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  • Carrier-Free Enzyme Immobilization

    Fundamentals and Innovations in Biocatalysis
    • 1st Edition
    • Mehdi Mohammadi + 1 more
    • English
    Carrier-Free Enzyme Immobilization: Fundamentals and Innovations in Biocatalysis explores innovative techniques for immobilizing enzymes without the use of inert carriers, highlighting their advantages, applications, and integration into modern biocatalytic processes. This comprehensive volume provides a detailed examination of the principles, methods, and practical applications of carrier-free enzyme immobilization, making it an essential resource for advancing biocatalysis. The book begins by introducing the concept of enzyme immobilization and the transition from traditional carrier-bound methods to innovative carrier-free techniques. It discusses the fundamental principles behind carrier-free immobilization, including the types of cross-linkers used and the advantages in enhancing enzyme stability and activity.The book also covers various methods for the structural characterization of carrier-free immobilized enzymes. With a strong focus on practical implementation, the book examines the applications of carrier-free immobilized enzymes across different industries, highlighting the pros and cons of the method. It explores novel approaches for producing carrier-free immobilized biocatalysts and provides a comparative analysis of carrier-free versus traditional carrier-bound immobilization techniques. The book also addresses the challenges associated with implementing carrier-free immobilization in industrial processes and proposes potential solutions to overcome these obstacles.This book is an essential resource for biochemists, chemical engineers, and researchers in biotechnology who are involved in enzyme research and development. It also serves as a valuable reference for graduate students and postdoctoral fellows in fields related to biochemistry, chemical engineering, and biotechnology. Industry professionals in biotechnology, food production, environmental science, and pharmaceuticals will find this book highly beneficial for understanding and applying carrier-free immobilization methods in their processes.

  • Plant Peptides

    Enzymatic Production and Health-Promoting Effects
    • 1st Edition
    • Tolulope Joshua Ashaolu + 2 more
    • English
    Plant Peptides: Enzymatic Production and Health-Promoting Effects provides up-to-date insights on the enzymatic production, bioactivity, and applications of plant-derived peptides. This comprehensive volume explores the role of plant-based proteins (PBPs) as sustainable alternatives to traditional animal proteins, highlighting their environmental and climatic benefits. The book examines the enzymology of proteolytic enzymes used to generate bioactive peptides from PBPs, detailing their bioaccessibility, stability, and bioavailability. It offers an in-depth analysis of the multifarious biological activities of these peptides, including their antioxidant, antimicrobial, and metal-binding properties. The book also addresses the technological and biological properties, limitations, and challenges of plant-based bioactive peptides for industrial uses. With a strong focus on practical implementation, the book discusses emerging strategies and advanced technologies for producing and analyzing bioactive peptides, such as in silico analysis, fermentation, and peptidomics. It provides insights into future research directions and potential applications, emphasizing the health-promoting effects of plant-based peptides in combating obesity, diabetes, hypertension, cancer, and neurodegenerative diseases. This book is an essential resource for food science researchers, nutritionists, and students of food science and nutrition. It also serves as a valuable reference for teachers, scientists, food supplement producers, food businesses, and biosciences and medical students interested in the latest advancements in plant-based proteins and bioactive peptides.

  • Environmental Antimicrobial Resistance

    A Complete Handbook
    • 1st Edition
    • Dijendra Nath Roy + 1 more
    • English
    Environmental Antimicrobial Resistance: A Complete Handbook provides a comprehensive exploration of the challenges and solutions related to antimicrobial resistance (AMR) in the environment. This book addresses the global scenarios, sources of antimicrobial drugs, and the fate and transport of these drugs in the environment and living organisms. It explains the approach, protocols, and experiments for detecting and mitigating antimicrobial resistance phenomena, making it an essential resource for understanding and combating AMR. The book highlights the silent pandemic of AMR, emphasizing the mismanagement of antimicrobials in humans and animals as key contributors. It discusses the global impact, including the economic burden on low- and middle-income countries, and the efforts of the WHO Global Antimicrobial Resistance and Use Surveillance System (GLASS). With a systematic approach, the book provides researchers and academicians with routine and advanced knowledge in the field of environmental antimicrobial resistance, including detection and mitigation strategies. This handbook is designed to meet the educational needs of students and professionals in life sciences, environmental science, microbiology, and pharmacy. It offers comprehensive coverage of the current status, reasons for emerging drug-resistant microorganisms, and solutions for mitigating environmental antimicrobial resistance.

  • Healthcare 5.0

    Applications of Artificial Intelligence, Machine Learning, IoMT, and Big Data
    • 1st Edition
    • Yugal Kumar + 2 more
    • English
    Healthcare 5.0: Applications of Artificial Intelligence, Machine Learning, IoMT, and Big Data addresses the urgent need for innovation in today’s complex healthcare data landscape, characterized by pandemics, aging populations, and escalating chronic conditions. This book introduces the concept of ‘Healthcare 5.0’ as an interconnected, data-driven, and patient-centric framework, where advanced technologies—such as AI, ML, IoMT, Big Data, and Large Language Models (LLMs)—converge to optimize care, streamline operations, and deliver personalized, predictive solutions that meet real-world challenges. Comprising six comprehensive sections, the book moves from core AI applications in electronic health records, drug discovery, data management, and privacy, through cutting-edge big data analytics for precise disease forecasting and diagnosis. It explores new research advances in the Internet of Medical Things including connected device architectures and their fusion with AI for dynamic decision-making. The third section focuses on data analytics in telemedicine, remote care, system usability, and integration in Healthcare 5.0. The personalized healthcare section details analysis and applications in AI- and IoT-powered assistance, and real-time monitoring. The last section explores the development of LLMs and their applications in medical imaging, clinical decision support, predictive analytics, system architectures, as well as the ethical challenges of their deployment in healthcare. Healthcare 5.0: Applications of Artificial Intelligence, Machine Learning, IoMT, and Big Data serves as an essential resource for graduate students, researchers, and engineers in computer science, data science, and biomedical informatics. It bridges theory and practical application, offering interdisciplinary insights, foundational background, detailed case studies, and guidance on navigating the next generation of healthcare data systems. Whether for research or real-world innovation, readers gain the tools to design, analyze, and implement intelligent healthcare data solutions for a rapidly evolving digital era.

  • Combinatorial Enzyme Therapy Against ESKAPE Pathogenic Biofilms

    • 1st Edition
    • Awanish Kumar + 1 more
    • English
    Combinatorial Enzyme Therapy Against ESKAPE Pathogenic Biofilms offers the latest insights into ESKAPE pathogen biofilms, including their formation, structure, and resistance mechanisms and highlights innovative therapeutic strategies to combat them, with a specific focus on combinatorial enzyme therapies. The book begins with an overview of the significant burden these pathogens impose across healthcare and the food industry, laying the groundwork for understanding the intricate relationship between antibiotic resistance and biofilm dynamics. It advocates novel approaches through combinatorial enzymatic therapy, detailing the mechanisms and synergies of various enzymes in effectively dismantling biofilms. With insights into cutting-edge delivery systems, including nanotechnology and the integration of CRISPR-Cas systems and artificial intelligence, the book charts a course for the future of advanced therapeutic strategies. It concludes by addressing regulatory considerations, positioning combinatorial enzyme therapy as a promising frontier in the fight against persistent infections caused by ESKAPE pathogens

  • Cranial Nerve Compression Syndromes

    A Multidisciplinary Guide to Management
    • 1st Edition
    • Florian Roser + 1 more
    • English
    Cranial Nerve Compression Syndromes: A Multidisciplinary Guide to Management is a comprehensive volume exploring the entire pathophysiology of cranial nerve pathologies, from diagnosis to treatment options. Following a multidisciplinary approach, this volume integrates perspectives from neurosurgery, neurology, radiology, and pain management from experts in the field. An ideal resource for clinicians and researchers, this volume discusses the latest research on multi-modality, collaborative and cutting edge treatment options, with advanced surgical techniques, including microvascular decompression and endoscopic procedures with clear guidance.

  • Emergent Nanotherapeutics in Diabetic Complications

    • 1st Edition
    • Awanish Kumar + 1 more
    • English
    Emergent Nanotherapeutics in Diabetic Complications explores how cutting-edge nanotechnology is transforming the treatment of diabetes-related disorders beyond glycemic control. This comprehensive volume examines targeted, multifunctional nanoplatforms designed to address the wide range of comorbidities linked to diabetes, including vascular complications, metabolic dysfunctions, and impaired wound healing. Structured in five parts, the book spans from current nanoformulation strategies to emerging innovations such as CRISPR-Cas9 delivery, AI-guided nanoparticles, and 3D/4D printed nanostructures. Bridging the gap between preclinical research and clinical application, it offers valuable guidance on stimuli-responsive systems, biocompatible materials, and regulatory pathways. Emergent Nanotherapeutics in Diabetic Complications is essential for medical professionals, biomedical engineers, and pharmaceutical scientists seeking scalable, next-generation solutions for managing diabetic complications through nanomedicine.

  • The Kidney

    • 1st Edition
    • Ahmed El-Hashash + 2 more
    • English
    The Kidney, Volume 7 in the Stem Cell Innovation in Health and Disease series explores the emerging potential of stem cell therapies in treating kidney diseases. With their natural regenerative and anti-inflammatory properties, stem cells offer a promising approach to restoring essential kidney functions and mitigating damage. This volume highlights how stem cell therapies may modulate immune responses, promote tissue repair, and replace damaged kidney cells, offering hope for chronic and acute renal conditions. Key developments include the injection of mesenchymal stem cells (MSCs) into damaged kidneys, where they can differentiate into kidney cell types and aid in healing. Urine-derived stem cells have also shown significant potential in improving kidney function in preclinical studies. Additionally, innovative techniques like incorporating MSCs into compact dialysis machines are being explored, enabling delivery of pro-repair factors directly to the kidneys during blood filtration. While there are currently no FDA-approved stem cell treatments for kidney diseases, ongoing clinical trials aim to evaluate their safety and efficacy. This volume compiles cutting-edge research, discussing various cell sources, underlying mechanisms, observed therapeutic outcomes, and the practical challenges of clinical translation. By presenting a clear picture of current advances and future directions, The Kidney serves as a vital resource for scientists, clinicians, and health innovators seeking to harness stem cell technology in nephrology.

  • Hypoxia-induced Tumor Heterogeneity and Immune Evasion

    Clinical Interventions
    • 1st Edition
    • Benjamin Bonavida + 1 more
    • English
    Hypoxia-induced Tumor Heterogeneity and Immune Evasion: Clinical Interventions explores how hypoxic stress within the tumor microenvironment drives cancer progression, immune escape, and resistance to therapy. This volume integrates foundational and cutting-edge insights into tumor biology, immunology, and therapeutic innovation. The book is structured into five parts, covering tumor heterogeneity, hypoxia-driven mechanisms, immune evasion, clinical diagnostics, and future directions. It brings together global experts to examine how hypoxia shapes tumor evolution, alters immune responses, and influences treatment outcomes. Topics include metabolic reprogramming, angiogenesis, immune suppression, and hypoxia-targeted therapies, with emphasis on translational relevance. This resource benefits researchers, clinicians, and advanced students by offering a comprehensive, up-to-date synthesis of a rapidly evolving field. It supports deeper understanding of tumor complexity and equips readers with knowledge to inform experimental design, clinical strategies, and therapeutic development in oncology.

  • Biopolymers for 3D Tissue Engineering

    Processing and Applications
    • 1st Edition
    • Narendra Reddy + 1 more
    • English
    Biopolymers for 3D Tissue Engineering: Processing and Applications explores the critical role of biopolymers in advancing tissue engineering and 3D cell culture—key technologies in drug discovery, personalized medicine, and disease treatment. Scaffolds form the foundation of these applications, yet current options—primarily synthetic polymers like polypropylene, polyethylene, or polystyrene, and some natural materials such as collagen and silk fibroin—are often expensive and lack optimal properties such as biocompatibility, biodegradability, and mechanical stability. This book addresses the global effort to develop next-generation scaffolds that overcome these limitations. Biopolymers offer a compelling solution, with inherent biodegradability, biocompatibility, and sustainability. They are abundant, cost-effective, and derived from renewable sources, making them ideal for medical applications. However, their processing poses significant challenges, as many biopolymers resist dissolution in common solvents and lack thermoplastic behavior. This book provides a comprehensive overview of the structure, properties, and processability of biopolymers, with a focus on innovative techniques for converting them into functional scaffolds suitable for 3D cell culture. Unlike existing literature that emphasizes biomaterial properties or applications, this is the first book to focus exclusively on biopolymers for tissue engineering. It covers carbohydrates, proteins, and synthetic biopolymers in a single, authoritative source, making it invaluable for students, researchers, professionals, and industry stakeholders. By bridging the gap between material science and biomedical application, Biopolymers for 3D Tissue Engineering offers both a scientific foundation and practical insights to accelerate the development of sustainable, high-performance scaffolds for next-generation healthcare solutions.

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