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Elsevier

Books in Chemistry

Chemistry topic areas include: physical and theoretical, computational, organic, organometallic and inorganic, pharmaceutical and medicinal, analytical and bioanalytical, nuclear, general, nanochemistry, geochemistry, materials and polymer, as well as environmental, green and sustainable chemistry.

  • Distillation

    Operation and Applications
    • 1st Edition
    • Andrzej Gorak + 1 more
    • English
    Distillation: Operation and Applications—winner of the 2015 PROSE Award in Chemistry & Physics from the Association of American Publishers—is a single source of authoritative information on all aspects of the theory and practice of modern distillation, suitable for advanced students and professionals working in a laboratory, industrial plants, or a managerial capacity. It addresses the most important and current research on industrial distillation, including all steps in process design (feasibility study, modeling, and experimental validation), together with operation and control aspects. This volume features an extra focus on distillation applications.

  • Advances in Planar Lipid Bilayers and Liposomes

    • 1st Edition
    • Volume 20
    • English
    Although the origin and the basic meaning of the terms "planar lipid bilayers" and "liposome" have not changed during the years, the present advances in the scientific, technological, biomedical and consumer product fields are remarkable. Ever since its launch the "Advances in Planar Lipid Bilayers and Liposomes’ (APLBL) has provided a global platform for a community of researchers having very broad scientific interests in theoretical, experimental and simulation studies on lipid and cell membrane micro and nanostructures. Ranging from artificial lipid membranes to cell membranes, controlled release of functional molecules, drug delivery to cancer cells, pharmaceutical formulations to food products, the applications are simply enormous. An assortment of chapters in APLBL represents both an original research as well as comprehensives reviews written by world leading experts and young researchers.

  • Strategies and Tactics in Organic Synthesis

    • 1st Edition
    • Volume 10
    • Michael Harmata
    • English
    A classic in the area of organic synthesis, Strategies and Tactics in Organic Synthesis provides a forum for investigators to discuss their approach to the science and art of organic synthesis. Rather than a simple presentation of data or a secondhand analysis, we are given stories that vividly demonstrate the power of the human endeavor known as organic synthesis and the creativity and tenacity of its practitioners. Firsthand accounts of each project tell of the excitement of conception, the frustration of failure and the joy experienced when either rational thought or good fortune gives rise to the successful completion of a project. This book series shows how synthesis is really done, and we are educated, challenged and inspired by these accounts, which portray the idea that triumphs do not come without challenges. We also learn that we can meet challenges to further advance the science and art of organic synthesis, driving it forward to meet the demands of society, in discovering new reactions, creating new designs and building molecules with atom and step economies that provide solutions through function to create a better world.

  • Writing Reaction Mechanisms in Organic Chemistry

    • 3rd Edition
    • Kenneth A. Savin
    • English
    Writing Reaction Mechanisms in Organic Chemistry, Third Edition, is a guide to understanding the movements of atoms and electrons in the reactions of organic molecules. Expanding on the successful book by Miller and Solomon, this new edition further enhances your understanding of reaction mechanisms in organic chemistry and shows that writing mechanisms is a practical method of applying knowledge of previously encountered reactions and reaction conditions to new reactions. The book has been extensively revised with new material including a completely new chapter on oxidation and reduction reactions including stereochemical reactions. It is also now illustrated with hundreds of colorful chemical structures to help you understand reaction processes more easily. The book also features new and extended problem sets and answers to help you understand the general principles and how to apply these to real applications. In addition, there are new information boxes throughout the text to provide useful background to reactions and the people behind the discovery of a reaction. This new edition will be of interest to students and research chemists who want to learn how to organize what may seem an overwhelming quantity of information into a set of simple general principles and guidelines for determining and describing organic reaction mechanisms.

  • Sampling Systems Theory and Its Application

    International Series of Monographs on Electronics and Instrumentation
    • 1st Edition
    • Ya. Z. Tsypkin
    • D. W. Fry + 1 more
    • English
    Sampling Systems Theory and its Application, Volume 2 is a two-chapter text that focuses on closed pulse systems. The first chapter highlights the fundamentals of closed pulse systems. This chapter particularly tackles the equations, transfer functions, stability, frequency, characteristics, processes, and synthesis of these systems. The second chapter discusses the automatic temperature, ranging, and frequency control system and non-contact servo-system of closed pulse systems. This chapter also looks into the smoothing and prediction of discrete data in digital computers. This book will prove useful to mathematicians, engineers, and physicists.

  • Metabolism of Vitamins and Trace Elements

    Comprehensive Biochemistry
    • 1st Edition
    • Volume 21
    • Marcel Florkin + 1 more
    • English
    Comprehensive Biochemistry, Volume 21: Metabolism of Vitamins and Trace Elements focuses on the processes, reactions, methodologies, and principles involved in the metabolism of vitamins and trace elements, including catabolism, enzymatic synthesis, absorption, and metabolic functions. The selection first elaborates on the biosynthesis of thiamine and riboflavin and metabolism of vitamin B6. Topics include absorption and transport of vitamin B6, catabolism of vitamin B6, mechanism of riboflavin synthetase from yeast, enzymatic synthesis of thiamine, biogenesis of thiazole, and interconversion of various forms of vitamin B6. The book also ponders on the biosynthesis of pantothenic acid and coenzyme A and metabolism of biotin, analogues, folic acid, pteridine derivatives, and cobalamins. Discussions focus on the uses of radioactive cobalamins in metabolic studies, absorption of cobalamins, pteroylpolyglutamate... and biosynthesis of folate compounds, interconversions, and degradations. The manuscript examines the metabolism and metabolic function of trace elements, including iron, zinc, copper, manganese, molybdenum, selenium, fluorine, and iodine. The selection is a vital source of data for researchers interested in the metabolism of vitamins and trace elements.

  • Periodic Precipitation

    A Microcomputer Analysis of Transport and Reaction Processes in Diffusion Media, with Software Development
    • 1st Edition
    • H. K. Henisch
    • English
    Containing illustrations, worked examples, graphs and tables, this book deals with periodic precipitation (also known as Liesegang Ring formation) in terms of mathematical models and their logical consequences, and is entirely concerned with microcomputer analysis and software development. Three distinctive periodic precipitation mechanisms are included: binary diffusion-reaction; solubility modulation, and competitive particle growth. The book provides didactic illustrations of a valuable investigational procedure, in the form of hypothetical experimentation by microcomputer. The development of appropriate software is described and the resulting programs are available separately on disk. The software (for IBM compatible microcomputers; 5 1/4 and 3 1/2 inch disks available) will be sold separately by, The Carnation Press, PO Box 101, State College, PA 16804, USA.

  • Fusarium

    Mycotoxins, Taxonomy, Pathogenicity
    • 1st Edition
    • Volume 2
    • J. Chelkowski
    • English
    Specialists from a number of different disciplines have contributed to this book which presents actual basic and applied findings on Fusarium species, on their metabolites and taxonomy, in connection with pathogenicity to cereal plants and potato tubers. Over 100 metabolites produced by Fusaria are described together with results of studies on their occurrence in agricultural products, their metabolism in farm animals, and possibilities of elmination and detoxification during technological processes. Pathogenic Fusarium species are described from the point of view of their taxonomy, profiles of produced metabolites, ecology, pathogenicity and interaction with cereal tissues. Finally, some actual solutions to avoid cereal grain contamination are discussed, mainly in connection with agricultural practices and breeding programmes.The interdisciplinary and comprehensive nature of the book makes it particularly useful to all who are studying or teaching plant pathology, plant breeding, animal nutrition and any other area in which Fusaria and their metabolites play an important role.

  • Advances in Steroid Biochemistry and Pharmacology

    • 1st Edition
    • M. H. Briggs + 1 more
    • English
    Advances in Steroid Biochemistry and Pharmacology, Volume 4 provides information pertinent to the fundamental aspects of steroid biochemistry and pharmacology. This book covers a variety of topics, including cellular biochemistry, pituitary hormones, corticosteroids, and steroid hormones. Organized into seven chapters, this volume begins with an overview of the potential effects of steroids on cellular biochemistry. This text then examines the development of sleep-monitoring methods, together with methods of plasma sampling that enable very frequent specimen to be taken without disturbing the subject. Other chapters consider the usefulness of sleep-related growth hormone release in diagnosis in both children and adult. This book discusses as well the versatile effect of corticosteroids on the cellular components of the connective tissue. The final chapter deals with the functioning of the adrenal cortex and its control by adrenocorticotropic hormone (ACTH). This book is a valuable resource for biochemists, histochemists, biologists, pharmacologists, clinicians, and experimental endocrinologists.

  • Photobiology, Ionizing Radiations

    • 1st Edition
    • Volume 27
    • Marcel Florkin + 1 more
    • English
    Comprehensive Biochemisty, Volume 27: Photobiology, Ionizing Radiations deals with the aspects of bioenergetics, immunochemistry, photobiology, and molecular phenomena that underlie the evolution of organisms. This book discusses the types of phototropic response, action spectra in the further ultraviolet, and structure and light-absorbing properties of the photoreceptor cells. The preliminary remarks on visual pigment structure, synopsis of extracted systems, oxidation of proteins, and effects of ultraviolet radiation and photoreactivation are also elaborated. This text likewise covers the chemical nature of photoreactivable damage, reversibility of potentiated flowering response, and primary reactions in algae and higher plants. This volume is beneficial to biochemists and specialists researching on ionizing radiations.

  • Distillation: Equipment and Processes

    • 1st Edition
    • Andrzej Gorak + 1 more
    • English
    Distillation: Equipment and Processes—winner of the 2015 PROSE Award in Chemistry & Physics from the Association of American Publishers—is a single source of authoritative information on all aspects of the theory and practice of modern distillation, suitable for advanced students and professionals working in a laboratory, industrial plants, or a managerial capacity. It addresses the most important and current research on industrial distillation, including all steps in process design (feasibility study, modeling, and experimental validation), together with operation and control aspects. This volume features an extra focus on distillation equipment and processes.

  • Transport Properties of Chemicals and Hydrocarbons

    • 2nd Edition
    • Carl L. Yaws
    • English
    Covering more than 7,800 organic and inorganic chemicals and hydrocarbons, Transport Properties of Chemical and Hydrocarbons, Second Edition is an essential volume for any chemist or chemical engineer. Spanning gases, liquids, and solids, the book covers all critical properties (including viscosity, thermal conductivity, and diffusion coefficient). From C1 to C100 organics and Ac to Zr inorganics, the data in this handbook is a perfect quick reference for field, lab, or classroom use. By collecting a massive – but relevant – amount of information in one source, the handbook enables engineers to spend more time developing new designs and processes, and less time collecting vital properties data. This is not a theoretical treatise, but an aid to the practicing engineer in the field, on day-to-day operations and long-range projects.

  • Thermophysical Properties of Chemicals and Hydrocarbons

    • 2nd Edition
    • Carl L. Yaws
    • English
    Compiled by an expert in the field, the book provides an engineer with data they can trust. Spanning gases, liquids, and solids, all critical properties (including viscosity, thermal conductivity, and diffusion coefficient) are covered. From C1 to C100 organics and Ac to Zr inorganics, the data in this handbook is a perfect quick reference for field, lab or classroom usage. By collecting a large – but relevant – amount of information in one source, the handbook enables engineers to spend more time developing new designs and processes, and less time collecting vital properties data. This is not a theoretical treatise, but an aid to the practicing engineer in the field, on day-to-day operations and long range projects.

  • Studies in Natural Products Chemistry

    • 1st Edition
    • Volume 43
    • English
    Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then determine the structures and biological activity of natural products rapidly, thus opening up exciting opportunities in the field of new drug development to the pharmaceutical industry. The series also covers the synthesis or testing and recording of the medicinal properties of natural products, providing cutting edge accounts of the fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis and pharmacology of a diverse array of natural products.

  • Organic Chemistry

    Structure, Mechanism, and Synthesis
    • 1st Edition
    • Robert J. Ouellette + 1 more
    • English
    Organic Chemistry provides a comprehensive discussion of the basic principles of organic chemistry in their relation to a host of other fields in both physical and biological sciences. This book is written based on the premise that there are no shortcuts in organic chemistry, and that understanding and mastery cannot be achieved without devoting adequate time and attention to the theories and concepts of the discipline. It lays emphasis on connecting the basic principles of organic chemistry to real world challenges that require analysis, not just recall. This text covers topics ranging from structure and bonding in organic compounds to functional groups and their properties; identification of functional groups by infrared spectroscopy; organic reaction mechanisms; structures and reactions of alkanes and cycloalkanes; nucleophilic substitution and elimination reactions; conjugated alkenes and allylic systems; electrophilic aromatic substitution; carboxylic acids; and synthetic polymers. Throughout the book, principles logically evolve from one to the next, from the simplest to the most complex examples, with abundant connections between the text and real world applications. There are extensive examples of biological relevance, along with a chapter on organometallic chemistry not found in other standard references. This book will be of interest to chemists, life scientists, food scientists, pharmacists, and students in the physical and life sciences.

  • Heterogeneous Catalytic Materials

    Solid State Chemistry, Surface Chemistry and Catalytic Behaviour
    • 1st Edition
    • Guido Busca
    • English
    Heterogeneous Catalytic Materials discusses experimental methods and the latest developments in three areas of research: heterogeneous catalysis; surface chemistry; and the chemistry of catalysts. Catalytic materials are those solids that allow the chemical reaction to occur efficiently and cost-effectively. This book provides you with all necessary information to synthesize, characterize, and relate the properties of a catalyst to its behavior, enabling you to select the appropriate catalyst for the process and reactor system. Oxides (used both as catalysts and as supports for catalysts), mixed and complex oxides and salts, halides, sulfides, carbides, and unsupported and supported metals are all considered. The book encompasses applications in industrial chemistry, refinery, petrochemistry, biomass conversion, energy production, and environmental protection technologies.

  • The Economics of Natural Gas in Developing Countries

    • 1st Edition
    • John C. Gault
    • English
    The Economics of Natural Gas in Developing Countries provides information pertinent to the utilization of natural gas in developing countries. This book examines the potential domestic uses of natural gas as well as its export possibilities. Organized into 13 chapters, this book begins with an overview of the policies that provide adequate incentives for gas development in order to maximize the availability of gas for domestic uses. This text then examines the worldwide demand and supply of natural gas. Other chapters consider the requirements for gas-trade projects, which consists of a substantial market in the importing region and a significant gas reserve in the exporting country. This book discusses as well the differences between oil and gas development in terms of cost, marketing, technology, and government regulation. The final chapter deals with the significant potential for natural gas. This book is a valuable resource for economists, engineers, and engineering consultants.

  • The Chemistry of Germanium

    Tin and Lead
    • 1st Edition
    • E. G. Rochow + 1 more
    • J. C. Bailar + 2 more
    • English
    Pergamon Texts in Inorganic Chemistry, Volume 14: The Chemistry of Germanium, Tin, and Lead focuses on the properties, characteristics, transformations, and reactions of lead, germanium, and tin. The book focuses on germanium and compounds of Ge(I) and Ge(II). Discussions focus on germanium(II) compounds of phosphorus and arsenic, germanium(II) imide and nitride, monohalides, analytical determination, biological activity, chemical behavior of germanium, and production and industrial use of germanium. The text then elaborates on organogermanium compounds, complexes of germanium(IV), and tin. Topics include nuclear magnetic resonance, chemical properties of tin metal, isotopes of tin, occurrence and distribution of tin, and fluorogermanates and chlorogermanates. The manuscript takes a look at nuclear magnetic resonance, extraction, industrial and commercial utilization, toxicity, and chemical properties of metallic lead. The publication is a vital source of data for researchers interested in the chemistry of lead, germanium, and tin.

  • The Alkaloids

    Chemistry and Physiology
    • 1st Edition
    • R. H. F. Manske
    • English
    The Alkaloids: Chemistry and Physiology, Volume XI focuses on alkaloids and their structures. This book discusses the distribution of indole alkaloids in plants, ajmaline-sarpagine alkaloids, cinchophyllamine and isocinchophyllamine, and Voacanga alkaloids. The alkaloids of Vinca rosea L, eburnamine-vincamine alkaloids, heteroyohimbane group, and dimeric alkaloids of calabash curare are also elaborated. This publication likewise covers the alkaloids lacking the tryptamine bridge, alkaloids of undetermined structure, and chemistry of colchicine alkaloids. Other topics include the monoterpenoid alkaloids containing a pyridine or piperidine ring, tobacco alkaloids, alkaloids of Astrocasia phyllanthoides, and aspidospermtidine group. This volume is beneficial to chemists and researchers concerned with alkaloid chemistry.

  • The Alkaloids

    Chemistry and Physiology
    • 1st Edition
    • R. H. F. Manske
    • English
    The Alkaloids: Chemistry and Physiology, Volume VIII: The Indole Alkaloids focuses on the advances in the chemistry of indole alkaloids. This book discusses the tryptamine and its derivatives, postulated biosyntheses of the physostigmine ring system, and source of the alkaloids. The simple lysergic acid amides, mass spectra of mitraphylline and rhynchophylline, and alkaloids of gelsemium species are also elaborated. This text likewise covers the determination of the structure of the alkaloids, stereochemistry of cinchonamine, dimeric alkaloids of calabash curare, and chemistry of the reserpine group. Other topics include the biology of ergot and short history of its active principles up to the discovery of ergotamine. This volume is recommended for chemists and researchers interested in indole alkaloids.

  • The Alkaloids

    Chemistry and Physiology
    • 1st Edition
    • R. H. F. Manske + 1 more
    • English
    The Alkaloids: Chemistry and Physiology, Volume I deals with the chemistry and pharmacology of the alkaloids. This book discusses the sources of alkaloids and their isolation, alkaloids in grafts, position in nitrogen metabolism, and factors affecting alkaloid formation. The structure of the necic acids, common sources of different senecio alkaloids, alkaloids of hemlock, and chemistry of the tropane alkaloids are also elaborated. This text likewise covers the elucidation of the structure of strychnine and brucine; consequences of alkaloid formation; and structure of the alkaloids. This volume is a good source for chemists and researchers interested in the field of alkaloid chemistry.

  • The Alkaloids

    Chemistry and Physiology
    • 1st Edition
    • R. H. F. Manske
    • English
    The Alkaloids: Chemistry and Physiology, Volume VI: Supplement to Volumes I and II updates the chemistry of the alkaloids by linking developments to the content of earlier volumes. This book discusses the taxonomic position of the alkaloids in plants, external factors governing alkaloid formation, pyrrolidine alkaloids, and structure of the necines. The alkaloids of the pomegranate root bark, alkaloids of Sedum spp, structure of dioscorine, and reactions of morphine and codeine are also elaborated. This publication likewise covers the chemistry of colchicine, alkaloids derived from dibenzofuran, and biological effects of the amaryllidaceae alkaloids. This volume is a good reference for chemists and specialists conducting work on alkaloids.

  • The Alkaloids

    Chemistry and Physiology
    • 1st Edition
    • R. H. F. Manske + 1 more
    • English
    The Alkaloids: Chemistry and Physiology, Volume III reviews the chemistry of the alkaloids. This book discusses the chemistry of the cinchona alkaloids, alkaloids of Angostura bark, quinazoline alkaloids, and stereochemistry of the C15-lupin alkaloids. The tables of physical constants of the jaborandi alkaloids, pharmacology of the ?-phenethylamines, and synthesis of the ephedra bases are also elaborated. This publication likewise covers the extraction and industrial preparation of the alkaloids, minor alkaloids, furoquinoline group, and alkaloids of Dichroa febrifuga. Other topics include pilocarpine and isopilocarpine, veratrum alkaloids, and chemistry of the ?-phenethylamines found in plants. This volume is a good reference for chemists and specialists conducting work on alkaloids.

  • Cis-Trans Isomeric Carotenoids, Vitamins A and Arylpolyenes

    • 1st Edition
    • L. Zechmeister
    • English
    Cis-Trans Isomeric Carotenoids, Vitamins A, and Arylpolyenes focuses on the reactions, characteristics, and properties of cis-trans isomeric carotenoids, vitamins A, and arylpolyenes. The publication first takes a look at carotenoids, number, types, and properties of cis carotenoids, and cis-trans isomerism and UV spectra. Discussions focus on simple theoretical interpretation of spectral phenomena, spectra at extremely low temperatures, relative stabilities, melting points, rotatory power, and historical remarks on the stereoisomerism of polyenes. The text then ponders on the preparation of cis carotenoids by direct rearrangement of the all-trans form and total synthesis and naturally occurring cis and polycis carotenoids. The manuscript examines some general remarks on configurational assignments, configurational assignments in certain stereoisomeric sets, and lower-molecular weight carotenoid-carboxyli... acids. Topics include bixin set, stereoisomeric sets with two aromatic terminal groups, stereoisomeric sets with one hydroaromatic and one aliphatic terminal group, configuration and infrared spectrum, and stereoisomeric types. The manuscript also elaborates on vitamins A and retinenes, cumulenes with aromatic terminal groups, and polyene azines. The publication is a dependable source of information for researchers interested in cis-trans isomeric carotenoids, vitamins A, and arylpolyenes.

  • The Alkaloids

    Chemistry and Physiology
    • 1st Edition
    • R. H. F. Manske + 1 more
    • English
    The Alkaloids: Chemistry and Physiology, Volume II focuses on strychnine and morphine alkaloids. This book discusses the elucidation of the structure of morphine, codeine, and thebaine; synthetic hydrophenanthrenes related to the morphine alkaloids; and stereochemistry of the morphine alkaloids and sinomenine. The elucidation of the constitution of sinomenine, biological effects of colchicine, chemistry of individual alkaloids, and alkaloids of gelsemium species are also elaborated. This text likewise covers the isolation of the alkaloids, phenanthrene nucleus of morphine, fission around the nitrogen atom, and synthetic hydrophenanthrenes related to the morphine alkaloids. This volume is useful to chemists and researchers conducting work on alkaloid chemistry.

  • The Alkaloids

    Chemistry and Physiology
    • 1st Edition
    • R. H. F. Manske
    • English
    The Alkaloids: Chemistry and Physiology, Volume IX focuses on alkaloid chemistry. This book discusses the occurence of known aporphines in plants, reductions with sodium in liquid ammonia, alkaloids related to corydaline, and quaternary alkaloids containing an N-methyl group. The phthalideisoquinolin... alkaloids, alkaloids containing one diphenyl ether linkage, trisisobutylisoquino... alkaloids, and alkaloids of Platydesma campanulata are also elaborated. This publication likewise covers the stereochemistry of the ring nitrogen in the tropanes, pharmacologically active synthetic tropanium salts, and alkaloids of apocynaceae. Other topics include the isolation and purification of salamandra alkaloids, biological activity of tylophora alkaloids, and structure of himbosine. This volume is valuable to chemists and researchers interested in alkaloids and their structures.

  • Theory of Dispersed Multiphase Flow

    Proceedings of an Advanced Seminar Conducted by the Mathematics Research Center The University of Wisconsin-Madison May 26-28, 1982
    • 1st Edition
    • Richard E. Meyer
    • English
    Mathematics Research Center Symposium: Theory of Dispersed Multiphase Flow covers the proceedings of an advanced seminar conducted by the Mathematics Research Center of the University of Wisconsin-Madison on May 26-28, 1982. The book focuses on solutions of long chain polymers in liquids, magnetic control of particle suspensions in fluid streams, aerosols, dense granular flows, and ice crystals or vapor bubbles dispersed in river waters. The selection first elaborates on the effects of interactions between particles on the rheology of dispersions; rheology of concentrated macromolecular solutions; and a survey of results in the mathematical theory of fluidization. Discussions focus on Rayleigh-Taylor instabilities, linear instability theory, steady solutions, general theory for polymer solutions and suspensions, electrostatically concentrated suspensions, and pair interaction theories. The text then examines instability in settling of suspensions due to Brownian effects; enhanced sedimentation in vessels having inclined walls; and simple kinetic theory of Brownian diffusion in vapors and aerosols. The text takes a look at the simulation of aerosol dynamics, continuum modeling of two-phase flows, multiphase mixture theory for fluid-particle flows, and mixture theory for turbulent diffusion of heavy particles. Topics include plane gravity flow, decomposition and averaging, isothermal flows of dilute suspensions, kinematics and the equations of motion, diffusional regularization, kinematic waves, and aerosol formation and growth in uniform systems. The selection is a valuable source of data for researchers interested in the theory of dispersed multiphase flow.

  • Small Molecular Immunomodifiers of Microbial Origin

    Fundamental and Clinical Studies of Bestatin
    • 1st Edition
    • Hamao Umezawa
    • English
    Small Molecular Immunomodifiers of Microbial Origin: Fundamental and Clinical Studies of Bestatin focuses on the results of experimental and clinical studies suggesting that bestatin and small molecular weight immunity-enhancing agents can contribute to the treatment of cancer and resistant infections. The selection first offers information on the screening, discoveries, and genetics of microbial secondary metabolites and activity of bestatin. Topics include the effect of bestatin on colony formation of murine bone marrow progenitor cells in vitro; antitumor effect of bestatin on murine transplantable tumors; and structures and properties of bestatin, amastatin, forphenicine, and esterastin. The text then examines the effects of bestatin on DNA and RNA metabolism in T-cells and levamisole and bestatin in immunodefficient aged mice. The text examines the influence of bestatin on the lymphoid system in humans, natural killer activity, and bone marrow. The preliminary phase I study of bestatin in lung cancer cases and malignant skin tumors are discussed. Topics include dosage schedule, clinical findings, and changes in immunological parameters. The selection is a vital reference for readers interested in the applications of bestatin in the treatment of cancer and resistant infections.

  • Handbook of Solvents

    Volume 1: Properties
    • 2nd Edition
    • George Wypych
    • English
    Each chapter in this volume is focused on a specific set of solvent properties which determine its choice, effect on properties of solutes and solutions, properties of different groups of solvents and the summary of their applications' effect. This includes effects on health and environment (given in tabulated form), swelling of solids in solvents, solvent diffusion and drying processes, nature of interaction of solvent and solute in solutions, acid-base interactions, effect of solvents on spectral and other electronic properties of solutions, effect of solvents on rheology of solution, aggregation of solutes, permeability, molecular structure, crystallinity, configuration, and conformation of dissolved high molecular weight compounds, methods of application of solvent mixtures to enhance the range of their applicability, and effect of solvents on chemical reactions and reactivity of dissolved substances.

  • Synthetic Analgesics

    Morphinans: Benzomorphans
    • 1st Edition
    • J. Hellerbach + 2 more
    • D. H. R. Barton + 1 more
    • English
    Synthetic Analgesics provides a comprehensive discussion of morphinans and 6,7-benzomorphans. Morphinans belong to a class of compounds possessing the main structural skeleton of morphine. Chemists have attempted to modify the morphine molecule in order to obtain analgesics without side-effects and addictive properties. The book is organized into two parts. Part A discusses the chemistry and pharmacology of morphinans, covering the syntheses of analgesics with morphine-like activity, N-methyl-morphinan, 3-hydroxy-N-methyl-m... and analogous compounds, toxicity and analgesic action of morphinan, and morphinans with anti-morphine activity. Part B deals with the chemistry and pharmacology of 6,7-benzomorphans; and opiate antagonists in the benzomorphan series.

  • Fundamental Aliphatic Chemistry

    Organic Chemistry for General Degree Students
    • 1st Edition
    • P. W. G. Smith + 1 more
    • English
    Organic Chemistry for General Degree Students is written to meet the requirements of the London General Internal examination and degree examinations of a similar standing. It will also provide for the needs of students taking the Part 1 examination for Graduate Membership of the Royal Institute of Chemistry, or the Higher National Certificate, whilst the treatment is such that Ordinary National Certificate courses can be based on the first two volumes Within the limits broadly defined by the syllabus, the aim of this first volume is to provide a concise summary of the important general methods of preparation and properties of the main classes of aliphatic compounds. Due attention is paid to practical considerations with particular reference to important industrial processes. At the same time, the fundamental theoretical principles of organic chemistry are illustrated by the discussion of a selection of the more important reaction mechanisms. Questions and problems are included, designed to test the student’s appreciation of the subject and his ability to apply the principles embodied therein. A selection of questions set in the relevant examinations is also included.

  • Synthetic Analgesics

    Diphenylpropylamines
    • 1st Edition
    • Paul A. J. Janssen
    • D. H. R. Barton + 1 more
    • English
    Synthetic Analgesics, Part I: Diphenylpropylamines deals with the methods of synthesis, the physical and chemical properties, and the ""analgesic"" activity of diphenylpropylamines... Topics covered include the ""analgesic"" activity of methadone, morphine, pethidine, and codeine in animals; diamines and derivatives; R875 and related basic tertiary amides; esters derived from amino acids and secondary and tertiary alcohols; and ketimines, acyl ketimines, and ketones. This book is comprised of 21 chapters and begins with a brief background on the first chemical and pharmacological experiments on diphenylpropylamines... followed by a discussion on ""analgesic"" activity in humans and animals. The ""analgesic"" activity of methadone, morphine, pethidine, and codeine in animals is considered. The following chapters explore a variety of compounds such as 3:3-diphenylpropylam... tertiary alcohols, secondary alcohols, primary alcohols, nitriles, diamines and derivatives, primary and secondary amides, acids and acid chlorides, and aldehydes. Sulfones, dissociation constants, and configurational studies are also described. This monograph will be a useful resource for researchers and practitioners in the fields of organic chemistry, analytical chemistry, and pharmacology.

  • The Isoquinoline Alkaloids

    A Course in Organic Chemistry
    • 1st Edition
    • K. W. Bentley
    • Robert Robinson
    • English
    The Isoquinoline Alkaloids: A Course in Organic Chemistry is a description of the chemical structures of alkaloids. The book discusses the processes for degradation of isoquinoline alkaloids to recognizable compounds such as oxidation and exhaustive methylation. The associated processes in removing the nitrogen atom are also explained. The commonly used Hofmann process and the interpretation of its result are evaluated in the degradation of alkaloids. The cactus ""pellote"" used by Mexican Indians to induce hallucinatory experiences is examined. The active ingredient is identified as mescaline; its composition is analyzed to contain one primary amino and three methoxyl groups. The different syntheses made to duplicate mescaline are described. The structures of morphine, codeine, and thebain, which are all alkaloids of opium, are also analyzed. Another example of a principal alkaloid found in a plant is emetine found in the root of the ipecac. The pharmacological bases of emetine are isolated and noted as emetamine, cephaeline, psychotrine, and O-methylpsychotrine. The text also traces many other structural relationships within the subgroups of the isoquinoline alkaloids. Chemists, students and professors in organic chemistry, and laboratory technicians whose work is related to pharmacology will find this book informative.

  • Aromatic Chemistry

    Organic Chemistry for General Degree Students
    • 1st Edition
    • P. W. G. Smith + 1 more
    • English
    Organic Chemistry for General Degree Students, Volume 2: Aromatic Chemistry covers the simple heteroaromatic systems and the chemistry of their functional groups. This book is divided into 11 chapters that also describe the properties of the aromatic compounds. The first chapters discuss the benzene structure and reactivity; nitro compounds and aromatic nitration; aromatic and side-chain halogenated compounds; general properties of aromatic sulfonic acids; and the mechanism of sulfonation. The succeeding chapters explore the analysis and general reactions of nucleophilic replacements, as well as the synthesis of sulfonic acid derivatives. These topics are followed by discussions on the basic properties of phenols and the reactions involving hydroxyl group. The last chapters examine the behavior of diazonium and the preparation of benzaldehyde. The book can provide useful information to scientists, chemists, students, and researchers.

  • Annual Reports on NMR Spectroscopy

    • 1st Edition
    • Volume 82
    • Graham A. Webb
    • English
    Nuclear magnetic resonance (NMR) is an analytical tool used by chemists and physicists to study the structure and dynamics of molecules. In recent years, no other technique has gained such significance as NMR spectroscopy. It is used in all branches of science in which precise structural determination is required and in which the nature of interactions and reactions in solution is being studied. Annual Reports on NMR Spectroscopy has established itself as a premier means for the specialist and non-specialist alike to become familiar with new techniques and applications of NMR spectroscopy. This is an invaluable resource for organic, inorganic, analytical and physical chemists, biochemists, structural biologists, physicists, and all those studying and using NMR spectroscopy.

  • Advances in Planar Lipid Bilayers and Liposomes

    • 1st Edition
    • Volume 19
    • English
    Advances in Planar Lipid Bilayers and Liposomes volumes cover a broad range of topics, including main arrangements of the reconstituted system, namely planar lipid bilayers as well as spherical liposomes. The invited authors present the latest results of their own research groups in this exciting multidisciplinary field.

  • Organic Chemistry Concepts and Applications for Medicinal Chemistry

    • 1st Edition
    • Joseph E. Rice
    • English
    Organic Chemistry Concepts and Applications for Medicinal Chemistry provides a valuable refresher for understanding the relationship between chemical bonding and those molecular properties that help to determine medicinal activity. This book explores the basic aspects of structural organic chemistry without going into the various classes of reactions. Two medicinal chemistry concepts are also introduced: partition coefficients and the nomenclature of cyclic and polycyclic ring systems that comprise a large number of drug molecules. Given the systematic name of a drug, the reader is guided through the process of drawing an accurate chemical structure. By emphasizing the relationship between structure and properties, this book gives readers the connections to more fully comprehend, retain, apply, and build upon their organic chemistry background in further chemistry study, practice, and exams.

  • Homolytic Aromatic Substitution

    International Series of Monographs on Organic Chemistry
    • 1st Edition
    • G. H. Williams
    • D. H. R. Barton + 1 more
    • English
    Homolytic Aromatic Substitution deals with the theoretical aspects of homolytic aromatic substitution reactions. The effect of various kinds of free radicals on the substitution of atoms or groups (usually hydrogen) attached to aromatic nuclei is examined, and the preparative use of homolytic substitution reactions is also considered. This book is comprised of seven chapters and begins with an introduction to the general characteristics of homolysis, along with homolytic and heterolytic aromatic substitution. The discussion then turns to the various theoretical approaches used to rationalize aromatic substitution, particularly those that are germane to a consideration of the problems of orientation and reactivity in homolytic substitution. The following chapters explore homolytic arylation reactions, including those between aryl radicals and aromatic substrates; relative rates of arylation and partial rate factors for phenylation; the reaction mechanism underlying intramolecular arylation; and homolytic alkylation reactions. The final chapter deals with hydroxylation and some other substitution reactions such as benzoyloxylation, acetyloxylation, halogenation, amination and amidation, and mercuration. This monograph will be of interest to organic chemists.

  • The Organic Chemistry of Drug Design and Drug Action

    • 3rd Edition
    • Richard B. Silverman + 1 more
    • English
    The Organic Chemistry of Drug Design and Drug Action, Third Edition, represents a unique approach to medicinal chemistry based on physical organic chemical principles and reaction mechanisms that rationalize drug action, which allows reader to extrapolate those core principles and mechanisms to many related classes of drug molecules. This new edition includes updates to all chapters, including new examples and references. It reflects significant changes in the process of drug design over the last decade and preserves the successful approach of the previous editions while including significant changes in format and coverage. This text is designed for undergraduate and graduate students in chemistry studying medicinal chemistry or pharmaceutical chemistry; research chemists and biochemists working in pharmaceutical and biotechnology industries.

  • Rotating Electrode Methods and Oxygen Reduction Electrocatalysts

    • 1st Edition
    • Wei Xing + 2 more
    • English
    Rotating Electrode Methods and Oxygen Reduction Electrocatalysts provides the latest information and methodologies of rotating disk electrode and rotating ring-disk electrode (RDE/RRDE) and oxygen reduction reaction (ORR). It is an ideal reference for undergraduate and graduate students, scientists, and engineers who work in the areas of energy, electrochemistry science and technology, fuel cells, and other electrochemical systems.

  • Practical Three-Way Calibration

    • 1st Edition
    • Alejandro Olivieri + 1 more
    • English
    Practical Three-Way Calibration is an introductory-level guide to the complex field of analytical calibration with three-way instrumental data. With minimal use of mathematical/statist... expressions, it walks the reader through the analytical methodologies with helpful images and step-by-step explanations. Unlike other books on the subject, there is no need for prior programming experience and no need to learn programming languages. Easy-to-use graphical interfaces and intuitive descriptions of mathematical and statistical concepts make three-way calibration methodologies accessible to analytical chemists and scientists in a wide range of disciplines in industry and academia.

  • Concerning Amines

    Their Properties, Preparation and Reactions
    • 1st Edition
    • David Ginsburg
    • Robert Robinson
    • English
    Concerning Amines: Their Properties, Preparation and Reactions attempts to describe the accumulated knowledge on the properties of amines. This text first discusses nitrogen atom contained in amines, along with the basicity, geometry, nomenclature, occurrence, reaction, and preparation of these derivatives of ammonia. This book then explains the stereochemistry of the amino group and of quaternary ammonium compounds. Amine salts; absolute configuration of asymmetric amines; and influence of amino group are also tackled. This text also looks into the amino group in heterocyclic aromatic systems. This book concludes by explaining the syntheses of heterocyclic amines, enamines, and further reactions of carbonyl compounds with amines, including the Eschweiler, Vilsmeyer, and von Braun reactions. This publication will be invaluable to those interested in studying the properties of amines, such as chemists and students of chemistry.

  • Studies in Natural Products Chemistry

    • 1st Edition
    • Volume 42
    • English
    Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then determine the structures and biological activity of natural products rapidly, thus opening up exciting new opportunities in the field of new drug development to the pharmaceutical industry.The series also covers the synthesis or testing and recording of the medicinal properties of natural products, providing cutting edge accounts of the fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis and pharmacology of a diverse array of natural products.

  • Fundamentals of Advanced Omics Technologies: From Genes to Metabolites

    • 1st Edition
    • Volume 63
    • English
    Fundamentals of Advanced Omics Technologies: From Genes to Metabolites covers the fundamental aspects of the new instrumental and methodological developments in omics technologies, including those related to genomics, transcriptomics, epigenetics, proteomics and metabolomics, as well as other omics approaches such as glycomics, peptidomics and foodomics. The principal applications are presented in the following complementary volume. The chapters discuss in detail omics technologies, DNA microarray analysis, next-generation sequencing technologies, genome-wide analysis of methylation and histone modifications, emerging nanotechniques in proteomics, imaging mass spectrometry in proteomics, recent quantitative proteomics approaches, and advances in high-resolution NMR-based metabolomics, as well as MS-based non-targeted metabolomics and metabolome analysis by CE-MS, global glycomics analyses, foodomics, and high resolution analytical tools for quantitative peptidomics. Key aspects related to chemometrics, bioinformatics, data treatment, data integration and systems biology, deep-sequencing data analysis, statistical approaches for the analysis of microarray data, the integration of transcriptome and metabolome data and computational approaches for visualization and integration of omics data are also covered.

  • Progress in Medicinal Chemistry

    • 1st Edition
    • Volume 53
    • English
    Progress in Medicinal Chemistry provides a review of eclectic developments in medicinal chemistry. This volume continues in the serial's tradition of providing an insight into the skills required of the modern medicinal chemist; in particular, the use of an appropriate selection of the wide range of tools now available to solve key scientific problems, including g-secretase modulators, P2X7 antagonists as therapeutic agents for CNS disorders, N-type calcium channel modulators for the treatment of pain, and more.

  • Key Chiral Auxiliary Applications

    • 2nd Edition
    • Gregory Roos
    • English
    Key Chiral Auxiliary Applications, Second Edition is a detailed compilation of chiral auxiliary applications organized by type of transformation. Continuing from the most important and relevant auxiliaries described in its predecessor, the three-volume set Compendium of Chiral Auxiliary Applications (2001), as well as advances in the field, the book provides a vital and timely resource for chemists in the field. Each reaction class includes a series of tables and graphical abstracts of real reactions from the literature and patents to enable easy review and comparison of results. This anticipated edition is based on a screening of nearly 40,000 auxiliary reaction applications, with details supplied for the more than 13,000 selected representative entries: synthetic route, reagents, yields, diastereomeric/enant... excesses, and characterization data. Updated and streamlined with more than 60% new material, Key Chiral Auxiliary Applications provides valuable guidance and reliable content for selecting the best auxiliary for a specific asymmetric synthetic transformation.

  • Flow Analysis

    A Practical Guide
    • 1st Edition
    • Victor Cerda + 3 more
    • English
    Flow Analysis: A Practical Guide reviews flow techniques for automating chemical analysis with the goal of increasing efficiency and producing better analytical results. Various applications for flow techniques are reviewed including industrial process monitoring (for example, foods and beverages, drugs and pharmaceuticals); as well as agricultural, life science, radioactivity, and environmental analysis with an emphasis on the latter. This book is a valuable resource for young scientists or graduate-level students who want to learn how to introduce flow techniques into their experiments, and for experts who need specific and technical details to develop complete experimental systems.

  • Studies in Natural Products Chemistry

    • 1st Edition
    • Volume 41
    • English
    Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then determine the structures and biological activity of natural products rapidly, thus opening up exciting new opportunities in the field of new drug development to the pharmaceutical industry. The series also covers the synthesis or testing and recording of the medicinal properties of natural products.

  • Annual Reports on NMR Spectroscopy

    • 1st Edition
    • Volume 81
    • Graham A. Webb
    • English
    Nuclear magnetic resonance (NMR) is an analytical tool used by chemists and physicists to study the structure and dynamics of molecules. In recent years, no other technique has gained such significance as NMR spectroscopy. It is used in all branches of science in which precise structural determination is required and in which the nature of interactions and reactions in solution is being studied. Annual Reports on NMR Spectroscopy has established itself as a premier means for the specialist and non-specialist alike to become familiar with new techniques and applications of NMR spectroscopy.

  • Proceedings of MEST 2012: Electronic Structure Methods with Applications to Experimental Chemistry

    • 1st Edition
    • Volume 68
    • Philip E. Hoggan
    • English
    Advances in Quantum Chemistry presents surveys of current topics in this rapidly developing field that has emerged at the cross section of the historically established areas of mathematics, physics, chemistry, and biology. It features detailed reviews written by leading international researchers. This volume focuses on the theory of heavy ion physics in medicine.

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