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Elsevier

Books in Life sciences

  • Bacterial Immunoglobulin–Binding Proteins

    Applications in Immunotechnology
    • 1st Edition
    • Michael D. P. Boyle
    • English
    Bacterial Immunoglobulin-Bindi... Proteins: Applications in Immunotechnology, Volume 2 covers the state of knowledge of bacterial immunoglobulin-bindi... proteins. The book focuses on practical approaches to isolation, characterization, and use of bacterial immunoglobulin-bindi... proteins. The majority of these studies involve the type I Fc-binding protein (staphylococcal protein A) and the type III Fc-binding protein (streptococcal protein G). Physiological chemists, pediatricians, and microbiologists will find the book invaluable.

  • Photosynthesis

    The Biochemistry of Plants
    • 1st Edition
    • M. D. Hatch + 1 more
    • English
    The Biochemistry of Plants: A Comprehensive Treatise, Volume 8: Photosynthesis provides information pertinent to the biochemistry of photosynthesis. This book focuses on the photosynthesis of higher plants but some consideration is given to algal and bacterial photosynthesis. Organized into 11 chapters, this volume begins with an overview of the excitation of a light-harvesting pigment by an absorbed light quantum. This text then discusses the evidence to support the hypothesis that chlorophyll–protein complexes are represented at the supramolecular level by some of the intramembranous particles seen on chloroplast freeze-fracture faces. Other chapters consider the absorption of light energy by accessory pigments and transferred to chlorophyll in the blue-green, red, and brown algae. This book discusses as well that certain cyanobacteria respond to the color of the incident light by altering their biliprotein composition. The final chapter deals with dark reaction of photosynthesis. This book is a valuable resource for plant biochemists, neurobiochemists, molecular biologists, senior graduate students, and research workers.

  • The Cell

    Biochemistry, Physiology, Morphology
    • 1st Edition
    • Jean Brachet + 1 more
    • English
    The Cell: Biochemistry, Physiology, Morphology, Volume I focuses on the advancements of processes, techniques, and approaches used in studies on the structure and functions of cells. The selection first offers information on the optical methods in cytology, fixation and staining, and autoradiography. Discussions focus on microscopical analysis, techniques related to autoradiography, staining for electron microscopy and light microscopy, fixation, electron microscope in cytology, and X-ray microscopy of cells. The text then takes a look at the quantitative microscopical techniques for single cells and quantitative microchemical techniques of histo- and cytochemistry. The manuscript ponders on micrurgical studies on living cells, isolation of subcellular components, and "tissue culture," cellular autonomy, and cellular interrelations. Topics include standardization procedures, factors influencing the choice of isolation procedure, future applications and extensions of micrurgy, and applications of micrurgy to the study of living cells. The effects of radiations on cells, acquisition of biological specificity, and nucleocytoplasmic interactions in eggs and embryos are also discussed. The selection is a dependable reference for researchers interested in pursuing further studies on the biochemistry, physiology, and morphology of cells.

  • Plants and Organelles

    A Compilation from the GenBank® and EMBL data libraries
    • 1st Edition
    • Edwin J. Atencio + 2 more
    • English
    Nucleotide Sequences 1986/1987, Volume IV: Plants and Organelles presents data that reflect the information found in GenBank Release 44.0 of August 1986. This book provides information pertinent to the unique international collaboration between two leading nucleotide sequence data libraries, one based in Europe and one in the United States. Organized into two sections, this volume begins with an overview of the sequences, some basic identifying information, and some of the biological annotations. This text then discusses the EMBL Nucleotide Sequence Data Library, an international center of fundamental research with its main focus in the fields of cell biology, molecular structures, instrumentation, and differentiation. This book discusses as well the GenBank database established in 1982 by the National Institute of General Medical Sciences of the U.S National Institutes of Health. This book is a valuable resource for molecular biologists and other investigators collecting the large number of reported DNA and RNA sequences and making them available in computer-readable form.

  • The Antigens

    Volume III
    • 1st Edition
    • Michael Sela
    • English
    The Antigens, Volume III is a comprehensive treatise covering all aspects of antigens, including their chemistry and biology as well as their immunologic role and expression. Topics covered range from microbial polysaccharides and lymphocytic receptors for antigens to antigenic determinants and antibody-combining sites. Allergens and the genetics of allergy are also explored. Comprised of seven chapters, this volume begins with a review of microbial polysaccharides as antigens, followed by a discussion on antigenic determinants and their specific reaction with antibody-combining sites. The reader is then introduced to the reaction of antigens with their specific receptors on lymphocytes. The next four chapters are concerned with several categories of more complex antigens which, in most cases, have yet to be characterized adequately at a molecular level: allergens, histocompatibility antigens, antigens of Mycoplasmatales and chlamydiae, and animal viruses. The book concludes with an analysis of virus infections and the immune responses they elicit. This monograph will be of interest to practitioners and researchers in immunology, experimental and clinical medicine, biochemistry, and other disciplines.

  • Molecular Aspects of Animal Development

    • 1st Edition
    • Rudolf Weber
    • English
    The Biochemistry of Animal Development, Volume III: Molecular Aspects of Animal Development provides an account of the developments in the molecular approach to vertebrate development with particular emphasis on the functions of nucleic acids. The book discusses topics on oocyte maturation, transcriptional patterns in early development, the post-transcriptional control of gene expression, and the significance of gene amplification. Morphogenetic substances, growth-promoting proteins, and the functional differentiation of mitochondria in embryonic systems are covered as well. Biochemists, biologists, and zoologists will find the book invaluable.

  • Biochemistry of Metabolism

    The Biochemistry of Plants
    • 1st Edition
    • David D. Davies
    • English
    The Biochemistry of Plants: A Comprehensive Treatise, Volume 11: Biochemistry of Metabolism provides information pertinent to the chemical and biochemical aspects of metabolism. This book discusses the control mechanisms of metabolism. Organized into nine chapters, this volume begins with an overview of the history of biochemistry and discusses the developments in the kinetics of regulatory enzymes. This text then examines a theory that explains how subunit interactions modulate the rate of conversion of a substrate into a product. Other chapters consider some relation between cell-wall elongation and cell-wall charge density and explore the subcellular localization of the enzymes of glycolysis. This book discusses as well the regulation of glycolysis and the pentose phosphate pathway. The final chapter deals with the pathways of C1 metabolism that are of prime importance, as the synthesis of several cellular constituents depends directly or indirectly on folate metabolism. This book is a valuable resource for plant biochemists, neurobiochemists, molecular biologists, senior graduate students, and research workers.

  • Meiosis and Mitosis

    Biochemistry, Physiology, Morphology
    • 1st Edition
    • Jean Brachet + 1 more
    • English
    The Cell: Biochemistry, Physiology, Morphology, Volume III: Meiosis and Mitosis covers chapters on meiosis and mitosis. The book discusses meiosis with regard to the meiotic behavior of chromosomes; the anomalous meiotic behavior in organisms with localized centromeres and in forms with nonlocalized centromeres; and the nature of the synaptic force. The text also describes the mechanism of crossing over; the relationship of chiasmata to crossing over and metaphase pairing; and the reductional versus equational disjunction. The process of mitosis and the physiology of cell division are also considered. The book further tackles the significance of cell division and chromosomes; the essential mitotic plan and its variants; the preparations for mitosis; and the transition period. The text also demonstrates the time course of mitosis; the mobilization of the mitotic apparatus; metakinesis; the metaphase; the mitotic apparatus; anaphase; telophase; cytokinesis; and the physiology of the dividing cell. Physiological reproduction; mitotic rhythms and experimental synchronization; and the blockage and stimulation of division are also encompassed. Biologists, microbiologists, zoologists, and botanists will find the book invaluable.

  • Conformation in Biology and Drug Design

    The Peptides: Analysis, Synthesis, Biology, Vol. 7
    • 1st Edition
    • Sidney Udenfriend + 2 more
    • English
    The Peptides: Analysis, Synthesis, Biology, Volume 7: Conformation in Biology and Drug Design focuses on the analysis of peptides, emphasizing the use of physical methods in peptide conformational analysis and the relationship of conformational properties of peptides to biological properties. This book consists of nine chapters. Chapter 1 provides a brief overview of the perspective on the application of physical methods to peptide conformational analysis. The use of circular dichroism (CD) spectroscopy to examine the conformational properties of peptides in solution is elaborated in Chapter 2, while the use of fluorescence spectroscopy to examine the special relationships of aromatic side-chain groups to one another is discussed in Chapter 3. In Chapter 4, the use of various theoretical methods to calculate the conformations of peptides is described. The methods used to stimulate peptide conformations and dynamics are outlined in Chapter 5. The last four chapters examine various aspects of the use of nuclear magnetic resonance (NMR) in peptide conformational analysis. This volume is suitable for biologists, specialists, and researchers interested in peptides and proteins.

  • Disorders of Mineral Metabolism

    Trace Minerals
    • 1st Edition
    • Felix Bronner + 1 more
    • English
    Disorders of Mineral Metabolism, Volume I: Trace Minerals covers the pathophysiology of clinically relevant minerals and elements. This volume focuses on minerals whose average daily intake is under 50 mg. This text is composed of 12 chapters that tackle the clinical relevance and essentiality of various trace minerals in the human body, with particular emphasis on the disorders due to their abnormal metabolism. The trace mineral and elements considered in this volume include iron, coppers, zinc, lead, nickel, manganese, chromium, molybdenum, cadmium, aluminum, tin, lithium, and fluoride. Each chapter discusses the properties, body requirements, analysis, nutritional interactions, and toxicity of the mineral. This book will prove useful to biochemists, pathophysiologists, and workers in the medical field.

  • Mollusca

    Metabolic Biochemistry and Molecular Biomechanics
    • 1st Edition
    • Peter W. Hochachka
    • English
    The Mollusca, Volume 1: Metabolic Biochemistry and Molecular Biomechanics provides information pertinent to the advances in the traditional areas of biochemistry and in other developed areas that have become a part of molluskan biochemistry. This book discusses the developments in the various aspects of molecular biomechanics and environmental biochemistry. Organized into 11 chapters, this volume begins with an overview of the phylum Mollusca. This text then provides information about the general features of the main classes and their evolution, the anatomical organization of mollusks, and a classification of the primary taxonomic groups of mollusks. Other chapters consider the functional mechanical properties of two protein rubbers found in molluskan connective tissues. This book discusses as well the mechanical properties of molluskan mucins. The final chapter deals with the significance of quinone tanning in mollusks. This book is a valuable resource for researchers of the Mollusca and other phyla, as well as to teachers and qualified graduate students. Biochemists and physiologists will also find this book useful.

  • Recent Progress in Hormone Research

    Proceedings of the 1991 Laurentian Hormone Conference
    • 1st Edition
    • C. Wayne Bardin
    • English
    Recent Progress in Hormone Research, Volume 48 provides information pertinent to endocrine research dealing with all aspects of biological organization. This book covers a variety of topics, including differentiation of the embryo, development and growth at puberty, maintenance of adult well-being, and aging. Organized into 29 chapters, this volume begins with an overview of the role of oncogenes in fetal development. This text then compares the molecular descriptions of the genes for growth hormone and prolactin receptors to receptors for s variety of other hormones, peptide, and growth factors. Other chapters consider the three-dimensional structure of the growth hormone receptor. This book discusses as well the conventional and nonconventional uses of human growth hormone, with emphasis on the wide availability of protein that is possible only through molecular biology. The final chapter deals with the effect of hormones on primate behavior. This book is a valuable resource for geneticists and biologists.

  • Penicillins and Cephalosporins

    • 1st Edition
    • Robert B. Morin + 1 more
    • English
    Chemistry and Biology of ?-Lactam Antibiotics, Volume 1: Penicillins and Cephalosporins provides information pertinent to the study of antibiotics containing the ?-lactam moiety. This book discusses the occurrence of a group of ?-lactam antibiotics structurally related to cephalosporin C. Organized into five chapters, this volume begins with an overview of the mechanism of action of ?-lactam antibiotics that caused many microbiologists to develop screening tools for the detection of the ?-lactam moiety. This text then discusses the discovery of the nocardicins, the thienamycins, and olivanic acids. Other chapters provide a summary of the essential penicillin sulfoxide chemistry that gave rise to many compounds. This book discusses as well the ability of chemists to predict the level of biological activity of a compound from knowledge of its structure through theoretical and physicochemical studies. The final chapter deals with quantitative structure–activity relationships. This book is a valuable resource for microbiologists, chemists, and scientists.

  • Bacteria and Bacteriophage

    A Compilation from the GenBank® and EMBL data libraries
    • 1st Edition
    • Edwin J. Atencio + 2 more
    • English
    Nucleotide Sequences 1986/1987, Volume V: Bacteria and Bacteriophage presents data that reflect the information found in GenBank Release 44.0 of August 1986. This book provides information pertinent to the unique international collaboration between two leading nucleotide sequence data libraries, one based in Europe and one in the United States. Organized into two sections, this volume begins with an overview of the sequences, some basic identifying information, and some of the biological annotations. This text then discusses the EMBL Nucleotide Sequence Data Library, an international center of fundamental research with its main focus in the fields of cell biology, molecular structures, instrumentation, and differentiation. This book discusses as well the GenBank database established in 1982 by the National Institute of General Medical Sciences (NIGMS) of the U.S National Institutes of Health (NIH). This book is a valuable resource for molecular biologists and other investigators collecting the large number of reported DNA and RNA sequences and making them available in computer-readable form.

  • Metabolic Regulation

    Metabolic Pathways
    • 3rd Edition
    • Henry J. Vogel
    • English
    Metabolic Pathways, Third Edition, Volume V: Metabolic Regulation presents the regulation of metabolism in terms of the control of protein synthesis. This book discusses the significance of the control of metabolism in regard to the remarkable mechanisms involved and to the provision of an effective conceptual framework for appreciating the workings of the cell. Organized into 15 chapters, this edition begins with an overview of the numerous and diversified activities of a living cell. This text then examines the ability of living organisms to regulate the storage and mobilization of metabolizable energy. Other chapters consider the cytochrome system that represents the final common path of oxidation and coupled phosphorylation in the eukaryotic cell. This book discusses as well the profound changes that cell metabolism undergoes during differentiation. The final chapter deals with the chemical and genetic bases of the induction response in Gram-positive bacteria. This book is a valuable resource for biologists and physicians.

  • Metabolic Conjugation and Metabolic Hydrolysis

    Volume III
    • 1st Edition
    • William H. Fishman
    • English
    Metabolic Conjugation and Metabolic Hydrolysis, Volume III is a comprehensive account of the status of metabolic conjugation and metabolic hydrolysis. Topics covered range from the metabolism of steroid hormone conjugates and the genetic control of acid hydrolases to acetylation of drugs. Biochemical mechanisms in methyl group transfer are also discussed, along with the bilirubin conjugates of the human bile. Comprised of eight chapters, this volume first looks at the biosynthesis of animal glycoproteins before turning to an analysis of the metabolism of the conjugates of steroid hormones. The reader is then introduced to the genetic mechanisms that regulate acid hydrolases; control of metabolic hydrolysis in the lysosome-vacuolar apparatus; and the biochemical mechanisms underlying methyl group transfer. The final chapter is devoted to membrane phosphohydrolases, with emphasis on certain common features of membrane enzymes or of enzymes associated with membranes. Membrane transferases and hydrolases are also considered, including adenosine triphosphatase and adenyl cyclase. This book will be a useful resource for biologists, biochemists, physiologists, and pharmacologists.

  • Amino Acids and Derivatives

    The Biochemistry of Plants
    • 1st Edition
    • B. J. Miflin
    • English
    The Biochemistry of Plants: A Comprehensive Treatise, Volume 5: Amino Acids and Derivatives provides information pertinent to the fundamental aspects of plant biochemistry relating to the metabolism of amino acids with emphasis on amino acids present in proteins. This book discusses the metabolism of sulfur and nitrogen from the inorganic sources available to plants through their incorporation into organic compounds. Organized into 17 chapters, this volume begins with an overview of some aspects of the biochemistry of symbiotic nitrogen fixation. This text then examines the ultrastructure and metabolism of the developing nodule with particular emphasis on interactions between the host legumes and the bacterial symbiont. Other chapters consider the characteristics of the enzymes involved in nitrate and nitrite reduction. The final chapter deals with the essential roles of amino acids and other soluble nitrogenous compounds in plant metabolism. This book is a valuable resource for plant biochemists, neurobiochemists, molecular biologists, senior graduate students, and research workers.

  • The Biology of B-Lactam Antibiotics

    • 1st Edition
    • Robert B. Morin + 1 more
    • English
    The Biology of ß-Lactam Antibiotics

  • Reactions of Antibodies with Soluble Antigens

    Methods in Immunology and Immunochemistry, Vol. 3
    • 1st Edition
    • Curtis A. Williams + 1 more
    • English
    Methods in Immunology and Immunochemistry, Volume III: Reactions of Antibodies with Soluble Antigens provides information pertinent to antigen–antibody and hapten–antibody reactions in vitro, in free solution and in gels. This book presents the development of research in immunology and immunochemistry. Organized into three chapters, this volume begins with an overview of protein–antiprotein reactions. This text then discusses the inhibitory activity of protein fragments, which suggested that antigenic combining sites of proteins were limited regions of the whole antigen molecule. Other chapters consider the measurement of inhibitory activity, which is still the principal assay to characterize antigenic sites of proteins. This book discusses as well the immunological techniques prior to the development of gel-diffusion methods. The final chapter deals with fluorescence labeling techniques that provide powerful approaches for exploring the thermodynamic and kinetic parameters of antigen–antibody interactions. This book is a valuable resource for mathematicians and immunologists.

  • Other Vertebrates and Invertebrates

    A Compilation from the GenBank® and EMBL data libraries
    • 1st Edition
    • Edwin J. Atencio + 2 more
    • English
    Nucleotide Sequences 1986/1987, Volume III: Other Vertebrates and Invertebrates presents data that reflect the information found in GenBank Release 44.0 of August 1986. This book provides information pertinent to the unique international collaboration between two leading nucleotide sequence data libraries, one based in Europe and one in the United States. Organized into three sections, this volume begins with an overview of the sequences, some basic identifying information, and some of the biological annotations. This text then discusses the EMBL Nucleotide Sequence Data Library, an international center of fundamental research with its main focus in the fields of cell biology, molecular structures, instrumentation, and differentiation. This book discusses as well the GenBank database established in 1982 by the National Institute of General Medical Sciences of the U.S National Institutes of Health. This book is a valuable resource for molecular biologists and other investigators collecting the large number of reported DNA and RNA sequences and making them available in computer-readable form.

  • The Antigens

    Volume I
    • 1st Edition
    • Michael Sela
    • English
    The Antigens, Volume I is a comprehensive treatise covering all aspects of antigens, including their chemistry and biology, structure and function, their initiation of the immune response, and the nature of the products of this response. The nature of the reaction of antigens with antibodies and with sensitized cells is also explored. Comprised of seven chapters, this volume begins with a discussion on the antigenic functions of nucleic acids as well as their immunogenicity, hapten functions, and serologic reactions. The reader is then introduced to the immunochemistry and antigenic determinants of enzymes, along with the structure and phylogeny of immunoglobulins and immunoglobulin allotypes. The evolution of proteins and their structure and function is also considered, paying particular attention to evolution by the random fixation of selectively neutral alleles, the rates of protein evolution, gene duplication, and divergence or convergence. The final chapter is devoted to the chemistry and biology of immunoglobulin E as well as the regulation of formation of their antibodies. This book will be of interest to practitioners and researchers in immunology, experimental and clinical medicine, biochemistry, and other disciplines.

  • The Cell Surface: Mediator of Developmental Processes

    • 1st Edition
    • Stephen Subtelny + 1 more
    • English
    The Cell Surface: Mediator of Developmental Processes contains the papers presented at the 38th Symposium of the Society for Developmental Biology, held at the University of British Columbia in Vancouver, Canada in June 1979. The compendium is divided into three parts. The first part provides a summary of the status of the knowledge about the cell surface, which includes the plasma membrane, its associated cytoskeleton and the variety of surface-associated macromolecules. The second portion focuses on the early development of the cell surface. A wide spectrum of techniques, systems, and results in the study of the cell surface are presented. The last part shows a variety of experimental systems in which the cell surface figures prominently in important developmental events. The results from experiments on plant symbiosis, mammalian teratocarcinomas, adhesion and cell shape, and various extracellular macromolecules are detailed extensively. Cytologists, microbiologists, biologists, and other scientists in allied fields will find the publication very insightful.

  • Monoclonal Antibodies Against Bacteria

    Volume III
    • 1st Edition
    • Alberto J. L. Macario + 1 more
    • English
    Monoclonal Antibodies Against Bacteria, Volume III covers the basis for understanding developments of practical importance in the health sciences within the area of microbiology and infectious diseases, focusing on advances made possible by monoclonal antibodies. This 12-chapter volume specifically considers the basic principles of hybridoma technology. The introductory chapters deal with treponemal antigens of significance for understanding syphilis, yaws, pinta, salmonellosis, and other gastroenteropathies. The subsequent chapters highlight pediatric infections and the strategies for molecular analyses of bacterial antigens, focusing on cell walls, S layers, and sheaths. The remaining chapters examine the bacterial toxins involved in gaseous gangrene and other forms of cell damage, such as diphtheria, caries and periodontal diseases, and bacteria relevant to animal sciences. This book will prove useful to internists, pediatricians, surgeons, dentists, veterinarians, clinical pathologists, and laboratory technologists.

  • Antigen-Antibody Reactions In Vivo

    Methods in Immunology and Immunochemistry, Vol. 5
    • 1st Edition
    • Curtis A. Williams + 1 more
    • English
    Methods in Immunology and Immunochemistry, Volume V: Antigen-Antibody Reactions In Vivo deals primarily with immune phenomena in tissues or in cell preparations. This book covers a variety of topics, including anaphylaxis, tolerance, immune suppression with chemical agents, radiation effects, antibody synthesis in vitro, immunological methods, and applied electron microscopy. Organized into 10 chapters, this volume begins with an overview of systemic anaphylaxis investigations in other more resistant species. This text then presents the analysis of mechanisms involved in the pathogenesis of the Arthus phenomenon, which shed light on the understanding of other lesions of hypersensitivity. Other chapters consider the effects of antigen–antibody interaction on connective tissue. This book discusses as well the degree and duration of acquired tolerance. The final chapter deals with the application of electron microscopy in the elucidation of the mechanisms of immune reactions. This book is a valuable resource for immunologists, students, and research workers.

  • Disorders of Auditory Function

    Volume III
    • 1st Edition
    • Ian G. Taylor + 1 more
    • English
    Disorders of Auditory Function, Volume III presents the proceedings of the Third Conference of the British Society of Audiology, held at the University of Manchester on July 18–20, 1979. This book provides information pertinent to five major areas of interest to the principles and practice of audiology, namely, pediatric audiology, communication, vestibular function, noise-induced hearing loss, and aural rehabilitation. Organized into four sections encompassing 29 chapters, this volume begins with an overview of the conditions that occur in the first years of life that may result in hearing impairment. This text then examines the methods for the early identification of hearing loss. Other chapters consider the implementation of an effective mass hearing screening program for neonates. This book discusses as well the rules and strategies that hearing-impaired children are using to interpret word order. The final chapter reviews the development in British audiology. This book is a valuable resource for otologists, audiologists, and physicians.

  • Metabolic Conjugation and Metabolic Hydrolysis

    Volume I
    • 1st Edition
    • William H. Fishman
    • English
    Metabolic Conjugation and Metabolic Hydrolysis, Volume I is a comprehensive account of the main conjugation mechanisms and hydrolytic reactions. Topics covered range from the metabolic conjugates of steroids and N-hydroxy compounds to the effects of conjugated steroids on enzymes. The glucuronic acid pathway is also discussed, along with sulfoconjugation and sulfohydrolysis. Comprised of eight chapters, this volume first looks at the history of conjugation mechanisms before proceeding to developments in metabolic conjugations. The isolation, recognition, enzymic formation and hydrolysis, and the possible significance of steroid N-acetylglucosaminid... and glucosides are considered. The book also examines the mechanisms involved in the enzymic formation of N-hydroxy compounds; the pathways by which N-hydroxy compounds may be further metabolized in vivo; and the chemical properties of conjugates of N-hydroxy compounds, particularly as these properties are related to the generation of reactive cations or free radicals in vivo. The possible role of conjugates of N-hydroxy compounds in the mechanism of carcinogenesis by aromatic amines and their N-acyl derivatives is also analyzed. Finally, glycoprotein and mucopolysaccharide hydrolysis and the role of hydrolases in cellular death are described. This monograph will be a useful resource for biologists, biochemists, physiologists, and pharmacologists.

  • Photosynthesis

    The Biochemistry of Plants
    • 1st Edition
    • M. D. Hatch + 1 more
    • English
    The Biochemistry of Plants: A Comprehensive Treatise, Volume 10: Photosynthesis provides information pertinent to the biochemistry of photosynthesis. This book discusses the advances in the field of photosynthesis and emphasizes that not only certain synthetic bacteria and microalgae but also other aquatic phototrophs possess mechanisms for concentrating CO2 or bicarbonate in their cells. Organized into six chapters, this volume begins with an overview of the ways of minimizing the wasteful oxygenase reaction catalyzed by the enzyme. This text then examines the molecular basis underlying the structure of the chloroplast thylakoid membrane and its biogenesis during the maturation of the chloroplast. Other chapters consider the dynamics of the thylakoid membrane, including the role of protein phosphorylation and the lateral distribution of electrical charge and protein components. This book discusses as well the molecular processes governing the development of the organelle. This book is a valuable resource for plant biochemists, neurobiochemists, molecular biologists, senior graduate students, and research workers.

  • Analytical Microbiology

    Volume II
    • 1st Edition
    • Frederick Kavanagh
    • English
    Analytical Microbiology, Volume II is a six-chapter work that covers the significant changes and improvements made in the theory and practice of analytical microbiology. The first chapter is devoted to the theoretical aspects of assaying of specific compounds. These topics are followed by discussions of the theoretical and practical aspects of diffusions assays, as well as the theoretical developments of photometric methods of assay, including their improvement resulting from automation. A chapter explores the assay methods for various antibiotic groups. Another chapter discusses the advances in assay technology and analytically important interrelations among the folic acid complex. The last chapter describes a simple diffusion method designed for the assay of certain amino acids in a wide variety of samples. This book will prove useful to analytical microbiologists.

  • Clinical Biochemistry of Domestic Animals

    • 2nd Edition
    • J. J. Kaneko + 1 more
    • English
    Clinical Biochemistry of Domestic Animals, Second Edition, Volume I, is a major revision of the first edition prompted by the marked expansion of knowledge in the clinical biochemistry of animals. In keeping with this expansion of knowledge, this edition is comprised of two volumes. Chapters on the pancreas, thyroid, and pituitary-adrenal systems have been separated and entirely rewritten. Completely new chapters on muscle metabolism, iron metabolism, blood clotting, and gastrointestinal function have been added. All the chapters of the first edition have been revised with pertinent new information, and many have been completely rewritten. This volume contains 10 chapters and opens with a discussion of carbohydrate metabolism and associated disorders. Separate chapters follow on lipid metabolism, plasma proteins, and porphyrins. Subsequent chapters deal with liver, pancreatic, and thyroid functions; the role of the pituitary and adrenal glands in health and disease; the function of calcium, inorganic phosphorus, and magnesium metabolism in health and disease; and iron metabolism.

  • Lipids: Structure and Function

    The Biochemistry of Plants
    • 1st Edition
    • P. K. Stumpf
    • English
    The Biochemistry of Plants: A Comprehensive Treatise, Volume 4: Lipids: Structure and Function provides information pertinent to the fundamental aspects of plant lipid biochemistry. This book covers a variety of topics, including oxidative enzymes, glyoxylate cycle, lipoxygenases, ethylene biosynthesis, phospholipids, and carotenoids. Organized into 19 chapters, this volume begins with an overview of the different techniques for use in the analysis of plant lipids. This text then outlines the concepts of membrane lipid structure and discusses the relationship between membrane lipid structure and function. Other chapters consider the role that lipid structure plays in regulating physiological function. This book discusses as well the biochemical mechanism by which the double bond is introduced in the biosynthesis of ethylene. The final chapter deals with the results of studies on the biosynthesis of cyclopropanoid, cyclopropenoid, and cyclopentenyl fatty acids in higher plants. This book is a valuable resource for plant biochemists, neurobiochemists, molecular biologists, senior graduate students, and research workers.

  • Major Methods of Peptide Bond Formation

    The Peptides Analysis, Synthesis, Biology, Vol. 1
    • 1st Edition
    • Erhard Gross + 1 more
    • English
    The Peptides: Analysis, Synthesis, Biology, Volume 1: Major Methods of Peptide Bond Formation provides comprehensive and critical reviews of important developments in three major areas of peptide research—analysis, synthesis, and biology. This book discusses the nature of the peptide bond, coupling between amino acid residues, and catalysis of active ester reactions. The formation of hydrazides, reactions of carbodiimides with amines, and mixed carbonic anhydride method of peptide synthesis are also elaborated. This publication likewise covers the control of racemization during peptide synthesis, strategies for minimizing racemization during amide-forming steps, and assays for chiral purity. This volume is suitable for students, specialists, and scientists from a broad range of disciplines concerned with peptides.

  • Synthetic Peptides

    Volume 3
    • 1st Edition
    • George R. Pettit
    • English
    Synthetic Peptides discusses racemization, protecting group techniques, peptide bond-forming methodology, amino acids, and dipeptide syntheses. The book explains solid phase synthesis methods, cyclopeptides, nucleopeptides, chromopeptides of the actinomycin D type, and cites examples of syntheses of peptides of different sizes. The text describes tripeptides, tetrapeptides, pentapeptides, hexapeptides, and also undecapeptides to nonadecapeptides. Riniker and colleagues explain the revised structures (for the human and porcine hormone, Asn for Asp at position 25 and Glu for Gin at position 30) for the 39-unit adrenocorticotropic hormone. A synthesis of the 32-unit human calcitonin M is associated with the fragment condensation approach to complex peptides. The book also reviews cyclodepsipeptide valinomycin based on the possible transport of a potassium ion through biological membranes by this substance and the synthesis of a D-Pro analog. The text describes the cyclic decapeptide antibiotic gramicidin S, belonging to a family of similar substances isolated from Bacillus brevi, that can treat certain eye-threatening infections. The book can prove beneficial for biochemists, micro-biologists, cellular investigators, and researchers involved in physiology, oncology or therapeutics.

  • The Antigens

    Volume IV
    • 1st Edition
    • Michael Sela
    • English
    The Antigens, Volume IV is a comprehensive treatise covering all aspects of antigens, including their chemistry and biology as well as their immunologic role and expression. Topics covered range from the immune reactions of lipids and lipid model membranes to the immunology of antibiotics and protective antigens of bacteria. Antigens of pathogenic fungi are also explored, along with adjuvants and antigenic competition. Comprised of seven chapters, this volume begins with a review of lipids as antigens, followed by a discussion on the immunological aspects of antibiotics. The next two chapters are concerned with more complex antigens, namely, bacteria and fungi, as well as the relationship between immunity and infection. The last three chapters deal with three important areas of immunology: antigenic competition, adjuvants, and lectins. In particular, the chemistry of lectins and their application to immunology are examined. This monograph will be of interest to practitioners and researchers in immunology, experimental and clinical medicine, biochemistry, and other disciplines.

  • The Antigens

    Volume II
    • 1st Edition
    • Michael Sela
    • English
    The Antigens, Volume II is a comprehensive treatise covering all aspects of antigens, including their chemistry and biology as well as their immunologic role and expression. Topics covered range from protein antigens and blood group antigens to low molecular weight antigens and immunoglobulin A. The idiotypy of antibodies is also explored, along with the application of antibodies to the measurement of substances of physiological and pharmacological interest. Comprised of six chapters, this volume begins with a discussion on the molecular bases of antigenicity and immunogenicity of proteins, followed by a chapter dealing with blood group antigens. The immunologic effects of low molecular weight antigens are then considered, together with their elicitation of allergic reactions and their tolerance and specific inhibition of the immune response. The next chapter focuses on the use of antibodies to measure substances of physiological and pharmacological interest, with emphasis on the general principle of quantitative immunoassay. The book also analyzes the idiotypy of antibodies before concluding with a description of the antibody functions of immunoglobulin A. This monograph will be of interest to practitioners and researchers in immunology, experimental and clinical medicine, biochemistry, and other disciplines.

  • Metabolic Pathways

    Energetics, Tricarboxylic Acid Cycle, and Carbohydrates
    • 3rd Edition
    • David M. Greenberg
    • English
    Metabolic Pathways, Third Edition, Volume I: Energetics, Tricarboxyl Acid Cycle, and Carbohydrates provides information pertinent to the determination of the sequential steps of the different metabolic pathways and the isolation and characterization of the enzymes catalyzing the several steps. This book discusses the chemical steps in the metabolism of the constituents of major significance in living organisms. Organized into seven chapters, this edition begins with an overview of the concept of free energy and the various methods of obtaining free energy data. This text then examines the relations between free energy and other quantities of direct interest, such as equilibrium constants, electromotive forces, and heats of reactions. Other chapters consider the transformation of energy from one form to another that is accomplished in living systems by specialized structures. The final chapter deals with the importance of L-ascorbic acid in the prevention of scurvy and its mode of action at the molecular level. This book is a valuable resource for biochemists.

  • Cell Biology

    A Laboratory Handbook
    • 1st Edition
    • Julio E Celis
    • English
    Cell Biology: A Laboratory Handbook, Volume 3 is a handbook on cell biology and covers topics ranging from transfer of macromolecules and small molecules to cloning of embryos, transgenics, and gene targeting. Cell-free extracts, permeabilized cell systems, and expression systems are also discussed, along with proteins. Comprised of 58 chapters, this volume begins with a detailed account of microinjection of RNA, DNA, and proteins into somatic cells, followed by an analysis of computer-automated capillary microinjection of macromolecules into living cells. The reader is then introduced to syringe loading as a method for inserting macromolecules into cells in suspension; electroporation of cells; and the use of liposomes in drug targeting. Subsequent chapters focus on the cloning of rabbit embryos by nuclear transplantation; gene targeting by homologous recombination in embryonic stem cells; production and isolation of recombinant viruses; and gel electrophoresis. This book will be of interest to geneticists and molecular biologists.

  • Alcohol and Aldehyde Metabolizing Systems

    Intermediary Metabolism and Neurochemistry
    • 1st Edition
    • Ronald G. Thurman + 2 more
    • English
    Alcohol and Aldehyde Metabolizing Systems, Volume III: Intermediary Metabolism and Neurochemistry contains some of the papers presented at the Second International Symposium on Alcohol and Aldehyde Metabolizing Systems, held at the University of Pennsylvania in October 1976. Experts in the field from a wide variety of backgrounds tackled the problems of alcohol and aldehyde metabolism, discussed research findings, and examined controversial issues such as the effects of alcohol and aldehydes on intermediary metabolism. Comprised of 64 chapters, this volume begins with an analysis of the non-equilibrium behavior of biochemical systems, followed by a discussion on the configurational specificity of glycolytic enzymes. The reader is methodically introduced to redox compartmentation and the measurement of intracellular compartmentation of metabolites in rat liver; effect of chronic alcohol and oxygen tension on the development of hepatic necrosis in rats; and actions of ethanol metabolism on fatty acid synthesis in the liver. Subsequent chapters focus on regional metabolic rate in the central nervous system as related to function; effects of tetrahydroisoquinoli... derivatives of catecholamines and aldehydes on tyrosine hydroxylase; and lowering of blood acetaldehyde levels as a therapeutic approach to alcoholism. This book will be of value to practitioners and researchers from a variety of disciplines, including neurochemistry, biochemistry, physiology, cell biology, and pharmacology.

  • The Mouse in Biomedical Research

    Normative Biology, Immunology, and Husbandry
    • 1st Edition
    • Henry L. Foster + 2 more
    • English
    The Mouse in Biomedical Research, Volume III: Normative Biology, Immunology, and Husbandry focuses on the normative biology, immunology, and husbandry of laboratory mice. Topics covered range from gnotobiotics and gastrointestinal microflora to animal health surveillance and health delivery systems, along with environmental monitoring. The management and design of breeding and research facilities are also discussed. Comprised of 18 chapters, this volume begins with an overview of studies involving gnotobiotic mice, the induction of gnotobiosis, and microbiological testing of gnotobiotic animals. Maintenance of breeding colonies of gnotobiotic animals is also considered, together with the shipment of gnotobiotes and laboratory facilities for using gnotobiotes. The reader is then introduced to management and design of breeding and research facilities for gnotobiotic mice; practical factors associated with providing adequate nutrition for laboratory mice; and environmental and equipment monitoring. Subsequent chapters deal with the basic biology of the mouse, including anatomy, embryology, reproductive physiology, physiology, endocrinology, hematology, clinical biochemistry, and gastrointestinal microflora. The book also examines immunoglobulins and immunoglobulin genes; lymphocyte immunogenetics; immune response disorders; and biomethodology and surgical techniques. This monograph will be useful to biologists, immunologists, researchers, and others those who use mice in the laboratory or are concerned with the production and maintenance of colonies of mice.

  • Hepatic Plasma Proteins

    Mechanisms of Function and Regulation
    • 1st Edition
    • Barbara H. Bowman
    • English
    Hepatic Plasma Proteins: Mechanisms of Function and Regulation covers the mechanisms of function, inherited variation, and regulation of genes encoding the plasma proteins synthesized in the liver. The book discusses the physiological and clinical implications of human plasma protein abnormalities; the acute-phase reactants; and the variety of human plasma proteinase inhibitors. The text also describes the plasma protein vehicles (transferrin, ceruloplasmin, transthyretin, haptoglobin, hemopexin, and the vitamin D binding protein), as well as cytokines and transcription factors involved in the regulatory process. The protein and gene anatomies are discussed in terms of evolutionary relationships and genetic variations, especially those with mutations causing clinical manifestations. The book also encompasses the mechanisms responsible for tissue specific and developmental expression of plasma protein genes. Geneticists, biochemists, molecular biologists, physicians, and other students of biology will find the book invaluable.

  • Primates

    A Compilation from the GenBank® and EMBL data libraries
    • 1st Edition
    • Edwin J. Atencio + 2 more
    • English
    Nucleotide Sequences 1986/1987, Volume I: Primates presents data that reflect the information found in GenBank Release 44.0 of August 1986. This book provides information pertinent to the unique international collaboration between two leading nucleotide sequence data libraries, one based in Europe and one in the United States. Organized into one section, this volume begins with an overview of the sequences, some basic identifying information, and some of the biological annotations. This text then discusses the EMBL Nucleotide Sequence Data Library, an international center of fundamental research with its main focus in the fields of cell biology, molecular structures, instrumentation, and differentiation. This book discusses as well the GenBank database. This book is a valuable resource for molecular biologists and other investigators collecting the large number of reported DNA and RNA sequences and making them available in computer-readable form.

  • Agglutination, Complement, Neutralization, and Inhibition

    Methods in Immunology and Immunochemistry, Vol. 4
    • 1st Edition
    • Curtis A. Williams + 1 more
    • English
    Methods in Immunology and Immunochemistry, Volume IV: Agglutination, Complement, Neutralization, and Inhibition provides information pertinent to direct and indirect agglutination reactions. This book covers a variety of topics, including complement-fixation procedures, isolation of complement components, hemolytic intermediates, complement-related proteins, and neutralization reactions. Organized into three chapters, this volume begins with an overview of test-tube agglutinations that are preferred for blood grouping with saline agglutinins that require more than a few minutes for agglutination. This text then describes blood group antibodies that agglutinate red blood cells suspended in saline. Other chapters consider the classical pathway of complement utilization. This book discusses as well the complexity of events leading to hemolysis of erythrocytes by complement. The final chapter deals with the ability of antitoxin to neutralize diphtheria toxin and explains the quantitative relationships between antigen and antibody. This book is a valuable resource for immunologists, scientists, and research workers.

  • The Receptors

    Volume III
    • 1st Edition
    • P. Michael Conn
    • English
    The Receptors, Volume III deals with receptors for interferons, hormones, and growth factors as well as for ?-aminobutyric acid, tuftsin, somatomedin, and insulin. Prolactin and nicotine receptors are also considered, along with the protein tyrosine kinase activity of hormone and growth factor receptors. Comprised of 12 chapters, this volume begins with a detailed account of secretory component (SC) as a receptor for polymeric immunoglobulins and the importance of SC-polymeric immunoglobulin A interactions in the mucosal immune system. The discussion then turns to interferon receptors and what is known about the fate of interferons and their receptors after binding; the use of muscimol in ligand-binding studies aimed at characterizing ?-aminobutyric acid receptors; and the role of protease nexins in the interaction of proteases with cells and in the regulation of proteolytic activity in the interstitial fluid immediately surrounding cells. Subsequent chapters focus on receptor regulation of phosphoinositides and calcium; effects of phospholipid turnover on receptor function; dynamics of tuftsin receptors; and the structure, function, and regulation of somatomedin receptors. The book also examines the internalization and intracellular processing of insulin receptors before concluding with an analysis of prolactin and nicotine receptors. This monograph will be a valuable resource for students and practitioners in fields ranging from cell biology and biochemistry to physiology, endocrinology, and pharmacology.

  • Biochemical and Molecular Aspects of Selected Cancers

    • 1st Edition
    • Thomas G. Pretlow + 1 more
    • English
    Biochemical and Molecular Aspects of Selected Cancers, Volume I provides an overview of important topics and prototypes in cancer research. The book consists of papers provided by outstanding investigators in diverse disciplines in different areas of cancer research. This volume focuses on topics relevant to cancers in humans. It covers such topics as tumor-suppressor genes and human neoplasia; protein kinase C in neoplastic cells; and extracellular matrix interactions with tumor-progressing cells: tumor versus cell type-specific mechanisms. Structural and functional characteristics of human melanoma; steroid hormones and hormone receptors in neoplastic diseases; and patterns and significance of genetic changes in neuroblastomas are expounded as well. Oncologists, biochemists, cytologists, and other researchers in allied fields will find the book invaluable.

  • Alcohol and Aldehyde Metabolizing Systems

    Enzymology and Subcellular Organelles
    • 1st Edition
    • Ronald G. Thurman + 2 more
    • English
    Alcohol and Aldehyde Metabolizing Systems, Volume II: Enzymology and Subcellular Organelles contains some of the papers presented at the Second International Symposium on Alcohol and Aldehyde Metabolizing Systems, held at the University of Pennsylvania in October 1976. Experts in the field from a wide variety of backgrounds tackled the problems of alcohol and aldehyde metabolism, discussed research findings, and examined controversial issues ranging from the molecular structure of enzymes to the clinical actions of alcohol in humans. Comprised of 43 chapters, this volume begins by comparing the enzymatically catalyzed oxidation of glyceraldehyde-3-pho... and lactate, followed by an analysis of liver alcohol dehydrogenase and its mechanism of action. The reader is methodically introduced to the kinetics and mechanism of activated liver alcohol dehydrogenase; structural and functional changes in different alcohol dehydrogenases during evolution; and localization and properties of aldehyde reductase. Subsequent chapters deal with the correlation between the activity of acetaldehyde dehydrogenase and the structure of mitochondria; the distribution of subcellular organelles; and peroxisomes and microsomes. This book will be of value to practitioners and researchers from a variety of disciplines, including biochemistry, physiology, cell biology, and pharmacology.

  • Plant Metabolism

    • 1st Edition
    • H. E. Street + 1 more
    • English
    Plant Metabolism, Second Edition focuses on the processes, principles, and methodologies involved in the metabolism of higher plants. The book first elaborates on cell structure and function, enzymes, and catabolism. Discussions focus on the control of respiration, conservation of the energy liberated in respiration, chemical pathways of respiration, enzymes in the living cell, prosthetic groups and coenzymes, protein nature of enzymes, general structure of plant cells, and osmotic behavior of cells. The manuscript then tackles anabolism and secondary plant products. Topics include phenylpropanoids, flavonoids, isoprenoid compounds, assimilation of nitrogen and sulfur, synthesis of sucrose and polysaccharides, location of the photosynthetic apparatus, influence of external factors on the rate of photosynthesis, and general nature of photosynthesis. The text takes a look at growth and differentiation, absorption, secretion, and translocation, secondary plant products, and regulation of metabolism. The publication is a valuable source of data for plant science experts and researchers interested in plant metabolism.

  • The Mind–Body Problem

    A Psychobiological Approach
    • 1st Edition
    • Mario Bunge
    • Mario Bunge
    • English
    The Mind–Body Problem: A Psychobiological Approach examines the mind-body problem from a psychobiological perspective. It intends to show that the idea of a separate mental entity is not only unwarranted by the available data and the existing psychological models, but collides head-on with the most fundamental ideas of all modern science and is thus a stumbling block to progress. The book abandons ordinary language in favor of the state space language, which is mathematically precise and is shared by science and scientific philosophy. Comprised of 10 chapters, this monograph begins with an overview of the mind-body problem and its main proposed solutions, classified into main genera: psychophysical monism and psychophysical dualism. In particular, ten views on the mind-body problem are analyzed, along with three main varieties of materialism with regards to the problem: eliminative, reductive (or leveling), and emergentist. The discussion then turns to the notion of a concrete or material system, based on the assumption that behavior is an external manifestation of neural processes. Subsequent chapters explore the specific functions of the central nervous system; sensation and perception; behavior and motivation; memory and learning; thinking and knowing; and consciousness and personality. The book also considers sociality and social behavior in animals before concluding with an assessment of a psychological explanation of the mind, with emphasis on dualism and monism. This work will be of interest to students, academicians, practitioners, and investigators in the fields of psychobiology, psychology, neurophysiology, and philosophy.

  • Processing and Turnover of Proteins and Organelles in the Cell

    FEBS Federation of European Biochemical Societies: 12th Meeting, Dresden, 1978
    • 1st Edition
    • S. Rapoport + 1 more
    • English
    Processing and Turnover of Proteins and Organelles in the Cell is a collection of papers that tackles the problems of post-translational processes, along with the dynamics of cell components. The materials in the title are organized thematically. The text first presents articles dealing with post-translational processing, such as the mode of anchoring of sucrase-isomaltase to the small intestinal brush-border membrane and its biosynthetic implications, as well as the decay and restoring in succinate dehydrogenase. The next papers discuss topics related to the selective degradation of proteins, such as selective control of proteinase action in yeast cells and studies of the mechanism and selectivity of intracellular protein breakdown. The final set of papers covers the turnover of organelles, which includes biogenesis and turnover of peroxisomes, and the effect of oxygen on the synthesis of mitochondrial proteins in Saccharomyces cerevisiae. The book will be of great use to microbiologists and biochemists. Scientists from biological science disciplines will also benefit from the text.

  • A Laboratory Manual of Analytical Methods of Protein Chemistry

    Volume 4
    • 1st Edition
    • P. Alexander + 1 more
    • English
    A Laboratory Manual of Analytical Methods of Protein Chemistry, Volume 4 provides information pertinent to the fundamental aspects of protein chemistry. This book discusses the simple and accurate methods of estimating specific proteins. Organized into six chapters, this volume begins with an overview of the composition of acids and experimental conditions for the acid hydrolysis of proteins. This text then examines the advantages of high-voltage electrophoresis for amino acid analysis, which are paralleled by equal advantages in the peptide separation field. Other chapters consider the simple technique of estimating specific proteins, which is one of several based on the phenomenon of antigen-antibody precipitation in gels. This book discusses as well the summations of analyses in weight percentages of the various residues and of the nitrogen of each constituent. The final chapter deals with the electrical properties of molecules. This book is a valuable resource for physicists and research workers.

  • Molecular and Cellular Aspects of Muscle Function

    Proceedings of the 28th International Congress of Physiological Sciences Budapest 1980, (including the proceedings of the satellite symposium on Membrane Control of Skeletal Muscle Function)
    • 1st Edition
    • E. Varga + 2 more
    • English
    Advances in Physiological Sciences, Volume 5: Molecular and Cellular Aspects of Muscle Function covers the proceedings of the 28th International Congress of Physiological Sciences, held in Budapest in 1980 (including the proceedings of the satellite symposium on Membrane Control of Skeletal Muscle Function). The book focuses on the molecular and cellular facets of skeletal muscle function. The selection first offers information on the mechanical properties of cross-bridges and their relation to muscle contraction; molecular basis of functional specialization in muscle as induced by innervation; and electrical properties of crustacean muscle membranes. The text then ponders on contractile protein isoforms in developing muscle; effect of age and exercise on minced gastrocnemius muscle regeneration; and contractile proteins of rat gastrocnemius during its regeneration after mincing. The publication examines the behavior of myosin projections in frog striated muscle during isometric contraction; energetics of contracting muscle and its relation to crossbridge mechanisms; and time course of chemical change and energy production during contraction of frog skeletal muscle. The physiological analysis of human myopathy and adaptation in normal and diseased muscle are also discussed. The selection is a vital source of data for readers interested in the cellular and molecular aspects of muscle function.

  • Genetics and the Quality of Life

    • 1st Edition
    • Charles Birch + 1 more
    • English
    Genetics and the Quality of Life covers the papers and report of a consultation on Genetics and the Quality of Life, held in Zurich on June 25-29, 1973, organized by the sub-unit on Church and Society of the World Council of Churches in cooperation with the Christian Medical Commission. The book focuses on the interrelation of genetics and quality of life. The selection first elaborates on genetics and moral responsibility and ethics and the new biology. Discussions focus on breakdown of values, genetically determined debility versus socially determined debility, ethical problems, and genetic inequality and moral responsibility. The text then examines ethical issues raised by eugenics, judging the social values of scientific advances, ethical problems raised by genetics, and problems raised by eugenics in Africa. Topics include the right to an adequate physical and mental endowment, genetic engineering, euphenics, constraints imposed by genetics, fertilization of human ova in vitro, and ethical questions in eugenics. The manuscript reviews findings on genetics and the quality of life, sociogenetic problems and public opinion, social and ethical problems in caring for genetically handicapped children, ethical problems in genetic counselling, and psychological issues in counselling the genetically handicapped. The selection is a dependable source of information for researchers interested in the connection of genetics and quality of life.

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