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Academic Press

    • Reverse Aging

      Current Research and Future Directions
      • 1st Edition
      • Sandeep Kumar Singh + 1 more
      • English
      Reverse Aging: Current Research and Future Directions explores the integrated approach of aging and reverse aging to present a comprehensive understanding of the biological, genetic, and molecular mechanisms associated with aging. By targeting fundamental aging mechanisms, strategies are being developed to reverse and repair damage and potentially lead to greater healthspan benefits and optimal longevity. The book opens with the fundamentals of aging and how genetic, environmental, and lifestyle variables affect the biological, psychological, and social processes that lead to aging before delving into a comprehensive review of the hallmarks of aging. Next, an overview of the concept of reverse aging is presented, and subsequent chapters examine specific reverse aging models and approaches. The book explores use of cellular reprogramming techniques, provides an overview of the molecular processes that underlie NANOG-mediated reversal aging, and discusses the possible contribution of IGF-1/PKA signaling reduction to reverse aging via HSC-based therapies. The developing science of rejuvenating stems cells, histone modification, and stimulation of autophagic activity to facilitate the removal of cellular debris and reduce the impact of aging on various organ systems as well as novel concepts of mRNA enhanced cell therapy, immunological-driven signaling, mitochondrial modulations, cell-cycle regulation, and metabolic reprogramming for reserve aging are all examined. The wide range of nutritional therapies, phytochemical, prescription medications, and nutraceuticals impacting the aging process is reviewed, and the book closes with discussion of the revolutionary role AI has on anti-aging research and where the field is headed. In conclusion, the book emphasizes the importance of targeting fundamental aging mechanisms to extend health and achieve optimal longevity and provides insights into the potential implications for healthcare and aging research, highlighting the need for collaborative efforts and interdisciplinary perspectives to address the challenges of population aging and develop effective strategies for healthy aging practices.

    • Modern Energy Storage

      The Key to Energy System Transformation
      • 1st Edition
      • Huaiguang Jiang
      • English
      Modern Energy Storage: The Key to Energy System Transformation is a unique reference designed to give students and researchers the most advanced information on technologies in energy storage systems.Energy storage is a complex system, often containing several energy storage techniques to complement each other. This reference covers those techniques by looking at li-ion battery-based energy storage systems and all indispensable technologies in different scenarios or real applications including Compressed Air Storage, Power to gas systems, Pumped Thermal, Liquid Air Storage, Thermochemical storage, and more.Compiled by global experts and considering latest advances related to full recyclable process, second use, pollution reduction, and low-carbon industry & economy, which will boost the real applications of the energy storage systems. By addressing the current challenges of energy storage technologies and potential solutions, this comprehensive text uses algorithms, methods, and programs as a technical-encycloped... for energy-storage-relat... areas such as Electric vehicles, Intelligent Transportation, Environment, and smart cities.Designed to inform, advise, and create discussion about the energy transition, climate, low carbon power and economy, the contributors provide abundant and valuable materials and references for the students, researchers, engineers, professors in in energy, engineering and environmental areas.

    • Sports Medicine and the Pelvic Floor

      Science to Practice
      • 1st Edition
      • Gráinne M. Donnelly
      • English
      Sports Medicine and the Pelvic Floor: Science to Practice shines a spotlight on a critical but often overlooked aspect of female athlete health: the pelvic floor. Bringing together the expertise of international clinicians and researchers, this book highlights persistent gaps in knowledge and practice, offering valuable direction for future research. It educates professionals on how to effectively screen, treat, and rehabilitate athletes, emphasizing that pelvic floor dysfunction can profoundly impact engagement, athletic performance, and overall well-being. By addressing this traditionally taboo subject, the authors provide evidence-based insights that call for the pelvic floor to be considered as essential in sports medicine.Sections discuss practical strategies for screening and supporting athletes, managing or alleviating symptoms, and ensuring a safe return to sport, all while prioritizing long-term pelvic health. This is an indispensable resource for anyone working with female athletes, blending science and clinical experience to advance care in this vital area.

    • Two Sides of Nanovaccines and Nanomedicines in Cancer Treatments

      • 1st Edition
      • Tuan Anh Nguyen + 2 more
      • English
      Two Sides of Nanovaccines and Nanomedicines in Cancer Treatments provides a balanced exploration of the dual roles of nanotechnologies in oncology. Structured in four parts, the book begins with foundational knowledge of nanovaccines and nanomedicines, detailing their applications in cancer care and highlighting their precision in targeting cancer cells while reducing systemic toxicity. Importantly, the book addresses potential drawbacks, discussing side effects and safety concerns associated with these innovations. The final section emphasizes ethical, regulatory, and safety challenges, underscoring the need for careful oversight as nanotechnologies advance. For the academic audience, this book serves as a vital resource, offering insights that equip researchers and healthcare professionals to make informed decisions regarding clinical applications. Its focus on both the benefits and risks, alongside forward-looking perspectives, ensures that readers are well-prepared for future developments in the field of nanomedicine and cancer therapy.

    • 2D and 3D Cellular Screening Models and AI Guided Analysis

      • 1st Edition
      • Volume 204
      • English
      2D and 3D Cellular Screening Models and AI Guided Analysis provides a comprehensive overview of the latest advancements in cellular screening models, with a particular focus on both 2D and 3D systems. It explores the development, application, and comparative benefits of 2D monolayer cultures and 3D organoids, spheroids, and tissue-engineered constructs for biomedical research and drug discovery.

    • Host-Microbe Co-metabolism System in Health and Disease

      • 1st Edition
      • Xiao Zheng + 1 more
      • English
      Host-Microbe Co-metabolism System in Health and Disease is an easy-to-follow reference of research progress in host-microbiome co-metabolism system (HMMS) and how this frontier could imply a better understanding of health, disease, and the discovery of novel drugs. The book summarizes recent studies that are progressing to complete a panorama of the host-microbiome co-metabolism system (HMMS) in health and disease. It discusses how sophisticated bioanalytical tools, tractable model organisms, and artificial intelligence could be integrated to answer key biological questions related to HMMS in the broader context of human health and drug discovery.

    • The Itch Spectrum

      • 1st Edition
      • Xinzhong Dong + 2 more
      • English
      "The Itch Spectrum: The Neurological and Immunological Basis of Itch and Dermatological Disorders" covers the latest research on the itch signalling pathway from the skin to the brain. With a multidisciplinary approach, this book will cover the mechanisms underlying the sensation of itch from the fields of neuroscience, immunology, genetics, and dermatology as they have intersected in the study of one somatosensory system. The purpose of this comprehensive reference is to summarize the revelatory discoveries in the field of itch and provide a comprehensive overview of what is known about this remarkable sensation and how various pathologies contribute to chronic pruritis.

    • High Entropy Materials

      Fundamentals and Potential Applications
      • 1st Edition
      • An-Chou Yeh + 3 more
      • English
      High Entropy Materials: Fundamentals and Potential Applications covers the fundamental science of high entropy materials (HEMs) and advances in the development of various structural and functional HEMs: topics covered include strength and ductility combination; hydrogen embrittlement resistance; shape memory properties; fatigue properties as well as detailed reviews of high-entropy superalloys; refractory high entropy alloys; ferroelectric high entropy oxides; nanocrystal library for catalytic applications; water splitting for hydrogen production; thermoelectric properties; lithium and sodium batteries; high-entropy polymers; high-entropy coatings for elevated temperatures and wear resistance; and AI-based approaches to explore the high entropy materials composition space. The book is written by international experts in the field including the director and principal investigators of the High Entropy Materials Center in Taiwan: the first research center dedicated to the development of HEMs

    • Immunological Aspects of Preterm Birth

      Phenotypes of Preterm Birth, Immune Mechanisms, and Pathway Forward
      • 1st Edition
      • Volume 4
      • Irina Burd MD
      • English
      Immunological Aspects of Preterm Birth: Phenotypes of Preterm Birth, Immune Mechanisms, and Pathway Forward bridges reproductive immunology of preterm birth to subtypes, phenotypes, and bedside prevention and treatment. The book reviews the role of the different immune mechanisms during pregnancy that lead to preterm birth, along with the fetal programming effects that are connected to maternal immune activation. In addition, it discusses immune cells and their products and cytokines and chemokines as central for the success of the pregnancy.While our knowledge on the role of immune cells and the inflammatory process in preterm birth has grown exponentially in the last 10 years, connecting basic science to clinical science and the development of new therapeutics has not progressed as rapidly. This book assists researchers in understanding the basic immunologic mechanisms and inflammatory processes associated with preterm birth and fills an urgent need for the development of therapeutics in this space.

    • Moving Toward Nonanimal Approaches in Medical Research and Testing

      • 1st Edition
      • Gail A. Van Norman + 1 more
      • English
      Moving Toward Nonanimal Approaches in Medical Research and Testing pioneers a single-source guide for researchers regarding nonanimal research tools and methodologies and their many advantages and applications in place of animals. This book is presented in three parts: historical, ethical, legislative, and scientific contexts on the need to shift away from animal-based research and testing; the latest advances in nonanimal tools and methods for biomedical research and testing of human therapeutics and other compounds, including microphysiological systems, bioprinting, biobanks, and artificial intelligence; and achieving a practical shift toward these powerful approaches, including advocacy for legal, regulatory, and policy change, securing funding for nonanimal studies, and how to overcome bias against nonanimal methods. This book, primarily directed to researchers in biomedicine, human medical therapeutics, and toxicology, will also appeal to researchers in industry, providing overview and insights about the latest applications of nonanimal research tools and methods for product development and testing. Clinicians who wish to understand the reliability of testing therapeutics with nonanimal versus animal methods, as well as advocacy groups seeking an up-to-date understanding of ethical, economic, political, and scientific considerations in moving toward nonanimal approaches, will also find significant value in this text. Finally, legislators and those involved in regulatory review and oversight will benefit from this single comprehensive source for developing a basic understanding of nonanimal research and human safety.

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