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Elsevier

Academic Press

  • The Alkaloids

    • 1st Edition
    • Volume 97
    • English
    The Alkaloids, Volume 97 continues the longstanding tradition of this authoritative series, presenting in-depth and up-to-date reviews on the chemistry and biology of alkaloids. This volume features comprehensive chapters on the chemistry and biology of phthalide alkaloids, the structure, biological activity, and chemical synthesis of Myrioneuron alkaloids, and the chemistry of quinoline alkaloids. Together, these contributions provide critical insights into alkaloid structures, biosynthetic origins, biological activities, and synthetic strategies. This volume serves as an essential reference for researchers and advanced students working in natural products chemistry, medicinal chemistry, chemical biology, and pharmacognosy.

  • Avian Models of Development

    • 1st Edition
    • Volume 173
    • English

  • Drug Discovery Stories, Volume 3

    From Bench to Bedside
    • 1st Edition
    • Bin Yu
    • English
    Drug Discovery Stories: From Bench to Bedside, Volume 3 presents a collection of cases on the development of highly successful pharmaceuticals. The coverage of chapters in the book include the structural biology and biological functions of the targets of interest, the identification of hit compounds, hit-to-lead optimization, binding mode of the key compounds with the target of interest, key biological and PK data of lead compounds, clinical results if any, other candidate compounds in preclinical and clinical stage against the same target, and other relevant points in the journey to develop the drug. Chapters in this volume in the Drug Discovery Stories series include a discussion of technological innovations in drug discovery, the impact of AI and Machine Learning, and then move on to discuss drugs like Landiolol, Deuruxolitinib, Berdazimer sodium, Cefepime, Aprocitentan, Givinostat, Vadadustat, Danicopan, Tovorafenib, Lazertinib, Journavx, Symbravo, Grafapex, Alyftrek, and Tryngolza. A final chapter provide conclusions on all cases presented in the book. Drug Discovery Stories: From Bench to Bedside, Volume 3 accurately reflects the current advancements in drug discovery by sharing the path researchers took that led them to create these impactful drugs. This book aims to not only cater to the drug discovery community but also engage other communities involved in chemical biology, synthetic chemistry, and pharmacology.

  • Advances in Mitochondrial Drug Delivery

    From Molecular Mechanisms to Clinical Translation
    • 1st Edition
    • Prashant Kesharwani
    • English
    Advances in Mitochondrial Drug Delivery: From Molecular Mechanisms to Clinical Translation addresses the critical need for a comprehensive resource on mitochondrial-target... drug delivery systems. As recent advancements in drug delivery systems (DDS) have shown substantial promise in treating diseases linked to mitochondrial dysfunction, there is a pressing demand for a consolidated reference that covers both the foundational aspects and the latest innovations in this field. The book's Table of Contents encompasses a wide range of topics, beginning with the fundamentals of mitochondrial biology and drug delivery, followed by various mitochondrial-target... drug delivery strategies. It further explores advanced applications of these systems in treating cancer, neurodegenerative diseases, cardiovascular conditions, and more. Additionally, the book discusses future directions, clinical translation, and regulatory challenges, ensuring a holistic view of the subject matter. Advances in Mitochondrial Drug Delivery offers significant benefits to researchers, students, and professionals in pharmaceutical sciences and nanotechnology. By integrating diverse perspectives from leading experts, the book serves as an essential resource for understanding the complexities of mitochondrial-target... therapies, thereby fostering advancements in drug delivery systems and therapeutic strategies.

  • Autophagy – Part D

    • 1st Edition
    • Volume 407
    • English

  • The Plasticity of Sex

    The Molecular Biology and Clinical Features of Genomic Sex, Gender Identity and Sexual Behavior
    • 2nd Edition
    • Marianne Legato J
    • English
    The Plasticity of Sex: The Molecular Biology and Clinical Features of Genomic Sex, Gender Identity and Sexual Behavior, Second Edition offers a thorough exploration of the biological, clinical, and social dimensions of human sexuality. This updated edition emphasizes the increasing recognition of the diversity of sexual identities and behaviors, particularly the spectrum between traditional male and female categories. It consolidates evidence-based research on the molecular and developmental biology of sex, gender identity, and sexual behavior, presenting a comprehensive resource for biomedical researchers, clinicians, and medical students. A key theme of this edition is the growing understanding of human sexuality as fluid and diverse, shaped by a variety of genetic, hormonal, and environmental factors. Over recent decades, there has been heightened interest in issues like gender identity, genital ambivalence, and sexual transition, with both the general public and medical professionals seeking more knowledge and guidance on these topics. The book underscores the need for a more inclusive approach, incorporating voices from diverse communities and recognizing the importance of broadening the scope of research beyond narrow sample sizes and traditional binary frameworks. The new edition highlights the ongoing challenges in understanding and addressing variations in human sexuality and the need for continued dialogue between science, society, and legal systems to create more inclusive frameworks for care and support. This work serves as an essential reference for anyone involved in the study or treatment of human sexuality.

  • Remote Sensing and Machine Learning in Conservation

    Applications and Techniques
    • 1st Edition
    • Alireza Sharifi
    • English
    In Remote Sensing and Machine Learning in Conservation: Applications and Techniques, readers will discover how cutting-edge technology is transforming our understanding of the natural world. This book explores how remote sensing and machine learning are being used to monitor wildlife populations, map critical habitats, predict the effects of climate change, and identify poaching hotspots. From the analysis of satellite imagery to the use of drones and artificial intelligence, this book provides a comprehensive overview of the latest tools and techniques available to conservationists. Written by a renowned expert in spatial information research, this book introduces readers to the exciting new possibilities opened by the combination of remote sensing and machine learning. Early chapters provide an overview of both emerging technologies and their integration into habitat mapping, species distribution, environmental monitoring, and climate change adaptation. Central chapters explore real-world applications and case studies for combating poaching, managing urban expansion, controlling invasive species, and more. Final chapters explore the funding and policy landscape and conclude with a reflection on the role of these technologies in transforming conservation practices. By equipping readers with an overview of these technologies, case studies of their real-world applications, and sample code, datasets, and open-source tools, Remote Sensing and Machine Learning in Conservation: Applications and Techniques promotes the innovative use of these technologies to address global environmental challenges. This is an essential resource for conservationists, resource managers, environmental scientists, and academics studying novel technological applications to conservation issues.

  • Numerical Modelling of Offshore Wind Energy Systems

    • 1st Edition
    • Yang Yang + 2 more
    • English
    Numerical Modelling of Offshore Wind Energy Systems, the latest release in Elsevier's Wind Energy Engineering series, is a thorough, systematic guide to numerical modeling and code development in the offshore wind energy field. The book begins by introducing offshore wind energy and reviewing widely-used numerical simulation tools and the fundamental knowledge essential for performing fully coupled analysis of offshore wind turbines. The second part of the book focuses on numerical modeling techniques for fixed-bottom turbines followed by detailed coverage of floating turbines. In both cases, in-depth case studies are presented to help readers understand the dynamic behavior of the relevant systems.The final section of the book explores numerical modelling techniques as applied to novel concepts and future trends, including twin-rotor wind energy systems, integration with marine energy resources, multi-energy hybrid floating systems, and other areas. This latest volume will be of interest to all those involved in the design, development, and installation of offshore wind turbines, floating energy systems, and wave-wind-current hybrid systems, including researchers, students, engineers, and other practitioners.

  • Omics Applications in Clinical Medicine

    • 1st Edition
    • Luis María Vaschetto
    • English
    Omics-Driven Healthcare: The Future of Medicine is a comprehensive reference piece that explores the potential of personalized medicine, where treatments are tailored to individual patients based on their unique genetic makeup. "Omics-Driven Healthcare: The Future of Medicine" bridges the critical gap between the exponentially growing omics technologies and their practical application in clinical settings. With approximately 18 chapters, this book is designed for advanced students and entry-level researchers in medical genetics and precision medicine who require a thorough understanding of omics technologies and their applications in healthcare. This book is an essential resource for anyone looking to gain insights into the latest advancements and real-world applications of omics technologies, and how these powerful tools are transforming the diagnosis, treatment, and prevention of diseases.

  • Practical Guide to Diagnosing and Treating Ocular Tumors

    • 1st Edition
    • Maura Di Nicola + 1 more
    • English
    Practical Guide to Diagnosing and Treating Ocular Tumors provides practical guidance on the diagnosis and management of ocular tumors. This comprehensive guide highlights the strengths, limitations, and applications of all imaging modalities in ocular oncology. It not only discusses new treatments in ocular oncology (including belzupacap sarotalocan and darovasertib for uveal melanoma, mTOR inhibitors for retinal astrocytic hamartomas in patients with ocular involvement of tuberous sclerosis complex, and belzutifan for retinal hemangioblastomas in patients with Von Hippel Lindau disease), but also offers a comprehensive and practical review of the techniques, complications, and applications of well-established treatments.Ophthalmo... and ocular oncologists will find this to be a practical guide to diagnosing and treating surface and intraocular tumors using a novel approach that will instruct readers on how to utilize and interpret multimodal imaging correctly to diagnose ocular tumors. Readers will gain an understanding of the risks and benefits of different treatment modalities and the most appropriate use scenario in each tumor type.

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