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Books in Molecular biology cellular biology and genetics

This collection offers insights into gene expression, cell signalling, and genetic regulation. Supporting researchers, clinicians, and students, it features advanced techniques, genetic engineering, and disease mechanisms, fostering innovations in personalized medicine, regenerative therapies, and molecular diagnostics.

  • Protein Termini Part A

    • 1st Edition
    • Volume 718
    • English
    Protein termini represent a major route to protein regulation. From the moment the very first amino acid of a polypeptide chain exits the ribosome there is potential for steering from the cellular environment. This volume of Methods in Enzymology Modifications and Targeting of Protein Termini focuses on Protein N-termini and C-termini and their modifications which include acetylation, arginylation, myristoylation and oxidation. Also, the impact of terminal modifications is covered, in particular the impact on protein turnover and the ubiquitin E3 ligases which specifically recognize protein N-termini (N-degrons) and C-termini (C-degrons). In addition to the detailed methods and laboratory protocols, the chapters include informative overviews and reviews of the different subfields.

  • Digital Health Maturity: Quality, Interoperability, and Innovation

    • 1st Edition
    • Siaw-Teng Liaw + 3 more
    • English
    Digital Health Maturity: Quality, Interoperability, and Innovation provides a roadmap to move from endless pilots and ad hoc system purchase to a systematic, stepwise, and integrated approach to increasing digital health capacity. Specific guidelines, tools, and use cases are discussed to show how the digital health maturity metamodel (DHM3) can be put into actual practice. The book discusses topics such as foundations of digital health and how to put them into practice; organizational considerations for implementation; and best practices, tools, and pitfalls to avoid. In addition, it discusses the future of digital transformation and the impact of a global adherence to digital health. It is a valuable resource for researchers, students, policy makers, governments and anyone who is interested in learning more about digital health and its benefits worldwide.

  • Epigenetics Methods

    • 2nd Edition
    • Trygve O. Tollefsbol
    • English
    Epigenetics Methods, Second Edition offers an extensive overview of the tools that enhance translational epigenetics studies. This edition includes updated and revised chapters, along with newly added topics such as MALDI-TOF-MS for analyzing DNA methylation and the RIP assay for lncRNA binding. Specialists provide step-by-step guidance on methods used to study various epigenetic mechanisms. The book covers both fundamental and advanced techniques, making it an essential resource for researchers in this dynamic field. In addition to DNA methylation and histone modification techniques, the book also explores chromatin evaluation, enzyme analyses, and non-coding RNAs as epigenetic modulators.New chapters discuss recent advancements like single-cell epigenomics, epigenetic editing, and computational epigenetics. The volume addresses reproducibility issues and offers consensus-driven methods to unify approaches across experiments and labs. This edition is a vital reference for understanding and employing cutting-edge epigenetics methods.

  • Healthcare Applications of Neuro-Symbolic Artificial Intelligence

    • 1st Edition
    • Boris Galitsky
    • English
    Healthcare Applications of Neuro-Symbolic Artificial Intelligence provides a comprehensive introduction to the field of neuro-symbolic (NS) artificial intelligence (AI), presenting the most recent advances in deep learning and integration of NS systems and large language models (LLMs). This book evaluates traditional approaches, current approaches, as well as the author’s own approach to NS, to create hybrid architectures and reasoning techniques to overcome the limitations of most existing AI systems such as deep learning, neural networks, and symbolic AI.This book will be a welcome resource for researchers and graduate students in AI, natural language processing, and biomedical informatics, as well as professionals in software development looking to redesign current systems to leverage LLMs through the health application of NS architecture.

  • The Emerging Genomic Landscape of Complex Immune-Mediated Traits

    • 1st Edition
    • Volume 114
    • English
    The Emerging Genomic Landscape of Complex Immune-Mediated Traits, Volume 114 in the Advances in Genetics series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Unraveling the Interplay of Genetic Variants and Epigenetic Signatures in Complex traits, Crosstalk between T Cell Gene Regulation and Intestinal Epithelial Cells: Insights into Mucosal Immunity, Understanding the link between regulatory RNA regions and genomic variation with coeliac disease, Interplay Between the Host Genome, Autoimmune Disease and Infection, and Organoids and gut-on-chip as powerful tools to model the genetics of intestinal mucosal inflammation.

  • Pharmacoepigenetics

    • 2nd Edition
    • Volume 10
    • Ramón Cacabelos
    • English
    Pharmacoepigenetics, Second Edition, Volume Ten in the Translational Epigenetics series, is a comprehensive reference on the role of epigenetics and epigenomics in drug discovery and development. Here, leading international researchers from across academia, clinical settings, and the pharmaceutical industry discuss the influence of epigenetics and epigenomics in human pathology, epigenetic biomarkers for disease prediction, diagnosis, and treatment, current epigenetic drugs, and the application of epigenetic procedures in drug development. Throughout the book, chapter authors offer a balanced and objective discussion of the future of pharmacoepigenetics and its crucial contribution to the growth of precision and personalized medicine.This new edition has been fully revised to address recent advances in epigenetics, from new natural and synthetic compounds with epigenetic effects to the role of epigenetics in the pathogenesis of a growing number of complex diseases, including further cancers, cardiovascular disorders, and brain disorders. Newly identified molecular components in the functional architecture of the epigenetic machinery, as well as practical and relevant pharmacoepigenetics topics related to COVID-19 and other world health challenges are also discussed.

  • Metagenomics for Microbiology

    • 2nd Edition
    • Jacques Izard + 1 more
    • English
    Metagenomics for Microbiology, Second Edition unveils the intricate and diverse world of microbial communities, emphasizing their critical roles in health, disease, and ecosystem functionality. This updated edition addresses the significant challenges in the field and introduces promising approaches to make metagenomics research more feasible. Through comprehensive revisions and over five new chapters, readers are equipped with the latest research data and analyses, advancing their understanding of microbial principles. Notably, this edition provides a robust foundation for the design and analysis of omics studies, focusing on technological underpinnings and practical applications. It remains an essential resource for characterizing microbial consortia.

  • Cytokine-Based Immunotherapy - Part A

    • 1st Edition
    • Volume 396
    • English
    Cytokine-Based immunotherapy, Volume 396, Part A delves into the intricate world of cytokines, vital signaling proteins that orchestrate the immune response and their pivotal role in modulating various immune functions. From their fundamental mechanisms to their therapeutic applications, this book offers a thorough examination of the latest trends and developments in leveraging cytokines for immunotherapy. The book includes chapters such as Cytokine-driven cancer immune evasion mechanisms, which explores how cytokines contribute to cancer cells' ability to evade the immune system. Cytokine-based immunotherapy in hematolymphoid malignancies is also explored, discussing the use of cytokines in treating blood cancers.Targeting TNF-alpha examines the immunotherapeutic approach for alleviating neuropathic pain. The key role of immunomodulatory cytokines for the development of novel nk cell-based cancer therapies focuses on the importance of cytokines in developing new cancer treatments. Finally, complexities in the clinical development of TGFβ inhibitors covers the challenges in creating inhibitors for TGFβ.

  • Biosensing the Future

    Wearable, Ingestible and Implantable Technologies for Health and Wellness Monitoring Part A
    • 1st Edition
    • Volume 215
    • English
    Biosensing the Future: Wearable, Ingestible and Implantable Technologies for Health and Wellness Monitoring, Part A, Volume 215 offers a comprehensive exploration of biosensing technologies and their transformative impact on modern healthcare. Chapters in this new release include Technologies and emerging trends in wearable biosensing, Implantable biosensors: advancements and applications, Neural implants: restoring function and enhancing quality of life, Ingestible biosensors: monitoring health from within, Ingestible biosensors for monitoring digestive health and nutritional monitoring, and much more.Other chapters cover Ingestible biosensors for drug delivery monitoring, Artificial intelligence in wearable biosensing: enhancing data analysis and decision-making, Wearable Privacy, Ethical and regulatory landscape of wearable, ingestible, and implantable technologies, Characterization of skeletal muscle contraction using a flexible and wearable ultrasonic sensor, and more.

  • Immuno-oncology and Immunotherapy Part D

    • 1st Edition
    • Volume 196
    • English
    Immuno-oncology and immunotherapy, Part D, Volume 196 in the Methods in Cell Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Investigating the endothelial-immune axis in cancer, Establishing Tyro3, Axl, and Mertk Chinese Hamster Ovary (CHO) Reporter Cell Lines for Cancer Immunology and Therapeutic Applications, Amino acid analog-based labelling of the immunomodulatory cancer secretome, Human and mouse iNKT cell expansion and engineering with viral vectors, Next-generation deconvolution of the tumor microenvironment with omnideconv, and much more.Additional sections cover Comprehensive prediction of tumor neoantigens with NextNEOpi, Ex vivo profiling of organotypic tumor spheroids in 3D microfluidic culture, A flow cytometry-based assay for evaluation of T cell activation and degranulation in coculture systems, An adenosine production assay suitable for 2D and 3D cancer cell culture, Determination of lactate in the tumor interstitial fluid, Combined in vitro differentiation and cell sorting-based isolation of highly pure mouse bone marrow-derived basophils, Organ-on-Chip immunostaining method for three-dimensional identification and study of immune cells responding to drug-treated tumor cells, and much more.

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