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Elsevier

Academic Press

  • PROTACs Overcome Resistance to Cancer Therapies

    • 1st Edition
    • Daohong Zhou
    • English
    PROTACs Overcome Resistance to Cancer Therapies explores the transformative potential of proteolysis targeting chimeras (PROTACs) in addressing one of oncology’s greatest challenges: drug resistance. Edited by Dr. Daohong Zhou, this volume brings together leading experts to present the latest advances in targeted protein degradation for cancer treatment. The book covers foundational principles of PROTAC design, mechanisms of action, and their advantages over traditional small molecule inhibitors. It delves into strategies for targeting undruggable proteins, overcoming resistance in various cancer types, and mitigating emerging resistance to PROTACs.Case studies include BCL-xL, KRAS, STAT3, and EGFR-targeting PROTACs, with insights into clinical translation and precision medicine. This resource equips cancer researchers, oncologists, and pharmaceutical scientists with practical guidance and cutting-edge knowledge. It serves as both a reference and a roadmap for developing next-generation therapeutics, making it essential for those advancing cancer drug discovery and translational medicine.

  • An Essential Guide to Radiation Dosimetry for Medical Applications

    Principles, Technologies, and Clinical Applications
    • 1st Edition
    • Jayachandran Venkatesan + 1 more
    • English
    An Essential Guide to Radiation Dosimetry for Medical Applications: Principles, Technologies, and Clinical Applications provides a comprehensive overview of the fundamental concepts, advanced methodologies, and emerging technologies in radiation dosimetry. This book serves as an essential resource for researchers, clinicians, and students involved in cancer research, bioinformatics, medical physics, radiology, and radiation therapy, offering in-depth insights into both theoretical principles and practical applications. The content covers core topics such as radiation interactions, dosimetry materials, and simulation techniques, alongside clinical and diagnostic applications.In addition, it also explores innovative approaches like artificial intelligence, nanodosimetry, and quality assurance, ensuring readers stay current with technological advancements. This book benefits the academic audience by enhancing their knowledge of dosimetry science and fostering the development of safer, more effective radiation practices. It supports education, research, and clinical decision-making, ultimately advancing the field of radiation physics and improving patient outcomes.

  • Food Packaging from Plant-Based By-products

    Sustainable Materials and Applications
    • 1st Edition
    • Preetam Sarkar + 3 more
    • English
    Food Packaging from Plant-Based By-products: Sustainable Materials and Applications addresses the growing need for sustainable, eco-friendly packaging solutions derived from agricultural plant by-products. The book benefits its audience by delivering up-to-date scientific knowledge, practical case studies, and strategies to overcome technical challenges in the packaging industry. The book’s extensive table of contents covers extraction methods, characterization techniques, and applications of biopolymers from diverse plant by-products such as mango, grape, citrus, apple, tomato, wheat, rice, and legumes. It also explores advanced topics including nanocomposites, active and intelligent packaging, regulatory frameworks, consumer acceptance, and industrial scale-up processes. Each chapter is authored by experts from multiple countries, ensuring a global perspective on sustainable packaging innovations. Food Packaging from Plant-Based By-products: Sustainable Materials and Applications provides a comprehensive resource for researchers, industry professionals, and policymakers focused on developing innovative food packaging systems that improve food quality and safety while reducing environmental impact. It equips the readers with valuable insights to drive innovation, regulatory compliance, and consumer acceptance of sustainable packaging technologies worldwide.

  • Rare and Complex Liver Diseases

    • 1st Edition
    • Ansgar Wilhelm Lohse + 2 more
    • English
    Rare and Complex Liver Diseases is a comprehensive guide that fills a critical gap in the literature, providing up-to-date, practical advice. The book is organized into distinct sections, each dedicated to a specific category of liver diseases. Topics covered include Autoimmune Liver Diseases such as Autoimmune Hepatitis (AIH) and Primary Biliary Cholangitis (PBC); Cholestatic Liver Diseases including Biliary Atresia and Alagille Syndrome; Vascular Liver Diseases like Budd-Chiari Syndrome and Non-cirrhotic Portal Hypertension; Metabolic Liver Diseases such as Wilson Disease and Alpha-1 Antitrypsin Deficiency; Structural Liver Diseases including Polycystic Liver Disease; and Rare Liver Tumors like Cholangiocarcinoma and Hemangioendothelioma... chapters cover Liver Disease in Pregnancy and delve into Quality of Life issues, offering evidence-based insights and practical strategies for improving patient well-being. This book serves as an indispensable resource for gastroenterologists, hepatologists, internists, and researchers specializing in liver diseases. It equips these professionals with the knowledge and practical advice necessary to improve patient outcomes and advance their field of study.

  • Aging and Troponin

    Clinical Implications and Uses Beyond Diagnosis
    • 1st Edition
    • Gary Tse + 3 more
    • English
    Aging and Troponin: Clinical Implications and Uses Beyond Diagnosis examines the multifaceted role of troponin in clinical medicine, with a special focus on aging. This comprehensive reference provides essential technical knowledge, diagnostic and prognostic applications, and model development insights from leading experts in clinical biochemistry, pathology, and epidemiology. The book emphasizes the impact of aging on troponin test results and their interpretation, addressing age-related disorders such as renal failure. Sections cover the technical aspects of troponin assays, comparing traditional and high-sensitivity assays and exploring point-of-care testing advancements.The book also examine age-related changes and intra- and inter-individual variability in troponin levels, focuses on diagnostic applications, including troponin as a biomarker for cardiac injury and dysfunction, and the effects of age, sex, and renal impairment on diagnostic sensitivity and specificity, and discusses troponin's prognostic value for mortality in various conditions, including heart disease, sepsis, and COVID-19, and its role as a marker of organ biological age. The final section offers cutting-edge insights into the clinical applicability of troponin testing, highlighting the benefits of incorporating high-sensitivity assays into clinical workflows and providing perspectives and age-related considerations from practicing physicians on implementation and evidence-based practice.

  • Sustainable Science and Technologies for Agriculture and Environment

    SDG Perspectives
    • 1st Edition
    • M. Iqbal R. Khan + 2 more
    • English
    Organized into five thematic sections, Sustainable Science and Technologies for Agriculture and Environment situates contemporary advances—spanning soil microbial ecology and biostimulants, nanotechnology, predictive computational modeling, and integrative omics—within the framework of the United Nations' Sustainable Development Goals and surveys how each contributes to measurable progress toward those targets.The book bridges two scales of inquiry that are often treated apart. At the level of the field, it addresses how productivity can be enhanced without depleting natural capital, drawing on biological inputs, nutrient enrichment of staple foods, and the accounting of emissions from cultivation. At the level of the organism, it traces the physiological and genetic mechanisms through which plants withstand abiotic stresses such as drought, salinity, and heat, together with the breeding and selection approaches that consolidate such resilience.Connectin... the two are cross-cutting methods—engineered materials, algorithmic forecasting, and molecular analysis—whose capabilities are assessed alongside their limitations.For researchers, graduate students, and practitioners alike, the value lies in seeing discovery and deployment held in a single frame, in the service of a common end: to secure food and nutritional sufficiency while safeguarding the integrity of the natural world.

  • Combinatorial Enzyme Therapy Against ESKAPE Pathogenic Biofilms

    • 1st Edition
    • Awanish Kumar + 1 more
    • English
    Combinatorial Enzyme Therapy Against ESKAPE Pathogenic Biofilms offers the latest insights into ESKAPE pathogen biofilms, including their formation, structure, and resistance mechanisms. In addition, the book highlights innovative therapeutic strategies to combat them, with a specific focus on combinatorial enzyme therapies. It begins with an overview of the significant burden these pathogens impose across healthcare and the food industry, laying the groundwork for understanding the intricate relationship between antibiotic resistance and biofilm dynamics. The book advocates for novel approaches through combinatorial enzymatic therapy, detailing the mechanisms and synergies of various enzymes in effectively dismantling biofilms.With insights into cutting-edge delivery systems, including nanotechnology and the integration of CRISPR-Cas systems and artificial intelligence, the book charts a course for the future of advanced therapeutic strategies. It concludes by addressing regulatory considerations, positioning combinatorial enzyme therapy as a promising frontier in the fight against persistent infections caused by ESKAPE pathogens.

  • Hysteroscopy and Female Infertility

    Diagnostic and Therapeutic Approaches in Clinical Practice
    • 1st Edition
    • Salvatore Giovanni Vitale
    • English
    Hysteroscopy and Female Infertility: Diagnostic and Therapeutic Approaches in Clinical Practice addresses the growing global challenge of infertility by focusing on the critical role of hysteroscopy in diagnosing and managing uterine factors that impair female fertility. The book fills a significant gap by providing an up-to-date, practical guide, including recent advances in hysteroscopic technology, such as AI-assisted diagnostics, to improve reproductive outcomes. Chapters cover a broad spectrum of uterine abnormalities such as polyps, fibroids, adhesions, Müllerian anomalies, endometritis, adenomyosis, and isthmocele, combining detailed diagnostic criteria, operative techniques, and evidence on reproductive outcomes.The inclusion of ultrasound correlations, decision-making algorithms, and QR-linked high-definition surgical videos enhances usability for both learning and clinical application. The book equips gynecologists, reproductive endocrinologists, and fertility specialists with a comprehensive, evidence-based resource designed to improve diagnostic precision and therapeutic efficacy.

  • Machine Learning and Urban Health

    Advancing Wellness through Data Analytics
    • 1st Edition
    • Deepak Kumar + 3 more
    • English
    Machine Learning and Urban Health: Advancing Wellness through Data Analytics explores how advanced data analytics and machine learning are reshaping the future of urban wellness. As cities worldwide evolve into highly interconnected, technology-driven spaces, new opportunities—and challenges—emerge for ensuring sustainable urban health. This timely volume addresses the critical question: how can we harness the power of data to improve health outcomes in complex urban environments? From predicting disease outbreaks to identifying vulnerable populations and optimizing resource allocation, this book highlights how machine learning is transforming the public health landscape.Drawing on real-world case studies and diverse datasets—including environmental sensors, population health indicators, and urban infrastructure metrics—the book provides actionable insights for researchers, policymakers, urban planners, and public health professionals. It emphasizes not only technical innovation but also the ethical and equitable use of health data to reduce disparities and enhance quality of life for all city residents.

  • Lobular Breast Cancer

    An All-Round Multidisciplinary Overview
    • 1st Edition
    • GIovanni Corso + 1 more
    • English
    Lobular Breast Cancer: An All-Round Multidisciplinary Overview is a comprehensive academic resource that addresses the complex biology, diagnosis, and treatment of invasive lobular breast cancer. This book synthesizes current research and clinical practices, offering an integrated perspective from leading international experts. It covers key topics such as genetics, pathology, imaging, surgical approaches, and systemic therapies, emphasizing recent advances and future directions. The content is organized into clearly delineated sections, including epidemiology, molecular biology, imaging techniques, and therapeutic strategies, with dedicated chapters on emerging technologies like artificial intelligence. The multidisciplinary approach ensures that clinicians and researchers gain a thorough understanding of lobular breast cancer’s unique features, diagnostic challenges, and tailored treatment options, fostering evidence-based decision-making. This book benefits its academic audience by providing up-to-date, evidence-based insights, practical guidance for clinical management, and a foundation for future research. It supports professionals in staying current with evolving standards, improving patient outcomes, and advancing scientific knowledge in this specialized field.

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