
Advances in Hepatorenal Syndrome Research
Untangling Pathophysiology, Improving Diagnostic Strategies, and Therapeutic Innovations
- 1st Edition - March 1, 2026
- Editor: Justin Belcher
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 3 2 9 9 4 - 4
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 3 2 9 9 5 - 1
Advances in Hepatorenal Syndrome Research: Untangling Pathophysiology, Improving Diagnostic Strategies, and Therapeutic Innovations is a comprehensive review of the histor… Read more

Advances in Hepatorenal Syndrome Research: Untangling Pathophysiology, Improving Diagnostic Strategies, and Therapeutic Innovations is a comprehensive review of the historical perspectives, prevalence, and prognosis of HRS, offering insights into its evolving clinical recognition and shifting paradigms of pathophysiology. Explore the multifaceted pathophysiology of HRS as experts navigate the complexities of cardiac dysfunction, inflammatory cytokines, and other modern understandings shaping the field. Explore differential diagnosis, uncovering alternative etiologies and current diagnostic criteria, while shedding light on biomarkers and novel diagnostic tests revolutionizing patient assessment. Contents will also guide readers through the utility of point-of-care ultrasound in intravascular volume assessment sets the stage for exploring medical therapy options, including vasoconstrictors and albumin usage. Written by a team of experts, this comprehensive reference highlights the intricate pathophysiology of hepatorenal syndrome while delivering the most up-to-date insights into diagnostic and therapeutic approaches. Historically overshadowed by grim prognoses, hepatorenal syndrome has undergone a renaissance of interest due to recent breakthroughs, revolutionizing treatment paradigms. Whether you're a seasoned practitioner or a burgeoning researcher immersing yourself in this dynamic field, this resource offers a thorough examination, encompassing novel diagnostic criteria, innovative biomarkers, and state-of-the-art treatments.
- Covers the pathophysiology of hepatorenal syndrome and how it sits into the spectrum of acute kidney injury in patients with cirrhosis
- Presents current diagnostic criteria for hepatorenal syndrome and how novel diagnostic tests are moving it from a diagnosis of exclusion to one with objective diagnostic features
- Recommends management of vasoconstrictor therapy and how and when dialysis should be considered
Practicing nephrologists, hepatologists, critical care physicians, hospital pharmacists
1. Historical Perspective, Prevalence and Prognosis
2. Pathophysiology
3. Differential Diagnosis
4. Biomarkers and Novel Diagnostic Tests
5. Point of Care Ultrasound (POCUS)
6. Medical Therapy
7. Dialysis, TIPS and Invasive Therapies
8. Transplantation
9. Risk Factors and Prophylaxis
10. Management of Patients Ineligible for Transplantation
2. Pathophysiology
3. Differential Diagnosis
4. Biomarkers and Novel Diagnostic Tests
5. Point of Care Ultrasound (POCUS)
6. Medical Therapy
7. Dialysis, TIPS and Invasive Therapies
8. Transplantation
9. Risk Factors and Prophylaxis
10. Management of Patients Ineligible for Transplantation
- Edition: 1
- Published: March 1, 2026
- Language: English
JB
Justin Belcher
Dr. Belcher graduated from Williams College before attending medical school at Drexel University College of Medicine, where he was elected to Alpha Omega Alpha, and subsequently completing his internship, residency, and Chief Residency in Internal Medicine at George Washington University. While completing his research fellowship in Nephrology at Yale, he received a PhD in 2015 from the Investigative Medicine Program. The primary focus of his research is acute kidney injury (AKI) in patients with cirrhosis including the use of novel biomarkers to enhance diagnosis, therapeutic decisions and prognosis. This interest led to his co-founding HRS-HARMONY, a multi-disciplinary North American research consortium dedicated to researching AKI in this setting, with a focus on hepatorenal syndrome.
Affiliations and expertise
Yale University School of Medicine and VA Connecticut Healthcare, USA