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Elsevier

Academic Press

  • Aging and Troponin

    Clinical Implications and Uses Beyond Diagnosis
    • 1st Edition
    • Gary Tse + 3 more
    • English
    Aging and Troponin: Clinical Implications and Uses Beyond Diagnosis examines the multifaceted role of troponin in clinical medicine, with a special focus on aging. This comprehensive reference provides essential technical knowledge, diagnostic and prognostic applications, and model development insights from leading experts in clinical biochemistry, pathology, and epidemiology. The book emphasizes the impact of aging on troponin test results and their interpretation, addressing age-related disorders such as renal failure. Sections cover the technical aspects of troponin assays, comparing traditional and high-sensitivity assays and exploring point-of-care testing advancements.The book also examine age-related changes and intra- and inter-individual variability in troponin levels, focuses on diagnostic applications, including troponin as a biomarker for cardiac injury and dysfunction, and the effects of age, sex, and renal impairment on diagnostic sensitivity and specificity, and discusses troponin's prognostic value for mortality in various conditions, including heart disease, sepsis, and COVID-19, and its role as a marker of organ biological age. The final section offers cutting-edge insights into the clinical applicability of troponin testing, highlighting the benefits of incorporating high-sensitivity assays into clinical workflows and providing perspectives and age-related considerations from practicing physicians on implementation and evidence-based practice.

  • Discrete Choices

    A Comprehensive Guide to Distributions and Inference for Categorical Data
    • 1st Edition
    • Jiju Gillariose + 2 more
    • English
    Discrete Choices: A Comprehensive Guide to Distributions and Inference for Categorical Data provides a unified and modern treatment of probability, inference, and modeling for categorical and discrete data. Although categorical outcomes are ubiquitous across statistics, data science, economics, epidemiology, and the social sciences, existing resources often treat these topics in fragmented ways, separating probability theory, inference, diagnostics, and applications into distinct texts. This book addresses that gap by presenting a coherent framework that begins with probability foundations and sampling theory, develops classical and hierarchical discrete distributions, and advances to modern likelihood-based and Bayesian inference. Core topics include Bernoulli, Binomial, Multinomial, and Poisson models; compound distributions such as the Beta–Binomial and Dirichlet–Multinomia... resampling methods; model diagnostics; and principled model selection. Advanced chapters extend this framework to high-dimensional categorical data, compositional data, network and relational structures, causal inference with multi-valued treatments, and fairness and bias diagnostics in categorical prediction. Extensive case studies and interactive hands-on data labs illustrate real-world applications in health, the social sciences, marketing, and text analytics, emphasizing reproducible and applied workflows.Balancing theoretical rigor with practical relevance, Discrete Choices: A Comprehensive Guide to Distributions and Inference for Categorical Data is suitable both as a graduate-level textbook and as a professional reference for researchers and practitioners working with discrete data.

  • Evidence Based Diagnosis and Management of Testicular Tumors

    • 1st Edition
    • Axel Heidenreich
    • English
    Evidence Based Diagnosis and Management of Testicular Tumors is a comprehensive reference that addresses the current needs of urologists, oncologists, and related specialists involved in testicular cancer care. This book synthesizes the latest research, clinical guidelines, and expert insights to facilitate accurate diagnosis, staging, and personalized treatment strategies. It emphasizes a multidisciplinary approach, integrating pathology, molecular genetics, imaging, and surgical techniques, to optimize patient outcomes and minimize long-term toxicity. The contents are organized into key sections covering epidemiology, pathology, staging, diagnostic evaluation, disease management, and follow-up. Each chapter begins with case scenarios and interactive questions, fostering active learning and decision-making skills. The book also dedicates sections to rare tumors and pediatric cases, ensuring broad applicability across age groups and tumor types. Visual content, including figures, flow charts, tables, and videos, enhances comprehension and procedural training. This reference aims to bridge the knowledge gap in current testicular cancer management, providing practitioners with practical, guideline-conforming advice. It supports clinicians in delivering individualized, risk-adapted care, ultimately improving survival rates and quality of life for patients. By combining expert perspectives with evidence-based protocols, this book serves as an essential resource for advancing clinical practice in testicular oncology.

  • Cell Death Part G

    • 1st Edition
    • Volume 214
    • English
    Cell Death Part G presents current methods and advances for studying the mechanisms, regulation, and biological significance of cell death. The volume covers experimental and analytical approaches relevant to apoptosis, necrosis, autophagy, and other cell death pathways in both basic and translational research.

  • Neurochemical Substrates of Addiction Medicine

    • 1st Edition
    • Mohammad Banazadeh + 2 more
    • English
    Neurochemical Substrates of Addiction Medicine offers an in-depth exploration of the complex interplay between neurochemistry and addiction, providing critical insights for researchers, clinicians, and students alike. This book is structured into four comprehensive sections, beginning with an examination of the distribution of neurotransmitters across key brain circuitry involved in addiction, such as the mesolimbic, striatal, frontal, insular, and thalamic systems. Each chapter meticulously describes how these circuits contribute to addictive behaviors and the underlying neurobiological mechanisms. The second section delves into the major neurotransmitter systems—including dopaminergic, glutamatergic, GABAergic, adrenergic, serotonergic, cholinergic, endogenous opioid, and purinergic systems—highlighting their roles in addiction.Following this, the book addresses the neuropharmacology of various drugs of abuse, including nicotine, opioids, alcohol, psychomotor stimulants, cannabinoids, psychedelics, sedative-hypnotics, caffeine, and antihistamines, detailing how these substances alter neurochemical pathways. The final section expands the discussion to behavioral addictions, exploring the neurochemical substrates associated with disorders such as pathological gambling, internet use, sexual addiction, and binge eating.

  • Molecular Pathology

    The Molecular Basis of Human Disease
    • 3rd Edition
    • Gregory J. Tsongalis + 1 more
    • English
    Molecular Pathology: The Molecular Basis of Human Disease, Third Edition is a comprehensive reference that explores the molecular mechanisms and basis of major human diseases. Expertly crafted, this book is designed for use as a teaching tool for medical students, biomedical graduate students, and allied health students. It serves as an advanced resource for pathology residents, postdoctoral fellows, basic scientists, and physician scientists engaged in disease-related research, presenting traditional pathology in the context of translational molecular medicine. In this new edition, the chapters have been fully updated and rearranged for better logical flow.Notably, four new chapters have been included, covering topics such as the pathogenesis of fibrotic diseases, mechanisms of mutation, molecular basis of soft tissue disease and pathology, and pathogenesis and pathophysiology. The book remains an invaluable reference for anyone seeking a deeper understanding of the molecular aspects of human disease.

  • Animal Stress Biology

    Applications across Natural and Man-made Systems
    • 1st Edition
    • Edward Narayan
    • English
    Animal Stress Biology: Applications across Natural and Man-made Systems provides the fundamental aspects of stress endocrinology with a major focus on the applications of stress research in animal welfare. Early sections introduce the basics of animal stress biology in major taxa. Latter sections explore how animal stress varies across species and settings and how this research can be applied to improve animal welfare. The book incorporates chapter summaries, key term definitions, global case studies, and discussion sections throughout, making it an indispensable resource to students and early career professionals, as well as specialists in agriculture, zoos, clinical research settings, and resource management.Stress plays an integral part in the maintenance of homeostasis in animals and is a useful measure of animal responses to management interventions across natural, agricultural, and clinical settings. Written by experts in the field of animal stress biology, this book is systematically structured for easy student navigation.

  • Proteolytic Enzymes and their Inhibitors in Infectious Pathogens

    • 1st Edition
    • Theresa Coetzer
    • English
    Proteolytic enzymes are found in all life forms, where they catalyze peptide bond hydrolysis during essential biological processes. Proteases of various pathogens have also been shown to use endogenous protease inhibitors to regulate the activity of host proteolytic enzymes encountered during infection.Proteolyti... Enzymes and their Inhibitors in Infectious Pathogens brings together key experts to provide a thorough discussion of proteolytic enzymes and their endogenous inhibitors found in parasites, bacteria, and viruses. The book focuses on the respective roles of the different catalytic classes of proteolytic enzymes and their protein-protease inhibitors at the host-infectious organism interface, and how this knowledge may inform drug and vaccine design. Following a foundational overview of proteases and macromolecular inhibitors of pathogenic organisms, authors discuss recent research on distinct classes of proteolytic enzymes in pathogens. Classes include aspartic proteases, cysteine proteases, metalloproteases, serine proteases, and threonine proteases with experts contributing chapters on distinct enzymes and inhibitors. New methods to identify protease substrates and inhibitors are also provided, with step-by-step protocols to advance new research and drive drug discovery.

  • Rational 'Co-Design' of Targeted Anticancer Therapeutics

    Integrating Immuno-Oncology, Biomaterials, and Translational Systems
    • 1st Edition
    • Y. Manojkumar + 3 more
    • English
    Rational 'Co-Design' of Targeted Anticancer Therapeutics: Integrating Immuno Oncology, Biomaterials, and Translational Systems presents a unified, system level framework that designs molecules, carriers, and delivery pathways concurrently for clinically translatable cancer therapies. The book details how electronic structure, molecular recognition, biomaterial compatibility, immune microenvironment dynamics, and ADMET/AI models integrate into end to end decision frameworks—from in silico prediction to experimental validation and regulatory readiness. Readers gain a pragmatic path to faster, safer translation: case informed guidance, co design checklists, and criteria for affordability, scalability, and sustainability enable researchers and advanced students to move beyond fragmented, sequential development toward robust therapeutic systems.

  • Neurobiology of Depression

    Road to Novel Therapeutics
    • 2nd Edition
    • João L. de Quevedo + 2 more
    • English
    Neurobiology of Depression: Road to Novel Therapeutics, Second Edition follows the success of the first edition, synthesizing the basic neurobiology of major depressive disorder (MDD) with discussions on the latest research advances, including interacting pathways implicated in the pathophysiology of MDD, omics technologies, genetic approaches, and novel optogenetic techniques revolutionizing depression research. This new edition includes comprehensive foundational understandings of the disorder and highlights recent advances, aiding advanced students and researchers in their understanding of MDD. The book introduces new chapters exploring groundbreaking topics such as the neurobiology of treatment-resistant depression, the antidepressant mechanisms of ketamine, and the link between depression and Alzheimer's disease. Additionally, it covers the neurobiology of suicide in depression, the impact of psychedelics as therapy, and the unique aspects of bipolar depression. This edition also examines computational models in depression, the neurobiology of psychotherapy, and the putative mechanisms of action for vagus nerve stimulation as a therapeutic approach. These additions help to provide a broader and more comprehensive understanding of depression and its treatment.

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