Physiology, Medicine, and Health Sciences
Catalyzed by Biomedical Engineering Modeling
- 1st Edition - March 1, 2027
- Latest edition
- Authors: Dhanjoo N. Ghista, Kayalvizhi Mohan
- Language: English
Physiology, Medicine, and Health Sciences: Catalyzed by Biomedical Engineering Modeling is a quantitative handbook for mathematical and quantitative analysis of anatomical struct… Read more
Description
Description
Physiology, Medicine, and Health Sciences: Catalyzed by Biomedical Engineering Modeling is a quantitative handbook for mathematical and quantitative analysis of anatomical structures, physiological and organ systems, medical tests and surgical procedures. This book’s purpose is to demonstrate how fundamental mathematical modeling can be incorporated into physiology, medicine, and health sciences research, application, and clinical practice to make these disciplines more quantitative and computational, and hence more explanatory and informative. The book also provides quantitative formulation of medical procedures, towards supporting the growing field of precision medicine. Each chapter includes a robust introduction to the BME and mathematical concepts necessary to understand their application to the indicated medical and biological systems, beginning with Intrinsic Anatomy, showing how anatomical structures are intrinsically optimally designed for their functional performance, such as the intrinsic hyperboloid shape of the spinal vertebral body (as a lightweight, high-strength structure), and the ellipsoidal shape of the left ventricle that enables it to contract efficiently. Other BME and modelling concepts covered include: Physiological Engineering, in quantifying physiological systems and developing indices for assessing their function and dysfunction leading to medical diagnostics; Precision Medicine, by developing biomedical engineering formulation of medical diagnostic and assessment methods and indices, including the new concept of non-dimensional indices in medical assessment, such as cardiac contractility index for risk of heart failure and diabetes index for accurate diagnosis of diabetes; and, Computational Surgery, involving surgical design of prosthetic devices based on the intrinsic design of the fractured structure, such as the design of the spinal vertebral body cage for fractured vertebral body to preserve its intrinsic hyperboloid shape. Each chapter provides in-depth guidance on the engineering and mathematical concepts, methodology, and procedures for applying the formulas and equations to the appropriate biomedical and physiological systems, as well as step-by-step procedures for creating models for a wealth of specific applications.
Key features
Key features
- Includes real-world examples and case studies that illustrate how BME and mathematics are used in medical research, clinical practice, and healthcare management
- Equips the audience with the knowledge and tools to design experiments, collect data, and analyze results using BME and mathematical techniques, potentially leading to more robust and impactful research outcomes
- Provides readers with a solid foundation in BME and mathematical concepts and techniques relevant to physiology, medicine, and health sciences
Readership
Readership
Biomedical engineers, biomedical and clinical researchers as well as biomedical and clinical professionals who are interested in pursuing further studies or research and need a stronger mathematical foundation
Table of contents
Table of contents
1. STEM Model of Medicine (STEM2) in Education and Clinical Care: New Era of Integrated Biomedical Engineering and Medicine
Section 1. Glucose-Insulin Regulatory System Physiology and Diabetes Diagnostics
2. Glucose-Insulin Regulatory System Model and formulation of Nondimensional Diabetes Indices for Accurate Diagnosis of Diabetic Subjects
3. Analysis of OGTT Blood Glucose and Insulin Responses, and Diagnostic Indices to categorize patients as normal or diabetic or at risk of becoming diabetic
4. Digitizing Diabetes Care Through Technology and Data: Strategies for Modern Challenges
Section 2. Lung Ventilation Physiology and Ventilation Index for Lung disorders
5. Lung Ventilation Modeling and formulation of Ventilatory Index for Lung Disease Diagnosis
6. Nondimensional Lung Ventilatory Index for Weaning Mechanically Ventilated COPD patients
Section 3. Cardiovascular Physiology and Medicine
7. Left Ventricular Contractility Indices, for depicting (1) normal well- contracting left ventricles, and (ii) cardiomyopathic left ventricles at risk of heart failure
8. Analysis of Arterial Pulse Wave Propagation: Determination of Pulse Wave Velocity and Arterial Stiffness
9. Determination of Aortic Pressure Waveform due to the blood pumped by the Left Ventricle into the Aorta, and Measure of Aortic Stiffness and Arteriosclerosis
10. Left Ventricular Twisting model to Simulate Left ventricular Contraction and Pressure increase during Isovolumic Contraction, caused by myocardial fiber contraction and angle decrease
11. Cardiac Flow Analysis and its application to Flow in the Left Ventricle to study Vortex dynamics
12. Bioelectricity to Electrocardiology: Theory of ECG and VCG
13. ECG Principles, Signal components interpretation, Signal Processing methods, Bioelectric principles in ECG diagnosis
Section 4. Spinal Physiology and Orthopedic Engineering
14. Spinal Lumbar Vertebral Body, Intrinsically Designed as a Functionally Optimal Structure
15. Spinal Intervertebral Disc, Intrinsically Designed as an Optimal structure for its Function
16. Analysis of the Helical Plate for Spiral Fracture Fixation of Bones
17. Biomechanics of Back Pain: Prevention through Postural Energization of Spinal Structures, Treatment through Percutaneous Discectomy
Section 5. Renal Physiological Engineering and Dialysis Technology
18. Kidney Function and Failure, Artificial Kidney Function by Hemodialysis and Peritoneal Dialysis
19. Renal Physiological Engineering: Analysing its Anatomy and Functions, for regulation of urine concentration by the counter-current mechanism in the loop of Henle
20. Mathematical Modeling of Epithelial Transport in the Kidney
Section 6. Neuronal Physiology and Engineering
21. Neuroscience, Science of the Brain and its Functions, Genes Expression and Neuronal Mechanisms
22. Nerve Conduction: Action Potential development & propagation: Nerve conduction Analysis, Nerve Impulse Transmission
23. Brain Health and Neuroplasticity: How Meditation transforms the Brain, promotes Psychosomatic Health, and regulates its Cognitive Function
Section 7. Healthcare Management and Personalized Healthcare
24. Hospital and Healthcare Management Program
25. Personalized Healthcare with Applications in
(i) Cardiac Fitness Index from Treadmill Heart Rate monitoring
(ii) Diabetes detection Index by CGM device
(iii) Yoga Meditation for preventive and curative care FINALE
26. Physiological Nondimensional Indices in Medical Assessment for Accurate Diagnosis of Organs Dysfunction, Physiological Disorders and Disease States
Section 1. Glucose-Insulin Regulatory System Physiology and Diabetes Diagnostics
2. Glucose-Insulin Regulatory System Model and formulation of Nondimensional Diabetes Indices for Accurate Diagnosis of Diabetic Subjects
3. Analysis of OGTT Blood Glucose and Insulin Responses, and Diagnostic Indices to categorize patients as normal or diabetic or at risk of becoming diabetic
4. Digitizing Diabetes Care Through Technology and Data: Strategies for Modern Challenges
Section 2. Lung Ventilation Physiology and Ventilation Index for Lung disorders
5. Lung Ventilation Modeling and formulation of Ventilatory Index for Lung Disease Diagnosis
6. Nondimensional Lung Ventilatory Index for Weaning Mechanically Ventilated COPD patients
Section 3. Cardiovascular Physiology and Medicine
7. Left Ventricular Contractility Indices, for depicting (1) normal well- contracting left ventricles, and (ii) cardiomyopathic left ventricles at risk of heart failure
8. Analysis of Arterial Pulse Wave Propagation: Determination of Pulse Wave Velocity and Arterial Stiffness
9. Determination of Aortic Pressure Waveform due to the blood pumped by the Left Ventricle into the Aorta, and Measure of Aortic Stiffness and Arteriosclerosis
10. Left Ventricular Twisting model to Simulate Left ventricular Contraction and Pressure increase during Isovolumic Contraction, caused by myocardial fiber contraction and angle decrease
11. Cardiac Flow Analysis and its application to Flow in the Left Ventricle to study Vortex dynamics
12. Bioelectricity to Electrocardiology: Theory of ECG and VCG
13. ECG Principles, Signal components interpretation, Signal Processing methods, Bioelectric principles in ECG diagnosis
Section 4. Spinal Physiology and Orthopedic Engineering
14. Spinal Lumbar Vertebral Body, Intrinsically Designed as a Functionally Optimal Structure
15. Spinal Intervertebral Disc, Intrinsically Designed as an Optimal structure for its Function
16. Analysis of the Helical Plate for Spiral Fracture Fixation of Bones
17. Biomechanics of Back Pain: Prevention through Postural Energization of Spinal Structures, Treatment through Percutaneous Discectomy
Section 5. Renal Physiological Engineering and Dialysis Technology
18. Kidney Function and Failure, Artificial Kidney Function by Hemodialysis and Peritoneal Dialysis
19. Renal Physiological Engineering: Analysing its Anatomy and Functions, for regulation of urine concentration by the counter-current mechanism in the loop of Henle
20. Mathematical Modeling of Epithelial Transport in the Kidney
Section 6. Neuronal Physiology and Engineering
21. Neuroscience, Science of the Brain and its Functions, Genes Expression and Neuronal Mechanisms
22. Nerve Conduction: Action Potential development & propagation: Nerve conduction Analysis, Nerve Impulse Transmission
23. Brain Health and Neuroplasticity: How Meditation transforms the Brain, promotes Psychosomatic Health, and regulates its Cognitive Function
Section 7. Healthcare Management and Personalized Healthcare
24. Hospital and Healthcare Management Program
25. Personalized Healthcare with Applications in
(i) Cardiac Fitness Index from Treadmill Heart Rate monitoring
(ii) Diabetes detection Index by CGM device
(iii) Yoga Meditation for preventive and curative care FINALE
26. Physiological Nondimensional Indices in Medical Assessment for Accurate Diagnosis of Organs Dysfunction, Physiological Disorders and Disease States
Product details
Product details
- Edition: 1
- Latest edition
- Published: March 1, 2027
- Language: English
About the authors
About the authors
DG
Dhanjoo N. Ghista
Dr. Dhanjoo N. Ghista is President of the University 2020 Foundation and a world authority in Biomedical Engineering. Dr. Ghista is author and editor of numerous books on subjects ranging from Biomedical Engineering to Cardiology science and technology, and he is the inventor of novel medical diagnostic and surgical procedures. Dr. Ghista is a pioneer in the field of Biomedical Engineering in Translational Medicine. He promotes a new STEMbased model of Medicine for precision medicine and surgery, as well as the role of universities in contributing sustainable community development. Dr. Ghista has an international standing in academia, having set up programs and departments at universities in responsible academic-administrative positions (from Department Head to CAO/Provost), and has even been involved in planning universities. Dr. Ghista has taught courses in Engineering, Physics, Biomedical Engineering, medical sciences, sports science, and hospital management. His research involvements and publications include Biomedical Engineering, Medicine, Cognitive Science and therapy, sports science, sustainable communities, and the role of university in society. Dr. Ghista is the author/editor of Biomedical Engineering Modeling for Medical Assessment, Volumes 1-3, Springer; Coronary Artery Bypass Grafting Design Simulations, Lambert Academic Publishing; Cardiac Perfusion and Pumping Engineering, World Scientific Publishing; Applied Biomedical Engineering Mechanics, CRC Press; and Orthopaedic Mechanics Procedures and Devices, Academic Press; among many others.
Affiliations and expertise
President, University 2020 Foundation, Palo Alto, CA, USAKM
Kayalvizhi Mohan
Dr. Kayalvizhi Mohan is an experienced Head of Department with a demonstrated history of working in the higher education industry. Skilled in Cognitive Science, Biomedical Engineering, Cognitive Neuroscience, Matlab, and Research, he is a strong education professional with a Doctor of Philosophy (Ph.D.) focused in Biomedical/Medical Engineering from Madras Institute of Technology campus Anna University.
Affiliations and expertise
Chennai Institute of Technology, Anna University, India