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Organic Mechanochemistry
A New Tool for Sustainable Synthesis
- 1st Edition - February 17, 2025
- Author: Davor Margetic
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 2 3 8 3 4 - 5
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 2 3 8 3 5 - 2
Organic Mechanochemistry: A New Tool for Sustainable Synthesis presents the greener chemical method to a broader reading audience, including chemical practitioners. Descriptions of… Read more
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Request a sales quoteOrganic Mechanochemistry: A New Tool for Sustainable Synthesis presents the greener chemical method to a broader reading audience, including chemical practitioners. Descriptions of each method, followed by examples on sustainability aspects and applications give readers a better understanding and realization of its possibilities. Mechanochemistry, a nonconventional method for inducing the chemical reaction by application of mechanical energy in solid state, has been recognized as beneficial as mechanochemically conducted reactions hold diverse environmental sustainability advantages in manufacturing processes.
- Outlines the background of the field, as well as considerations of mechanochemistry
- Expands on green chemistry and sustainable chemistry
- Covers several examples of the implementation of the technique, from traditional organic synthesis to catalysis, cocrystals, and polymorphism to materials and polymers
Graduate students and researchers working with Synthetic Chemistry, Medicinal Chemistry, Sustainable Chemistry, and Environmental Chemistry
- Title of Book
- Cover image
- Title page
- Table of Contents
- Copyright
- Preface
- List of abbreviations
- Chapter 1. Introduction to mechanochemistry
- 1.1 Definition and basic principles of mechanochemistry
- 1.2 Historical overview of organic mechanochemistry
- 1.3 Contribution of mechanochemical activation to principles of green chemistry
- Chapter 2. Description of method
- 2.1 Mechanochemical equipment
- 2.1.1 Milling tools
- 2.1.2 In situ spectroscopic techniques
- 2.2 Technical Parameters
- 2.3 Milling additives
- 2.3.1 Solid additives
- 2.3.2 Liquid additives
- 2.3.3 Ionic liquid-assisted grinding
- 2.3.4 Polymer-assisted grinding
- 2.3.5 Ion- and liquid-assisted grinding
- 2.4 Safety aspects considerations
- 2.5 Transfer of conventional reaction to mechanochemical conditions
- Chapter 3. Green aspects of mechanochemistry
- 3.1 Introduction
- 3.2 Green metrics
- 3.2.1 Environmental factor
- 3.2.2 Process mass intensity
- 3.2.3 Reaction mass efficiency
- 3.2.4 Atom economy
- 3.2.5 EcoScale
- 3.2.6 Space-time yield
- 3.3 The assessment of the sustainability of mechanochemical methods
- 3.4 Energy consumption
- 3.5 Cost of production
- Chapter 4. Applications
- 4.1 Introduction
- 4.2 Synthesis of fine organic chemicals
- 4.2.1 Peptide bond formation
- 4.2.2 C–C coupling reactions
- 4.2.2.1 Mizoroki–Heck coupling
- 4.2.2.2 Sonogashira coupling
- 4.2.2.3 Suzuki-Miyaura coupling
- 4.2.2.4 Negishi coupling
- 4.2.3 Copper-catalyzed azide-alkyne cycloaddition reaction
- 4.2.4 Unusual and unprecedented reactions
- 4.3 Preparation of active pharmaceutical ingredients
- 4.3.1 Synthesis of some known drugs and pharmacological agents
- 4.3.2 Pharmaceutical cocrystals, polymorphs, salts, and solvates
- 4.3.2.1 Preparation of polymorphs
- 4.3.2.2 In situ study of the formation of cocrystal polymorphs
- 4.4 Extraction of bioactive compounds from natural sources
- 4.5 Synthesis of organometallic compounds
- 4.6 Applications in organic material science
- 4.6.1 Metal-organic frameworks
- 4.6.2 Hydrogen-bonded organic frameworks
- 4.6.3 Covalent organic frameworks
- 4.6.4 Applications of MOFs
- 4.6.5 Carbon materials
- 4.6.5.1 Fullerenes
- 4.6.5.2 Nanotubes
- 4.6.5.3 Polyaromatic materials
- 4.6.5.4 Graphenes
- 4.6.5.5 Nanofibers
- 4.6.5.6 Nanoparticles
- 4.6.5.7 Organic–inorganic hybrid materials
- 4.7 Polymeric materials
- 4.7.1 Synthesis of polymers
- 4.7.2 Polymer recycling
- Chapter 5. Perspectives of mechanochemistry
- 5.1 Introduction
- 5.2 Application to various organic transformations
- 5.3 Mechanistic understanding
- 5.3.1 Theoretical work: Implementation of computations
- 5.3.2 Experimental work: In situ monitoring
- 5.4 Development of novel equipment and improvement of existing
- 5.5 Scale-up of reactions
- 5.6 Incorporation in university teaching curriculum
- 5.6.1 An introductory mechanochemical experiment for university curriculum
- Appendix: Picture tutorial on the process or procedure of mechanochemical reaction
- The pictorial tutorial of the CuAAC reaction of benzyl azide and phenylacetylene
- CuAAC reaction procedure 1 – benzyl azide
- CuAAC reaction 2 – benzyl bromide
- Author index
- Subject index
- No. of pages: 218
- Language: English
- Edition: 1
- Published: February 17, 2025
- Imprint: Elsevier
- Paperback ISBN: 9780443238345
- eBook ISBN: 9780443238352
DM
Davor Margetic
Dr. Davor Margetić is senior research scientist and acting head of the division of organic chemistry and biochemistry at Ruđer Bošković research Institute in Zagreb, Croatia. He is the head of the laboratory for physical organic chemistry and Professor of physical organic chemistry at Rijeka University.He graduated with a degree in chemical engineering at Zagreb University and continued in the field of organic syntheses with Ms.Sc. and Ph.D. studies in the field of theoretical and physical organic chemistry (Zagreb). The completion of his Ph.D. was followed by a postdoctoral research studies at the Centre for Molecular Architecture, Central Queensland University, Australia. There he worked with Professors Ronald Warrener and Doug Butler for 9 years (synthetic organic and computational chemistry). In 2002, he returned to Croatia to take up a position at RBI, and in 2009 he was promoted to senior research scientist (an equivalent of full professor at the university). Research interests of Dr. Margetić include the synthesis and investigation of theoretically interesting molecules, the study of reaction mechanisms, computational organic chemistry, and the development of environmentally-friendly organic reactions using novel techniques (extreme high pressures, microwave irradiation, and mechanochemistry). During his scientific career, Dr. Margetić has published 90 research papers, 42 electronic conference papers, and 9 book chapters. He has authored one book: "Microwave Assisted Cycloaddition Reactions" with Nova Science Publishers, New York (2011); and edited two books: Croatica Chemica ActA Special issue dedicated to the 70th birthday of Professor Z. B. Maksić (2009), and Special issue dedicated to 70th birthday of Professor M. Eckert-Maksić (2014).
Affiliations and expertise
Division of Organic Chemistry and Biochemistry, Ruđer Bošković Institute, Bijenička, Zagreb, CroatiaRead Organic Mechanochemistry on ScienceDirect