Targeting DNA Repair Mechanisms, Tumor Genetics, and Signaling Pathways
Synergistic Approaches in Gastrointestinal Cancer Treatment
- 1st Edition - May 1, 2026
- Latest edition
- Editors: Ganji Purnachandra Nagaraju, Bassel F-El-Rayes
- Language: English
- Paperback ISBN:9 7 8 - 0 - 4 4 3 - 4 3 9 7 6 - 6
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 4 3 9 7 7 - 3
Targeting DNA Repair Mechanisms, Tumor Genetics, and Signaling Pathways: Synergistic Approaches in Gastrointestinal Cancer Treatment offers a detailed examination of the biolog… Read more
Targeting DNA Repair Mechanisms, Tumor Genetics, and Signaling Pathways: Synergistic Approaches in Gastrointestinal Cancer Treatment offers a detailed examination of the biological complexities driving gastrointestinal (GI) cancers, including colorectal, gastric, liver, and pancreatic malignancies. By synthesizing the latest research, this book addresses the critical demand for innovative treatments in GI oncology. It explores the interconnections between DNA repair mechanisms, tumor genetics, and essential cellular signaling pathways, revealing their significance in cancer progression and therapeutic intervention. Insightful discussions highlight how these molecular aspects contribute to personalized medicine, paving the way for more effective, individualized strategies to combat GI cancers.
Additionally, the book stands out by illustrating the benefits of combining targeted therapies, which can enhance overall treatment effectiveness and help overcome clinical resistance. Real-world case studies and contributions from leading experts provide a practical bridge between laboratory discoveries and clinical practice. This comprehensive resource encourages collaboration among researchers and clinicians, promoting a holistic approach to understanding GI cancer biology.
Additionally, the book stands out by illustrating the benefits of combining targeted therapies, which can enhance overall treatment effectiveness and help overcome clinical resistance. Real-world case studies and contributions from leading experts provide a practical bridge between laboratory discoveries and clinical practice. This comprehensive resource encourages collaboration among researchers and clinicians, promoting a holistic approach to understanding GI cancer biology.
- Provides a thorough examination of the complex mechanisms underlying gastrointestinal cancers, including DNA repair pathways, tumor genetics, and cellular signaling
- Bridges the gap between basic research findings and their clinical applications, featuring real-world case studies and expert insights
- Highlights novel therapeutic approaches, including combination therapies and personalized medicine
- Addresses treatment resistance and promotes collaborative strategies
Scientists specializing in cancer biology, molecular biology, genetics, and related fields
1. Introduction to Gastrointestinal Cancers: An Overview of Current Challenges
2. Understanding DNA Repair Mechanisms: The Key Players in Genomic Stability
3. The Genetic Landscape of Gastrointestinal Tumors: Key Alterations and Pathways
4. The Role of Signaling Pathways in Tumorigenesis
5. The Role of DNA Damage Response in Cancer Progression
6. Synergistic Approaches in GI Cancer Therapy: Concepts and Strategies
7. Targeting DNA Repair and Signaling Pathways: A Novel Paradigm in Gastrointestinal Cancer Treatment
8. Inhibiting Homologous Recombination: Therapeutic Implications in GI Cancers
9. The Role of PARP Inhibitors in Enhancing Chemotherapy Efficacy
10. Exploiting the Synthetic Lethality Concept in Gastrointestinal Tumors
11. Combination Therapies: Chemotherapy and DNA Repair Inhibition in GI Cancers
12. Immunotherapy and DNA Repair: A Dual Approach to Combat GI Cancers
13. Radiation Therapy: Targeting DNA Repair Mechanisms for Enhanced Outcomes
14. Emerging Biomarkers: Predicting Response to DNA Repair and Signaling Targeting Therapies
15. Clinical Trials: Evidence for Synergistic Approaches in GI Cancer Treatment
16. Future Directions: Novel Targets and Strategies in DNA Repair, Signaling for GI Cancers
17. Integrating Genomics with Immunotherapy for GI Cancers: A Synergistic Approach
18. Conclusion: Integrating Synergistic Approaches for Personalized GI Cancer Treatment
2. Understanding DNA Repair Mechanisms: The Key Players in Genomic Stability
3. The Genetic Landscape of Gastrointestinal Tumors: Key Alterations and Pathways
4. The Role of Signaling Pathways in Tumorigenesis
5. The Role of DNA Damage Response in Cancer Progression
6. Synergistic Approaches in GI Cancer Therapy: Concepts and Strategies
7. Targeting DNA Repair and Signaling Pathways: A Novel Paradigm in Gastrointestinal Cancer Treatment
8. Inhibiting Homologous Recombination: Therapeutic Implications in GI Cancers
9. The Role of PARP Inhibitors in Enhancing Chemotherapy Efficacy
10. Exploiting the Synthetic Lethality Concept in Gastrointestinal Tumors
11. Combination Therapies: Chemotherapy and DNA Repair Inhibition in GI Cancers
12. Immunotherapy and DNA Repair: A Dual Approach to Combat GI Cancers
13. Radiation Therapy: Targeting DNA Repair Mechanisms for Enhanced Outcomes
14. Emerging Biomarkers: Predicting Response to DNA Repair and Signaling Targeting Therapies
15. Clinical Trials: Evidence for Synergistic Approaches in GI Cancer Treatment
16. Future Directions: Novel Targets and Strategies in DNA Repair, Signaling for GI Cancers
17. Integrating Genomics with Immunotherapy for GI Cancers: A Synergistic Approach
18. Conclusion: Integrating Synergistic Approaches for Personalized GI Cancer Treatment
- Edition: 1
- Latest edition
- Published: May 1, 2026
- Language: English
GN
Ganji Purnachandra Nagaraju
Dr. Nagaraju obtained his MSc and his PhD, both in Biotechnology, from Sri Venkateswara University in Tirupati, Andhra Pradesh, India. He received his DSc from Berhampur University in Berhampur, Odisha, India. Dr. Nagaraju’s research focuses on translational projects related to gastrointestinal malignancies. He has published over 100 research papers in highly reputed international journals and has presented more than 50 abstracts at various national and international conferences. Dr. Nagaraju is author and editor of several published books in Elsevier and Springer Nature. He serves as editorial board member of several internationally recognized academic journals. Dr. Nagaraju has received several international awards including FAACC. He also holds memberships with the Association of Scientists of Indian Origin in America (ASIOA), the Society for Integrative and Comparative Biology (SICB), The Science Advisory Board, The RNA Society, The American Association for Clinical Chemistry (AACC) and the American Association of Cancer Research (AACR).
Affiliations and expertise
Assistant Professor, School of Medicine, Division of Hematology and Oncology, University of Alabama, Birmingham, AL, USABF
Bassel F-El-Rayes
Bassel F. El-Rayes, M.D., is the deputy director of the UAB O’Neal Comprehensive Cancer Center, a senior scientist at the O’Neal Cancer Center, a professor of Medicine and the director of the Division of Hematology & Oncology in the UAB Department of Medicine. Dr. El-Rayes is focused translational research and drug development in gastrointestinal cancer with special emphasis on pancreatobiliary and neuroendocrine cancers. El-Rayes has served as principal investigator on several peer-reviewed NCI grants, investigator-initiated trials and multi-institutional trials. He has published more than 250 peer-reviewed scientific articles. He has served on several national committees, including the NCI Neuroendocrine Tumor Task Force and the National Committee of the American Society of Clinical Oncology for the development of guidelines for the management of central venous catheters in patients with cancer.
Affiliations and expertise
O'Neal Cancer Center, USA