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Elsevier

Books in Molecular biology cellular biology and genetics

This collection offers insights into gene expression, cell signalling, and genetic regulation. Supporting researchers, clinicians, and students, it features advanced techniques, genetic engineering, and disease mechanisms, fostering innovations in personalized medicine, regenerative therapies, and molecular diagnostics.

  • Cell Death Part B

    • 1st Edition
    • Volume 206
    • English
    Cell Death Part B continues the comprehensive exploration of cellular mechanisms governing the fate of cells in health and disease. This volume delves deeper into the molecular pathways, regulatory networks, and biological consequences of various cell death modalities, including apoptosis, necrosis, autophagy, ferroptosis, pyroptosis, and other emerging forms.

  • Structural Studies of Amyloid-Forming Peptides

    • 1st Edition
    • Volume 729
    • English
    Structural Study of Amyloid-β, Volume 729 in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters on important topics such as the Extraction of Amyloids from Neurodegenerative Disease Tissues for Structural Analysis, Cryo-EM Structure Determination of Amyloid Fibrils: Methodology, Insights, and Practical Tools, Methods for studying molecular architecture of Ab aggregates in tissues using cryo-ET, Cryo-EM methods to study binding between amyloid fibrils and chemical compounds or ligan, Dynamics studies of side-chains and hydration shells in amyloid-beta fibrils using deuterium and oxygen-17 solid-state NMR, and much more.Additional chapters cover the Technical aspects of pressure jump NMR applied to the study of Abeta and protein oligomerization, Characterizations of the beta-amyloid-membran... interaction intermediates, Time-resolved solid-state NMR studies of oligomer formation, Methods for characterizing the individual filament structures of amyloid peptide assemblies using atomic force microscopy, Single-molecule fluorescence spectroscopy and imaging on heterogeneous amyloid beta aggregation, Two-dimensional FT-IR methods on amyloid aggregation and folding pathways, and much more.

  • Cerebellum Development and Disease

    • 1st Edition
    • Volume 167
    • English
    Cerebellum Development and Disease, Volume 167 offers a comprehensive overview of the intricate processes underlying the formation, maturation, and function of the cerebellum, as well as the wide spectrum of disorders that can affect this essential brain region. Chapters in this new release cover Olivocerebellar circuit development as a substrate for dystonia pathogenesis, Simply complex – that structure of the cerebellar neuronal lineage, Ontogenesis and diversification of cerebellar glia: a developmental perspective, Purkinje cell diversification: a blueprint for cerebellar development, patterning, and evolution, On the Emergence of Folding in the Cerebellum, Scaling and regeneration in the developing cerebellum, ASTN2 in ASD and Neurodevelopmental Disorders, and much more.Additional sections focus on Stem cell-derived in vitro models of human cerebellar development, Development of Spinocerebellar System within the Precerebellar Network, and Cerebellum evo-devo. The book brings together leading experts in neurodevelopment, neurobiology, genetics, and clinical neurosciences to explore the molecular and cellular mechanisms guiding cerebellar development, from embryogenesis to adulthood.

  • Artificial Intelligence for Multi-omics Analysis Part A

    • 1st Edition
    • Volume 221
    • English
    Artificial Intelligence for Multi-omics Analysis, Part A, Volume 221 in the Progress in Molecular Biology and Translational Science series, highlights new advances in the field, with this new volume presenting interesting chapters on topics such as an Introduction to Artificial Intelligence in Multi-omics Analysis, Multi‐omics application in health and diseases, Artificial Intelligence in Genomics Analysis, Artificial Intelligence in Single-cell and Spatial Transcriptomics Data, Artificial Intelligence in the prediction of 3D chromatin structure and gene regulation, Artificial intelligence in Mass Spectrometry-based Proteomics, Integrating Artificial Intelligence into Metabolomics for Predicting Diseases, and more.Additional chapters cover Artificial Intelligence in Microbial Metagenomics, Artificial Intelligence in Interactomics, Artificial Intelligence Integration in Medical Imaging Data, AI in biomolecular structural data analysis, Artificial intelligence in Cryo-Electron Microscope data, Explainable artificial intelligence for multi-omics data, and Multi-Omics Cancer Stratification: from Statistical to Deep Learning Perspective.

  • Cell Death Part A

    • 1st Edition
    • Volume 205
    • English
    Cell Death, Part A, Volume 205 explores the diverse mechanisms and methodologies underlying cell death, providing an up-to-date resource for researchers and clinicians in the biomedical sciences. Chapters in this new release include Methodologies for Monitoring Alkaliptosis in Cancer Cells, Protein-complementat... assay and DISC analysis, Detecting phosphorylated MLKL in murine tissues, Establishment of different cell death models (Apoptosis, Necroptosis, Pyroptosis), Implementation of the FENIX assay to determine anti-ferroptotic properties of test compounds, CRISPR-Cas9 knockout screens to identify drug resistance genes in Acute Myeloid Leukemia, and much more.Additional chapters cover Cell death assays for the detection of acute kidney tubular necrosis, Methods of cell death imaging by Incucyte and similar platforms, Super-resolution microscopy-based assessment of organellar redox-active iron distribution and its relevance for ferroptosis, Monitoring inflammasome activation by analyzing ASC specks and oligomerization, LPS-induced sepsis/ and TNF-induced SIRS (In vivo cell death models), Evaluating protease activation and inactivation of gasdermin cell death effectors, and Measurement of plasma membrane rupture via confocal microscopy.

  • Fundamentals of Molecular Structural Biology

    • 2nd Edition
    • Subrata Pal
    • English
    Fundamentals of Molecular Structural Biology, Second Edition reviews the mathematical and physical foundations of molecular structural biology, covering the latest advancements. The book begins with historical perspectives before exploring mathematical concepts, physical aspects of chemistry, the chemical basis of biology, structural analysis, visualization, protein folding, transcription, RNA processing, cell signaling, and computational molecular biology. Additionally, this new edition delves into AI fundamentals and applications, including AlphaFold and RoseTTAFold. This fully updated edition provides a detailed overview of the fundamental concepts across molecular structural biology and acts as an ideal guide for researchers and advanced students.Given the increasingly interdisciplinary nature of this subject, this book provides early career researchers and those shifting into an adjacent field a "fundamentals" resource to get them up-to-speed on the foundations of a particular field.

  • Immunomodulators - Part A

    • 1st Edition
    • Volume 151
    • English
    Immodulators, Volume 151 explores the pivotal role immodulators play in regulating immune responses for health and disease management. The book provides an in-depth overview of various classes of immunomodulatory agents, including biologics, small molecules, natural compounds, and synthetic drugs, examining their mechanisms of action and therapeutic applications. Chapters in this new release include Marine-Derived Polysaccharides and Peptides as Next-Generation Immunomodulators: Molecular Mechanisms, Therapeutic Potential, and Translational Challenges, Advances in Immunomodulation: From Dietary Influence to Computational Precision, iPSC-derived immunotherapy for Tau and Alzheimer's disease, and much more.Additional sections cover Antibodies targeting amyloid-β and Tau oligomers in Alzheimer's Disease, Biosimilars: Antibody and Nanobody Based Therapeutic Approaches Towards Protein Misfolding Diseases, Immunomodulator drugs: mechanisms of action and systemic effects, Microbiome and microbial products as immunomodulators: implication for gastrointestinal cancers, Integration of Network pharmacology, docking, and dynamics analysis to investigate the immunomodulatory activity of Pongamia pinnata, Transcriptomic Insights into Epigenetic and Immunomodulatory Roles of Nuclear Histone Genes in Bladder Cancer: A bioinformatics Approach, Utilizing DREIMT Database for Drug Prioritization in Immunomodulatory Therapy for Psoriasis and Psoriatic Arthritis, and many additional topics.

  • 2D and 3D Cellular Screening Models and AI Guided Analysis

    • 1st Edition
    • Volume 204
    • English
    2D and 3D Cellular Screening Models and AI Guided Analysis, Volume 204 explores the development, application, and comparative benefits of 2D monolayer cultures and 3D organoids, spheroids, and tissue-engineered constructs for biomedical research and drug discovery. Chapters in this new release include High throughput CellTiter-glo viability assessment, Assessing viability of cancer cell spheroids in 3D drug screening, 3D killing assay of cancer spheroids by cytotoxic T lymphocytes in anchored microfluidic droplets, Use of micropatterning for 3D cell culture, Use of microfluidic chip devices for assessing the effect of radiation on 3D cell culture models, and much more.Additional chapters cover A 3D model for assessing regulated cell death modalities, YOLO detection model for Cell Viability assessment, Bioinformatics and AI/ML approaches using multi-omics data to accelerate diagnosis and delivery of precision care, Automated image analysis and machine learning for the assessment of mitochondrial membrane potential, Assessing cancer cell heterogeneity in patient-derived tumoroids, Assessment of lysosomal drug sequestration and release using fluorescence microscopy, Assessment of T cell toxicity in ex-vivo models of cancer, Three-dimensional Organoid Screening using Leica Thunder Microscope, Using vascularized organoids-on-chip for assessing systemic drug delivery, and many more interesting and timely topics.

  • Autophagy – Part A

    • 1st Edition
    • Volume 403
    • English
    Autophagy – Part A, Volume 403 explores the fundamental biological process of autophagy. Beginning with the historical discovery and molecular mechanisms of autophagy, the book delves into its regulation, physiological roles, and significance in maintaining cellular homeostasis. Chapters in this new release include Ciliophagy: Maintaining Primary Cilium Homeostasis to Prevent Cilium-Related Diseases, Unraveling the interplay of glycolysis, lactylation, and autophagy, Autophagy and Type 2 Diabetes: Bridging the Gap in Metabolic Health, Autophagy in Cancer Cachexia: From Mechanisms to Therapeutic Opportunities, Glycophagy: A Selective Autophagy Pathway for Glycogen Degradation, Role of Autophagy in Adipose Tissue: Implications for Metabolic Health, and more.

  • Epigenetic Regulation of Cancer - Part E

    • 1st Edition
    • Volume 400
    • English
    Epigenetic Regulation of Cancer, Part E, Volume 400 in the International Review of Cell and Molecular Biology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of hot topics, including Epigenetic regulation of cancer, Phytochemicals with epigenetic properties and their role in melanoma therapy, Epigenetic Insights of MicroRNAs: Pioneering Cancer Detection via Advanced Biosensors, Epigenetic Regulation of Autophagy in Cancer: A Double-Edged Sword in Tumor Progression and Therapy Resistance, Epigenetic Regulation via Histone Modifications in Ovarian Cancer, The current findings and potential applications of breast cancer epigenetics, and much more.Other chapters cover the Application of bioinformatics and data science in studies of cancer epigenetics, and much more.

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