Protein Misfolding in Neurodegenerative Diseases
- 1st Edition - March 17, 2025
- Latest edition
- Authors: Neha Gogia, Sandeep Kumar Singh, Vidyadhara Devarunda Jaganath
- Language: English
Protein Misfolding in Neurodegenerative Diseases is a comprehensive review of proteome homeostasis in neurons, and in the brain. Beginning with an introduction on factors involved… Read more
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Description
Description
Protein Misfolding in Neurodegenerative Diseases is a comprehensive review of proteome homeostasis in neurons, and in the brain. Beginning with an introduction on factors involved in the formation and aggregation of misfolded proteins, chapters then discuss the precise cellular and molecular mechanisms involved in these processes and their role in neurodegeneration and disease. Additional topics of focus include protein clearance mechanisms like protein quality control, disease-modifiers, molecular druggable targets, novel therapeutics, and emerging techniques that block or delay disease onset or progression. This volume is relevant for researchers working with neurodegenerative diseases, including Alzheimer's disease, Parkinson’s disease, ALS, Creutzfeldt-Jakob disease, and more.
Key features
Key features
- Discusses underlying cellular and molecular mechanisms altered in protein-associated neurodegenerative disorders
- Describes methods for detection and analysis of protein aggregates
- Features advancements in therapeutics and emerging techniques to treat these disorders
- Covers implications in a variety of neurodegenerative diseases, including Alzheimer's, Parkinson’s, ALS, Creutzfeldt-Jakob disease, Cystic fibrosis, Gaucher's disease, and Polyglutamine diseases, including Huntington’s and other related proteinopathies
Readership
Readership
Neuroscientists, neurologists, cell and molecular biologists, structural biologists, computational biologists, bioinformaticians
Table of contents
Table of contents
2. Determinants of protein misfolding, aggregation in neuronal cell death
3. Classification, structure, and function of protein aggregates in proteinopathies
4. Protein aggregation and cellular and molecular mechanisms in neurodegenerative disease
5. Advances in methods to detect and study protein aggregation
6. Organelle specific protein quality control
7. Molecular chaperones and co-chaperones in proteostasis
8. The ubiquitin-Proteasome System (UPS) and Autophagy lysosomal proteolytic pathways
9. Alterations in protein quality control
10. Alternate mechanisms to maintain proteome homeostasis
11. Advances in developing novel therapeutics, strategies, approaches and use of emerging techniques
12. Challenges in translating laboratory findings to drug development
13. Advancements in drug delivery technologies for protein misfolding diseases
Product details
Product details
- Edition: 1
- Latest edition
- Published: March 20, 2025
- Language: English
About the authors
About the authors
NG
Neha Gogia
SS
Sandeep Kumar Singh
Dr. Sandeep Kumar Singh is Assistant Professor in the All India Institute of Medical Sciences (AIIMS), Nagpur, India. He obtained his PhD in Biotechnology from Banaras Hindu University and conducted postdoctoral research in the Department of Neurobiology at the University of Chicago. Dr. Singh brings 17 years of experience in neuroscience, molecular biology, neurodegenerative diseases, aging, nutraceuticals, and nanomedicines. He is a member of several scientific societies, including the American Academy of Neurology, International Society of Neurochemistry, Society of Neurochemistry, Indian Academy of Neurosciences, and Alzheimer’s and related Disorders Society of India. Dr. Singh has published five books, including Elsevier’s A New Era in Alzheimer’s Research and Genome Editing for Neurodegenerative Diseases.
VD