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Academic Press

  • Molecular and Cellular Biology Approaches and Applications in Modern Drug Discovery

    • 1st Edition
    • Mithun Rudrapal + 1 more
    • English
    Molecular and Cellular Biology Approaches and Applications in Modern Drug Discovery is an essential guide that bridges the latest advances in molecular and cellular biology to revolutionize drug discovery. The book explores a wide range of tools and techniques, and their application to drug discovery, including genetic engineering, gene therapy, regenerative medicine, developmental biology, molecular diagnostics, biomarkers, RNA therapeutics, molecular immunology, and vaccine development. It also considers multi-omics approaches, biophysical methods, epigenetics and epigenomics, biomedical engineering, nanotechnology, artificial intelligence, bioinformatics, structural and computational approaches, and more. This comprehensive volume covers critical domains such as transcriptomics, proteomics, genomics, genetics, and cell signalling pathways, providing an in-depth understanding of their pivotal roles in drug development. It is an invaluable reference for researchers and advanced students working in these areas across molecular biology, biochemistry, pharmacology, biotechnology and related fields.

  • Pharmaceutical QbD with Design of Experiments

    Statistical Tools and Applications in Drug Delivery Systems
    • 1st Edition
    • Khushwant Yadav
    • English
    Pharmaceutical QbD with Design of Experiments: Statistical Tools and Applications in Drug Delivery Systems offers comprehensive coverage of best practices in pharmaceutical manufacturing. The first section discusses the principles and basics of Quality by Design (QbD). Part two covers the foundational statistical principles and tools for the Design of Experiments (DoE). Section three is dedicated to the applications of QbD for conventional formulations. The next section provides ample coverage of applications to Novel Drug Delivery Systems (NDDS), including micro and nano-particles. The final section discusses the application of QbD for the optimization of pharmaceutical processes and equipment.Researcher... in pharmaceutical manufacturing will benefit from this thorough statistical review, while students in this field will gain practical insights the experienced chapter authors provide in case studies. Industry professionals can find solutions to their particular problems within the insights and strategies shared in this book.

  • Super-Resolution Nanoscopy for Protein Imaging

    • 1st Edition
    • Varun Vyas
    • English
    Super-Resolution Nanoscopy for Protein Imaging decodes the intricate world of protein visualization using cutting-edge nanoscopic techniques. This comprehensive guide is crafted to equip master students, PhD candidates, and early-stage researchers with essential knowledge and practical insights into advanced protein imaging technologies. The book covers foundational principles, innovative methodologies, and real-world applications, providing a complete resource for mastering the complexities of protein imaging. This book offers a unique compilation of diverse nanoscopic methods, overcoming the limitation of technique-specific texts currently available.By collecting scattered information into a single volume, it delivers an in-depth exploration of imaging techniques, from Atomic Force Microscopy (AFM) to Electron Microscopy (EM), and Single Molecule Fluorescence Imaging. Each section delves into instrumentation, sample preparation, data analysis, and the latest developments, making it an indispensable reference for understanding how to visualize proteins in their natural environments.

  • Shared Research Resources

    Best Practices in Management and Administration
    • 1st Edition
    • Andrew Vinard + 2 more
    • English
    Shared Research Resources: Best Practices in Management and Administration brings together best practices and case studies from research institutions around the world. Covering all areas of management, with examples and applications specific to the research environment, this is the perfect reference to build managerial skills. The first part is dedicated to introducing Shared Research Resources (SRR) management. The second part covers all aspects of staffing. Part three contains complete coverage of operations, including service development, instrument procurement, marketing, management software, customer support, safety, maintenance and repair. Part four is dedicated to fiscal management, budgeting, and reporting.Part five covers strategic management. Part six is devoted to the sustainability of the core facility. The final part covers assessment, including annual reports, program reviews, and audits. This book is a complete reference targeted at SRR managers and staff who need to keep updated with current best practices and case studies. It is also important reading for research institution managers and function leaders.

  • Artificial Intelligence Based Primary Care

    Artificial Intelligence and Human Cognition in General Practice and Family Medicine
    • 1st Edition
    • Anthony C. Chang + 5 more
    • English
    Artificial Intelligence Based Primary Care: Artificial Intelligence and Human Cognition in General Practice and Family Medicine provides a comprehensive look into the integration of artificial intelligence within primary care. This book aims to bridge the gap between data scientists and primary care clinicians by presenting potential AI applications, implementation challenges, and real-world clinical scenarios in an accessible manner. Comprised of 5 sections and 20 chapters, it offers both theoretical insights and practical guidance for family medicine practitioners.Additi... the book includes a chapter dedicated to a day in the life of a General Practitioner, showcasing the practical impact of AI. It also features an extra compendium listing the Top 100 articles and best books on Artificial Intelligence. This resource is invaluable for academics, researchers, and clinicians eager to expand their knowledge in this emerging field.

  • Neuroinclusive Teaching Strategies, Course Design, and Student Support in Higher Education

    • 1st Edition
    • Meera Rastogi + 2 more
    • English
    The Handbook of Evidence-based Neuroinclusive Teaching, Course Design, and Student Support in Higher Education: Promoting Evidence-Based Neuroinclusive Teaching, Course Design, and Student Support in Higher Education is a comprehensive handbook addressing the critical research-to-practice gap in post-secondary education for neurodiverse students by providing actionable, evidence-based practices aimed at fostering neuroinclusive environments. Recognizing the emerging field of neurodiversity studies, this book challenges traditional norms shaped by a neurotypical viewpoint and promotes a deeper understanding of cognitive diversity. With a holistic approach, it explores three essential pillars: teaching, support services, and community partnerships, including critical resources. Readers will learn to implement strengths-based instructional methods, design equitable course structures, and develop effective support systems tailored to neurodiverse learners. Covering foundational concepts and instructional strategies, this handbook serves as a vital resource for educators committed to enhancing the educational experiences and outcomes of all students.

  • Advanced Ultrasound with Imaging Correlations of Diffuse Liver Diseases

    • 1st Edition
    • Riccardo De Robertis
    • English
    Advanced Ultrasound with Imaging Correlations of Diffuse Liver Diseases is an essential guide addressing the critical need for detailed comparisons between advanced ultrasound (US) techniques and CT/MRI findings in the evaluation of liver diseases. While many books on liver US exist, few provide the in-depth analysis and practical guidelines necessary for accurate diagnosis and effective treatment planning. This book fills that gap, offering a multiparametric approach to the assessment of fibrotic and steatotic liver diseases, ensuring clinicians and researchers have the most current and thorough information at their disposal. Inside, readers will find essential topics such as the indications for liver US in diffuse liver diseases, advanced US techniques for assessing liver fibrosis and steatosis, and the correlation between US, CT, and MRI findings. Key chapters cover the basics of liver ultrasound, conventional Doppler and microvascular flow imaging, ultrasound elastography, and the quantification of liver steatosis. Additionally, the book explores cutting-edge topics like artificial intelligence in liver ultrasound and the application of US in pediatric patients. Contributions from leading experts in the field ensure that each chapter provides valuable insights and practical advice. Advanced Ultrasound with Imaging Correlations of Diffuse Liver Diseases is an indispensable resource for scientists, researchers, and clinicians alike. It offers clear guidelines on performing liver ultrasounds, understanding and interpreting results, and making informed comparisons with CT and MRI findings. By integrating advanced imaging techniques and providing comprehensive correlations, this book enhances diagnostic accuracy and supports the development of effective treatment strategies for diffuse liver diseases, making it a vital addition to your medical library.

  • PFAS Contamination

    Global Prevalence, Toxicological and Ecotoxicological Impacts, and Mitigation Strategies
    • 1st Edition
    • Saranya Narayanasamy + 1 more
    • English
    PFAS Contamination: Global Prevalence, Toxicological and Ecotoxicological Impacts, and Mitigation Strategies offers a comprehensive overview of per- and polyfluoroalkyl substances (PFAS), highlighting their global environmental prevalence, toxicological effects and health risks, and state-of-the-art remediation approaches. This book taps into the increasing recognition of PFAS as “forever chemicals” and explores the widespread contamination of these compounds in water, soil, and air along with their toxicological effects on human health and the ecosystem. It highlights recent advancements in detection methods as well as physicochemical, biological, and emerging remediation technologies, including plasma-based technologies, bioremediation, and advanced nanotechnology-based methods, such as plasma technology, bioremediation, and adsorption methods, with case studies illustrating successful applications. It also examines policy frameworks, regulatory measures, and public health impact of PFAS. PFAS Contamination serves as a vital resource for environmental toxicologists, environmental scientists, environmental consultants, engineers, and regulators studying PFAS prevalence, toxicity mechanisms, remediation, and practical strategies for mitigating PFAS contamination and fostering a deeper understanding of the global efforts to address this critical issue.

  • Multiple Faces of Takotsubo Syndrome

    Clinical Presentations, Mechanisms and Advanced Diagnostic Insights
    • 1st Edition
    • Luca Saba + 1 more
    • English
    Multiple Faces of Takotsubo Syndrome: Clinical Presentaions, Mechanisms and Advanced Diagnostic Insights offers a thorough and up-to-date review of Takotsubo syndrome and the role of advanced imaging techniques in improving diagnosis, monitoring, and management of this complex cardiac condition. With rapid advancements in understanding Takotsubo syndrome and imaging technologies, there is a critical need for a text that integrates the latest research, clinical insights, and cutting-edge imaging methods, providing a holistic resource for those managing this evolving condition. The book is structured into six detailed sections. It begins with an introduction to Takotsubo syndrome, covering its historical background, prevalence, and key clinical characteristics. Subsequent chapters delve into epidemiology, risk factors, and psychological aspects, including the impact of COVID-19 and other viral infections. The clinical manifestations, management, prevention, and treatments are thoroughly discussed, along with complications and prognosis. The basic science section explores the pathophysiological mechanisms, the heart-brain axis, and multi-organ involvement. A significant focus throughout is placed on invasive and non-invasive imaging modalities, including angiography, echocardiography, cardiac MRI, computed tomography, and nuclear imaging. Future directions highlight emerging biomarkers and imaging techniques for personalized medicine, and real-world case studies provide practical insights for clinicians. Multiple Faces of Takotsubo Syndrome: Clinical Presentaions, Mechanisms and Advanced Diagnostic Insights offers invaluable benefits to scientists, researchers, and clinicians alike. The special focus on cutting-edge imaging technologies enables a deeper understanding of disease mechanisms and new avenues for innovation. The book connects foundational research with real-world clinical applications, offering practical guidance for managing patients with Takotsubo syndrome. The unique emphasis on advanced imaging modalities enhances diagnosis, management, and prognosis, making this text an essential resource for those dedicated to advancing the care and treatment of Takotsubo syndrome.

  • The Renaissance in GPCR Research and Drug Discovery

    Receptor Function, Receptor Structure, New Techniques, and Characterization of Drug Activity
    • 1st Edition
    • Terry P. Kenakin
    • English
    The Renaissance in GPCR Research and Drug Discovery: Receptor Function, Receptor Structure, New Techniques, Characterization of Drug Activity, Drug Discovery is a comprehensive reference for pharmacology researchers. It focuses on utilizing novel aspects of GPCR function for therapeutic advantage and applying new chemical types to modify GPCR behavior. Recent advancements have revitalized GPCR discovery, opening unexplored avenues for new drug development. The book's content is meticulously divided into five distinct parts, covering evolutionary perspectives, novel functions, investigative technologies, therapeutic modalities, and a broad range of GPCR ligands.Beyond these key topics, the book delves into the evolution of GPCRs as drug targets, the mechanisms behind their novel functions, and the latest technologies driving research and discovery. It also highlights new and recently approved therapeutic modalities and provides a broad coverage of GPCR ligands. Edited and authored by leading researchers, this book serves as an essential reference for drug discovery researchers and medicinal chemists, as well as AI researchers exploring this drug discovery space.

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