Growth Hormone and Related Disorders: From Clinics to Diagnosis
- 1st Edition, Volume 131 - April 1, 2026
- Editor: Marta Araujo Castro
- Language: English
- Hardback ISBN:9 7 8 - 0 - 4 4 3 - 4 3 1 7 2 - 2
- eBook ISBN:9 7 8 - 0 - 4 4 3 - 4 3 1 7 3 - 9
An excess of growth hormone (GH) results in accelerated growth and in childhood, the clinical manifestation is gigantism. When GH excess has its onset after epiphyseal fusion at… Read more
An excess of growth hormone (GH) results in accelerated growth and in childhood, the clinical manifestation is gigantism. When GH excess has its onset after epiphyseal fusion at puberty, the overgrowth of soft tissue and bone results in acromegaly. This volume covers various topics related to growth hormone and its associated disorder when there is a GH excess, including their pathophysiology, clinical presentation and diagnosis. The volume includes a total of 8 chapters that provide a comprehensive overview of the synthesis, regulation, and various disorders related to growth hormone, including acromegaly and gigantism. The chapters have been written by experts in the field of pituitary tumors.
- Growth hormone releasing hormone (GHRH) stimulates GH synthesis and secretion while somatostatin (SST) inhibits GH production and release. GH stimulates IGF-I production that inhibits GH secretion at hypothalamic and pituitary levels
- Acromegaly is a rare, adult-onset endocrine disorder caused by GH hypersecretion by the pituitary gland and it is usually due to a pituitary tumor
- Gigantism is a rare condition that occurs in children and it is caused by the overproduction of GH before the growth plates of the long bones have closed, leading to excessively tall stature and rapid growth
Endocrinology, Genetics, Internal Medicine, Clinical Biochemistry and Neurosurgery.
1. Growth hormone: synthesis and regulation
Pedro Iglesias
2. GH and GnRH-gonadotropin secretion
Adriana De Sousa Lages and Valentim Lopes
3. Co-Secreting Pituitary Adenomas in Acromegaly: Classification, Diagnosis, and Treatment Strategies
Betina Biagetti Sr. and Marta Araujo-Castro
4. Growth hormone and glycemic metabolism
Eider Pascual-Corrales
5. Acromegaly: pathophysiology and etiology
Frederic Castinetti
6. Acromegaly: biochemical diagnosis
Luís Miguel Cardoso
7. Acromegaly and clinical manifestations
Rocio Villar-Taibo, Eva Fernández Rodríguez and Ignacio Bernabeu Moron
8. Gigantism
Pedro Marques, Sara Donato and Catarina Regala
9. Acromegaly and genetics
Luís Antonio Castaño
10. Molecular markers of response to medical therapy in acromegaly
Manel Puig
11. Acromegaly and histopathology
Iban Aldecoa
Pedro Iglesias
2. GH and GnRH-gonadotropin secretion
Adriana De Sousa Lages and Valentim Lopes
3. Co-Secreting Pituitary Adenomas in Acromegaly: Classification, Diagnosis, and Treatment Strategies
Betina Biagetti Sr. and Marta Araujo-Castro
4. Growth hormone and glycemic metabolism
Eider Pascual-Corrales
5. Acromegaly: pathophysiology and etiology
Frederic Castinetti
6. Acromegaly: biochemical diagnosis
Luís Miguel Cardoso
7. Acromegaly and clinical manifestations
Rocio Villar-Taibo, Eva Fernández Rodríguez and Ignacio Bernabeu Moron
8. Gigantism
Pedro Marques, Sara Donato and Catarina Regala
9. Acromegaly and genetics
Luís Antonio Castaño
10. Molecular markers of response to medical therapy in acromegaly
Manel Puig
11. Acromegaly and histopathology
Iban Aldecoa
- Edition: 1
- Volume: 131
- Published: April 1, 2026
- Language: English
MC
Marta Araujo Castro
Marta Araujo-Castro, MD., PhD., is an endocrinologist of the Endocrinology and Nutrition Department of the Ramón y Cajal University Hospital in Madrid, Spain. She is the coordinator of the Neuroendocrinology & Adrenal Unit of the Endocrinology Department of her hospital. Her main clinical focus and research is on pituitary and adrenal gland disorders. She is the principal investigator and coordinator of the ACRO-SPAIN Registry, the SPAIN-ALDO Registry and the PHEO-PARA-RISK Study of the Spanish Society of Endocrinology & Nutrition (SEEN). Furthermore, in the last years she has received several awards related to adrenal and pituitary disorders (Cushing´s syndrome, acromegaly, adrenal incidentalomas, pheochromocytomas and so on). She is the current coordinator of the adrenal diseases group of the SEEN, a member of the scientific board of the working group of Aldosterone Producing Adenomas (APA) of ENSAT, coordinator of the Pituitary Committee of the Ramón y Cajal University Hospital and the principal investigator of the group of Endocrine-Metabolic, Digestive and Nutrition Surgery of the Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS).
She has more than 150 Medline listed manuscripts, cited >1000 times. More information
Dr. Araujo-Castro is a member of the SEEN, the European Endocrine Society (ESE), Spanish Group of Neuroendocrine Tumors (GETNE), European Network for the Study of Adrenal Tumors (ENSAT), Endocrine Society, SEEN and other many medical societies.
She actively participates in several national and international congresses with presentations related to adrenal pathology. Moreover, Dra. Araujo-Castro is a professor of the master’s degree in Endocrine Oncology Pathology at TECH University; she holds the title of master’s degree in research Methodology in Health Sciences of the Laboratory of Applied Statistics of the Autonomous University of Barcelona (UAB) (Spain) and the Diploma in Statistics in Health Sciences of the UAB.
about my professional profile below:
Researchgate: https://www.researchgate.net/profile/Marta-Araujo-Castro
Twitter: Marta_Araujo_C
ORCID: https://orcid.org/0000-0002-0519-0072
Affiliations and expertise
Ramón y Cajal University Hospital, Madrid, Spain