively to improve outcomes in highest-risk infants.Chapters cover resuscitation and respiratory care, circulatory support, neurological care, fluid management, nutrition support, and infection control. Final chapters are devoted to sharing details of the Japanese NICU clinical environment as well as best practices for extremely preterm infant follow-up after NICU discharge. Researchers and clinicians worldwide will find this title to be an invaluable resource in improving outcomes for this most vulnerable population.

  • Advances in Cancer Research

    • 1st Edition
    • Volume 164
    • English
    the latest release in this ongoing, well-regarded serial, provides invaluable information on the exciting and fast-moving field of cancer research, with this updated edition covering chapters on A bioinformatic-driven prediction of MDA9 transcriptional variants’ roles in cancer progression and treatment, Redox, cysteines, and kinases - A triad sustaining myeloid leukemia, The RAF cysteine-rich domain: structure, function, and role in disease , Membrane Potential: a new hallmark of cancer, Recent Advances and Progress in Immunotherapy of Solid Cancers, and much more.Other sections explore Precision Medicine: Non-Invasive Therapeutic Agent Delivery with Focused Ultrasound and Microbubbles and Anti-Cancer Activity of Capsaicin and its Analogs in Gynecological Cancers.

  • Encyclopedia of the Human Brain

    • 2nd Edition
    • Jordan H. Grafman
    • English
    Encyclopedia of the Human Brain, Second Edition, Seven Volume Set builds on the success of the first edition, providing neuroscience researchers with the ideal ‘one-stop’ resource on all topics related to human brain understanding. Given the length of time since the first edition published, EHB2 is thoroughly revised, with substantial updates on many new and exciting topics, including areas such as human neuroimaging, non-invasive brain stimulation, molecular biology (including genetics and epigenetics), and the clinical diagnoses of brain disorders, along with chapters exploring the introduction of new theoretical and methodological ideas in areas ranging from cognitive neuroscience to evolution of the human brain.In total, there are 440 articles – a vast increase from 224 previously - thus reflecting the huge explosion in neuroscience research during the last 20 years. EHB2 provides a brand new generation of neuroscientists with the perfect tool with which to learn and master the fundamentals of how and why the human brain operates as it does.

  • Artificial Intelligence and Multimodal Signal Processing in Human-Machine Interaction

    • 1st Edition
    • Abdulhamit Subasi + 2 more
    • English
    Artificial Intelligence and Multimodal Signal Processing in Human-Machine Interaction presents an overview of an emerging field that is concerned with exploiting multiple modalities of communication in both Artificial Intelligence and Human-Machine Interaction. The book not only provides cross disciplinary research in the fields of multimodal signal acquisition and sensing, analysis, IoTs (Internet of Things), Artificial Intelligence, and system architectures, it also evaluates the role of Artificial Intelligence I in relation to the realization of contemporary Human Machine Interaction (HMI) systems.Readers are introduced to the multimodal signals and their role in the identification of the intended subjects, mental state and the realization of HMI systems are explored, and the applications of signal processing and machine/ensemble/dee... learning for HMIs are assessed. A description of proposed methodologies is provided, and related works are also presented. This is a valuable resource for researchers, health professionals, postgraduate students, post doc researchers and faculty members in the fields of HMIs, Brain-Computer Interface (BCI), Prosthesis, Computer vision, and Mental state estimation, and all those who wish to broaden their knowledge in the allied field.

  • Postharvest Technologies and Quality Control of Shrimp

    • 1st Edition
    • Nilesh Nirmal + 2 more
    • English
    Postharvest Technologies and Quality Control of Shrimp provides the most updated and comprehensive knowledge on conventional chemical additives, novel natural preservatives, innovative technologies, and packaging solutions employed to enhance the quality and safety of shrimp and shrimp products. The book disseminates current developments in natural preservatives as well as advancements in new technologies to extend the shelf-life of shrimp and their products during different storage conditions. Edited by experts in the field of fisheries and seafood science, this book provides its readership with a broad overview of shrimp postharvest quality losses.The authors have gathered a wealth of recent information and guidance on the utilization of natural preservatives and novel technologies for the quality control of shrimp. Subsequent chapters discuss the impact of handling, processing, and storage on shrimp postharvest quality, followed by various preservatives and technologies employed to retard described quality losses. The book concludes with a discussion of safety and regulation issues related to food additives.

  • Tyrosinase

    • 1st Edition
    • Volume 56
    • English
    Tyrosinase, Volume 56 in The Enzymes series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Overview on tyrosinases (genetics, molecular biology, phylogenetic relationship), Catalytic mechanism of tyrosinases, Structural characterization of tyrosinases, Assay methods of tyrosinase activity and inhibition, Natural products as tyrosinase inhibitors, Drug design of tyrosinase inhibitors, Peptide and peptidomimetic tyrosinase inhibitors, Computational studies of tyrosinase inhibitors, Bacterial tyrosinases and their inhibitors, and Biomedical applications of tyrosinases and tyrosinase inhibitors.

  • Nanomedicine in Translational Research

    Status and Future Challenges
    • 1st Edition
    • Kaladhar Kamalasanan + 1 more
    • English
    Nanomedicine in Translational Research: Status and Future Challenges harnesses the current developments and future directions of diagnostic and therapeutic solutions in clinical scenarios. This book integrates nanomedicine and biomaterials to develop healthcare technology for improved patient care and clinical practices, through applications using theranostics, biomaterials, 3-D printing, regenerative medicines, and nanosystems.Those in this multidisciplinary field will need to improve procedures and protocols, as well as regulatory guidelines and their clinical implications. This book will be highly useful as it is written by experts in the field for researchers working in the areas of nanotechnology, biomaterials, drug delivery, and pharmaceuticals for chronic diseases.

  • Traditional Starch Food Products

    Application and Processing
    • 1st Edition
    • Marney Pascoli Cereda + 1 more
    • English
    Traditional Starch Food Products: Application and Processing is the fourth volume of the “Underground Starchy Crops of South American Origin” book series. Organized in five volumes, this series brings information on the applied level of producing and using starch from a range of plants grown in tropical and subtropical areas that have South American origin.This book describes the use of starchy roots, tubers and rhizomes in food, medicine, local culture, and religion, emphasizing the vital roles they play in indigenous Andean or Amazonian communities, offering cultural identity and economic value.The book’s comprehensive exploration highlights the multifaceted world of underground starchy crops, emphasizing the challenges to their successful development and preservation.Edited by a team of experts with solid background on starch extraction research, these books are aimed at all those involved in research and development, new technology processes and quality control and legislation in the field of starch.

  • The Kidney of the Critically Ill Pregnant Woman

    • 1st Edition
    • Jorge Hidalgo + 2 more
    • English
    The Kidney of the Critically Ill Pregnant Woman is a volume in the Critical Care in Obstetrics series. It’s a novel reference to educate physicians, nurses, and all allied healthcare personnel caring for pregnant women with kidney compromise. The authors have gathered the best evidence-based material explicitly focused on severe kidney complications in pregnant patients and postpartum. Among the chapters, the book covers medical-surgical complications that any patient can present, such as acute kidney injury during pregnancy, kidney disease, and hypertension complications specific to pregnancy.

  • Mononuclear Non-heme Iron Dependent Enzymes Part B

    • 1st Edition
    • Volume 704
    • English
    Mononuclear Non-heme Iron Dependent Enzymes, Volume 704, Part B focuses on methods for studying, characterizing, and leveraging the chemistry of mononuclear non-heme iron dependent enzymes. Chapters in this new release include Observing extradiol dioxygenases in action through a crystalline lens, Methods used to determine the structure of the oxygenase component of naphthalene 1,2-dioxygenase, Expression, purification, kinetics, and crystallization of non-heme mononuclear iron enzymes: biphenyl, phthalate, terephthalate dioxygenase, Substitution of the Mononuclear, Non-heme Iron Cofactor in Lipoxygenases for Structural Studies: Non-heme iron enzyme dependent reactions, and much more.Other sections cover Cyclopropanation and aziridination catalyzed by non-heme iron and 2-oxogluatarate dependent enzymes, Expression, purification, and characterization of non-heme Iron-dependent mono-oxygenase OzmD in Oxazinomycin Biosynthesis, Isonitrile Biosynthesis by a Non-Heme Iron(II)-Dependent Oxidases/Decarboxyla... Functional analysis of an a-ketoglutarate-depe... non-heme iron oxygenase in fungal meroterpenoid biosynthesis, Spectroscopic and Computational Studies of a Bifunctional Iron- and 2-oxoglutarate Dependent Enzyme, AsqJ, and much more.

  • Hazardous Chemicals

    Overview, Toxicological Profile, Challenges, and Future Perspectives
    • 1st Edition
    • Jaspal Singh + 2 more
    • English
    Hazardous Chemicals: Overview, Toxicological Profile, Challenges, and Future Perspectives offers comprehensive coverage of hazardous chemicals and their routes of exposures, mechanism of toxicity, hazard control measures, handling and storage, emergency guidelines, and safety measures.The book is organized into specific classifications of chemical hazards: pesticides, fertilizers, insecticides, automotive, paint and paint solvents, chemical manufacturing solvents, dyes, cleaning agents, pharmaceuticals, and radioactive products. It discusses the health risk and environmental impact of these toxic substances. It also provides management strategies including risk assessment, risk management, and risk communication. Hazardous Chemicals is a practical resource for researchers, academics, industry professionals, graduate and postgraduate students in toxicology and environmental science engaged in the evaluation of toxic substances and human health concerns.

  • Non-Traumatic Acute Surgical Problems

    An Infographic Guide
    • 1st Edition
    • Constantine P. Spanos
    • English
    Non-Traumatic Acute Surgical Problems: An Infographic Guide is curated to offer a comprehensive understanding of acute surgical challenges, excluding trauma. Tailored specifically for medical students navigating their surgical rotations and seasoned instructors in the field, this guide serves as an indispensable resource. Each chapter serves as a path through the intricacies of acute surgical conditions with clarity and depth. Contents provide insight into the complexities of acute cholecystopathy, appendicitis, and acute pancreatitis, providing invaluable insights into diagnosis and sophisticated management strategies. This book navigates through the labyrinth of gastrointestinal bleeding scenarios, encompassing upper, lower, and variceal bleeding, as well as formidable challenges like caustic ingestion and esophageal perforation. Contents further cover vascular emergencies, unraveling the mysteries of aortic dissection, peripheral arterial embolism, and hypercoagulability, while mastering essential principles for timely and effective intervention. Coverage includes the subtleties of urological emergencies such as renal colic, pyelonephritis, and testicular torsion, alongside gynecological conditions including ectopic pregnancy and pelvic inflammatory disease.With a wealth of information, thoughtfully structured in an accessible format, this book not only empowers but emboldens its readers. Equipped with knowledge, insight, and confidence, individuals traversing the realm of acute surgical problems are fortified to navigate the challenges of real-world clinical settings with unwavering competence and assurance.

  • Tea in Health and Disease Prevention

    • 2nd Edition
    • Victor R. Preedy + 1 more
    • English
    While there is a nearly universal agreement that drinking tea can benefit health, information on the benefits or adverse effects of drinking tea is scattered, leaving definitive answers difficult to ascertain. Tea in Health and Disease Prevention, Second Edition, once again addresses this problem, bringing together all the latest and most relevant information on tea and its health effects into one comprehensive resource. This book covers compounds in black, green, and white teas and explores their health implications, first more generally, then in terms of specific organ systems and diseases. With over 75% brand new content, this fully reorganized, updated edition covers a wider range of tea varieties and beneficial compounds found in tea, such as epigallocatechin gallate and antioxidants.Tea in Health and Disease Prevention, Second Edition, is an organized, efficient resource that will help readers find quick answers to questions and will help inspire further studies for those interested in tea research. This is a must-have reference for researchers in food science and nutrition, as well as nutritionists and dieticians.

  • Functional Foods

    Principles and Technology
    • 2nd Edition
    • Mingruo Guo
    • English
    Functional Foods: Principles and Technology, Second Edition covers the definition, history, and development trends of functional foods. Specifically, this updated edition discusses the chemistry of functional components and their physiological properties of functional foods, including antioxidants, dietary fiber, pre-, pro-, and paraprobiotics, symbiotics, and postbiotics, selected nutritional supplements, soy and soy foods, human milk biochemistry and infant formula, sports drinks chemistry, and formulation aspects. This book is sure to be of interest to food and nutrition researchers, pharmacologists, and those teaching and studying related fields.

  • Coffee in Health and Disease Prevention

    • 2nd Edition
    • Victor R. Preedy + 1 more
    • English
    Coffee in Health and Disease Prevention, Second Edition, presents a comprehensive look at the compounds in coffee, their benefits (or adverse effects), and explores coffee as it relates to specific health conditions. Embracing a holistic approach, this book covers the coffee plant, coffee production and processing, the major varieties of coffee, and its nutritional and compositional properties. Coffee’s impact on human health, disease risk, and prevention comprises the majority of the text. Diseases covered including Alzheimer’s, anxiety and depression, asthma, diabetes, cancer, and more. This book also covers coffee’s impact on organs and organ systems, including the cardiovascular system, the nervous system, and the gut microbiome.Coffee in Health and Disease Prevention, Second Edition, is the only book on the market that covers all varieties of coffee in one volume and their potential benefits and risks to human health. This is an essential reference for researchers in nutrition, dietetics, food science, biochemistry, and public health.

  • Childhood Obesity

    From Basic Knowledge to Effective Prevention
    • 1st Edition
    • Luis Moreno
    • English
    Childhood Obesity: From Basic Knowledge to Effective Prevention brings together field experts, taking a multifactorial approach to understand the scope and various causes of the issue and offer the latest in treatment and prevention strategies and resources. Beginning with basic concepts and definitions, chapters progress to cover worldwide prevalence and trends, genetic and epigenetic origins, metabolic programming, and neuroendocrine control of appetite and satiety. Further, this book examines social determinants and lifestyle behaviors contributing to risk factors as well as complications associated with childhood obesity.Final chapters discuss multidisciplinary treatment, strategies for prevention, and current worldwide policies aimed to address obesity in children. This fundamental reference is a vital resource for both researchers and practicing clinicians in pediatric medicine.

  • Biscuit, Cookie and Cracker Production

    Process, Production and Packaging Equipment
    • 2nd Edition
    • Iain Davidson
    • English
    Biscuit, Cookie and Cracker Production, Second Edition is a practical reference that brings a complete description of the process and equipment necessary for automated food production in the food/biscuit industry. The book describes the existing and emerging technologies in biscuit making and production, making it a valuable asset to R&D personnel and students in food technology and engineering areas. The second edition brings 370 new photos and images for updated equipment. Additional chapters covering energy usage and baking efficiency are also included, along with data on energy usage and energy saving.Iain Davidson shares his almost 50 years of experience in the biscuit baking industry worldwide with students, researchers or people joining a biscuit making company.

  • Programa para mejorar la gestión del dolor crónico

    12 sesiones para reaprender a vivir plenamente
    • 1st Edition
    • Carolina BAEZA-VELASCO + 1 more
    • Spanish
    Este libro está pensado para el paciente, concebido como una auténtica guía práctica, es una herramienta de seguimiento y de motivación que le ayudará a centrarse en su objetivo, a no cejar en sus esfuerzos por mitigar el dolor cotidiano y a recuperar la calidad de vida. Las distintas intervenciones psicológicas incluidas no pretenden curar el dolor, sino ayudar a los pacientes a desarrollar recursos psicológicos y a adoptar herramientas eficaces para afrontar mejor el sufrimiento.

  • Cutting Edge Artificial Intelligence, Spatial Transcriptomics and Proteomics Approaches to Analyze Cancer

    • 1st Edition
    • Volume 163
    • English
    Cutting Edge Artificial Intelligence, Spatial Transcriptomics and Proteomics Approaches to Analyze Cancer, Volume 163 in the Advances in Cancer Research series, highlights new advances in the field, with this new volume presenting interesting topics on the Impact of thermal processing on food flavonoids, Bioinformatics and bioactive peptides from foods: does it work together?, Food off-flavor volatiles generation, characterization and advances in novel strategies for mitigating off-flavor perception, Innovations in Food Packaging for a Sustainable and Circular economy, Upcycling of seafood side streams for circularity, Edible insects in foods, Effect of novel food processing technologies on Bacillus cereus spores, and more.

  • Advances in Immunology

    • 1st Edition
    • Volume 163
    • English
    Advances in Immunology, Volume 163, the latest release in a long-established and highly respected publication, presents current developments and comprehensive reviews in immunology. Sample chapters include The role of autophagy in RIP1 mediated cell death and intestinal inflammation, IL-17 family cytokines in inflammatory or autoimmune kin diseases, and more.​​​​​​

  • CRISPR-Cas-Based Genome Editing for Treating Human Diseases-Part A

    • 1st Edition
    • Volume 208
    • English
    CRISPR-Cas-Based Genome Editing for Treating Human Diseases-Part A, Volume 208 represents CRISPR-Cas systems for genome editing. Currently, CRISPR-Cas systems are proven a key technology for targeted genome editing, which is acting as a simple, rapid, and cost-effective solution. CRISPR-Cas9 system is being used in microbial genome editing, mammalian genome editing, disease models, and more. It has shown potential in human disease treatment. However, it is not easy to find CRISPR-Cas systems genome editing in a single source.This volume offers CRISPR-Cas systems for human diseases, bacterial disease, gut microbiome editing, viral disease, protozoan disease, fungal disease, stem cell therapy, CRISPR in epigenetics, CRISPR in cancer, autoimmune and blood disorders. In addition, it highlights a number of aspects of the CRISPR-Cas systems that can help the basic understanding of students, researchers, clinicians, entrepreneurs, and stakeholders to perform their research with great interest.

  • Handbook of Neural Engineering

    A Modern Approach
    • 1st Edition
    • Stephanie Willerth
    • English
    Handbook of Neural Engineering: A Modern Approach provides a comprehensive overview of the field from biology to recent technological advances through an interdisciplinary lens. The book is divided into three sections: 1) Biological Considerations for Neural Engineering, 2) Neural Engineering Strategies, and 3) Emerging Technologies for Neural Engineering. It provides the first comprehensive text that addresses this combination of subjects. Neurodegenerative diseases, including Alzheimer’s, Parkinson’s and Multiple Sclerosis, represent an enormous healthcare burden, and many of these diseases lack true cures, making it imperative to study the biological systems that become disordered to understand potential treatment options.This book covers the basic neurobiology and physiology, common neural engineering strategies, and emerging technologies in this field. It is designed to support an upper year/graduate elective course in neural engineering, and will provide a foundational overview of the field for interdisciplinary researchers, clinicians, engineers, and industry professionals. The handbook provides readers with a strong base in both biological and engineering principles along with the concepts necessary to implement solutions using Neural Engineering.

  • Advances in Agronomy

    • 1st Edition
    • Volume 188
    • English
    Advances in Agronomy, Volume 188, the latest release in this leading reference on agronomy, contains a variety of updates and highlights new advances in the field, each written by an international board of authors.

  • Myopathies and Tendinopathies of the Diabetic Foot

    Anatomy, Pathomechanics, and Imaging
    • 1st Edition
    • Claude Pierre-Jerome
    • English
    Myopathies and Tendinopathies of the Diabetic Foot: Anatomy, Pathomechanics, and Imaging is a unique reference of valuable instructive data that reinforces the understanding of myopathies and tendinopathies related to diabetes-induced Charcot foot. Diabetic myopathies usually precede other complications (i.e., deformity, ulceration, infection) seen in the diabetic foot. Oftentimes, these myopathies may be isolated especially during their initial stage. In the absence of clinical information relevant to diabetes, the solitaire occurrence of myopathies may lead to confusion, misinterpretation, and misdiagnosis. The misdiagnosis can cause delay of management and consequent high morbidity. This book emphasizes the complications of diabetic myopathies and tendinopathies and all their aspects, including pathophysiology, pathomechanics, imaging protocols, radiological manifestations, histological characteristics, and surgical management.Diabetes type II and its complications (diabetic myopathies and tendinopathies) have reached a dreadful high incidence worldwide. Likewise, the need for better understanding of these complications becomes indispensable. In this book, the readers of all genres will find all they need to know about these conditions. This book serves as a classic academic reference for educators, healthcare specialists, healthcare givers, and healthcare students.

  • Mononuclear Non-heme Iron Dependent Enzymes

    • 1st Edition
    • Volume 703
    • English
    Mononuclear Non-heme Iron Dependent Enzymes, Volume 703 focuses on methods for studying, characterizing, and leveraging the chemistry of mononuclear non-heme iron dependent enzymes. Chapters in this new release include Photoreduction for Rieske oxygenase chemistry, Insights into the Mechanisms of Rieske Oxygenases from Studying the Unproductive Activation of Dioxygen, Non-heme iron and 2-oxoglutarate enzymes catalyze cyclopropane and azacyclopropane formations, Obtaining precise metrics of substrate positioning in Fe(II)/2OG dependent enzymes using Hyperfine Sublevel Correlation Spectroscopy, Xe-pressurization studies for revealing substrate-entrance tunnels, and much more.Additional chapters cover A tale of two dehydrogenases involved in NADH recycling, Rieske oxygenases and/or their partner reductase proteins, Expression, assay and inhibition of 9-cis-epoxycarotenoi... dioxygenase (NCED) from Solanum lycopersicum and Zea mays, Biocatalysis and non-heme iron enzymes, In vitro analysis of the three-component Rieske oxygenase cumene dioxygenase from Pseudomonas fluorescens IP01, Structure and function of carbazole 1,9a-dioxygenase, Characterization of a Mononuclear Nonheme Iron-dependent Mono-oxygenase OzmD in Oxazinomycin Biosynthesis, and much more.

  • Fundamentals of Recombinant Protein Production, Purification and Characterization

    • 1st Edition
    • Deepti Yadav + 2 more
    • English
    Fundamentals of Recombinant Protein Production, Purification and Characterization is organized into nine chapters in a logical fashion that cover an introduction to recombinant proteins and expression in different host expression systems, extraction, purification and analysis of proteins. This important reference features protocols, along with the advantages and disadvantage of each expression hosts and characterization technique (presented in tabular format) and offers detailed coverage of all aspects of protein production and processing (upstream and downstream processing) in one place. Finally, the book ends with different characterization techniques. Production of recombinant proteins for biotechnological and therapeutic applications at a large scale is an essential need of mankind. With the huge application potential of therapeutic and industrial proteins, there has been increasing demand for effective and efficient bioprocessing strategies. Recent progress around recombinant DNA technologies and bioprocessing strategies has paved the way for efficient production of recombinant proteins. Important factors such as insolubility and cost of production need to be considered for large scale production of these recombinant proteins.

  • Chemokine Receptors in Health and Disease

    • 1st Edition
    • Volume 388
    • English
    This volume reviews the current research in Chemokine Receptors and their role in physiological processes in the body, as well as their role in different pathological conditions. Chemokine Receptors are important for the migration of different types of cells, including immune cells to lymphoid organs and non-lymphoid organs thanks to the interaction with chemokines. The presence of different chemokine receptors on the cells’ surface was studied in normal states and diseases, some of them correlating with migration of subsets that play pro-disease roles or other help controlling the condition. Currently, state-of-the-art technology is helping researchers to better identify gene and protein expression of chemokine receptors at the single cell level. This large new data reveals the complexity of co-expression of various markers in the same cells and as well among different types of cells. Moreover, chemokine receptors are also helpful to identify different stages among subsets, and their correlation with better or worst responses in disease. Finally, treatments designed to inhibit or to block chemokine receptors are designed and tested at the preclinical and clinical level with different results. Here, we focus on the main chemokine receptors described in the current literature that play a role in health and diseases such as infections, autoimmune disorders, and cancer.

  • Zinc in Plants

    Current Knowledge and Recent Advances
    • 1st Edition
    • Durgesh Kumar Tripathi + 4 more
    • English
    Zinc in Plants: Current Knowledge and Recent Advances addresses zinc hunger, the transport of zinc in the soil-plant interphase, zinc and abiotic stress in plants, and zinc and plant disease. Written by experts in the field, this title is an essential resource to all scientists and students interested in plant physiology, biochemistry and agriculture. During their life, plants encounter various challenges, including their normal development under changing environmental conditions. Zinc (Zn) is an essential component of thousands of proteins in plants, although it is toxic in excess, and is essential for many processes throughout the plant lifecycle.

  • Unveiling the History of Transplantation

    An Illustrated Review of the Boundaries, Fantasies and Realities
    • 1st Edition
    • Shi Chen
    • English
    Unveiling the History of Transplantation: An Illustrated Review of the Boundaries, Fantasies and Realities covers the key international figures involved in organ transplantation and related fields. It includes a discussion of the contributions of many Nobel Prize winners in Physiology and Medicine. The book introduces the whole process of transplantation and the latest research progress of cell, tissue, and organ transplantation: from initial exploration to maturity and on to widespread application. A key feature of this resource is that it includes a large number of unique historical photos and material related to organ transplantation as collected by the author from libraries worldwide.

  • mRNA Therapeutics

    Foundations, Innovations, and Clinical Applications
    • 1st Edition
    • Anya Hillery
    • English
    mRNA Therapeutics: Foundations, Innovations and Clinical Applications aims to provide a comprehensive text that covers all aspects of mRNA therapeutics, from the foundational science that underpins this disruptive new drug class, through the scientific and technological breakthroughs crucial for therapeutic success, to the current clinical applications and the innovative advances driving future directions. The book begins with foundational knowledge covering mRNA biology, the immune system, and vaccines. The second section addresses the major challenges associated with mRNA as a therapeutic modality, and the molecular engineering innovations and delivery technologies that have allowed these hurdles to be largely overcome. The third section describes the current and future clinical applications of mRNA therapeutics that are transforming, or are poised to transform, medicine and health. This includes the use of mRNA vaccines for COVID-19 and other infectious diseases, as well as mRNA's role in revolutionizing cancer immunotherapy, covering immunostimulants, cancer vaccines including personalized neoantigen vaccines, and CAR T cell technologies. Additional chapters describe the use of mRNA therapeutics for protein replacement therapy and gene-editing, as well as newer mRNA constructs, including self-amplifying mRNA. The final section addresses the safety and regulatory considerations of mRNA therapeutics, along with broader cultural issues including vaccine hesitancy, global vaccine inequality, and pandemic preparedness. Currently, mRNA texts either provide personal accounts from key players involved in COVID-19 vaccine development, with limited scientific depth, or focus on highly specialized, more esoteric applications of mRNA in advanced molecular biology. This book aims to bridge this gap by providing a scientifically rigorous and wide-ranging exploration of mRNA's role in therapeutics. This pioneering textbook serves as a vital addition to the academic canon, providing an essential tool for the current and next generation of students, scientists, researchers and professionals in a wide variety of related disciplines including molecular biology, biomedical engineering, pharmaceutical science, oncology, and the health sciences.

  • Metabolomics of Bladder Cancer

    An Emerging Application
    • 1st Edition
    • Vishwajeet Singh + 1 more
    • English
    Metabolomics of Bladder Cancer: An Emerging Application offers insights into the latest research methodologies and potential therapeutic applications. The book examines how applied research on the discovery of metabolomic biomarkers with prognostic and predictive value is needed to stratify patients into different risk groups, minimizing overtreatment and the risk of drug resistance development. In eight chapters, the book gives an in-depth analysis of recent findings in both fundamental and applied research, with a focus on the metabolomics approach and its potential for identifying major metabolic pathways that characterize various diseases and physiological states.It intuitively leads from the discovery of biomarkers for bladder cancer, to the metabolisms of glutamine and fatty acids and finalizes with a chapter on the metabolic effect of cancer therapy. Overall, this book is a comprehensive and insightful resource for researchers, clinicians, and academic professionals interested in the latest developments in bladder cancer research.

  • Artificial Intelligence for Drug Product Lifecycle Applications

    • 1st Edition
    • Alberto Pais + 3 more
    • English
    Artificial Intelligence for Drug Product Lifecycle Applications explains the use of artificial intelligence (AI) in drug discovery and development paths, including the clinical and postapproval phases. This book gives methods for each of the drug development steps, from the fundamentals to postapproval drug product. AI is a synergistic assembly of enhanced optimization strategies with particular applications in pharmaceutical development and advanced tools for promoting cost-effectiveness throughout the drug lifecycle. Specifically, AI brings together the potential to improve drug approval rates, reduce development costs, get medications to patients faster, and help patients comply with their treatments.Accelerat... pharmaceutical development and drug product approval rates will enable larger profits from patent-protected market exclusivity. This book offers the tools and knowledge to create the right AI strategy to extend the landscape of AI applications across the drug lifecycle. It is especially useful for pharmaceutical scientists, health care professionals, and regulatory scientists, as well as advanced students and postgraduates actively involved in pharmaceutical product and process development involving the use of artificial intelligence in drug delivery applications.

  • Self-powered Sensors

    A Path to Wearable Electronics
    • 1st Edition
    • Rajesh Kumar Dhanaraj + 4 more
    • English
    Self-powered Sensors: A Path to Wearable Electronics features recent developments in chemical, photonic, pharmaceutical, microbiological, biomimetic, and bio-inspired approaches for MEMS/NEMS and medicinal self-powered sensors. Unconventional nanomaterial sensors driven by self-sufficient energy are given a contemporary review, with a focus on the categorization of energy sources and comparisons of research involving self-powered solar, piezoresistive, triboelectric, and thermodynamic technologies. This book also focuses on the different techniques, materials, comparisons of fabrication of self-powered sensors as well as thermoelectric self-powered sensors and its implantable applications.

  • Forest Fungi

    Biodiversity, Conservation, Mycoforestry and Biotechnology
    • 1st Edition
    • Ahmed M. Abdel Azeem + 3 more
    • English
    Forest Fungi: Biodiversity, Conservation, Mycoforestry and Biotechnology explores sustainable option aspects of forest fungal research, from the selection of hosting plants, isolation, identification, fermentation, identification of secondary metabolites, omics-tools for better understanding the plant–fungus Interactions. Forests are the world’s greatest repository of terrestrial biomass, soil carbon and biodiversity. They provide a variety of provisioning, supporting, regulatory and cultural ecosystem services, which are crucial for the survival of human beings. Fungi play key roles in forest ecosystems as mutualists, saprobes and pathogens.

  • Biomechatronics

    • 2nd Edition
    • Marko B. Popovic
    • English
    Biomechatronics is rapidly becoming one of the most influential and innovative research directions defining the 21st century. The second edition Biomechatronics provides a complete and up-to-date account of this advanced subject at the university textbook level. This new edition introduces two new chapters – Animals Biomechatronics and Plants Biomechatronics – highlighting the importance of the rapidly growing world population and associated challenges with food production. Each chapter is co-authored by top experts led by Professor Marko B. Popovic, researcher and educator at the forefront of advancements in this fascinating field. Starting with an introduction to the historical background of Biomechatronics, this book covers recent breakthroughs in artificial organs and tissues, prosthetic limbs, neural interfaces, orthotic systems, wearable systems for physical augmentation, physical therapy and rehabilitation, robotic surgery, natural and synthetic actuators, sensors, and control systems. A number of practice prompts and solutions are provided at the end of the book. The second edition of Biomechatronics is a result of dedicated work of a team of more than 30 contributors from all across the globe including top researchers and educators in the United States (Popovic, Lamkin-Kennard, Herr, Sinyukov, Troy, Goodworth, Johnson, Kaipa, Onal, Bowers, Djuric, Fischer, Ji, Jovanovic, Luo, Padir, Tetreault), Japan (Tashiro, Iraminda, Ohta, Terasawa), Sweden (Boyraz), Turkey (Arslan, Karabulut, Ortes), Germany (Beckerle and Wiliwacher), New Zealand (Liarokapis), Switzerland (Dobrev), and Serbia (Lazarevic).

  • The Immunology of the Cat

    • 1st Edition
    • Ian R. Tizard
    • English
    The Immunology of the Cat makes available the first single-source, comprehensive review of the feline immune system, reporting on all immunologic aspects of diseases of the cat and its relatives and relating recent basic science to important clinical issues. The book opens with the evolution, domestication, and development of the cat then provides detailed information on immunity to infectious diseases, feline allergic diseases, the top feline autoimmune diseases, and feline immunodeficiencies. Content examines feline vaccines, hypersensitivity, cancer, nutrition, and the aged cat. Professionals in veterinary research and practice will appreciate complete information on all aspects of feline immunology in one essential resource.

  • Anandamide in Health and Disease

    • 1st Edition
    • Bernard Le Foll
    • English
    Anandamide in Health and Disease, a volume in the Molecular Mediators in Health and Disease: How Cells Communicate series, is a complete reference on the roles of anandamide in health and disease states. Following the characteristics of the series, this book provides a comprehensive overview of the effects of the mediator on human health.The book is divided into two parts, the first of which provides background information on biology, regulation, synthesis and degradation and modulation of anandamide. The second part is dedicated to covering the role of anandamide in various diseases. A comprehensive panel of authors cover several somatic and psychiatric disorders, such as anxiety disorders, mood disorders, psychosis and substance use disorders. Additionally, the role of anandamide across epilepsy, Alzheimer's disease, and digestive conditions is explored.Anandamide in Health and Disease is the perfect reference for bioscience researchers seeking to understand anandamide pharmacology, biochemistry, cellular, and molecular biology. Clinicians may also be interested in better understanding the wide-ranging health effects of the mediator.

  • Ectoparasitic Diseases

    • 1st Edition
    • James H. Diaz
    • English
    Ectoparasitic Diseases provides information on the diagnosis, treatment, and prevention of ectoparasitic conditions caused by arthropods of medical importance. The book discusses the manner in which arthropod ectoparasites threaten human health by bodily infestations, covering specific ectoparasites and the vector-borne infectious diseases transmitted by each. Chapters offer definitions, epidemiology, diagnosis, clinical manifestations, therapeutic treatments, and preventive measures. In addition, the book examines the public health, socioeconomic, and psychological impact from ectoparasitic infections.This book offers comprehensive coverage to researchers, practitioners, and advanced students studying ectoparasitic vector-borne diseases.

  • Bacterial Carbonic Anhydrases

    • 1st Edition
    • Volume 55
    • English
    Bacterial Carbonic Anhydrases, Volume 55 in The Enzymes series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Overview on bacterial CA genetic families, Bacterial α-CAs, Bacterial β-CAs, Bacterial γ-CAs, Bacterial ι-CAs, Sulfonamide bacterial CA inhibitors, Non-sulfonamide bacterial CA inhibitors, Helicobacter pylori CA inhibition, Neisseria gonorrhea CA inhibition, Vancomycin resistant enterococci CA inhibition, Pseudomonas aeruginosa CA inhibition, Mycobacterium tuberculosis CA inhibition, and Challenges for developing bacterial CA inhibitors as novel antibiotics.

  • Natural Biomaterials for Tissue Engineering

    • 1st Edition
    • Naveen Kumar + 6 more
    • English
    Natural Biomaterials for Tissue Engineering is a comprehensive reference that provides in-depth principles for supporting and enabling knowledge during the tissue production process, focusing on different cell systems. The tissue fabrication process is illustrated with specific examples for more than 30 tissues, which may soon lead to new tissue engineering therapies. The section coverage includes an overall introduction, decellularization protocols specific to each tissue, characterization, materials and methods, cell seeding process, preclinical evaluation in laboratory animals, clinical applications, limitations, conclusion, and future challenges. Readers may turn to this up-to-date coverage for a widespread understanding of regenerative medicine, which will be useful to students and experts alike.

  • Food-borne Delivery Systems of Functional Substances for Precision Nutrition

    • 1st Edition
    • Volume 112
    • English
    Food-Borne Delivery Systems of Functional Substances for Precision Nutrition, Volume 112 highlights new advances in the field, with this new volume presenting interesting chapters on a range of topics, including Biological activity, limitations, and steady-state delivery of functional substances for precision nutrition, Nanoparticles delivery systems of functional substances for precision nutrition, Micelles delivery systems of functional substances for precision nutrition, Microgel delivery systems of functional substances for precision nutrition, Emulsions delivery systems of functional substances for precision nutrition, and Microencapsule delivery systems of functional substances for precision nutrition, and much more.Other chapters focus on Liposomes' delivery systems of functional substances for precision nutrition, Hydrogel delivery systems of functional substances for precision nutrition, Vesicle delivery systems of functional substances for precision nutrition, and Future development trend of food-borne delivery systems of functional substances for precision nutrition.

  • Equine Welfare in Clinical Practice

    • 1st Edition
    • Virginia Wensley Koch
    • English
    Equine veterinarians frequently encounter behavior and welfare problems, but they generally focus only on the physical issues affecting their patients because they lack the training to address psychological, behavioral, or other welfare issues. This book is meant to remedy that lack. As the primary source of medical information for horse owners, veterinarians need to address the unmet need for medical professionals to deal with equine mental health problems through treatment or referral. Science tells us that mental health determines an animal’s welfare status. The public considers veterinarians to be animal welfare experts, so clinicians need to become familiar with animal welfare science. Knowledge of equine behavior science is important in assessing welfare, and even more importantly, the appropriate handling of horses requires behavioral expertise. Clients prefer veterinarians who handle patients with gentleness, and using persuasion instead of force improves equine welfare, handler safety, and practitioner effectiveness. Veterinarians who understand and can educate their clients in equine welfare and in safe and appropriate care and handling techniques will increase their business success and improve the lives of their clients and patients.The book’s topics are addressed by internationally recognized experts and are most important for those whose formal veterinary education neglected to cover animal psychology, behavior modifi cation, and animal welfare, but they also provide current information and useful practical tips for those already familiar with equine behavior/welfare science. Topics include practical welfare assessment; how horses learn (both good and bad habits); safe, appropriate, and fear-free training and handling techniques for both adult horses and foals; how equine behavior is affected by diet (and the microbiome), by the differences between horse and human senses and cognition, and by enrichment; differentiating medical from behavioral problems; and preventing and treating behavioral problems (including stereotypies). It describes the Equine Behavior Assessment and Research Questionnaire (E-BARQ), a tool that can assist veterinarians to introduce behavior into their practices in a simple and basic manner, and it offers guidance on resolving ethical dilemmas while advancing equine welfare. The final chapter offers resources for further study and access to specialists for consultation or referral. Ultimately, the book will serve its purpose if it helps improve the lives of horses, their owners, and their veterinarians.

  • Omega-3 Fatty Acids

    A Scientific Approach to Healthy Aging and Optimized Nutrition
    • 1st Edition
    • Peter Lembke
    • English
    Omega-3 Fatty Acids: A Scientific Approach to Healthy Ageing and Optimized Nutrition looks at the biochemistry of long chain fatty acids and their importance to health, well-being, and the reduction of inflammation in the body. Divided into two parts, the book first explains the history, chemical background, and physiological pathways of how EPA and DHA influence our inflammatory response and their importance as structural building blocks within our cell membranes. Readers will learn about increasing the anti-inflammatory effects from polyunsaturated-fatt... intake by combining Omega-3s and Omega-6s, as well as the differences, safety aspects, nutritional values of plant Omegas verse animal Omegas.In additions, sections will update on the benefits of different Omega fatty acids derived from various food sources such as seeds, fish, eggs, and nuts. Part Two is dedicated to healthy aging and discusses the results of numerous clinical trials and mechanisms of action that address heart, immune, bone, muscle, cognitive, and vision health. Readers will gain insight to methods of sustainable sourcing to ensure maximum benefits and optimized nutrition.

  • The Evolution of Immunotherapy Against Tumors

    An Historical Approach
    • 1st Edition
    • Domenico Ribatti
    • English
    The Evolution of Immunotherapy Against Tumors: An Historical Approach summarizes the literature concerning the development of the theory of immune surveillance against tumors. It discusses the evidence for and against this theory, along with the concept of immunoediting. Finally, current approaches in anti-tumor immunotherapy will be analyzed.The immune system plays a major role in the surveillance against tumors. To avoid attack from the immune system, tumor cells develop different strategies to escape immune surveillance. Evidence of immune surveillance comes from both animal models and clinical observations. Mice with a wide variety of immunodeficiencies have a high rate of tumor incidence and are more susceptible to transplanted or chemical carcinogen-induced tumors. Immunosuppressed patients have a high incidence of tumors. However, many patients develop cancer even in the presence of an apparently normal immune system. This indicates that tumor cells can escape immune surveillance.

  • Genetics and Epigenetics of Genitourinary Diseases

    • 1st Edition
    • Seyed Mohammad Kazem Aghamir
    • English
    Genetics and Epigenetics of Genitourinary Diseases aims to provide a comprehensive collection of data on genetics and epigenetics in almost all genitourinary diseases for researchers, clinicians, and graduate students.This book discusses several genetic and epigenetic changes like DNA methylation, mutations, single nucleotide polymorphisms, DNA rearrangements, chromosomal remodeling, microsatellite instability, and chromosomal instability (CIN) in genitourinary cancers.This book is split into 18 chapters, beginning with the importance of genetics and epigenetics in genitourinary diseases. It then goes on to cover the genetics and epigenetics of various diseases and tumors. Certain chapters present novel techniques of next-generation sequencing (NGS). Furthermore, RNA-Seq is discussed as a sequencing technique that uses NGS to reveal the presence and quantity of RNA in a biological sample.This book is a valuable resource for researchers, practitioners, and students in genetics and epigenetics who want to broaden their understanding of the field.

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