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Elsevier

Academic Press

  • The Zebrafish Model of Neurodegenerative Disorders

    Knowing the Unknown
    • 1st Edition
    • Wael Mohamed
    • English
    The Zebrafish Model of Neurodegenerative Disorders: Knowing the Unknown reveals a ground-breaking method for decoding neurodegenerative disorders such as Parkinson's, Alzheimer's, ALS, and Huntington's through the lens of the zebrafish. This volume bridges the divide between fundamental science and clinical innovation, demonstrating how the genetic malleability, transparent embryos, and conserved neural pathways of zebrafish provide unparalleled insights into neurodegeneration. It illustrates the potential to uncover concealed pathological mechanisms, expedite drug discovery, and surmount the translational failings that impede current research using this gold-standard model species. Featuring contributions from global experts, this volume is systematically structured into five topical sections for ease of navigation. These sections explore the role of cutting-edge tools such as CRISPR-Cas9, AI-driven phenotyping, and high-throughput drug screening in the study of α-synuclein aggregation in Parkinson's Disease and amyloid-β toxicity in Alzheimer's Disease. The volume offers real-world applications, comparative analyses of zebrafish and mammalian models, and actionable protocols that translate zebrafish discoveries to clinical trials. The Zebrafish Model of Neurodegenerative Disorders is designed to empower researchers, clinicians, and healthcare professionals by addressing existing gaps in knowledge, particularly fragmentation in protocols and the translational disconnect between preclinical models and human trials. By fostering an integrated understanding of zebrafish as a model for neurodegeneration, it enhances research reproducibility, accelerates drug discovery, and promotes ethical, scalable research practices. Whether used as a teaching resource or a reference for experimental design, this volume offers invaluable insights to advance the understanding and treatment of devastating neurodegenerative diseases.

  • Bioinformatics, Computational Biology, and Multi-Omics–Driven Probiotic Design for Gut Microbiome Engineering

    • 1st Edition
    • Naheed Mojgani + 3 more
    • English
    Bioinformatics, Computational Biology, and Multi Omics–Driven Probiotic Design for Gut Microbiome Engineering presents an interdisciplinary framework for applying artificial intelligence to microbiome science, probiotic development, and personalized nutrition. The book integrates bioinformatics, computational biology, and clinical insight to address current challenges in gut microbiome research and translation. The volume covers AI driven microbiome profiling, multi omics integration, computational modeling of host–microbe interactions, and predictive analytics. It progresses from foundational concepts to advanced applications, including AI assisted probiotic design, gut–brain axis research, regulatory considerations, and real world case studies supporting translational and clinical relevance. The book equips bioinformaticians, translational microbiome researchers, and clinician scientists with actionable methodologies, conceptual clarity, and validated examples. It supports evidence based decision making, accelerates translational research, and bridges discovery science with implementation in personalized nutrition and probiotic innovation.

  • Wilson and Mulcahy’s Prosthetic Urology

    A Comprehensive Guide to Surgery for Erectile Dysfunction and Male Incontinence
    • 1st Edition
    • Jay Simhan + 1 more
    • English
    Wilson and Mulcahy’s Prosthetic Urology: A Comprehensive Guide to Surgery for Erectile Dysfunction and Male Incontinence is a comprehensive reference that covers the surgical management of erectile dysfunction and male incontinence.This book's chapters cover a wide range of topics, including the history of penile prostheses, practice considerations, patient selection, placement techniques for malleable and inflatable penile prostheses, management of complications, and infection prevention and management. Additionally, specialized topics such as managing Peyronie's disease, priapism, and penile prosthesis placement in transgender patients are also addressed.Written by esteemed experts in the field, this reference offers valuable insights and guidance for healthcare professionals. Whether you are a practicing prosthetic urologist, a trainee looking to enhance your skills, or a device manufacturer aiming to improve surgical quality, this essential reference will elevate your knowledge and expertise.Tibor Imley's cover photo features Dr. Wilson and Dr. Mulcahy, after whom this title is named. This book honors their pioneering contributions to prosthetic urology.

  • A Comprehensive and Practical Guide in Clinical Trials

    • 2nd Edition
    • Brenda Wright
    • English
    The Comprehensive and Practical Guide in Clinical Trials, Second Edition offers a thorough update to the foundational handbook on clinical trial conduct. It reflects the evolving landscape of clinical research since 2017, incorporating new regulatory guidelines, innovations in device trials, and the shift to electronic data capture and management. This resource addresses the needs of clinical trial staff by detailing processes essential to successful trial execution. Covering all aspects of clinical research, the book includes chapters on trial phases, site selection, regulatory requirements, contracts, protocol development, informed consent, and data management. New chapters focus on project management, electronic source documents, and pharmacy operations. Each chapter integrates practical tools such as checklists, templates, and case studies to facilitate understanding and application. This handbook uniquely supports the entire clinical trial team—including investigators, coordinators, pharmacists, data managers, and regulatory personnel—by clarifying roles and responsibilities and illustrating how their tasks interconnect. Its accessible style and comprehensive scope make it an indispensable guide for planning, conducting, and closing clinical trials effectively and in compliance with international standards.

  • Capsule Endoscopy in Pediatric Patients from Theory to Practice

    • 1st Edition
    • Thomas M. Attard
    • English
    Capsule Endoscopy in Pediatric Patients from Theory to Practice is a practical and authoritative guide that empowers pediatric gastroenterologists, physicians, and trainees to navigate the complexities of Video Capsule Endoscopy (VCE) in children. With a focus on bridging knowledge gaps and providing practical insights, this book offers updated information on understanding and utilizing VCE in the pediatric population. The book covers the background and technical aspects of VCE, including guidance on setting up a pediatric VCE service and an overview of indications and limitations. It delves into practical aspects such as preprocedural preparation, artifact reduction techniques, and management of capsule retention. By exploring VCE in various disease conditions such as inflammatory bowel disease, gastrointestinal bleeding, hereditary polyposis syndromes, and chronic abdominal pain, readers gain a comprehensive understanding of diagnosis, surveillance, and management. Special content elements, including key terms, case studies, and a timeline of recent advances, enhance the learning experience. This essential resource empowers readers to optimize patient care, make informed decisions, and confidently navigate the realm of VCE in children.

  • SARS-CoV-2 Infection and the Development of Therapeutics

    • 1st Edition
    • Amit Kumar Nayak + 1 more
    • English
    SARS-CoV-2 Infection and the Development of Therapeutics provides thorough insights into the SARS-CoV-2 virus, viral infection and transmission, the emergence of variants, need for testing and rapid diagnosis, and the development of effective therapeutic interventions. This book begins with an introduction that highlights the urgent need for effective therapies against this virus. The second section dives into the pathophysiology of viral infections, providing valuable insights into transmission dynamics and the essential role of testing and rapid detection methods. The third section examines antiviral agents and treatments, addressing the numerous challenges in drug design, the immune response, and vaccine development.Finally, the fourth section tackles related issues such as co-infections in COVID-19 patients, the landscape of clinical trials, regulatory considerations, and future perspectives on antiviral therapies. With contributions from an international group of experts, this book offers a well-rounded understanding of the ongoing battle against SARS-CoV-2 and the COVID-19 disease it causes.

  • Marine Operations of Offshore Wind Turbines

    Autonomous Systems and Applications
    • 1st Edition
    • Zhengru Ren
    • English
    Marine Operations of Offshore Wind Turbines: Autonomous Systems and Applications, a new release in Elsevier's Wind Energy Engineering series, draws on the latest advances in marine operations to offer practical information on dynamics and automatic control. The book begins by introducing marine operations and offshore wind turbines, the fundamentals of dynamics and automatic control, and the definition of operability for marine operations before in-depth chapters cover numerical modeling and simulation tools, lifting operations for components, active control of offshore single-blade installation, modeling and control of full assembly installation and use of low-height mechanisms, and further technological developments.This is a valuable resource for all those looking to understand dynamics and automatic control techniques for offshore wind turbine operations, including researchers, students, engineers, R&D, policymakers, and industry professionals.

  • Mechanobiology and Mechanomedicine

    From Fundamentals to Applications
    • 1st Edition
    • Lifang Hu + 2 more
    • English
    Mechanobiology and Mechanomedicine: From Fundamentals to Applications offers an in-depth investigation of the role mechanical stimuli plays in biological systems, from cellular behavior to disease development. Organized into three parts, the book initially covers the fundamentals of mechanobiology, exploring cellular and molecular mechanobiology including mechanical force types, mechanosensors and transducers, mechanosensitive signaling pathways and nuclear mechanotransduction. In addition, the application of finite element modeling techniques in studying multiscale mechanobiology of bone are included. The second section focuses on mechanobiology more broadly in health and disease, spanning its role across bone, cartilage, the dental and periodontal tissues, muscle, the cornea and sclera, and in airways. Each chapter considers the molecular and cellular mechanisms of mechanotransduction in these areas, as well as its significance for associated physiological and pathological conditions. The final section examines novel technologies like high-resolution mechanical imaging, organoids and artificial intelligence, concluding with the translational potential of mechanomedicine and its therapeutic applications.Mechano... and Mechanomedicine: From Fundamentals to Applications serves as a comprehensive and systematic overview of mechanobiology, sharing insights into the latest research advances and clinical relevance. Taking an interdisciplinary approach, this book is ideal for scientists, researchers and advanced students working across a range of areas including molecular biology, cell biology, translational medicine, biomechanics, biomedical engineering, biotechnology and related fields.

  • Biopolymer-Based Therapeutics for Inflammation Modulation in Wound Care

    • 1st Edition
    • Neha Raina + 2 more
    • English
    Biopolymer-Based Therapeutics for Inflammation Modulation in Wound Care presents a comprehensive, biomarker-driven exploration of how natural and engineered biopolymers are transforming the management of acute, chronic, and non-healing wounds. Positioned at the intersection of biomaterials science, pharmaceutical innovation, and clinical practice, the book addresses one of the central challenges in wound care: persistent inflammation that delays tissue repair and regeneration. Beginning with the biological and clinical foundations of wound healing, the book systematically examines inflammatory pathways and key biomarkers such as TNF-α, IL-6, ROS, and VEGF.It then advances into in-depth coverage of natural biopolymers—includin... collagen, chitosan, hyaluronic acid, silk-derived polymers, and marine polysaccharides—and their roles in immune modulation, macrophage polarization, and redox balance. Dedicated sections explore advanced delivery platforms such as nanofibers, smart hydrogels, nanozymes, and stimuli-responsive dressings, alongside emerging precision technologies including 3D printing and AI-guided material design. With a strong translational focus, the book bridges laboratory research and real-world application, addressing regulatory pathways, manufacturing scalability, and commercialization challenges.

  • Spaceflight Ophthalmology and Medicine

    A Comprehensive Guide to Ocular Health and Related Systemic Health Risks in Astronauts and Space Travelers
    • 1st Edition
    • Ryung Lee + 4 more
    • English
    Spaceflight Ophthalmology and Medicine: A Comprehensive Guide to Ocular Health and Related Systemic Health Risks in Astronauts and Space Travelers provides a comprehensive exploration of ocular health issues faced by astronauts during space missions. The book brings together contributions from leading experts in various fields, addressing the multifaceted risk factors associated with spaceflight and their implications for vision and overall health. Sections examine risk factors for ophthalmic diseases, including the effects of microgravity, space radiation, and oxidative stress, and explore innovative approaches in spaceflight ophthalmology, such as advanced diagnostic techniques and potential treatments for ocular conditions specific to the space environment. This book serves as an essential resource for researchers, clinicians, and space medicine professionals. By offering insights into the latest research and practical applications, it enhances understanding of ocular health in space and promotes the development of effective strategies to ensure astronaut safety and mission success.

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