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Elsevier

Academic Press

  • Drug Discovery Stories, Volume 3

    From Bench to Bedside
    • 1st Edition
    • Bin Yu
    • English
    Drug Discovery Stories: From Bench to Bedside, Volume 3 presents a collection of cases on the development of highly successful pharmaceuticals. The coverage of chapters in the book include the structural biology and biological functions of the targets of interest, the identification of hit compounds, hit-to-lead optimization, binding mode of the key compounds with the target of interest, key biological and PK data of lead compounds, clinical results if any, other candidate compounds in preclinical and clinical stage against the same target, and other relevant points in the journey to develop the drug. Chapters in this volume in the Drug Discovery Stories series include a discussion of technological innovations in drug discovery, the impact of AI and Machine Learning, and then move on to discuss drugs like Landiolol, Deuruxolitinib, Berdazimer sodium, Cefepime, Aprocitentan, Givinostat, Vadadustat, Danicopan, Tovorafenib, Lazertinib, Journavx, Symbravo, Grafapex, Alyftrek, and Tryngolza. A final chapter provide conclusions on all cases presented in the book. Drug Discovery Stories: From Bench to Bedside, Volume 3 accurately reflects the current advancements in drug discovery by sharing the path researchers took that led them to create these impactful drugs. This book aims to not only cater to the drug discovery community but also engage other communities involved in chemical biology, synthetic chemistry, and pharmacology.

  • Lobular Breast Cancer

    An All-Round Multidisciplinary Overview
    • 1st Edition
    • Giovanni Corso + 1 more
    • English
    Lobular Breast Cancer: An All-Round Multidisciplinary Overview is a comprehensive academic resource that addresses the complex biology, diagnosis, and treatment of invasive lobular breast cancer. This book synthesizes current research and clinical practices, offering an integrated perspective from leading international experts. It covers key topics such as genetics, pathology, imaging, surgical approaches, and systemic therapies, emphasizing recent advances and future directions. The content is organized into clearly delineated sections, including epidemiology, molecular biology, imaging techniques, and therapeutic strategies, with dedicated chapters on emerging technologies like artificial intelligence. The multidisciplinary approach ensures that clinicians and researchers gain a thorough understanding of lobular breast cancer’s unique features, diagnostic challenges, and tailored treatment options, fostering evidence-based decision-making. This book benefits its academic audience by providing up-to-date, evidence-based insights, practical guidance for clinical management, and a foundation for future research. It supports professionals in staying current with evolving standards, improving patient outcomes, and advancing scientific knowledge in this specialized field.

  • RED: Women's Health From Menarche to Menopause

    • 1st Edition
    • Diana Vaamonde + 3 more
    • English
    RED: Women’s Health and Wellness from Menarche to Menopause provides a comprehensive, unique and holistic perspective on women’s health and wellbeing. From a contemporary health and behavioral science perspective, it presents an accessible and engaging exploration of the biological, psychological, behavioral, and sociocultural changes and challenges women may experience from menarche through menopause.The book offers a fresh perspective by highlighting lifestyle modification, emotional wellbeing, and social and environmental influences as important complements to conventional healthcare approaches. It addresses key dimensions of women’s health, including gender medicine, sexual health, trauma, lifestyle, eating behaviors and the influence of social constructs and technologies, while considering their implications for health and wellbeing.With contributions that bridge scientific evidence and practical application, this book provides a valuable reference for students and graduates, academics, researchers, healthcare professionals, and anyone interested in advancing knowledge and understanding of women’s health.

  • Neurobiology of Psychiatric Disorders: New Perspectives on Mental Illness Associated with High Penetrance Genetic Variants

    New Perspectives on Mental Illness Associated with High Penetrance Genetic Variants
    • 1st Edition
    • Noboru Hiroi
    • English
    "The Neurobiology of Psychiatric Disorders" provides a conceptually innovative framework to understand psychiatric disorders including autism spectrum disorders, schizophrenia, intellectual disability, bipolar disorder, and ADHD. This book will allow readers to learn diverse mechanistic bases of psychiatric disorders causally associated with genetic variants. Because rare genetic variants have unprecedentedly high levels of penetrance for psychiatric disorders, this book provides reliable genetic links and their mechanistic substrates, thereby providing the starting points of precision medicine.

  • Remote Sensing and Machine Learning in Conservation

    Applications and Techniques
    • 1st Edition
    • Alireza Sharifi
    • English
    Remote Sensing and Machine Learning in Conservation: Applications and Techniques presents a structured, decision-oriented guide to the responsible use of Earth observation, geospatial analysis, and artificial intelligence in biodiversity conservation and ecosystem management. It connects conservation questions with appropriate evidence, data preparation, model development and validation, uncertainty communication, ecological interpretation, and decision-ready outputs.Beginning with the foundations of remote sensing, it explains major machine-learning and deep-learning approaches, from supervised classification to Vision Transformers and reinforcement learning. Chapters then show how remote sensing and GeoAI support habitat mapping, species distribution modeling, biodiversity assessment, ecosystem-change detection, water and coastal conservation, wildlife monitoring, climate adaptation, invasive-species detection, restoration planning, and threat monitoring.Dedicated chapters translate theory into practice through project design, cloud-based platforms, open data, reproducible workflows, validation, dashboards, and operational monitoring, and address data governance, privacy, bias, accountability, Indigenous and local knowledge, participation, and responsible use. The closing chapter examines foundation models, multimodal GeoAI, ecosystem digital twins, real-time and edge AI, participatory monitoring, and future research priorities, helping readers move from tool-driven analysis toward scientifically grounded and actionable conservation evidence.

  • Propolis

    Science, Innovation, and Healthcare Applications
    • 1st Edition
    • Jairo Kenupp Bastos
    • English
    Propolis: Science, Innovation, and Healthcare Applications is a key reference for understanding the diverse applications of propolis in healthcare and industry. As a natural product derived from bees, propolis has a long history and notable potential in pharmacology and biotechnology. This book serves as a consolidated resource that brings together current knowledge, research, and developments related to propolis, including coverage of three types—Brazilian green propolis (BrGPs), red propolis (RP), and poplar propolis (PP)—making it valuable for both scholars and practitioners. The Table of Contents covers a broad range of topics, including the origin and formation of propolis, its chemical composition, and contemporary analytical methods. It also examines the biological properties of propolis, such as its antimicrobial, antiviral, and neuroprotective effects, along with information on regulatory standards and future research areas. Each chapter is structured to provide a balance of theoretical context and practical insights. Designed for academics, researchers, and industry professionals, the book offers detailed technical information and guidance on quality control and regulatory compliance. By addressing key issues in the commercialization of propolis-based products, this reference supports a deeper understanding and effective utilization of this natural substance.

  • Quantum Computing for Internet of Things

    • 1st Edition
    • Volume 145
    • English
    Quantum Computing for Internet of Things, published as Volume 147 of the serial Advances in Computers, provides a comprehensive examination of the convergence of quantum computing and the Internet of Things (IoT). The volume introduces the fundamental principles of quantum computing, including qubits and quantum mechanics, and explores the architectures, enabling technologies, and intelligent applications that underpin modern IoT ecosystems. It highlights how quantum technologies can enhance IoT performance, security, optimisation, and data processing capabilities across diverse application domains.The volume presents emerging advances in quantum-enabled IoT systems, including distributed quantum computing frameworks, quantum machine learning approaches, quantum simulation tools, and novel optimisation techniques tailored to IoT environments. Case studies and application-focused chapters demonstrate the use of quantum methods in military systems, climate change analysis, and healthcare analytics. The volume concludes by addressing key research challenges, implementation barriers, and future directions, making it a valuable resource for researchers and practitioners working at the intersection of quantum technologies and connected intelligent systems.

  • Biology of Aging Accelerators

    Fundamentals, Hallmarks and Therapeutic Interventions
    • 1st Edition
    • Sandeep Kumar Singh + 1 more
    • English
    Biology of Aging Accelerators: Fundamentals, Hallmarks and Therapeutic Interventions explores how biological, genetic, and environmental factors affect cellular and systemic homeostasis and lead to accelerated aging. The book begins with a historical perspectives, highlighting the growth in immune system deterioration, chronic illness, and social issues. It then examines the hallmarks of aging, including primary, antagonistic, and integrative characteristics that may or may not be contributors. Subsequent chapters explore basic concepts and key accelerators in human biology, the role of biological clocks, and mechanisms of aging accelerators such as cellular senescence, DNA damage, and mitochondrial dysfunction.The book also addresses how different organs age at different rates and the brain's role as the body's aging integrator and provides actionable insights into innovative therapies aimed at reducing or stopping the signs and symptoms of aging, including developments in medications, lifestyle adjustments, regenerative medicine, and cutting-edge technologies like stem cell therapy and CRISPR. By integrating scientific research and practical insights, this book offers a realistic perspective on anti-aging research and stimulates novel ideas for improving quality of life.

  • The Neurobiological Underpinnings of Addiction Medicine

    Focusing on Novel Approaches
    • 1st Edition
    • Mohammad Shabani + 3 more
    • English
    The Neurobiological Underpinnings of Addiction Medicine: Focusing on Novel Approaches provides a comprehensive review of the biological mechanisms that drive addiction and innovative strategies for treatment. This book begins by examining the crucial role of the microbiome and the gut-brain axis in various substance use disorders, including opioid, alcohol, neurostimulant, and cannabis use disorders. It highlights how gut health can significantly influence addiction behaviors and treatment outcomes. Following this, the second section discusses the interplay between addiction and neuropsychiatric disorders such as depression, anxiety, schizophrenia, ADHD, bipolar disorder, PTSD, and OCD.This section emphasizes the impact of neurotransmitter systems and intracellular pathways on the development and persistence of these disorders. The final section introduces cutting-edge methodologies reshaping addiction research, including multi-OMICS approaches and the implications of CRISPR-Cas9 technology. By integrating these diverse topics, this book offers vital insights for clinicians and researchers alike.

  • Biomechanics of Orofacial Organs and Structures

    • 1st Edition
    • Mohammad Ali Nazari + 2 more
    • English
    Biomechanics of Orofacial Organs and Structures provides fundamental knowledge in functional anatomy and innervation of the orofacial region, in mechanical characteristics of orofacial soft tissues, in the biomechanical modeling of the orofacial organs, and in their use in the context of clinical applications. The book covers the design of biomechanical models that take into account the anatomy, muscle organization, innervation, and specific mechanical properties of muscles and soft tissue. It also discusses how these functions work under normal conditions, and how they degrade after surgery in the context of aging, or in the context of neuropathy altering the efferent or afferent nervous system in the orofacial region.The book is organized into three parts:General knowledge about orofacial organs and structuresBiomechani... modelsClinical applicationsA new volume in the Biomechanics of Living Organs series, this book features the latest research developments in the truly multidisciplinary scientific domain that tackles the understanding and modeling of basic orofacial functions, which are essential for the quality of life of humans.

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