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Elsevier

Academic Press

  • Molecular Pathology

    The Molecular Basis of Human Disease
    • 3rd Edition
    • Gregory J. Tsongalis + 1 more
    • English
    Molecular Pathology: The Molecular Basis of Human Disease, Third Edition is a comprehensive reference that explores the molecular mechanisms and basis of major human diseases. Expertly crafted, this book is designed for use as a teaching tool for medical students, biomedical graduate students, and allied health students. It serves as an advanced resource for pathology residents, postdoctoral fellows, basic scientists, and physician scientists engaged in disease-related research, presenting traditional pathology in the context of translational molecular medicine. In this new edition, the chapters have been fully updated and rearranged for better logical flow.Notably, four new chapters have been included, covering topics such as the pathogenesis of fibrotic diseases, mechanisms of mutation, molecular basis of soft tissue disease and pathology, and pathogenesis and pathophysiology. The book remains an invaluable reference for anyone seeking a deeper understanding of the molecular aspects of human disease.

  • Animal Stress Biology

    Applications across Natural and Man-made Systems
    • 1st Edition
    • Edward Narayan
    • English
    Animal Stress Biology: Applications across Natural and Man-made Systems provides the fundamental aspects of stress endocrinology with a major focus on the applications of stress research in animal welfare. Early sections introduce the basics of animal stress biology in major taxa. Latter sections explore how animal stress varies across species and settings and how this research can be applied to improve animal welfare. The book incorporates chapter summaries, key term definitions, global case studies, and discussion sections throughout, making it an indispensable resource to students and early career professionals, as well as specialists in agriculture, zoos, clinical research settings, and resource management.Stress plays an integral part in the maintenance of homeostasis in animals and is a useful measure of animal responses to management interventions across natural, agricultural, and clinical settings. Written by experts in the field of animal stress biology, this book is systematically structured for easy student navigation.

  • Proteolytic Enzymes and their Inhibitors in Infectious Pathogens

    • 1st Edition
    • Theresa Coetzer
    • English
    Proteolytic enzymes are found in all life forms, where they catalyze peptide bond hydrolysis during essential biological processes. Proteases of various pathogens have also been shown to use endogenous protease inhibitors to regulate the activity of host proteolytic enzymes encountered during infection.Proteolyti... Enzymes and their Inhibitors in Infectious Pathogens brings together key experts to provide a thorough discussion of proteolytic enzymes and their endogenous inhibitors found in parasites, bacteria, and viruses. The book focuses on the respective roles of the different catalytic classes of proteolytic enzymes and their protein-protease inhibitors at the host-infectious organism interface, and how this knowledge may inform drug and vaccine design. Following a foundational overview of proteases and macromolecular inhibitors of pathogenic organisms, authors discuss recent research on distinct classes of proteolytic enzymes in pathogens. Classes include aspartic proteases, cysteine proteases, metalloproteases, serine proteases, and threonine proteases with experts contributing chapters on distinct enzymes and inhibitors. New methods to identify protease substrates and inhibitors are also provided, with step-by-step protocols to advance new research and drive drug discovery.

  • Rational 'Co-Design' of Targeted Anticancer Therapeutics

    Integrating Immuno-Oncology, Biomaterials, and Translational Systems
    • 1st Edition
    • Y. Manojkumar + 3 more
    • English
    Rational 'Co-Design' of Targeted Anticancer Therapeutics: Integrating Immuno Oncology, Biomaterials, and Translational Systems presents a unified, system level framework that designs molecules, carriers, and delivery pathways concurrently for clinically translatable cancer therapies. The book details how electronic structure, molecular recognition, biomaterial compatibility, immune microenvironment dynamics, and ADMET/AI models integrate into end to end decision frameworks—from in silico prediction to experimental validation and regulatory readiness. Readers gain a pragmatic path to faster, safer translation: case informed guidance, co design checklists, and criteria for affordability, scalability, and sustainability enable researchers and advanced students to move beyond fragmented, sequential development toward robust therapeutic systems.

  • Neurobiology of Depression

    Road to Novel Therapeutics
    • 2nd Edition
    • João L. de Quevedo + 2 more
    • English
    Neurobiology of Depression: Road to Novel Therapeutics, Second Edition follows the success of the first edition, synthesizing the basic neurobiology of major depressive disorder (MDD) with discussions on the latest research advances, including interacting pathways implicated in the pathophysiology of MDD, omics technologies, genetic approaches, and novel optogenetic techniques revolutionizing depression research. This new edition includes comprehensive foundational understandings of the disorder and highlights recent advances, aiding advanced students and researchers in their understanding of MDD. The book introduces new chapters exploring groundbreaking topics such as the neurobiology of treatment-resistant depression, the antidepressant mechanisms of ketamine, and the link between depression and Alzheimer's disease. Additionally, it covers the neurobiology of suicide in depression, the impact of psychedelics as therapy, and the unique aspects of bipolar depression. This edition also examines computational models in depression, the neurobiology of psychotherapy, and the putative mechanisms of action for vagus nerve stimulation as a therapeutic approach. These additions help to provide a broader and more comprehensive understanding of depression and its treatment.

  • Diagnostic Imaging Systems

    • 1st Edition
    • Ayman S. El-Baz + 1 more
    • English
    Neural engineering is an emerging and fast-moving interdisciplinary research area that combines engineering with (a) electronic and photonic technologies, (b) computer science, (c) physics, (d) chemistry, (e) mathematics, and (f) cellular, molecular, cognitive, and behavioral neuroscience. This helps us understand the organizational principles and underlying mechanisms of the biology of neural systems and to further to study the behavioral dynamics and complexity of neural systems in nature.The field of neural engineering deals with many aspects of basic and clinical problems associated with neural dysfunction, including (i) the representation of sensory and motor information, (ii) electrical stimulation of the neuromuscular system to control muscle activation and movement, (iii) the analysis and visualization of complex neural systems at multiscale from the single cell to system levels to understand the underlying mechanisms, (iv) development of novel electronic and photonic devices and techniques for experimental probing, the neural simulation studies, (v) the design and development of human–machine interface systems and artificial vision sensors, and (vi) neural prosthesis to restore and enhance the impaired sensory and motor systems and functions.To highlight this emerging discipline, Dr. Ayman El-Baz and Dr. Jasjit Suri have developed Advances in Neural Engineering, covering the broad spectrum of neural engineering subfields and applications. This Series includes 7 volumes in the following order: Volume 1: Signal Processing Strategies, Volume 2: Brain-Computer Interfaces, Volume 3: Diagnostic Imaging Systems, Volume 4: Brain Pathologies and Disorders, Volume 5: Computing and Data Technologies, Volume 6: Advanced Brain Imaging Techniques and Volume 7: Neural Science Ethics.Volume 3 provides a comprehensive review of diagnostic imaging systems and technologies, including brain tumor characterization and classification techniques, tumor segmentation using AI and deep neural networks, dynamic brain imaging analysis, and functional brain imaging. The authors discuss existing challenges in the domain of diagnostic imaging systems and suggest possible research directions.

  • Food Bioactives and Their Role in Human Health and Nutrition

    • 1st Edition
    • Sajad Ahmad Wani + 1 more
    • English
    Food Bioactives and their Role in Human Health and Nutrition, is a comprehensive resource offering an in-depth look at essential bioactive compounds, such as polyphenols, flavonoids, plant sterols, omega-3 fatty acids, and probiotics, highlighting their importance in promoting health and preventing chronic diseases. Readers will gain insights into the chemical structures, sources, and bioavailability of these compounds, along with practical dietary recommendations tailored to address common lifestyle-related health challenges such as obesity, diabetes, and cardiovascular disease. Food Bioactives and their Role in Human Health and Nutrition, also addresses emerging trends and challenges in the field, including personalized nutrition approaches and the integration of functional foods and nutraceuticals. It examines the role of food processing on the stability of bioactives, ensuring that health professionals are equipped with the latest knowledge to optimize nutritional strategies.

  • Primer on Cerebrovascular Research

    • 1st Edition
    • Dong-Eog Kim + 3 more
    • English
    Primer on Cerebrovascular Research provides both clinical and basic cerebrovascular knowledge that is required for physicians, vascular researchers, biomedical students, and trainees to understand or conduct evidence-based clinical practice and cutting-edge experimental research. This book outlines how to a design experimental cerebrovascular research in the context of clinical relevance, conduct the study using proper methods, analyze the data accurately, and make conclusions in an unbiased and statistically correct way. Chapters will include representative examples and experimental protocols.

  • Molecular Mechanisms of Cancer Resistance

    Emerging Technologies and Therapeutic Strategies
    • 1st Edition
    • Ahmet Acar
    • English
    Molecular Mechanisms of Cancer Resistance: Emerging Technologies and Therapeutic Strategies explores innovative tools and strategies designed to address the critical issue of drug resistance in cancer treatment. This comprehensive volume is tailored for researchers, clinicians, and students, offering insights into the latest advancements and methodologies in the field. The book covers essential topics such as molecular mechanisms of drug resistance, the tumor microenvironment, and emerging technologies like single-cell analysis and computational modeling. Each chapter features contributions from leading experts, providing a multi-dimensional perspective on both foundational concepts and cutting-edge research.By engaging with this book, the academic audience gains access to groundbreaking research and therapeutic strategies that enhance understanding and practice. The knowledge acquired will inspire collaboration and innovation, ultimately contributing to more effective and personalized cancer treatment approaches.

  • Pediatric Culinary Medicine

    Evidence, Opportunities, and Practice
    • 1st Edition
    • Maria R. Mascarenhas + 2 more
    • English
    Pediatric Culinary Medicine: Evidence, Opportunities, and Practice is a groundbreaking resource authored by diverse pediatric leaders, offering a comprehensive exploration of the rapidly evolving field of food as medicine. This book uncovers the history, benefits, and current research landscape, highlighting future opportunities for advancing pediatric health & development through culinary approaches. It provides practical insights into supporting children from diverse cultural and socioeconomic backgrounds, including those managing chronic conditions and those seeking to optimize wellness. Perfect for both newcomers and seasoned practitioners, this book will inspire innovative ways to integrate food into pediatric care. Packed with expert knowledge, this volume covers the evolution of culinary medicine, current research gaps, and practical strategies for real-world application in a pediatric setting. It features detailed chapters on dietary patterns that promote child health, culturally relevant practices, and policy opportunities, along with pathways for training and education, offering essential guidance for translating culinary medicine into meaningful, sustainable programs that improve pediatric health outcomes. Designed to serve a broad audience, Pediatric Culinary Medicine: Evidence, Opportunities, and Practice is an invaluable tool for researchers seeking to identify gaps and develop impactful studies and for pediatric healthcare providers aiming to implement evidence-based practices. It provides the foundational knowledge, successful models, and training resources needed to harness the power of food to transform child health. This book is a must-have for anyone committed to shaping the future of pediatric nutrition and wellness through culinary medicine.

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