Organic Mechanochemistry
A New Tool for Sustainable Synthesis
- 1st Edition - March 25, 2025
- Latest edition
- Author: Davor Margetic
- Language: English
Organic Mechanochemistry: A New Tool for Sustainable Synthesis presents the greener chemical method to a broader reading audience, including chemical practitioners. Descriptions of… Read more
Organic Mechanochemistry: A New Tool for Sustainable Synthesis presents the greener chemical method to a broader reading audience, including chemical practitioners. Descriptions of each method, followed by examples on sustainability aspects and applications give readers a better understanding and realization of its possibilities. Mechanochemistry, a nonconventional method for inducing the chemical reaction by application of mechanical energy in solid state, has been recognized as beneficial as mechanochemically conducted reactions hold diverse environmental sustainability advantages in manufacturing processes.
- Outlines the background of the field, as well as considerations of mechanochemistry
- Expands on green chemistry and sustainable chemistry
- Covers several examples of the implementation of the technique, from traditional organic synthesis to catalysis, cocrystals, and polymorphism to materials and polymers
Graduate students and researchers working with Synthetic Chemistry, Medicinal Chemistry, Sustainable Chemistry, and Environmental Chemistry
1. Introduction
1.1. Definition and basic principles of mechanochemistry (and historical overview)
1.2. Contribution of mechanochemical activation to principles of green chemistry References
2. Description of method
Introduction
2.1. Equipment (mortar and pestle grinding/automated ball milling), in situ monitoring, gaseous reagents
2.2. Technical parameters: material, ball size, time, frequency, volume, temperature
2.3. Additives: milling auxiliaries, liquids LAG, ILAG, POLAG
2.4. Safety issues
2.5. Transfer of conventional reaction to mechanochemical conditions References
3. Green aspects (solvents, time, energy, efficiency, catalysis) energy, Introduction Illustrated by examples of various organic reactions
4. Applications The focus is on organic molecules, inorganic compounds will be briefly mentioned in the introduction section Introduction
4.1. Synthesis of fine organic chemicals Selected reactions (important widely used organic transformations)
4.1.1. Peptide bond formation
4.1.2. C-C coupling Heck, Sonogashira, Suzuki
4.1.3. Click reactions (dipolar cycloadditions) Sharpless CuAAC
4.1.4. Other reactions unusual and unexpected, which differ from the solution
4.2. Preparation of active pharmaceutical ingredients APIs synthesis of some known drugs, preparation of cocrystals, polymorphs, salts
4.3. Extraction of bioactive compounds from natural sources (MCAE)
4.4. Synthesis of organometallic compounds
4.5. Applications in material science organic materials, metal-organic frameworks MOFs= organic-inorganic hybrid materials, carbon nanomaterials (graphenes, CNTs, nanofibers) organic nanomaterials (cellulose nanoparticles)
4.6. Polymers, PET recycling References
5. Perspectives of mechanochemistry Introduction Scale-up of reactions, In-situ monitoring, coupling with photochemistry, incorporation in teaching curriculum and university laboratories References
III Appendix: Picture tutorial on the process or procedure of mechanochemical reaction
IV Index of terms
V Author Index
1.1. Definition and basic principles of mechanochemistry (and historical overview)
1.2. Contribution of mechanochemical activation to principles of green chemistry References
2. Description of method
Introduction
2.1. Equipment (mortar and pestle grinding/automated ball milling), in situ monitoring, gaseous reagents
2.2. Technical parameters: material, ball size, time, frequency, volume, temperature
2.3. Additives: milling auxiliaries, liquids LAG, ILAG, POLAG
2.4. Safety issues
2.5. Transfer of conventional reaction to mechanochemical conditions References
3. Green aspects (solvents, time, energy, efficiency, catalysis) energy, Introduction Illustrated by examples of various organic reactions
4. Applications The focus is on organic molecules, inorganic compounds will be briefly mentioned in the introduction section Introduction
4.1. Synthesis of fine organic chemicals Selected reactions (important widely used organic transformations)
4.1.1. Peptide bond formation
4.1.2. C-C coupling Heck, Sonogashira, Suzuki
4.1.3. Click reactions (dipolar cycloadditions) Sharpless CuAAC
4.1.4. Other reactions unusual and unexpected, which differ from the solution
4.2. Preparation of active pharmaceutical ingredients APIs synthesis of some known drugs, preparation of cocrystals, polymorphs, salts
4.3. Extraction of bioactive compounds from natural sources (MCAE)
4.4. Synthesis of organometallic compounds
4.5. Applications in material science organic materials, metal-organic frameworks MOFs= organic-inorganic hybrid materials, carbon nanomaterials (graphenes, CNTs, nanofibers) organic nanomaterials (cellulose nanoparticles)
4.6. Polymers, PET recycling References
5. Perspectives of mechanochemistry Introduction Scale-up of reactions, In-situ monitoring, coupling with photochemistry, incorporation in teaching curriculum and university laboratories References
III Appendix: Picture tutorial on the process or procedure of mechanochemical reaction
IV Index of terms
V Author Index
- Edition: 1
- Latest edition
- Published: March 25, 2025
- Language: English
DM
Davor Margetic
Dr. Davor Margetić is senior research scientist and acting head of the division of organic chemistry and biochemistry at Ruđer Bošković research Institute in Zagreb, Croatia. He is the head of the laboratory for physical organic chemistry and Professor of physical organic chemistry at Rijeka University.He graduated with a degree in chemical engineering at Zagreb University and continued in the field of organic syntheses with Ms.Sc. and Ph.D. studies in the field of theoretical and physical organic chemistry (Zagreb). The completion of his Ph.D. was followed by a postdoctoral research studies at the Centre for Molecular Architecture, Central Queensland University, Australia. There he worked with Professors Ronald Warrener and Doug Butler for 9 years (synthetic organic and computational chemistry). In 2002, he returned to Croatia to take up a position at RBI, and in 2009 he was promoted to senior research scientist (an equivalent of full professor at the university). Research interests of Dr. Margetić include the synthesis and investigation of theoretically interesting molecules, the study of reaction mechanisms, computational organic chemistry, and the development of environmentally-friendly organic reactions using novel techniques (extreme high pressures, microwave irradiation, and mechanochemistry). During his scientific career, Dr. Margetić has published 90 research papers, 42 electronic conference papers, and 9 book chapters. He has authored one book: "Microwave Assisted Cycloaddition Reactions" with Nova Science Publishers, New York (2011); and edited two books: Croatica Chemica ActA Special issue dedicated to the 70th birthday of Professor Z. B. Maksić (2009), and Special issue dedicated to 70th birthday of Professor M. Eckert-Maksić (2014).
Affiliations and expertise
Division of Organic Chemistry and Biochemistry, Ruđer Bošković Institute, Bijenička, Zagreb, CroatiaRead Organic Mechanochemistry on ScienceDirect