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Elsevier

Books in Neuroscience

Elsevier's Neuroscience collection empowers educators, researchers, and students with actionable knowledge to drive collaborative research and advancements in the field. Content covers the nervous system's intricate workings, covering branches like Affective, Behavioral, and Cognitive neuroscience to investigate the neural basis of emotions, behavior, and cognitive functions. Spanning from Molecular and Cellular Neuroscience to Developmental Neuroscience, content provides insights into brain function in health and disease.

  • The Primate Nervous System, Part III

    • 1st Edition
    • Volume 15
    • Floyd E. Bloom + 2 more
    • English
    This volume is the third and final part of the planned coverage of the neurochemical circuitry of the primate central nervous system. The five chapters included in this volume complement and integrate magnificently with the two prior volumes. Included in the volume are the following: a two-fold exposition on the human forebrain, comprised of a comprehensive overview of the entire human forebrain, and a specific focus on the basal forebrain (a region critical for a wide range of human problems ranging from substance abuse to Alzheimer's disease), a critical synthesis of the primate basal ganglia (a region under intense scrutiny for the organization of motor programs, and for their dysfunctions in Parkinson's disease, Huntington's disease and other malfunctions), the chemical and anatomic details of the primate hippocampal formation in extenso, and lastly, a review of the rapidly growing literature on the mesocortical projection of dopaminergic circuits onto the primate frontal cortex ( a system highly linked to higher order mental abstractions, as well as the dysfunctions of schizophrenia). Scholars will recognize that the laying out of these status reports on our still vastly incomplete examination of the primate brains is an opportunity for progress.

  • Handbook of Molecular-Genetic Techniques for Brain and Behavior Research

    • 1st Edition
    • Volume 13
    • Wim E. Crusio + 1 more
    • English
    The book gives a broad overview of recombinant DNA techniques for the behavioral neuroscientist, with illustrative examples of applications. Species covered include rodents (mainly mice), Drosophila melanogaster, Caenorhabditis elegans and Danio rerio. Experimental techniques required to characterize the behavioral phenotypes of mutant animals is provided. Several aspects of novel molecular-genetic techniques are overviewed and possible research strategies are explained. The sections of the book start with general descriptions of techniques followed by illustrative examples.It is divided into six sections. Section 1, bioinformatics and genomics research. Section 2, top-down strategies, where the researcher starts with the phenotype and then analyzes the associated genes; bottom-up strategies, where the physiological chain leading to a phenotype is analyzed starting from the gene product. Section 3, transgenic approaches in rodents including overexpressing foreign genes and gene-targeting; systemic manipulation approaches directly targeting the central nervous system and methods used with invertebrates. Section 4, methods used to evaluate relevant behavioral phenotypes, including learning and aggression. Section 5, examples on molecular brain research in man. Section 6, ethical aspects of research in this field.

  • Adenosine Receptors and Parkinson's Disease

    • 1st Edition
    • Hiroshi Kase + 2 more
    • English
    This book is the first definitive overview on adenosine receptor antagonists and their application to the treatment of Parkinson's Disease. The effect of these novel non-dopamine drugs on vitro and in vivo systems clearly shows their potential for the treatment of this debilitating disease. This book covers how the Parkinson's disease antagonist drug, A2A, has been researched, developed, and tested. It is an essential book for researchers interested in the basal ganglia, purine biology, and Parkinson's Disease.

  • Psychology of Learning and Motivation

    Advances in Research and Theory
    • 1st Edition
    • Volume 39
    • English
    Psychology of Learning and Motivation publishes empirical and theoretical contributions in cognitive and experimental psychology, ranging from classical and instrumental conditioning to complex learning and problem solving. Each chapter provides a thoughtful integration of a body of work. Volume 39 includes in its coverage chapters on category learning, relational timing, infant memory, depression and memory, goals and choice, and more.

  • Disorders of Brain, Behavior, and Cognition: The Neurocomputational Perspective

    • 1st Edition
    • Volume 121
    • J.A. Reggia + 2 more
    • English
    This book contains selected contributions of papers, many presented at the Second International Workshop on Neural Modeling of Brain Disorders, as well as a few additional papers on related topics, including a wide range of presentations describing computational models of neurological, neuropsychological and psychiatric disorders. It is a unique, comprehensive review of the state-of-the-art of modeling cognitive and brain disorders, appealing to a multidisciplinary audience of clinicians, psychologists, neuroscientists, cognitive scientists, computer scientists, and other neural network researchers. The rest of the book is organized along four main themes, involving memory, neuropsychological, neurological and psychiatric disorders. In general, the cognitive disorders and these psychiatric diseases traditionally regarded as "functional" were modeled along functional lines, while those disorders traditionally viewed as "organic" neurological diseases generally drew more from knowledge of the underlying neurobiology and pathophysiology.

  • Nucleotides and their Receptors in the Nervous System

    • 1st Edition
    • Volume 120
    • P. Illes + 1 more
    • English
    The study of purinergic mechanisms has for long been focused on the actions of the nucleoside adenosine, whereby the contribution of nucleotides to the signaling systems has been underestimated.Based on the proceedings of a IUPHAR Satellite Conference held in Leipzig, Germany, this book offers a comprehensive update and overview of nucleotide release, the structure and function of nucleotide receptors, nucleotide-metaboliz... ecto-enzymes as well as the physiological functions of nucleotides in the nervous system. The physiology and molecular biology of receptors for ATP and other nucleotides are examined, as are the physiology and molecular biology of enzymes that hydrolyze extracellular nucleotides.At present, a pharmacology of the nucleotide signaling system is being developed. Of particular interest is the production of receptor subtype-specific antagonists and of drugs that selectively affect the extracellular lifetime of the nucleotide.An excellent source of reference for institutes of pharmacology, biochemistry, neurology, zoology, and physiology, and for the pharmaceutical industry.

  • Computational Neuroscience

    Trends in Research 1999
    • 1st Edition
    • J.M. Bower
    • English
    This volume includes papers originally presented at the 7th annual Computational Neuroscience Meeting (CNS'98) held in July of 1998 at the Fess Parker Doubletree Inn in Santa Barbara, California. The CNS meetings bring together computational neuroscientists representing many different fields and backgrounds as well as many different experimental preparations and theoretical approaches. The papers published here range from pure experimental neurobiology, to neuro-ethology, mathematics, physics, and engineering. In all cases the research described is focused on understanding how nervous systems compute. The actual subjects of the research include a highly diverse number of preparations, modeling approaches, and analysis techniques. Accordingly, this volume reflects the breadth and depth of current research in computational neuroscience taking place throughout the world.

  • Neuromuscular Junctions in Drosophila

    • 1st Edition
    • Volume 43
    • English
    Neuromuscular Junctions in Drosophila gathers the main contributions that research using the fruit fly Drosophila melanogaster has made in the area of synapse development, synapse physiology, and excitability of muscles and nerve cells. The chapters in this book represent a synthesis of major advances in our understanding of neuronal development and synaptic physiology, which have been obtained using the above approach.This book is directed to the general neuroscience audience: researchers, instructors, graduate students, and advanced undergraduates who are interested in the mechanisms of synapse development and physiology. However, the book will also be a valuable resource for those that use the fruit fly as a model system in their laboratories.

  • Advances in the Study of Behavior

    • 1st Edition
    • Volume 28
    • English
    Advances in the Study of Behavior continues to serve scientists across a wide spectrum of disciplines. Focusing on new theories and research developments with respect to behavioral ecology, evolutionary biology, and comparative psychology, these volumes foster cooperation and communication in these diverse fields.

  • Advances in Brain Vasopressin

    • 1st Edition
    • Volume 119
    • I.J.A. Urban + 2 more
    • English
    Advances in Brain Vasopressin elucidates the functions of the regulatory peptide vasopressin in the nervous system, and reviews the current status of this field at different levels.It deals with the cell biology and anatomy of the neurons that produce vasopressin in the brain, and provides an overview on the receptors of vasopressin and the signal transduction pathways that they activate, including the cellular responses that are triggered by vasopressin. Reviews are presented on the modulation of behavior induced by vasopressin in a number of different contexts, such as sex-linked and steroid-dependent behaviors, social behaviors, and learning and memory.Furthermore, the volume deals with several controversial issues in the field by presenting overlapping chapters from different research groups in order to provide the reader with current views.Highly relevant and useful, for those working on this "first" neuropeptide, and for young investigators entering the field, and in addition, shows how important a multidisciplinary approach is to unravelling the function of a neuropeptide in the brain.

  • The Histamine H<INF>3</INF> Receptor

    A Target for New Drugs
    • 1st Edition
    • Volume 30
    • R. Leurs + 1 more
    • English
    In the early eighties when the H3 receptor was identified, many thought that an H3 ligand, an agonist or an antagonist, would become available as a therapeutic agent. This has not occurred. The reason for this could be the fact that many investigators consider histamine mainly, if not only, as a mediator present in for example mast cells being released during allergic events. However, it has become apparent that histamine is an important neurotransmitter. Its role in the nervous system, especially in the central part of it, is rather extensive.The H3 receptor is mainly found as a presynaptic one, both on histaminergic neurons (the auto-type) and on other neuronal systems (the hetero-type). Both the H3 agonist and the H3 antagonist cause important pharmacological effects. Several ligands have become available now, including radiolabelled analogues.In this book, the current state of affairs with regards to the medicinal chemistry and pharmacology of the H3 receptor and the several ligands available are presented by a number of experts in the field. The book presents an extended review of what has happened since the first H3 paper appeared. The editors hope that publication of this work will lead to an increase in interest of both academia and industry for the H3 receptor, especially as a target for drug development.

  • Neuronal Degeneration and Regeneration: From Basic Mechanisms to Prospects for Therapy

    • 1st Edition
    • Volume 117
    • F.W. Van Leeuwen + 4 more
    • English
    This book is the result of the 20th International Summer School in Brain Research, organized in August 1997 in Amsterdam, by the Netherlands Institute for Brain Research at the Royal Netherlands Academy of Sciences. It is the first book that provides a complete overview of the field of neurodegeneration and regeneration including spinal cord injury, neurodegenerative diseases and therapy. Divided into five sections, the first two sections give an overview of fundamental research on nerve cell death, neuronal survival, neurite outgrowth and guidance. Extensive attention is given to the role of neurotrophins, their receptor tyrosine kinases and cell-adhesion molecules in development and regeneration of the nervous system. The third section of the book is devoted to research involving human neurodegenerative diseases and emerging treatment strategies. Section four focusses on recent advances in the understanding of pathophysiological mechanisms underlying neurodegenerative diseases, including Alzheimer's, Parkinson's and Huntington's diseases along with prion diseases. Novel insights into the neuropathological hallmarks of these diseases, as well as into transgenic animal models, the involvement of environmental factors, and genomic and mRNA changes that can cause neurodegeneration. The final section of this volume reveals recent developments in the use of cell and gene therapy to treat neurodegenerative disease and lesion-related deficits. Implantation of genetically modified cells, direct gene transfer with viral vectors and the first clinical trials with encapsulated genetically modified cells in patients suffering from amyotrophic lateral scelerosis are examples of new therapeutic strategies treating neurodegenerative diseases.The book is of particular interest to departments of neuroscience, neurological clinics and departments, the pharmalogical industry and medical libraries.

  • Nitric Oxide in Brain Development, Plasticity, and Disease

    • 1st Edition
    • Volume 118
    • R.R. Mize + 3 more
    • English
    Nitric oxide, "Molecule of the Year" in 1995, continues to be one of the most widely studied molecules in brain research. This excellent volume elucidates the implications of this gas in a variety of brain processes.The volume is divided into five sections, describing: the mechanisms underlying the release and action of Nitric Oxide in the CNS, and the distribution of Nitric Oxide in the brain using various techniques; how Nitric Oxide interacts with and regulates the N-methyl-D-aspartate receptor; the role of Nitric Oxide in pathway refinement and synapse stabilization in the developing CNS; the role of Nitric Oxide in adult brain plasticity including long-term potentiation and depression; and the role of Nitric Oxide in brain injury such as occurs during ischemia and other events produced by glutamate neurotoxicity, and in neuroprotective mechanisms that promote neuron survival.Nitric Oxide in Brain Development, Plasticity, and Disease is the first Progress in Brain Research volume to be published in abstracted form on the World Wide Web. It includes title pages, abstracts, selected figures, and complete references. It also includes a digital brain atlas for readers to view a mouse brain in a three-dimensional full-color rendition, and much more.

  • The Glutamate Synapse as a Therapeutic Target

    • 1st Edition
    • Volume 116
    • English
    This volume provides a comprehensive update on basic glutamate research, from a clinical perspective. Thus, emphasis is placed on how the different molecular players at the glutamate synapse interact to produce a postsynaptic response, how synaptic transmission is perturbed in epilepsy and other pathological conditions, and how glutamate may acquire toxic properties and lead to acute or chronic neurodegeneration. Promising targets for therapeutic strategies are discussed.A coherent picture is provided of the glutamate synapse and its molecular organization. The book therefore deals with each step in the signal process, from synthesis and vesicular uptake of glutamate to its clearance following receptor activation.

  • The Epilepsies

    Etiologies and Prevention
    • 1st Edition
    • Prakash Kotagal + 1 more
    • English
    Tremendous advances in our understanding of epilepsy have occurred in the last two decades. Techniques such as electroencephalograp... neuroimaging, neurosurgery and neuropsychology are giving us a better understanding of the pathogenesis of epilepsy. Additionally major breakthroughs are taking place in the laboratories of scientists studying genetics, embryogenesis, neuropathology, neurochemistry and pharmacology. These advances provide a much better understanding of why patients develop epilepsy, reshaping the way in which the epileptic patient is cared for. This book presents the most current information on the various etiologies of epilepsy, their treatments, and their possible prevention. Kotagal and Lüders have assembled 80 internationally known experts to compile this authoritative, comprehensive, and well-rounded work.The Epilepsies is a one-of-a-kind reference that will be of interest to specialists and basic scientists involved in the study of epilepsy, adult and pediatric neurologists, neurosurgeons, residents and fellows in these areas, and pediatricians who frequently encounter children with neurological problems. This major work brings together the most up-to-date research on the causes of epilepsy and other associated diseases which cause seizures. It presents data on infections, trauma, mesial temporal sclerosis, cerebral dysgenesis, brain tumors, vascular lesions, stroke, as well as genetic, metabolic and toxic causes of epilepsy. The book also looks at drug treatment and new surgical techniques that have proven useful in alleviating epileptic and other related seizures.

  • Handbook of Behaviorism

    • 1st Edition
    • William O'Donohue + 1 more
    • English
    Handbook of Behaviorism provides a comprehensive single source that summarizes what behaviorism is, how the various "flavors" of behaviorism have differed between major theorists both in psychology and philosophy, and what aspects of those theories have been borne out in research findings and continue to be of use in understanding human behavior.

  • CNS Regeneration

    Basic Science and Clinical Advances
    • 1st Edition
    • Mark H. Tuszynski + 1 more
    • English
    CNS Regeneration focuses on some of the leading current neurological disease models and methods for promoting central nervous system regeneration. Editors and authors are experts in the field, with experience in basic as well as applied neuroscience. In a comprehensive, logical manner, the book unites important basic science advances in neuroscience with novel medical strategies.

  • The Psychology of Music

    • 2nd Edition
    • Diana Deutsch
    • English
    The aim of the psychology of music is to understand musical phenomena in terms of mental functions--to characterize the ways in which one perceives, remembers, creates, and performs music. Since the First Edition of The Psychology of Music was published the field has emerged from an interdisciplinary curiosity into a fully ramified subdiscipline of psychology due to several factors. The opportunity to generate, analyze, and transform sounds by computer is no longer limited to a few researchers with access to large multi-user facilities, but rather is available to individual investigators on a widespread basis. Second, dramatic advances in the field of neuroscience have profoundly influenced thinking about the way that music is processed in the brain. Third, collaborations between psychologists and musicians, which were evolving at the time the First Edition was written, are now quite common; to a large extent now speaking a common language and agreeing on basic philosophical issues.The Psychology of Music, Second Edition has been completely revised to bring the reader the most up-to-date information, additional subject matter, and new contributors to incorporate all of these important variables.

  • The Primate Nervous System, Part II

    • 1st Edition
    • Volume 14
    • T. Hokfelt + 2 more
    • English
    This volume is the second in the planned coverage of the neurochemical circuitry of the primate central nervous system. While this volume contains only two chapters, their topics and the extraordinarily comprehensive coverage with which the authors have dealt with their topics, will nevertheless contribute equal amounts of knowledge, wisdom, and opportunities for future research extensions as have every volume in this unique series. As such, these chapters extend the goals of this primate series to develop a broad coverage of human and non-human primate chemical neuroanatomic details in a volume which makes clear the known and desirable appreciation for differences between and among subsets of primate brains.The first chapter covers the primate thalamus with equal emphases on new world, old world, pro-simian and human anatomic details and their differences. The second undertakes a comparably comprehensive examination of one of the most intensively studied regions of the primate brain, namely the primate visual cortex. While much has been studied, both chapters also reveal how much remains for future efforts in these enormously important regions which are the archetypes of primate sub-cortical and cortical function.

  • Perception and Cognition at Century's End

    History, Philosophy, Theory
    • 1st Edition
    • Julian Hochberg
    • English
    Perception and Cognition at Century's End contains cognitive psychology surveys that are up-to-date and historically based, as well as references to the development of cognitive psychology over the past century. The book can serve as a central or specialized text for a range of psychology courses.

  • Neurotransmitter Transporters

    • 1st Edition
    • Volume 296
    • John N. Abelson + 1 more
    • English
    General Description of the Series:Neurotransmit... Transporters focuses on biochemical, electrophysiological... pharmacological, molecular, and cell biological approaches used to study neurotransmitter transport systems. The articles provide detailed descriptions of procedures that should enable the reader to understand how they are accomplished and to repeat or adapt them for their own experimental needs. This book is the first to focus on methods that have been the basis for the rapid development of this area.General Description of the Series:The critically acclaimed laboratory standard for more than forty years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 300 volumes (all of them still in print), the series contains much material still relevant today--truly an essential publication for researchers in all fields of life sciences.

  • Animal Cognition in Nature

    The Convergence of Psychology and Biology in Laboratory and Field
    • 1st Edition
    • Russell P. Balda + 2 more
    • English
    In this book, the editors bring together results from studies on all kinds of animals to show how thinking on many behaviors as truly cognitive processes can help us to understand the biology involved. Taking ideas and observations from the while range of research into animal behavior leads to unexpected and stimulating ideas. A space is created where the work of field ecologists, evolutionary ecologists and experimental psychologists can interact and contribute to a greater understanding of complex animal behavior, and to the development of a new and coherent field of study.

  • Advances in Genetics

    • 1st Edition
    • Volume 38
    • English
    This volume of Advances in Genetics furthers the serial's goal of presenting topics of interest to both human and molecular geneticists. Topics of interest in this volume include:Expression patterns of regulatory genes and the role they play in developmentHereditar... ataxias and specific disease states where the genetic defect has been identifiedMinute genes, their mutations, and their molecular function in DrosophilaThe genetics and molecular biology of rhythm mutants and clock moleculesDouble strand breaks in DNA and their repair mechanisms

  • Human Aggression

    Theories, Research, and Implications for Social Policy
    • 1st Edition
    • Russell G. Geen + 1 more
    • English
    For centuries, scholars have debated the causes of aggression and the means to reduce its occurrence. Human Aggression brings together internationally recognized experts discussing the most current psychological research on the causes and prevention of aggression. Scholars, policy makers, practitioners, and those generally concerned with the growing issue of aggression find this a much needed reference work. Topics include how aggression is related to the usage of drugs, how temperature affects aggression, the effect of the mass media on aggression, violence by men against women, and the treatment of anger/aggression in clinical settings. The book also provides a comprehensive review of theory and methodology in the study of aggression.

  • Handbook of the Aging Brain

    • 1st Edition
    • Eugenia Wang + 1 more
    • English
    Handbook of the Aging Brain brings together diverse scientific disciplines to cover the most recent research findings in an easy-to-read summary. Scientists and clinicians will find a wide spectrum of subjects including gerontology, neurology, psychology, molecular biology, and cellular biology. The book includes general chapters on the neuroanatomy and neurobiology of the aging brain, and moves on to discussion of specifics including signal transduction, cell death, and specific cellular and neurological changes associated with dementia, Alzheimer's and Parkinson's Disease. Other chapters discuss the affect of aging on learning and memory, language, and cognition.

  • Molecular & Cellular Mechanisms of Neurotransmitter Release

    • 1st Edition
    • Volume 29
    • English
    This volume reviews recent findings on the regulation of exocytotic release of neurotransmitters from nerve terminals. Leading international investigators examine the properties and composition of the vesicles that store neurotransmitters and the molecular and cellular mechanisms that cause a vesicle to release transmitters in response to a nerve impulse.Coverage includes detailed analyses of quantal release of transmitters in the central and peripheral nervous systems. These studies shed new light on the questions of whether different transmitters are released together in fixed amounts and proportions, and whether and why effectors respond to such "transmitter quanta" in a quantal fashion. The book also highlights the relevance of research on neurotransmitter release to the study of various forms of synaptic plasticity, including higher functions such as learning and memory.

  • Eye Guidance in Reading and Scene Perception

    • 1st Edition
    • G. Underwood
    • English
    The distinguished contributors to this volume have been set the problem of describing how we know where to move our eyes. There is a great deal of current interest in the use of eye movement recordings to investigate various mental processes. The common theme is that variations in eye movements indicate variations in the processing of what is being perceived, whether in reading, driving or scene perception. However, a number of problems of interpretation are now emerging, and this edited volume sets out to address these problems. The book investigates controversies concerning the variations in eye movements associated with reading ability, concerning the extent to which text is used by the guidance mechanism while reading, concerning the relationship between eye movements and the control of other body movements, the relationship between what is inspected and what is perceived, and concerning the role of visual control attention in the acquisition of complex perceptual-motor skills, in addition to the nature of the guidance mechanism itself.The origins of the volume are in discussions held at a meeting of the European Society for Cognitive Psychology (ESCOP) that was held in Wurzburg in September 1996. The discussions concerned the landing effect in reading, an effect, that if substantiated, would provide evidence of the use of parafoveal information in eye guidance, and these discussions were explored in more detail at a small meeting in Chamonix, in February 1997. Many of the contributors to this volume were present at the meeting, but the arguments were not resolved in Chamonix either. Other leaders in the field were invited to contribute to the discussion, and this volume is the product. The argument remains unresolved, but the problem is certainly clearer.

  • Psychology of Learning and Motivation

    Advances in Research and Theory
    • 1st Edition
    • Volume 38
    • English
    @from:General Description of the SeriesThe Psychology of Learning and Motivation publishes empirical and theoretical contributions in cognitive and experimental psychology, ranging from classical and instrumental conditioning to complex learning and problem solving. Each chapter provides a thoughtful integration of a body of work. @from:General Description of the VolumeVolume 38 covers emotional memory, metacomprehension of text, and intertemporal choice.

  • Neural Aspects of Tactile Sensation

    • 1st Edition
    • Volume 127
    • J.W. Morley
    • English
    The world within reach is characterised to a large extent by our ability to sense objects through touch. Research into the sensation of touch has a long history. However, it is only relatively recently that significant advances have been made in understanding how information about objects we touch is represented in both the peripheral and central divisions of the nervous systems. This volume draws together the increasing body of knowledge regarding the mechanisms underlying tactile sensation and how they relate to tactile perception.Individua... chapters address; the response of mechanoreceptors to stimuli (including movement and shape), the role of the somatosensory cortex in processing tactile information, the psychophysics and neurophysiology of the detection and categorisation of somesthetic stimuli, perceptual constancy, recent findings in regard to short term and long term plasticity in the somatosensory cortex and the psychophysical correlates of this plasticity, and parallel versus serial information processing in the cortex.The authors look at past and current research, and comment on the direction of future investigation, relating findings from psychophysical studies of tactile behavior to our growing understanding of the underlying neural mechanisms.

  • Handbook of Developmental Neurotoxicology

    • 1st Edition
    • William Slikker Jr. + 1 more
    • English
    The Handbook of Developmental Neurotoxicology provides a comprehensive account of the impacts, mechanisms, and clinical relevances of chemicals on the development of the nervous system. The book is written by internationally recognized experts on developmental neurotoxicology, covering subjects from basic neuro-development to toxic syndromes induced by various chemicals. It is an important text for both students and professionals who are interested in developmental neurobiology and neurotoxicology.

  • Brain Function in Hot Environment

    • 1st Edition
    • Volume 115
    • H.S. Sharma + 1 more
    • English
    Although problems relating to hyperthermia and heat stroke are well known since biblical times, until now the influence of heat or hyperthermia on the central nervous system has not been well documented. This book is the first to describe in detail the influences of hyperthermia on the CNS using the modern technology which has developed in the last 50 years in neuroscience. Hyperthermia is a common feature during fever, radiotherapy of tumours and exercise in hot environment. Statistically, hyperthermia and/or heat stroke is currently recognised as the third largest killer in America after head and spinal trauma and heart failure. However, studies on the mechanisms of heat-induced death or damage to the CNS are still lacking. This book aims to define the probable mechanisms of brain damage in hyperthermia which could be responsible for death of victims. Rational therapeutic measures based on the experimental findings are also described.The most important new aspect of the CNS function in hyperthermia suggests that the basic mechanisms of cell injury appears to be quite similar in nature. The severity of cell injury depends chiefly on the magnitude of the primary insult. Thus, it appears that hyperthermic brain injury is similar to the situation of trauma, ischemia and infarction. Baring this in mind, this book describes suitable models for hyperthermic injury which could be highly relevant to the study of mechanisms of cell injury in the CNS and to test various neuroprotective agents which may be found useful in the treatment of various traumatic, ischemic or degenerative diseases.In general the book will increase our basic understanding of brain function in hot environment and increase our awareness regarding heat as an important factor influencing our brain function at a time when global warming is described as a potential hazard to the biological system.This book is a refereed collection of 24 chapters written by several eminent scientists from different disciplines involved in basic and applied research in the CNS from various parts of the globe. It is hoped that the new aspects of brain function in hot environment compiled in this volume will provide an up-to-date ready reference which may serve as a strong scientific stimulus to many workers in this emerging field of neuroscience. Stimulating the exploration of the subject with novel ideas and/or experimental and clinical approaches in the future.

  • Memory

    • 1st Edition
    • Elizabeth Ligon Bjork + 1 more
    • English
    Authored by the foremost researchers in cognitive psychology, the handbook Memory is an outstanding reference tool for all cognitive psychologists and interested professionals. Memory provides an excellent synopsis of the research and literature in this field, including comprehensive chapters on basic theory. The text discusses storage and access of information in both short-term and long-term memory; how we control, monitor, and enhance memory; individual differences in mnemonic ability; and the processes of retrieval and retention, including eye-witness testimony, and training and instruction.

  • Advances in the Study of Behavior

    Stress and Behavior
    • 1st Edition
    • Volume 27
    • English
    Advances in the Study of Behavior continues to serve scientists across a wide spectrum of disciplines. Focusing on new theories and research developments with respect to behavioral ecology, evolutionarybiology, and comparative psychology, these volumes foster cooperation and communication in these diverse fields.

  • The Other Side of the Error Term

    Aging and Development as Model Systems in Cognitive Neuroscience
    • 1st Edition
    • Volume 125
    • N. Raz
    • English
    It has been said more than once in psychology that one person's effect is another person's error term. By minimising and occasionally ignoring individual and group variability cognitive psychology has yieled many fine achievements. However, when investigators are working with special populations, the subjects, and the unique nature of the sample, come into focus and become the goal in itself. For developmental psychologists, gerontologists and psychopathologists, research progresses with an eye on their target populations of study. Yet every good study in any of these domains inevitably has another dimension. Whenever a study is designed to turn a spotlight on a special population, the light is also shed on the mainstream from which the target deviates.This book examines what we can learn about general and universal phenomena in cognition and its brain substrates from examining the odd, the rare, the transient, the exceptional and the abnormal.

  • System Theories and A Priori Aspects of Perception

    • 1st Edition
    • Volume 126
    • J.S. Jordan
    • English
    This book takes as a starting point, John Dewey's article, The Reflex Arc Concept in Psychology, in which Dewey was calling for, in short, the utilisation of systems theories within psychology, theories of behaviour that capture its nature as a vastly-complex dynamic coordination of nested coordinations. This line of research was neglected as American psychology migrated towards behaviourism, where perception came to be thought of as being both a neural response to an external stimulus and a mediating neural stimulus leading to, or causing a muscular response. As such, perception becomes a question of how it is the perceiver creates neural representations of the physical world. Gestalt psychology, on the other hand, focused on perception itself, utilising the term Phenomenological Field; a term that elegantly nests perception and the organism within their respective, as well as relative, levels of organisation. With the development of servo-mechanisms during the second world war, systems theory began to take on momentum within psychology, and then in the 1970s William T Powers brought the notion of servo-control to perception in his book, Behavior: The Control of Perception. Since then, scientists have come to see nature not as linear chain of contingent cause-effect relationships, but rather, as a non linear, unpredictable nesting of self referential, emergent coordinations, best described as Chaos theory. The implications for perception are astounding, while maintaining the double-aspect nature of perception espoused by the Gestalt psychologists. In short, system theories model perception within the context of a functioning organism, so that objects of experience come to be seen as scale-dependent, psychophysically-neu... phenomenological transformations of energy structures, the dynamics of which are the result of evolution, and therefore, a priori to the individual case. This a priori, homological unity among brain perception and world is revealed through the use of systems theories and represents the thrust of this book. All the authors are applying some sort of systems theory to the psychology of perception. However, unlike Dewey we have close to a century of technology we can bring to bear upon the issue. This book should be seen as a collection of such efforts.

  • International Review of Neurobiology

    • 1st Edition
    • Volume 42
    • English
    Volume 42 presents an in-depth review on Alzheimer's Disease as well as a look at several transcription factors.

  • Cerebral Asymmetries in Sensory and Perceptual Processing

    • 1st Edition
    • Volume 123
    • S. Christman
    • English
    The purpose of the book is to provide a comprehensive overview of hemispheric differences in sensory and perceptual processing. The first section of the book deals directly with the intra- and inter-hemispheric processing of spatial and temporal frequencies in the visual modality. The second section addresses the initial interaction between sensory and cognitive mechanisms, dealing with how the left and right cerebral hemispheres differ in their computation and representation of sensory information. The third section covers how attentional mechanisms modulate the nature of perceptual processing in the cerebral hemispheres. Section four consists of a single chapter which reviews evidence suggesting a functional linkage between upper and right visual field processing, on the one hand, and lower and left visual field processing on the other.

  • Measurement, Judgment, and Decision Making

    • 1st Edition
    • Michael H. Birnbaum
    • English
    Measurement, Judgment, and Decision Making provides an excellent introduction to measurement, which is one of the most basic issues of the science of psychology and the key to science. Written by leading researchers, the book covers measurement, psychophysical scaling, multidimensional scaling, stimulus categorization, and behavioral decision making. Each chapter provides a useful handbook summary and unlocks the door for a scholar who desires entry to that field. Any psychologist who manipulates an independent variable that affects a psychological construct or who uses a numerical dependent variable to measure a psychological construct will want to study this book.

  • Psychology of Learning and Motivation

    Advances in Research and Theory
    • 1st Edition
    • Volume 37
    • English
    The Psychology of Learning and Motivation publishes empirical and theoretical contributions in cognitive and experimental psychology, ranging from classical and instrumental conditioning to complex learning and problem solving. Each chapter provides a thoughtful integration of a body of work.

  • The Cerebellum and Cognition

    • 1st Edition
    • Volume 41
    • English
    The Cerebellum and Cognition pulls together a preeminent group of authors. The cerebellum has been previously considered as a highly complex structure involved only with motor control. The cerebellum is essential to nonmotor functions, and recent research has revealed new medically important roles of the cerebellum and cognitive processes.

  • Perceptual learning

    Advances in Research and Theory
    • 1st Edition
    • Volume 36
    • English
    The Psychology of Learning and Motivation publishes empirical and theoretical contributions in cognitive and experimental psychology, ranging from classical and instrumental conditioning to complex learning and problem solving. Each chapter provides a thoughtful integration of a body of work.

  • Tasting and Smelling

    • 1st Edition
    • Gary K. Beauchamp + 1 more
    • English
    Tasting and Smelling presents a comprehensive overview to research on these two important modes of perception. The book offers a review of research findings on the biophysics, neurophysiology, and psychophysicsof both senses, as well as discussing the emotional component associated with taste and smell, and clinical disorders affecting each of these two senses. Tasting and Smelling answers how odors and flavors are perceived, why we have favorites, and what happens when our senses go awry. This book is of interest to the researcher in perception, cognition, or neurophysiology.

  • Developing Brain Behaviour

    The Role of Lipids in Infant Formula
    • 1st Edition
    • John Dobbing
    • English
    Certain long chain polyunsaturated fatty acids (LCPUFAs) are thought to be essential components of the nutrition of infants, including those prematurely born, in the sense that they cannot be synthesises by the immature organism and must therefore be supplied in the diet. Breast milk contains these substances, but many manufactured infant formulae do not.An absence of dietary LCPUFAs has been thought to affect the development of the brain and retina, possibly leading to abnormalties in cognitive and visual function. Considerable multidisciplinary research has been carried out to investigate this proposition. Diets free from LCPUFAs have been compared with supplemented formulae, or with breast milk.The conclusions from this research were critically examined by a group of leading paediatricians, nutritionists, experts in visual science and developmental behavioural scientists at a 'Dobbing Workshop' held in the United States in late February, 1997. Each of the Chapters was precirculated to the whole group, commented on before the Workshop, and then exhaustively discussed. The Chapters and Commentaries which are published here have therefore undergone a more extensive peer-review process than is usually the case.

  • Serotonin Receptors and their Ligands

    • 1st Edition
    • Volume 27
    • B. Olivier + 2 more
    • English
    An international group of authors have produced an overview of the progress made in the medicinal chemistry of compounds (selectively) acting at serotonin receptors or serotonin transporters either as agonists, partial agonists or antagonists.Structur... - affinity relationships and structure - activity relationships of agonists, partial agonists, and antagonists of 5-HT receptors and uptake sites, are discussed. Structure, sequence homology and the effect of site-directed mutations of 5-HT receptors and the reuptake site on the binding of ligands show the tremendous impact of molecular biology on medicinal chemistry research. Also discussed is the pharmacology and (potential) clinical applications of ligands for the 5-HT receptors and the reuptake site. By developing elegant techniques of cloning and expression of serotonin receptor subtypes, their mutants and chimeras, a unique opportunity was offered to study the binding mode of serotoninergic ligands to their receptors and transporters.The distribution, structure and homologies of serotonin receptor subtypes and the structure of the serotonin transporter are also taken into account.The (potential) therapeutic applications of ligands of the different subtypes are described.Altogether an excellent addition to the Pharmacochemical Library series.

  • Time and Behaviour

    Psychological and Neurobehavioural Analyses
    • 1st Edition
    • Volume 120
    • C.M. Bradshaw + 1 more
    • English
    That time is both a dimension of behaviour and a ubiquitous controlling variable in the lives of all living things has been well recognized for many years.The last decade has seen a burgeoning of interest in the quantitative analysis of timing behaviour, and progress during the last five or six years has been particularly impressive, with the publication of several major new theoretical contributions.There has also been considerable progress in behavioural methodology during the past decade. In the area of reinforcement schedules, for example, the venerable interresponse–time schedule, fixed–interval peak procedure and interval bisection task have been complemented by a 'second generation' of incisive instruments for analyzing timing behaviour.Another area of recent development is the analysis of the neurobiological substrate of timing behaviour. Several research groups are currently studying the involvement of various central neurotransmitter systems in the timing behaviour, and the ability of centrally acting drugs and discrete brain lesions to alter timing processes. Yet another recent development in timing research is the growing dialogue between two fields that have grown up separately, although, superficially at least, they seem to have much in common: the experimental analysis of 'interval timing', traditionally the province of experimental psychology, and behavioural chronobiology. The last few years have seen a growing interest in the comparative properties of the internal 'clocks' that regulate biobehavioural rhythms with time bases in the circadian range or longer, and those that are entailed in timing of intervals in the range of seconds or minutes.All these areas of research, and others, are represented in the chapters that make up this volume. This book will help to promote further interactions among researchers who hail from disparate disciplines, but who share a common interest in the temporal properties of behaviour.

  • Advances in Pharmacology

    • 1st Edition
    • Volume 39
    • English
    Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular bases of drug action, both applied and experimental.

  • The Cerebellum: From Structure to Control

    • 1st Edition
    • Volume 114
    • C.I. De Zeeuw + 2 more
    • English
    Many of the cerebellar scientists of the established generation have contributed substantially to the quality of this issue. In addition, the book is marked by chapters from the coming generations of scientists who will determine the direction of cerebellar research for the next century. As in other fields of neuroscience, this research will be dominated by molecular neurobiology and new functional imaging techniques. Altogether, the book is pluriform and unique in that it is multidisciplinary, in that it promotes different views on cerebellar function, and that it is being published on the verge of different era's dominated by different generations of cerebellar scientists. The wealth of new information and ideas contained in these important papers will stimulate even more intensive research in the twenty-first century leading to a greater understanding of cerebellar function(s).

  • Anomia

    Neuroanatomical and Cognitive Correlates
    • 1st Edition
    • Harold Goodglass + 1 more
    • English
    Anomia is the inability to access spoken names for objects, most often associated with the elderly or those with brain damage to the left hemisphere. Anomia offers the state-of-the-art review of disorders of naming, written by acknowledged experts from around the world, approached from both clinical and theoretical viewpoints. Goodglass, known around the world for his research in aphasia and speech pathology, edits this first book devoted exclusively to naming and its disorders. Wingfield is known for his classic studies of lexical processing in aphasic and normal speakers. The book includes comprehensive literature reviews, a summary of relevant research data, as well as astudy of recent advances in cognitive analysis and anatomic findings. Anomia is an immensely useful work for all those involved in the study of language, particularly those in cognitive neuroscience, neurology, speech pathology, and linguistics.

  • Atlas of the Human Brain

    • 1st Edition
    • Juergen K Mai + 2 more
    • English
    This unique atlas of the human brain correlates studies of post mortem tissue with the in situ, cross-sectional brain and MRIs of the same brain in situ with in vivo images from normal volunteers. This atlas contains a series of maps, each featuring different aspects of brain morphology and topography. The atlas is divided into two sections: the Topographic and Topometric Atlas and the Myeloarchitectonic Atlas. The Topographic and Topometric atlas presents the surface anatomy of the brain over a topometric grid, together with corresponding in situ sections of the entire head, placed on stereotaxic grids in order to emphasize the brain. The part of the atlas is further divided into three sections: the Horizontal, the Coronal, and the Sagittal. The Myeloarchitectonic atlas presents 69 myelin-stained sections cut perpendicular to the intercommissural line depicting mainly subcortical structures. Each plate has corresponding schematic diagrams defining position, extent, and relationship of nuclei and pathways of the forebrain and mesencephalon.

  • The Primate Nervous System, Part I

    • 1st Edition
    • Volume 13
    • Floyd E. Bloom + 2 more
    • English
    This volume is a new, timely and fitting extension to the Handbook of Chemical Neuroanatomy, focussing on the neurochemical circuitry of the primate brain. The book will compliment the growing efforts to apply the analytical strategies of chemical neuroanatomy to the primate brain.The goal of this volume is to develop a broad-based coverage of human and non-human primate chemical neuroanatomic details together within a volume in which details on transmitters and systems can be appreciated.The eight comprehensive chapters that comprise this volume deal with large global concepts and datasets which not only create an initial coverage of the entire primate neuraxis, but also capture useful points of information on the chemical neuranatomy of the primate nervous system.An excellent, informative book, and a welcome addition to the sparse literature in this field.

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