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Elsevier

Academic Press

  • Enzymes

    • 2nd Edition
    • Malcolm Dixon + 1 more
    • English
    Enzymes, Second Edition provides information pertinent to the developments in the field of enzymology. This book presents the properties of enzymes as chemical catalysts or simply as chemical substances. Organized into 13 chapters, this edition begins with an overview of the range of action or specificity of enzymes. This text then discusses the special techniques employed in the isolation of enzymes and explores the considerable progress in the study of the properties and functions of enzymes. Other chapters consider the mechanism of enzyme catalysis by more direct methods, including the use of isotopes. This book discusses as well the mechanism of the biosynthesis of enzymes and the means by which their chemical structure is determined by the genetic material of the chromosomes. The final chapter deals with the essential aspects of the enzymatic system linking energy-producing processes with energy-utilizing processes. This book is a valuable resource for biochemists, physical chemists, and research workers.

  • Numerical Methods of Reactor Analysis

    • 1st Edition
    • Melville Clark + 1 more
    • V. L. Parsegian
    • English
    Numerical Methods of Reactor Analysis is an introduction to topics of numerical analysis frequently used in the nuclear reactor field. Emphasis is placed on methods by which machine calculations are performed on practical problems related to nuclear reactors. The multigroup diffusion methods and the Monte Carlo method are discussed. Comprised of six chapters, this volume begins by describing a simplified formulation of linear algebra, with emphasis on matrices and operations with matrices as well as the properties of special matrices. Following the introduction of a geometric interpretation of matrix equations, many matrix relations are derived, including relations used in nuclear engineering. The next chapter reviews the elementary properties of finite difference equations, with particular reference to techniques suited to digital computers. Subsequent chapters focus on numerical solutions of equations; multigroup diffusion methods; transport methods; and the Monte Carlo method. This book will be a valuable resource for first and second year graduate students taking an introductory course in reactor physics.

  • Lymphokines

    A Forum for Immunoregulatory Cell Products
    • 1st Edition
    • Edgar Pick
    • English
    Lymphokines: A Forum for Immunoregulatory Cell Products deals with immunoregulatory cell products that produce lymphokines. Topics covered include the purification and characterization of transfer factor; activation of cytotoxicity and/or suppressor activity in murine macrophages by lymphokines, lipopolysaccharide, and polyinosinic-polycyt... acid; and the role of clotting processes in the action of lymphokines on macrophages. A comparison of the immune-modulating effects of interferon and interferon inducers is also presented. Comprised of 13 chapters, this volume begins with a discussion on transfer factor and its ability to react specifically with antigens. The clinical uses of transfer factor are considered with special emphasis on its value as a prophylactic agent. The reader is then introduced to the subject of T cell regulation of the immunoglobulin E (IgE) response via potentiating and suppressor lymphokines, together with the possible clinical application of IgE suppressive factors in the treatment of atopic diseases. Subsequent chapters examine the evidence in favor of the existence of T cell-derived polyclonal B cell activator (PBA) playing a role in both normal antibody responses and autoimmune diseases; the role of suppressor T cells and the associated lymphokines in contact sensitivity in mice; and lymphokine action on macrophages. The book also analyzes the genetics of the response of human and mouse cells to interferons. This monograph will be helpful to practitioners and researchers in the fields of microbiology and immunology.

  • Biased Signaling in Physiology, Pharmacology and Therapeutics

    • 1st Edition
    • Brian J Arey
    • English
    Biased Signaling in Physiology, Pharmacology and Therapeutics is a unique and essential reference for the scientific community concerning how conformational-depen... activation is a common phenomenon across many classes of receptors or signaling molecules. It discusses the role of conformational dynamics in leading to signaling bias across different classes of receptors and signaling molecules. By providing a broader view of signaling bias, this resource helps to explain common mechanisms shared across receptor classes and how this can be utilized to elucidate their cellular activity and better understand their therapeutic potential. Written for both new and established scientists in pharmacology, cell biology, biochemistry, and signal transduction, as well as physicians, this book clearly illustrates how biased receptor signaling can be utilized to develop and understand complex pharmacology. Chapters are each focused on a specific class of receptor or other important topic and make use of real-world examples illustrating how the latest research in signal transduction has led to a better understanding of pharmacology and cell biology. This structure creates a basis for understanding that physiological signalling bias has been selected by nature in order to provide complex and tissue- specific biological responses in the face of limited receptors and signaling pathways. This book provides a framework to reveal that these physiological mechanisms are not restricted to one receptor type or family and thus presents receptor signaling from a newer, more global perspective.

  • Celiac Disease and Gluten

    Multidisciplinary Challenges and Opportunities
    • 1st Edition
    • Peter Koehler + 2 more
    • English
    Celiac Disease and Gluten: Multidisciplinary Challenges and Opportunities is a unique reference work—the first to integrate the insights of the causes and effects of celiac disease from the chemistry of reaction-causing foods to the diagnosis, pathogenesis, and symptoms that lead to proper diagnoses and treatment. With an estimated three million people in the United States alone affected by celiac disease, an autoimmune digestive disease, only five percent are properly diagnosed. Drawing on the connection between foods containing gluten and the resulting symptoms, this resource offers distinctive information that directly explores and links food science, medical diagnostics, and treatment information. A helpful tool for researchers and medical practitioners alike, Celiac Disease and Gluten: Multidisciplinary Challenges and Opportunities helps refine research targets, and provides a comprehensive overview on the multidisciplinary approaches to all crucial aspects related to celiac disease.

  • Commingled Human Remains

    Methods in Recovery, Analysis, and Identification
    • 1st Edition
    • Bradley Adams + 1 more
    • English
    Commingled human remains are encountered in situations ranging from prehistoric ossuaries to recent mass fatality incidents. Commingled Human Remains: Methods in Recovery, Analysis, and Identification brings together tools from diverse sources within the forensic science community to offer a set of comprehensive approaches to resolving issues associated with commingled remains. This edition focuses on forensic situations, although some examples from prehistoric contexts are also addressed. Commingling of bones and other body parts is a major obstacle to individual identification that must be addressed before other forensic determinations or research can proceed. Regardless of the cause for the commingling (transportation disaster, terrorist attack, natural disaster, genocide, etc.) it is critical that the proper experts are involved and that the proper techniques are employed to achieve the greatest success in making identifications. Resolution of commingling nearly always requires consideration of multiple lines of evidence that cross the disciplinary lines of modern forensic science. The use of archaeology, DNA, and forensic anthropology are several areas that are critical in this process and these are core topics presented in this book. Even a relatively “simple” mass fatality event can become very complicated once body fragmentation and commingling occur. Expectations associated with all phases of the process from recovery of remains to their final identification and release to next of kin must be managed appropriately.

  • Mouse Models of the Nuclear Envelopathies and Related Diseases

    • 1st Edition
    • Volume 109
    • English
    Volume 109 of Current Topics in Developmental Biology covers mouse models of the nuclear envelopathies and related diseases, with contributions from an international board of authors. The chapters provide a comprehensive set of reviews covering such topics as mouse models neurodegenerative diseases including Parkinson’s and dystonia, muscle ageing and sarcopenia, cardiac failure and repair, ageing and prospects lifespan extension, lipodystrophy and the significance in fat regulation, also identifying developmental mutations in mammals and nuclear envelope and LINC complex in disease.

  • The Stimulated Brain

    Cognitive Enhancement Using Non-Invasive Brain Stimulation
    • 1st Edition
    • Roi Cohen Kadosh
    • English
    The Stimulated Brain—which garnered an Honorable Mention for Biomedicine & Neuroscience at the 2015 PROSE Awards from the Association of American Publishers—presents the first integration of findings on brain stimulation from different research fields with a primary focus on Transcranial Electrical Stimulation (tES), one of the most frequently used noninvasive stimulation methods. The last decade has witnessed a significant increase in the amount of research exploring how noninvasive brain stimulation can not only modulate but also enhance cognition and brain functions. However, although Transcranial Magnetic Stimulation (TMS) and particularly tES have the potential to become more widely applicable techniques (as they come with none of the risks associated with deep brain stimulation) the reference literature on these neurotechnologies has been sparse. This resource provides a broad survey of current knowledge, and also marks future directions in cognitive and neuro-enhancement. It expands our understanding of basic research findings from animals and humans, including clear translational benefits for applied research and the therapeutic use of noninvasive brain stimulation methods. The book's coverage includes a primer that paves the way to a more advanced knowledge of tES and its physiological basis; current research findings on cognitive and neuro-enhancement in animals and typical and atypical human populations, such as neurological patients; and discussions of future directions, including specific neuroethical issues and pathways for collaboration and entrepreneurialism. The Stimulated Brain is the first book to provide a comprehensive understanding of different aspects of noninvasive brain stimulation that are critical for scientists, clinicians, and those who are interested in “stimulating their minds” by exploring this fascinating field of research.

  • Wine Science

    Principles and Applications
    • 4th Edition
    • Ronald S. Jackson
    • English
    Wine Science, Fourth Edition, covers the three pillars of wine science: grape culture, wine production, and sensory evaluation. It discusses grape anatomy, physiology and evolution, wine geography, wine and health, and the scientific basis of food and wine combinations. It also covers topics not found in other enology or viticulture texts, including details on cork and oak, specialized wine making procedures, and historical origins of procedures. New to this edition are expanded coverage on micro-oxidation and the cool prefermentative maceration of red grapes; the nature of the weak fixation of aromatic compounds in wine – and the significance of their release upon bottle opening; new insights into flavor modification post bottle; the shelf-life of wine as part of wine aging; and winery wastewater management. Updated topics include precision viticulture, including GPS potentialities, organic matter in soil, grapevine pests and disease, and the history of wine production technology. This book is a valuable resource for grape growers, fermentation technologists; students of enology and viticulture, enologists, and viticulturalists.

  • The Future of Energy

    • 1st Edition
    • Brian F. Towler
    • English
    Using the principle that extracting energy from the environment always involves some type of impact on the environment, The Future of Energy discusses the sources, technologies, and tradeoffs involved in meeting the world's energy needs. A historical, scientific, and technical background set the stage for discussions on a wide range of energy sources, including conventional fossil fuels like oil, gas, and coal, as well as emerging renewable sources like solar, wind, geothermal, and biofuels. Readers will learn that there are no truly "green" energy sources—all energy usage involves some tradeoffs—and will understand these tradeoffs and other issues involved in using each energy source.

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