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Organic Mechanochemistry
A New Tool for Sustainable Synthesis
- 1st Edition - February 1, 2025
- Author: Davor Margetic
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 2 3 8 3 4 - 5
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 2 3 8 3 5 - 2
Organic Mechanochemistry: A New Tool for Sustainable Synthesis presents the greener chemical method to a broader reading audience, including chemical practitioners. Descriptions of… Read more
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Request a sales quoteOrganic Mechanochemistry: A New Tool for Sustainable Synthesis presents the greener chemical method to a broader reading audience, including chemical practitioners. Descriptions of each method, followed by examples on sustainability aspects and applications give readers a better understanding and realization of its possibilities. Mechanochemistry, a nonconventional method for inducing the chemical reaction by application of mechanical energy in solid state, has been recognized as beneficial as mechanochemically conducted reactions hold diverse environmental sustainability advantages in manufacturing processes.
- Outlines the background of the field, as well as considerations of mechanochemistry
- Expands on green chemistry and sustainable chemistry
- Covers several examples of the implementation of the technique, from traditional organic synthesis to catalysis, cocrystals, and polymorphism to materials and polymers
Graduate students and researchers working with Synthetic Chemistry, Medicinal Chemistry, Sustainable Chemistry, and Environmental Chemistry
1.1. Definition and basic principles of mechanochemistry (and historical overview)
1.2. Contribution of mechanochemical activation to principles of green chemistry References
2. Description of method
Introduction
2.1. Equipment (mortar and pestle grinding/automated ball milling), in situ monitoring, gaseous reagents
2.2. Technical parameters: material, ball size, time, frequency, volume, temperature
2.3. Additives: milling auxiliaries, liquids LAG, ILAG, POLAG
2.4. Safety issues
2.5. Transfer of conventional reaction to mechanochemical conditions References
3. Green aspects (solvents, time, energy, efficiency, catalysis) energy, Introduction Illustrated by examples of various organic reactions
4. Applications The focus is on organic molecules, inorganic compounds will be briefly mentioned in the introduction section Introduction
4.1. Synthesis of fine organic chemicals Selected reactions (important widely used organic transformations)
4.1.1. Peptide bond formation
4.1.2. C-C coupling Heck, Sonogashira, Suzuki
4.1.3. Click reactions (dipolar cycloadditions) Sharpless CuAAC
4.1.4. Other reactions unusual and unexpected, which differ from the solution
4.2. Preparation of active pharmaceutical ingredients APIs synthesis of some known drugs, preparation of cocrystals, polymorphs, salts
4.3. Extraction of bioactive compounds from natural sources (MCAE)
4.4. Synthesis of organometallic compounds
4.5. Applications in material science organic materials, metal-organic frameworks MOFs= organic-inorganic hybrid materials, carbon nanomaterials (graphenes, CNTs, nanofibers) organic nanomaterials (cellulose nanoparticles)
4.6. Polymers, PET recycling References
5. Perspectives of mechanochemistry Introduction Scale-up of reactions, In-situ monitoring, coupling with photochemistry, incorporation in teaching curriculum and university laboratories References
III Appendix: Picture tutorial on the process or procedure of mechanochemical reaction
IV Index of terms
V Author Index
- No. of pages: 300
- Language: English
- Edition: 1
- Published: February 1, 2025
- Imprint: Elsevier
- Paperback ISBN: 9780443238345
- eBook ISBN: 9780443238352
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