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Elsevier

Academic Press

  • Predictive Digital Twins

    Foundations and Applications
    • 1st Edition
    • Agus Hasan
    • English
    Predictive Digital Twins: Foundations and Applications addresses the theoretical foundations, practical applications, and emerging trends associated with predictive digital twins. Specifically focusing on predictive capabilities, digital twins designated for this purpose are commonly known as predictive digital twins. Despite the growing recognition of their importance, discussions surrounding predictive digital twins remain fragmented and lacking a comprehensive resource. This gap becomes particularly pronounced in the academic world, where, as a university professor teaching a master's program course in digital twins, there arises a pressing need for a dedicated reference book to furnish students with a structured and in-depth exploration of predictive digital twins.The book fills the existing void in literature and academia, providing students, researchers, and practitioners with a valuable resource to enhance their understanding of this cutting-edge concept. The digital twin concept stands as a pivotal facilitator in the ongoing Industry 4.0 revolution, with one of its most significant advantages lying in its capacity to offer precise predictions.

  • Clinical Cancer Genomic Medicine

    • 1st Edition
    • Eamonn Maher + 3 more
    • English
    Clinical Cancer Genomic Medicine: Translational and Applied covers all major aspects of genetics and genomics in cancer development, diagnosis, and management, and their use in the clinical setting. The book explores not only the genetic basis of cancer, but also the role genomics plays in understanding the molecular basis of disease and how it can aid in diagnosis and treatment. Sections discuss the basics of oncogenomic and emerging technologies and specific cancer types, such as breast, gastrointestinal, ocular, skin, and pediatric. The book also includes knowledge on diagnostic cancer genomic techniques, surgical approaches, and ethical, legal, and social implications.This is a valuable resource for oncologists, clinicians, researchers, healthcare workers, and members of the biomedical field who need to understand more about the benefits of genetics and genomics for cancer and their applications in the clinical setting.

  • Brain Pathologies and Disorders

    • 1st Edition
    • Ayman S. El-Baz + 1 more
    • English
    Neural engineering is an emerging and fast-moving interdisciplinary research area that combines engineering with (a) electronic and photonic technologies, (b) computer science, (c) physics, (d) chemistry, (e) mathematics, and (f) cellular, molecular, cognitive, and behavioral neuroscience. This helps us understand the organizational principles and underlying mechanisms of the biology of neural systems and to further to study the behavioral dynamics and complexity of neural systems in nature.The field of neural engineering deals with many aspects of basic and clinical problems associated with neural dysfunction, including (i) the representation of sensory and motor information, (ii) electrical stimulation of the neuromuscular system to control muscle activation and movement, (iii) the analysis and visualization of complex neural systems at multiscale from the single cell to system levels to understand the underlying mechanisms, (iv) development of novel electronic and photonic devices and techniques for experimental probing, the neural simulation studies, (v) the design and development of human–machine interface systems and artificial vision sensors, and (vi) neural prosthesis to restore and enhance the impaired sensory and motor systems and functions.To highlight this emerging discipline, Dr. Ayman El-Baz and Dr. Jasjit Suri have developed Advances in Neural Engineering, covering the broad spectrum of neural engineering subfields and applications. This Series includes 7 volumes in the following order: Volume 1: Signal Processing Strategies, Volume 2: Brain-Computer Interfaces, Volume 3: Diagnostic Imaging Systems, Volume 4: Brain Pathologies and Disorders, Volume 5: Computing and Data Technologies, Volume 6: Advanced Brain Imaging Techniques and Volume 7: Neural Science Ethics.Volume 4 provides a comprehensive review of brain pathologies and disorders, including Parkinson’s Disease, Alzheimer’s Disease, Attention-Deficit/Hy... Disorder, and Tourette’s Syndrome. The authors discuss existing challenges in the domain of diagnosis, detection, analysis, treatment modalities, as well as possible research directions.

  • RNA-Binding Proteins Part B

    • 1st Edition
    • Volume 744
    • English
    Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

  • Rare and Complex Liver Diseases

    • 1st Edition
    • Ansgar Wilhelm Lohse + 2 more
    • English
    Rare and Complex Liver Diseases is a comprehensive guide that fills a critical gap in the literature, providing up-to-date, practical advice. The book is organized into distinct sections, each dedicated to a specific category of liver diseases. Topics covered include Autoimmune Liver Diseases such as Autoimmune Hepatitis (AIH) and Primary Biliary Cholangitis (PBC); Cholestatic Liver Diseases including Biliary Atresia and Alagille Syndrome; Vascular Liver Diseases like Budd-Chiari Syndrome and Non-cirrhotic Portal Hypertension; Metabolic Liver Diseases such as Wilson Disease and Alpha-1 Antitrypsin Deficiency; Structural Liver Diseases including Polycystic Liver Disease; and Rare Liver Tumors like Cholangiocarcinoma and Hemangioendothelioma... chapters cover Liver Disease in Pregnancy and delve into Quality of Life issues, offering evidence-based insights and practical strategies for improving patient well-being. This book serves as an indispensable resource for gastroenterologists, hepatologists, internists, and researchers specializing in liver diseases. It equips these professionals with the knowledge and practical advice necessary to improve patient outcomes and advance their field of study.

  • Cytomegalovirus

    From Biology to Clinical Aspects
    • 1st Edition
    • Adriana Calderaro
    • English
    Cytomegalovirus: From Biology to Clinical Aspects delves into the intricate world of Cytomegalovirus (CMV), offering a comprehensive exploration of its fundamental biology and clinical implications. This book serves as an essential resource for understanding CMV from its epidemiology and infection routes to its pathogenesis and immunity. It addresses the virus’s impact on various demographics and provides insights into diagnostic and treatment strategies. The book covers critical aspects such as vulnerability indicators, cellular damage, laboratory detection, and management strategies. It stands out as a valuable reference for current clinical practices and fundamental scientific knowledge on CMV, offering methods to interpret diagnostic results.

  • Understanding Mycotoxins

    Toxicity, Detection, Risk Assessment, and Prevention Strategies
    • 1st Edition
    • Vinay B. Raghavendra + 1 more
    • English
    Understanding Mycotoxins: Toxicity, Detection, Risk Assessment, and Prevention Strategies offers an in-depth exploration of their toxicological impact, detection techniques, and strategies for prevention and risk management. It addresses the critical health risks associated with mycotoxin exposure, including acute poisoning, carcinogenicity, and neurotoxicity, emphasizing the importance of accurate detection and effective mitigation measures. The book provides evidence-based insights into the mechanisms of mycotoxin toxicity, emerging threats, and the latest technological advances in analysis and detection. The book is structured into three detailed sections. The first section covers the fundamental aspects of mycotoxins, including their structures, biosynthetic pathways, sources of contamination, and health risks, supported by discussions on sampling, analytical techniques such as chromatography and spectroscopy, and the link between mycotoxins and diseases like cancer and neurological disorders. The second section delves into modern detection methods, highlighting advanced electrochemical sensors, immunoassays, biosensors, and innovative approaches utilizing machine learning, artificial intelligence, and nanotechnology for rapid and accurate identification of mycotoxins in various food matrices. The final section focuses on prevention and risk management, exploring detoxification strategies, mitigation techniques—including physical, chemical, biological, and emerging plasma and nanotechnology-based methods—and the regulatory frameworks that underpin safe food production and handling practices, aiming to reduce exposure and protect vulnerable populations globally.

  • Introduction to Practical EPR Spectroscopy

    • 1st Edition
    • Wilfred R. Hagen
    • English
    Introduction to Practical Electron Paramagnetic Resonance (EPR) Spectroscopy of randomly oriented molecules finds wide application in chemistry, biology, and many other related disciplines. This graduate-level text guides the reader along the winding road of the undocumented pitfalls and unwritten rules-of-thumb that come with undertaking practical EPR spectroscopy. The aim is to provide a truly practical and complete introduction to this widely used method. With the required quantum mechanics limited to an indispensable minimum, the book comprehensively treats the basic theoretical and practical aspects of the methodology to educate the reader to the level of an independent EPR researcher in all aspects, including problem posing, sample preparation, machine operation, data collection and interpretation, numerical analysis, and scientific reporting.Many EPR books have been written as expositions of the quantum-mechanical background of magnetic resonance, but without addressing critical practical questions in the lab including but not limited to:what knobs to turnhow to make sampleswhat programs to use (or not use)how to present experimental resultsIntroduction to Practical EPR Spectroscopy offers a complete preparation (both theoretical and practical) to be an independent EPR spectroscopist in what may be a non-specialist laboratory. It is written primarily for PhD, master’s and postdoctoral students and their tutors across biochemistry, organic, inorganic, bioinorganic and physical chemistry, molecular biology, microbiology, molecular physics, materials science, and geology.

  • The Transcription Factor NRF2

    Biology, Disease and Translational Opportunities
    • 1st Edition
    • Narendra Kumar Sharma + 1 more
    • English
    The Transcription Factor NRF2: Biology, Disease and Translational Opportunities offers a detailed and authoritative reference on NRF2, a key regulator of cellular defence against oxidative stress. This book thoroughly examines the latest research, from molecular mechanisms to clinical applications, highlighting NRF2’s essential function in cell protection, disease prevention, and its promise as a therapeutic target. The book opens with an introduction to NRF2 and its role in cellular homeostasis before exploring its molecular structure, regulation and signalling mechanisms. Its antioxidant response is then discussed, followed by its impact on inflammation, autophagy, and resistance to environmental and chemical stresses. Later chapters cover NRF2’s role in cancer, neurodegenerative, cardiovascular, autoimmune, and metabolic diseases. Cutting-edge techniques are also provided, including AI-based and systems biology tools. Case studies emphasize translational potential and therapeutic development.The Transcription Factor NRF2: Biology, Disease and Translational Opportunities equips researchers, clinicians, and advanced students with critical knowledge to understand NRF2’s multifaceted functions and therapeutic potential. It serves as an essential guide for advancing research and strategies targeting NRF2 in a diverse array of medical conditions, and is an ideal reference for those working across cell biology, molecular biology, biomedicine and related fields.

  • Responsive Leadership in Education

    Sustaining the Educational Village for Student Success
    • 1st Edition
    • Bethel E. Cager + 2 more
    • English
    Responsive Leadership in Education: Sustaining the Educational Village for Student Success introduces a transformative framework grounded in the African proverb, "It takes a village to raise a child." This essential resource explores the 5Rs of Responsive Leadership—Reflect, Relate, Represent, Respond, and Revisit—offering practical applications for educational leaders committed to fostering student success. Each chapter emphasizes the critical role of stakeholders, or "villagers," in achieving sustainable outcomes and dismantling oppressive practices. The preface sets the stage for the 5Rs framework, highlighting the urgency of responsive leadership in today's diverse educational landscape. It outlines how the book's structure and tools will empower readers to lead with equity, inclusion, and continuous improvement in mind. Each chapter opens with stakeholder vignettes and poses discussion questions that engage readers in connecting the principles to their own experiences. Case studies and reflective questions at the end of each chapter further ensure that insights can be translated into actionable strategies. By providing a practical, stakeholder-centered approach, this book equips educational communities to confront marginalization and create environments where every student can thrive.Responsive Leadership in Education: Sustaining the Educational Village for Student Success is an invaluable resource for educational leaders seeking to navigate current challenges, promoting equity, diversity, inclusion, and belonging in our schools while inspiring meaningful change.

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