Cholecystokinin

From Gallbladder to Cognition and Beyond

1st Edition - April 7, 2025
Editors: Christine Feinle-Bisset, Jens F Rehfeld
Language: English
Paperback ISBN:
9 7 8 - 0 - 4 4 3 - 2 3 7 2 0 - 1
eBook ISBN:
9 7 8 - 0 - 4 4 3 - 2 3 7 2 1 - 8

Cholecystokinin: From Gallbladder to Cognition and Beyond covers the biology, physiology and pathophysiological roles of cholecystokinin (CCK) peptides. It begins with a histor… Read more

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Cholecystokinin: From Gallbladder to Cognition and Beyond covers the biology, physiology and pathophysiological roles of cholecystokinin (CCK) peptides. It begins with a historical overview before providing in-depth chapters into the biology of CCK, from biogenesis to cell expression, including intestinal and extraintestinal endocrine cells, and the central and peripheral nervous system, and receptor function. CCK phylogenesis is explored across various species, including fish, birds, insects and amphibians. The physiology of CCK covers intestinal CCK secretion, the gallbladder and pancreas, and the role of CCK in the gut-brain axis, gastrointestinal motor function, appetite regulation, and cardiovascular function. Methods used for CCK research are also discussed. A number of chapters then covers the roles of CCK in various diseases, including metabolic diseases, tumors, psychiatric illness, the immune system and nociception, as well as potential therapeutic approaches targeting CCK receptors.

Cholecystokinin: From Gallbladder to Cognition and Beyond acts as a fundamental reference on all biological and clinical aspects of CCK. This volume is ideal for researchers interested in gaining in-depth knowledge about the physiological roles of CCK and its impact across health and disease.

Part I - History

1. Milestones in the CCK history
Jens F. Rehfeld, Christine Feinle-Bisset

Part II - Biology of CCK

2. Evolutionarily conserved roles of cholecystokinin signaling
Dick Nässel, Shunfan Wu

3. The biogenesis and cell-specific expression of cholecystokinin peptides
Jens F. Rehfeld, Christine Feinle-Bisset

4. Cholecystokinin in intestinal and extraintestinal endocrine cells
Marta Santoz Hernandez, Frank Reimann, Fiona M. Gribble

5. Cholecystokinin in the central and peripheral nervous system
Tomas Hökfelt, Swapnali Barde, Wen Zhong, Jufang He

6. Cholecystokinin 1 and cholecystokinin 2 receptors
Laurence J Miller

7. The relationship between cholecystokinin and gastrin
Jens F. Rehfeld

Part III - Physiology of CCK

8. Intestinal cholecystokinin secretion
Rashmi Chandra, Rodger A. Liddle

9. Cholecystokinin and the gut-brain axis
Kirsteen Browning, Amanda Page

Cholecystokinin and the gallbladder

Adrian A. M. Masclee, Gwen M. C. Masclee

11. Cholecystokinin and the exocrine pancreas
John A. Williams

12. Islet effects of cholecystokinin and exploitation in diabetes
Neil Tanday, Nigel Irwin, Peter Flatt

13. Cholecystokinin and gastrointestinal motor function
Javad Anjom Shoae, Michael Horowitz, Christine Feinle-Bisset

14. Effect of cholecystokinin on food intake and appetite
Frank A. Duca

15. Cholecystokinin, nutrient preference and taste aversion
Jo E. Lewis, Fiona M. Gribble, Frank Reimann

16. Cholecystokinin in peripheral and central cardiovascular control
Tony J. M. Verberne, Bashair M. Mussa

17. Cholecystokinin expression in the heart and its clinical implications
Jens P. Goetze, Jens F. Rehfeld

Part IV – Methods used for CCK research

18. Measurement of cholecystokinin in biological fluids
Jens F. Rehfeld, Jens P. Goetze

19. Cholecystokinin knockout mice: peripheral and central phenotypes
Chunmin C. Lo, Dennis D. Black, Patrick Tso

Part V - CCK in disease

20. Cholecystokinin in obesity and other disorders of eating
Kimberly R. Smith, Tim H. Moran

21. Cholecystokinin in tumors
Jens F. Rehfeld

22. Cholecystokinin and panic disorder
Jacques Bradwejn, Diana Koszycki

23. Cholecystokinin and the immune system
John J. Worthington

24. Cholecystokinin and its receptors in nociception and pain
Nesia A. Zurek, Sascha R. A. Alles

Part V – CCK-based novel therapeutic approaches

25. Potential novel therapeutics targeting cholecystokinin 1 receptors
Laurence J. Miller

Part VI - Conclusion

26. Reflections on cholecystokinin research - past, present and future
Jens F. Rehfeld, Christine Feinle-Bisset

Christine Feinle-Bisset

Professor Christine Feinle-Bisset has a PhD in Nutrition and GI Physiology from the University of Stuttgart-Hohenheim, Germany. After gaining research experience at the University of Sheffield, UK and the University of Zurich, Switzerland, she joined the University of Adelaide in 2000, where she is currently a Professorial Research Fellow and a lead investigator in the Centre of Research Excellence in Translating Nutritional Science to Good Health. Her research is clinical and relates to the impact of nutrients on appetite, GI motor and hormone function and perception, in health, obesity and functional dyspepsia. Her work has contributed significantly to current concepts of the role of gastrointestinal mechanisms, including gut hormones and gastrointestinal motor activity, in the regulation of energy intake in health and obesity, and symptom generation in functional dyspepsia. She has published more than 220 publications, with over 15,000 citations.

Affiliations and expertise

Professorial Research Fellow, Adelaide Medical School, Faculty of Health and Medical Sciences, University of Adelaide, Australia

Jens F Rehfeld

Professor Jens F. Rehfeld has an MD from the University of Aarhus, and later DMSc and DSc in Clinical Biochemistry from the University of Copenhagen. He became professor in Medical Biochemistry at University of Aarhus in 1975, and of Clinical Biochemistry, University of Copenhagen, in 1981. He was also administrative head of the Department of Clinical Biochemistry, Rigshospitalet, Copenhagen, until 2010. His main research theme is bioactive peptides (in particular gastrin, cholecystokinin, and insulin), their biosynthesis, methods for measurement, and clinical relevance. He has published approximately 1100 publications, including 650 original articles, 90 review articles, 55 textbook chapters, and 8 books, and has more than 43,000 citations.

Affiliations and expertise

Professor, Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Denmark

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