The Renaissance in GPCR Research and Drug Discovery
Receptor Function, Receptor Structure, New Techniques, and Characterization of Drug Activity
- 1st Edition - September 1, 2026
- Latest edition
- Editor: Terry P. Kenakin
- Language: English
The Renaissance in GPCR Research and Drug Discovery: Receptor Function, Receptor Structure, New Techniques, Characterization of Drug Activity, Drug Discovery is a compre… Read more
Beyond these key topics, the book delves into the evolution of GPCRs as drug targets, the mechanisms behind their novel functions, and the latest technologies driving research and discovery. It also highlights new and recently approved therapeutic modalities and provides a broad coverage of GPCR ligands. Edited and authored by leading researchers, this book serves as an essential reference for drug discovery researchers and medicinal chemists, as well as AI researchers exploring this drug discovery space.
- Covers the advances in the understanding of protein allostery and biased signaling that have revolutionized GPCR research in the past few years
- Introduces the new techniques providing tremendous advantages in the drug discovery field
- Edited and authored by the leading worldwide researchers in this area
I. The Evolution of GPCRs as Drug Targets for Therapy
2. GPCRs: From Low Hanging Fruit to Uncharted Territory
3. Orphan GPCRs: New Horizons for GPCR Therapeutics
II. GPCR Mechanisms for Novel Function
4. GPCR Biased Signaling
5. Mechanisms of GPCR Bias and GPCR ‘Decoy Receptors’
6. GPCRs as Nature’s Prototype Allosteric Machine
7. Biasing GPCRs with ligands: expectations and limitations
III. New Technologies to Investigate GPCR Function
8. The Structural Biology Revolution in GPCR Pharmacology
9. Conformational Biosensors / TRUPATH
10. Impact of Conformational Dynamics on GPCR Drug Discovery
11. The kinetics of GPCR signaling and drug action
IV. New Therapeutic Modalities for GPCRs
12. GPCR Mutation and Human Disease
13. GPCR Phenotypic Signaling in Human Stem Cells
V. GPCR Ligands
14. Intracellular GPCR Signaling
15. Antibodies as Drugs for GPCRs
- Edition: 1
- Latest edition
- Published: September 1, 2026
- Language: English
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