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Excitatory Amino Acids
Clinical Results with Antagonists
- 1st Edition - January 10, 1997
- Editor: Paul L. Herrling
- Language: English
- Paperback ISBN:9 7 8 - 0 - 1 2 - 3 9 9 5 0 6 - 3
- Hardback ISBN:9 7 8 - 0 - 1 2 - 5 4 6 8 2 0 - 6
- eBook ISBN:9 7 8 - 0 - 0 8 - 0 5 3 1 3 4 - 2
Glutamate is the major excitatory neurotransmitter in the brain and dysfunction of glutamate transmission is the likely cause of a variety of diseases including neurodegeneration… Read more
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Request a sales quoteGlutamate is the major excitatory neurotransmitter in the brain and dysfunction of glutamate transmission is the likely cause of a variety of diseases including neurodegeneration following cerebral ischemia, Huntington's chorea, amyotrophic lateral sclerosis, epilepsy, spasticity, emesis, chronic pain, and schizophrenia. Excitatory amino acid receptor agonists and antagonists are therefore of major interest as potential drugs for central nervous system disorders. Excitatory Amino Acids is the first book entirely dedicated to the results of human testing of modulators of excitatory amino acid neurotransmitters.
- Coverage of the field of excitatory amino acids from synaptic function to preclinical and clinical pharmacology
- Description of the development of NMDA (Nmethyl-d-aspartate) and non-NMDA antagonists
- Reports of potential drugs in early and late clinical stages of development
Neuroscientists; neuropharmacologists in the pharmaceutical industry, and neurologists
M. Schmutz, A. Arthur, H. Faleck, G. Karlsson, A. Kotake, L. Landwicki, L. LaRue, S. Markabi, D. Murphy, M. Powell, and D. Sauer, Selfotel.
P. Herrling et al., D-CPPene (SDZ EAA-494) A Competitive NMDA Antagonist: Pharmacology and Results in Humans.
J.D. Kristensen, Intrathecal Administration of a Competitive NMDA Receptor Antagonist for Pain Treatment.
A.G. Knapp, L.I. Matthews, and E.R. Gamzu, Clinical Experience with the NMDA Ion-Channel Blocker, Aptiganel Hydrochloride (CEROSTAT).
M.-L. Maccecchini, Development of ACPC: A Partial Agonist of the Glycine Site on the NMDA Receptor.
Carter et al., Ifenprodil and Eliprodil: Neuroprotective NMDA Receptor Antagonists and Calcium Channel Blockers.
D. Lodge and D.D. Schoepp, 3S, 8aR-6-[2-(1(2)H-tetrazole-5-y)ethyl] Decahydroisoquinoline-3-carboxylic Acid (LY293558) and Its Racemate (LY215490): A Selective and Competitive AMPA/Kainate Receptor Agonist.
L. Nordholm, M. Sheardown, and T. Honore, The NBQX Story.
E. Louvel, Riluzole in Amytrophic Lateral Sclerosis.
G.C. Plamer and J.B. Hutchinson, Preclinical and Clinical Aspects of Remacemide Hydrochloride.
P. Herrling et al., D-CPPene (SDZ EAA-494) A Competitive NMDA Antagonist: Pharmacology and Results in Humans.
J.D. Kristensen, Intrathecal Administration of a Competitive NMDA Receptor Antagonist for Pain Treatment.
A.G. Knapp, L.I. Matthews, and E.R. Gamzu, Clinical Experience with the NMDA Ion-Channel Blocker, Aptiganel Hydrochloride (CEROSTAT).
M.-L. Maccecchini, Development of ACPC: A Partial Agonist of the Glycine Site on the NMDA Receptor.
Carter et al., Ifenprodil and Eliprodil: Neuroprotective NMDA Receptor Antagonists and Calcium Channel Blockers.
D. Lodge and D.D. Schoepp, 3S, 8aR-6-[2-(1(2)H-tetrazole-5-y)ethyl] Decahydroisoquinoline-3-carboxylic Acid (LY293558) and Its Racemate (LY215490): A Selective and Competitive AMPA/Kainate Receptor Agonist.
L. Nordholm, M. Sheardown, and T. Honore, The NBQX Story.
E. Louvel, Riluzole in Amytrophic Lateral Sclerosis.
G.C. Plamer and J.B. Hutchinson, Preclinical and Clinical Aspects of Remacemide Hydrochloride.
- No. of pages: 156
- Language: English
- Edition: 1
- Published: January 10, 1997
- Imprint: Academic Press
- Paperback ISBN: 9780123995063
- Hardback ISBN: 9780125468206
- eBook ISBN: 9780080531342
PH
Paul L. Herrling
Paul L. Herrling is currently Head of Corporate Research at Sandoz Pharmacies in Basel, Switzerland.
Affiliations and expertise
Sandoz Research Institute, Berne, Switzerland