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Elsevier

Academic Press

  • Anorectal Malformations

    • 1st Edition
    • Ivo de Blaauw + 2 more
    • English
    Anorectal Malformations is an essential resource for pediatric surgical specialists and caregivers, providing a comprehensive approach to the diagnosis, treatment, and follow-up of patients with anorectal malformations. This book not only covers the latest surgical techniques but also delves into the intricacies of the condition, offering structured advice from a trusted organization, ERN eUROGEN, and addressing the significant gaps in literature related to this rare disease. The handbook is meticulously organized, beginning with an introduction to the ERN eUROGEN and ARMnet networks, followed by an exploration of key topics such as anatomy, embryology, genetics, and epidemiology of anorectal malformations. It details surgical procedures, including colostomy and reconstruction techniques, as well as non-surgical treatments for common complications like constipation and incontinence. The book also emphasizes long-term outcomes, global care networks, and patient perspectives, ensuring a holistic understanding of the patient journey.Anorectal Malformations is invaluable for clinicians, researchers, and healthcare professionals, providing the necessary insights to make accurate diagnoses, perform effective surgeries, and ensure proper follow-up care. It serves as a critical reference guide for anyone involved in the care of patients with anorectal malformations, ultimately improving clinical outcomes and enhancing the quality of life for affected individuals and their families.

  • Insect Bioactives

    Innovations in Food, Feed, Pharma and Cosmetics
    • 1st Edition
    • Abdalbasit Adam Mariod + 2 more
    • English
    Insect Bioactives: Innovations in Food, Feed, Pharma and Cosmetics serves as a comprehensive resource for researchers and professionals seeking to harness the power of insects as sustainable bioactive sources and beneficial health and wellness solutions. The book identifies the nutritional and chemical composition of insects, presenting them as versatile ingredients for the development of functional foods, nutraceuticals, animal feed and cosmetics. By examining how edible insects can be reared on agri-food by-products and organic waste, this volume illustrates how feeding strategies can influence their nutritional and bioactive profiles. The text also addresses potential allergenic risks and consumer behavior insights, equipping readers with strategies to promote acceptance of insect-based products in the market.Structured into eight sections, Insect Bioactives: Innovations in Food, Feed, Pharma and Cosmetics covers a wide array of topics essential for understanding insect bioactives. From the foundational overview of insect-based compounds to their applications in functional foods, animal feed, pharmaceuticals, and cosmetics, each section provides insights into the health benefits and technological innovations associated with insect bioactives. The text also discusses regulatory considerations and features case studies that showcase successful applications in various industries.

  • Cultural Dimensions of Ageism

    East Meets West Toward an Age-inclusive Society
    • 1st Edition
    • Takashi Yamashita + 1 more
    • English
    Cultural Dimensions of Ageism: East Meets West Toward an Age-Inclusive Society explores ageism in two contrasting nations—Japan and the United States—and their respective approaches to addressing it. Despite its longstanding presence, ageism remains an underrecognized form of discrimination and stereotyping. As populations age rapidly worldwide, ageism manifests with striking similarities and profound differences across cultures, significantly shaping the lives of older adults. Drawing on these cross-cultural perspectives, the book offers strategic solutions for combatting ageism in a transcultural context, providing valuable insights for building a more inclusive, respectful global society. This groundbreaking contribution integrates novel, critical cross-national insights from two distinct cultural zones: Japan, a super-aged society with the world's highest life expectancy, and the United States, an economically developed nation with demographically and culturally diverse populations. Readers will find comprehensive coverage of ageism, cross-cultural comparison, and global aging in one succinct resource. For scientists and researchers, the book offers cross-cultural observations of ageism research from East/Japan and West/North America, with reflective questions and key takeaways to facilitate engagement. Clinicians will benefit from increased knowledge about ageism in diverse global communities, enriched by case studies and personal stories that bring a human element to the research. This is an essential resource for anyone dedicated to understanding and addressing ageism in our rapidly aging world.

  • Decoding the JAK-STAT Pathway

    Emerging Insights and Clinical Applications Across Diseases
    • 1st Edition
    • Meenakshi Dhanawat + 1 more
    • English
    Decoding the JAK-STAT Pathway: Emerging Insights and Clinical Applications Across Diseases offers a comprehensive exploration of one of the most vital molecular signaling pathways in human health and immune regulation. This reference addresses the critical need for an integrated resource that connects fundamental immunological mechanisms with translational and clinical applications, particularly in autoimmune, inflammatory, and infectious diseases. The book covers the pathway’s physiological roles in cytokine signaling, immune homeostasis, and cellular communication, as well as its dysregulation in conditions such as rheumatoid arthritis, inflammatory bowel disease, neuroinflammation, and viral infections. Its chapters feature contributions from global experts, detailing recent advances in targeted therapies, including JAK inhibitors, and their potential for personalized medicine. The content is organized to highlight disease-specific roles, therapeutic strategies, and emerging research directions, making it an essential resource for immunologists, biomedical scientists, clinicians, and pharmaceutical researchers seeking an authoritative, up-to-date guide to the molecular and clinical aspects of JAK-STAT signaling. By elucidating how this pathway influences immune responses and disease progression, the book facilitates a deeper understanding of immune regulation and offers insights into novel treatment approaches, ultimately supporting advancements in immunotherapy and precision medicine across diverse patient populations worldwide.

  • A Comprehensive Guide to Surgical Oncology

    • 1st Edition
    • Aqeel Shakir Mahmood + 2 more
    • English
    A Comprehensive Guide to Surgical Oncology is an authoritative reference that meticulously covers the surgical management of various cancers. Each section delves into the latest surgical techniques, treatment protocols, and post-operative care strategies, supported by up-to-date research and clinical evidence. Enriched with detailed illustrations, case studies, and expert insights, this book is an indispensable resource for professionals and students alike. The primary purpose of this book is to provide a comprehensive, up-to-date resource that addresses the current challenges and advancements in surgical oncology. As cancer treatment evolves rapidly with continuous improvements in surgical techniques and multidisciplinary care, there is a pressing need for a new resource that synthesizes these developments into a coherent guide. This book aims to fill that gap by offering a thorough overview of the latest surgical oncology practices, thereby enhancing the knowledge and skills of its readers. This book solves several key problems for its readers by bridging the gap between rapidly advancing research and clinical practice, ensuring access to the latest information. It consolidates a vast amount of information into one comprehensive volume, saving readers the time and effort of consulting multiple sources. Providing practical guidance on the surgical management of a wide range of cancers, it helps practitioners make informed decisions in clinical settings. For students and trainees, it serves as a valuable educational tool that covers both foundational knowledge and advanced concepts in surgical oncology, offering multidisciplinary insights that foster a better understanding of the collaborative efforts required in cancer treatment.

  • Physiology, Medicine, and Health Sciences

    Catalyzed by Biomedical Engineering Modeling
    • 1st Edition
    • Dhanjoo N. Ghista + 1 more
    • English
    Physiology, Medicine, and Health Sciences: Catalyzed by Biomedical Engineering Modeling is a quantitative handbook for mathematical and quantitative analysis of anatomical structures, physiological and organ systems, medical tests and surgical procedures. This book’s purpose is to demonstrate how fundamental mathematical modeling can be incorporated into physiology, medicine, and health sciences research, application, and clinical practice to make these disciplines more quantitative and computational, and hence more explanatory and informative. The book also provides quantitative formulation of medical procedures, towards supporting the growing field of precision medicine. Each chapter includes a robust introduction to the BME and mathematical concepts necessary to understand their application to the indicated medical and biological systems, beginning with Intrinsic Anatomy, showing how anatomical structures are intrinsically optimally designed for their functional performance, such as the intrinsic hyperboloid shape of the spinal vertebral body (as a lightweight, high-strength structure), and the ellipsoidal shape of the left ventricle that enables it to contract efficiently. Other BME and modelling concepts covered include: Physiological Engineering, in quantifying physiological systems and developing indices for assessing their function and dysfunction leading to medical diagnostics; Precision Medicine, by developing biomedical engineering formulation of medical diagnostic and assessment methods and indices, including the new concept of non-dimensional indices in medical assessment, such as cardiac contractility index for risk of heart failure and diabetes index for accurate diagnosis of diabetes; and, Computational Surgery, involving surgical design of prosthetic devices based on the intrinsic design of the fractured structure, such as the design of the spinal vertebral body cage for fractured vertebral body to preserve its intrinsic hyperboloid shape. Each chapter provides in-depth guidance on the engineering and mathematical concepts, methodology, and procedures for applying the formulas and equations to the appropriate biomedical and physiological systems, as well as step-by-step procedures for creating models for a wealth of specific applications.

  • Pectin

    Sources, Technological Properties and Functional Applications
    • 1st Edition
    • F.A. Masoodi + 2 more
    • English
    Pectin: Sources, Technological Properties, and Functional Applications provides a comprehensive overview of pectin, detailing its structure, chemistry, properties, functionality, and diverse applications. The book offers valuable insights into how pectin's intrinsic properties affect its functionality and suitability for various end uses. It also explores the sourcing of pectin from food and agro-industrial sources, with a comparative assessment of conventional and emerging extraction technologies, and emphasis on sustainability through waste valorisation. The book is organized into three sections: Pectin Chemistry and Functionality, Valorisation of Agro-Industrial Waste Streams for Sourcing Pectin, and Functional Applications of Pectin in the Food Industry and Allied Arenas. It serves as a valuable resource for academicians, scientists, researchers, industry professionals, and students in Food Science, Chemistry, Chemical Engineering, Material Science, Pharmaceutical Sciences and related fields. Being particularly relevant to those working with food by-product valorization, hydrocolloids, biopolymers, colloid chemistry, and materials science, the book provides insights into the applications of pectin in food packaging, emulsification, encapsulation, and drug delivery.

  • The Alkaloids

    • 1st Edition
    • Volume 97
    • English
    The Alkaloids, Volume 97 continues the longstanding tradition of this authoritative series, presenting in-depth and up-to-date reviews on the chemistry and biology of alkaloids. This volume features comprehensive chapters on the chemistry and biology of phthalide alkaloids, the structure, biological activity, and chemical synthesis of Myrioneuron alkaloids, and the chemistry of quinoline alkaloids. Together, these contributions provide critical insights into alkaloid structures, biosynthetic origins, biological activities, and synthetic strategies. This volume serves as an essential reference for researchers and advanced students working in natural products chemistry, medicinal chemistry, chemical biology, and pharmacognosy.

  • Self-Learning AI in Healthcare

    Agentic Systems for Smarter Medicine
    • 1st Edition
    • Rajesh Kumar Dhanaraj + 4 more
    • English
    Self-Learning AI in Healthcare: Agentic Systems for Smarter Medicine covers the transformative potential of advanced artificial intelligence within modern medicine. The book addresses the critical need for self-learning and agentic AI systems that autonomously adapt, refine decision-making, and navigate complex clinical environments with minimal intervention. Chapters provide foundational insights into the rise of self-learning AI and neural networks tailored for adaptive medical systems. Subsequent chapters delve into unsupervised, semi-supervised, and reinforcement learning for autonomous healthcare decision-making, alongside decentralized edge AI approaches. Specialized sections cover personalized medicine, hospital workflow optimization, remote patient monitoring, early disease detection, federated learning for privacy preservation, and more.Further, this book explores AI applications in drug discovery, mental health support, radiology, digital twins, and medical robotics, culminating with an examination of future challenges, ethics, and regulatory frameworks shaping self-learning AI’s trajectory in healthcare. It is tailored to serve a diverse yet specialized audience spanning academic, professional, and research sectors. Healthcare IT professionals and clinical informatics specialists will gain practical guidance for implementing adaptive AI solutions within complex healthcare environments. AI researchers and data scientists focused on developing self-learning models will find cutting-edge methodologies and case studies that advance medical applications.

  • Peptide-Derived Drug Discovery

    Design Strategies, Discovery Methods and Applications in Therapeutic Challenges
    • 1st Edition
    • Jian Zhang
    • English
    Peptide-Derived Drug Discovery: Design Strategies, Discovery Methods and Applications in Therapeutic Challenges provides a comprehensive exploration of peptide-like drugs, detailing their structural features and physico-chemical properties while demonstrating their application in the rational design of drug-like peptides. The book also highlights the latest advancements in peptide science, focusing on innovative technologies such as high-throughput screening methods for the macrocyclic peptide-based drug discovery. By showcasing novel approaches and offering step-by-step strategies to overcome key development challenges, this book delivers cutting-edge knowledge to advance the development of next-generation peptide therapeutics

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