Molecular biology cellular biology and genetics print books and ebooks | Elsevier

Cryo-EM Methods and Management

1st Edition
Edward T. Eng + 2 more
English

Cryo-EM Methods and Management provides a detailed introduction to the latest advances of cryo-EM, from technical innovations to the logistical challenges of maintaining a modern cryo-EM facility. The book consists of four parts, beginning with an overview of cryo-EM. It then moves on to discuss Cryo-EM workflows, with chapters focusing on sample handling and preparation, data collection and hardware, and data procession and visualization. The third part centers on aspects of cryo-EM infrastructure and community building, considering facility set-up and management, monitoring facility performance, instrumentation monitoring , data sharing and standards, and training and development standards. The book then closes with a section looking towards future prospects for cryo-EM. This is an ideal reference for cryo-EM facility and lab managers, providing guidance to the often-overlooked aspect of facility building and management. Additionally researchers working with cryo-EM across molecular biology, structural biology, cell biology and biochemistry will benefit from this book.

Computational Approaches to Natural Products Discovery

1st Edition
Volume 730
English

Computational Approaches to Natural Products Discovery, Volume 720 provides descriptions of the latest techniques in computational methods for the study of natural products. Techniques covered are related to genome mining, natural product biosynthesis, natural product evolution, and natural product structure. Chapters in this new release cover Prediction of natural product bioactivity from BGC sequence to guide genome mining efforts, Genome mining for resistance genes to identify bioactive natural products with ARTS, Predicting lasso peptide structure with LassoPred, Predicting lanthipeptide structure with Rosetta, Using lsaBGC to investigate BGC Evolution, and an Analysis of BGC evolution with CORASON.

Medical and Health Genomics of South Asia

1st Edition
Dhavendra Kumar + 1 more
English

Medical and Health Genomics of South Asia, a new volume in the Genomic and Precision Medicine in Clinical Practice series, offers a thorough discussion of medical genomics as applied across South Asian nations, from India to Pakistan, Bangladesh, Sri Lanka, and Nepal, as well as in South Asian populations abroad. Here, global chapter authors consider genomic variation and the population heterogeneity of genetic, infectious, and lifestyle diseases in South Asia, along with successful modes of population health management for these inherited disorders and other applications of clinical genomics for improved individual health in the region.Adopting an applied approach, this book first reviews basic genomic models and population study formats, as well as the anthropological and genetic history of South Asia. The following sections examine genomic epidemiology and population health in the South Asian context; examples of genomic medicine's use in combating major health challenges in the region; genomic healthcare infrastructure; and related social, ethical, legal, and economic aspects central to impactful genomic medicine.

Chromatin Signaling and Diseases

2nd Edition
Olivier Binda + 2 more
English

Chromatin Signaling and Diseases, Second Edition, a volume in the Translational Epigenetics series, covers the molecular mechanisms that regulate gene expression, which governs embryonic development, growth, and human pathologies associated with aging, such as cancer. Although human genome sequencing continues to improve, molecular mechanisms regulating gene expression remain largely misunderstood. The impact of gene expression defects associated with malfunctioning chromatin signaling are considered in this update. In addition, this new edition has addresses developments in the field, from phase separation of membrane-less organelles and local segregation of factors to chromatinization of naked foreign DNA and cancer evolution as regulated by chromatin signaling.Chromatin signaling proposes that small protein domains recognize chemical modifications on the genome scaffolding histone proteins, facilitating the nucleation of enzymatic complexes at specific loci that then open up or shut down the access to genetic information, thereby regulating gene expression. The addition and removal of chemical modifications on histones, as well as the proteins that specifically recognize these are also considered.

Cell Death Part A

1st Edition
Volume 205
English

This comprehensive volume explores the diverse mechanisms and methodologies underlying cell death, providing an up-to-date resource for researchers and clinicians in the biomedical sciences. The book brings together leading experts to discuss both established and emerging approaches for studying cell death, with a strong emphasis on practical laboratory techniques and their applications in disease research and drug discovery.

RNases in Health and Diseases

From Housekeeping Enzymes to Moonlight Proteins

1st Edition
Ester Boix
English

RNases in Health and Diseases: From Housekeeping Enzymes to Moonlight Proteins presents a comprehensive exploration of the structural and functional properties of RNases, revealing their importance well beyond basic cellular maintenance. The book introduces readers to the evolving landscape of RNase research, including their multifaceted roles and newly discovered capabilities. Particularly notable are their contributions to the generation of non-coding signaling RNAs and their emerging potential as tools for diagnostics and therapy. The content is organized into three distinct sections, beginning with RNase structure and continuing with research methods and advanced tools for studying these enzymes.In addition to foundational knowledge, the final section investigates the connections between RNases and various diseases, illustrating their clinical relevance. This resource offers both researchers and students a broad perspective, making it valuable for anyone seeking a solid background in RNase biology. Readers will gain insights into recent breakthroughs, research techniques, and the therapeutic possibilities that position RNases at the forefront of biomedical innovation.

Sustainable Microalgal Biorefinery

1st Edition
Naim Rashid + 1 more
English

Sustainable Microalgal Biorefinery, a new release in the Developments in Microbial Cell Factories: From Design to Commercial Production series, introduces readers to the cellular biology of microalgae and explores their transformative potential across multiple industries. The book begins with a comprehensive overview of microalgae biorefinery systems, highlighting the latest research and the current challenges in the field. It delves into the essential properties of microalgae and investigates their applications in biofuel production, water purification, bioplastics, carbon capture, aquaculture feed, and the creation of high-value bioproducts for food, biotechnology, and pharmaceuticals.With a focus on recent advances, the text examines innovative photobioreactor designs and the role of genetic engineering in optimizing microalgal outputs. Beyond technological advancements, the book evaluates the social, environmental, and economic sustainability of microalgae-based solutions, emphasizing their contribution to achieving United Nations Sustainable Development Goals. It is an indispensable reference for researchers and professionals in cell biology, renewable energy, biotechnology, biochemical engineering, pharmaceutical sciences, and environmental science.

Apolipoprotein E in Health and Disease

Unravelling its Intricate Roles

1st Edition
Dileep Kumar + 2 more
English

Apolipoprotein E in Health and Disease: Unravelling its Intricate Roles offers a thorough investigation into Apolipoprotein E (ApoE), emphasizing its importance across a spectrum of health conditions. This book details ApoE’s structure, genetic diversity, and functional significance, exploring how this protein impacts cardiovascular health, Alzheimer’s disease, neurological disorders, metabolic syndrome, and more. Through well-researched chapters, it highlights ApoE’s influence on lipid metabolism, heart disease, and the genetic factors contributing to Alzheimer’s, establishing the foundation for precision medicine and targeted therapeutic interventions. Beyond its primary focus, the book also examines ApoE’s broader effects on cognitive decline, liver function, cancer susceptibility, and immune responses.It delves into the pharmacogenetics of ApoE, addressing how genetic variations shape medication effectiveness and treatment plans. Innovative topics such as infectious disease management, genetic engineering, and advanced drug delivery systems are discussed, making this resource valuable for researchers, clinicians, and students alike.

Cutting-Edge Technology for Plant Metabolite Profiling in Drug Discovery and Quality Control

1st Edition
Ramesh Kumar Ahirwar + 4 more
English

Cutting-Edge Technology for Plant Metabolite Profiling in Drug Discovery and Quality Control presents an in-depth overview of innovative approaches in plant metabolomics, focusing on their practical integration into industry. The book examines advanced techniques such as metabolic engineering, metabolite imaging, NMR analysis, microfluidics, and computational bioinformatics. These methods are crucial for identifying and optimizing bioactive compounds in plants, reflecting the growing demand for natural products and plant-derived therapeutics. Through detailed case studies, readers gain insight into real-world applications and scenarios, making this resource invaluable for professionals aiming to enhance accuracy and efficiency in metabolite profiling.In addition to pharmaceutical applications, the book explores the use of plant metabolomics in crop improvement, archaeological studies, cosmetic development, and food quality assurance. It offers a multidisciplinary perspective, highlighting the significant impact of plant metabolites across sectors such as molecular and cellular biology, biotechnology, and biochemistry. Specialists in pharmaceuticals, nutraceuticals, cosmetics, and agriculture will find this comprehensive guide essential for staying abreast of the latest advances and understanding the broad implications of plant metabolite research.

Unlocking the Secrets of Extracellular Vesicles and Exosomes

A Journey into the Cutting-Edge Frontier of Cellular Communication

1st Edition
Chandrashekhar Singh + 4 more
English

Unlocking the secrets of extracellular vesicles and exosomes: A journey into the cutting-edge frontier of cellular communication provides a comprehensive overview of the latest advances and research on extracellular vesicles (EVs) and exosomes. The book begins with a historical introduction to the field and how this has evolved since EVs were first observed, before exploring their cellular mechanisms and approaches to study their isolation, characterization, and function. It then delves into exosomes in health and disease, considering their role across cancer, regenerative medicine, neurological disorders, and metabolic disorders, highlighting their potential as biomarkers for disease diagnosis. The book moves on to discuss cutting-edge technology for the engineering of EVs and exosomes, considering how the integration of AI, machine learning, and nanotechnology can be utilized to expand the therapeutic capabilities of EV and exosome-based applications. It then closes with chapters covering novel applications in nutraceutical and cosmetic production, and a look towards the future potential of EVs and exosomes. Unlocking the secrets of extracellular vesicles and exosomes offer a thorough exploration of EV and exosome research, covering various dimensions from basic science to clinical applications and future perspectives. It is an ideal guide for researchers working across a diverse range of disciplines, including cell biology, molecular biology, biotechnology, therapeutics, and biomedicine.

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