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Studies in Natural Products Chemistry
- 1st Edition, Volume 41 - January 8, 2014
- Editor: Atta-ur- Rahman
- Language: English
- Hardback ISBN:9 7 8 - 0 - 4 4 4 - 6 3 2 9 4 - 4
- eBook ISBN:9 7 8 - 0 - 4 4 4 - 6 3 2 9 5 - 1
Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the mi… Read more
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Request a sales quoteNatural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then determine the structures and biological activity of natural products rapidly, thus opening up exciting new opportunities in the field of new drug development to the pharmaceutical industry.
The series also covers the synthesis or testing and recording of the medicinal properties of natural products.
- Describes the chemistry of bioactive natural products
- Contains contributions by leading authorities in the field
- A valuable resource for natural products and medicinal chemistry
Natural product chemists, medicinal chemists, pharmacologists as well as researchers, particularly those in academia and in the pharmaceutical industry
Contributors
Preface
Chapter 1: Recent Insights into the Emerging Role of Triterpenoids in Cancer Therapy: Part II
Abstract
Introduction
Antitumor Activity of Triterpenoids
Concluding Remarks
Chapter 2: Highlights of Pentacyclic Triterpenoids in the Cancer Settings
Abstract
Introduction to Triterpenoids
Cancer and Triterpenoids
Anticancer Activity of Natural Pentacyclic Triterpenoids
Semisynthetic Pentacyclic Triterpenoids and Cancer
Conclusions
Chapter 3: Immunomodulatory and Anticancer Activity of Sea Cucumber Triterpene Glycosides
Abstract
Introduction
Anticancer Activity
Immunomodulatory Activity
Conclusion
Acknowledgments
Chapter 4: Bioactive Annonaceous Acetogenins
Abstract
Introduction
Sources of ACGs
Quantitative and Qualitative Analysis of ACGs
Potential Health Benefits of ACGs
Toxicity
New Chemical Entities
Acknowledgment
Chapter 5: Bioactive Naphthoquinones from Higher Plants
Abstract
Introduction
Distribution of Naphthoquinones Within the Plant Kingdom
The Main Naphthoquinone-Containing Orders
Plant Cell, Tissue, and “Hairy” Root Cultures
Biological Activity of Naphthoquinones
Cytotoxicity and Anticancer Activity
Antibacterial Activity
Anti-Inflammatory Activity
Antiparasitic Activity
Antifungal
Discussion and Concluding Remarks
Chapter 6: Antiobesity Effects of Natural Products from an Epigenetic Perspective
Abstract
Introduction
Natural Products with Antiobesity Effects
DNA Methylation
Histone Modifications
Obesigenic Gene
Natural Products Affecting Epigenetic Mechanisms
Flavonoid-Related Compounds
Resveratrol
Curcumin
Organosulfur Compounds
Methyl Donor Metabolism
Conclusion
Chapter 7: Natural Polyphenols as Potent Inhibitors of DNA Methyltransferases
Abstract
Introduction
Epigenetics, DNA Methylation, and Cancer
Chemistry of DNA Methylation and Demethylation
Polyphenol Inhibitors of DNMT
Other Natural Product DNMTi
Conclusion
Acknowledgments
Chapter 8: The Chemistry and Bioactivity of Eucommia ulmoides Oliver Leaves
Abstract
Introduction
Chemistry of Compounds from E. ulmoides Oliver Leaves
Bioactivities of Compounds from E. ulmoides Leaves
Acknowledgments
Chapter 9: Aloe Vera Gel in Food, Health Products, and Cosmetics Industry
Abstract
Introduction
Aloe Vera Gel Chemistry
Medicinal Uses of Aloe Vera Juice
Aloe Vera Gel Applications
Aloe Vera as Food Supplement
Aloe Vera in Cosmetics
Processing of Aloe Vera Gel
Production Methods
Aloe Concentrate
Aloe Powder
Quality Control and Safety Aspects of Aloe Products
Conclusion
Chapter 10: Synthesis of Marine-Derived Carbasugar Pericosines
Abstract
Introduction
First Synthesis of (+)-Pericosine B by Donohoe
Synthesis of Epimer of Pericosine B: Synthesis of (+)-Pericosine C
Syntheses of Initially Assigned Pericosine A and Its Diastereomer
First Total Synthesis of Revised Pericosine A: Determination of Absolute Configuration
Syntheses of Pericosines Strating from D-Ribose via Ring-Closing Metathesis
Second-Generation Syntheses of Pericosines A and C by the Usami Group
Syntheses of (+)-Pericosines A–C by Stevenson
Synthesis of (−)-Pericosine B by the Usami Group
Chiral HPLC Analyses of Some Natural Pericosines
Syntheses of Pericosines via Ring-Closing Metathesis Starting from D-Ribose
Conclusion
Acknowledgments
Chapter 11: Bioactive Components from Leaf Vegetable Products
Abstract
Introduction
Ascorbic Acid
Polyphenols
Carotenoids
Tocopherols and Tocotrienols
Phytosterols
Melatonin
Sulfur Compounds
New Perspectives and Potential Applications of Leaf Vegetable Products
Concluding Remarks
Acknowledgments
Chapter 12: Milk Fat Globule Membrane Material: Isolation Techniques, Health-Beneficial Properties, and Potential Applications
Abstract
Introduction
Composition of MFGM
Structure of MFGM
Distribution of MFGM During Dairy Processing
Isolation and Purification of MFGM Material
Nutraceutical Properties of MFGM Components
Applications of MFGM Material
General Conclusions and Perspectives
Chapter 13: Determination of the Absolute Configuration of Natural Product Molecules Using Vibrational Circular Dichroism
Abstract
Introduction
Theoretical Background
AC Determination Using VCD
Calculations of Theoretical Spectra
Examples of Application
Concluding Remarks
Acknowledgments
Chapter 14: Bioactive Metabolites from Rare Actinomycetes
Abstract
Introduction
Bioactive Compounds from Rare Actinomycetes
Techniques for Isolation of Rare Actinomycetes
Antibiotics from Rare Actinomycetes: Structural and Chemical Diversity
Novel Classes of Antibiotics
Conclusion
Index
- No. of pages: 536
- Language: English
- Edition: 1
- Volume: 41
- Published: January 8, 2014
- Imprint: Elsevier
- Hardback ISBN: 9780444632944
- eBook ISBN: 9780444632951
AR
Atta-ur- Rahman
Atta-ur-Rahman, FRS, D.Phil., TI, SI HI, NI, is a leading scientist and scholar in the field of organic chemistry from Pakistan, especially renowned for his research in the various areas relating to natural product chemistry. With over 909 publications in the field of his expertise including 116 books largely published by leading publishers in Europe and USA and 27 patents, he is also credited for reviving the higher education and research practices in Pakistan.
Prof. Rahman was elected as Fellow of Royal Society (London) in July 2006 thereby becoming one of the 4 scientists from the Muslim world to have ever won this honor in the last 350 years when the Royal Society was established. He is also the only scientist from the Muslim world to have been conferred the UNESCO Science Prize in 1999.[11] He has been conferred honorary doctorate degrees by many universities including the degree of Doctor of Science (Sc.D.) by Cambridge University (UK) (1987) and an Honorary degree of Doctor of Education by Coventry University UK in November 2007. He was elected Honorary Life Fellow of Kings College, Cambridge University, UK in 2007. Prof. Atta-ur-Rahman was conferred the TWAS Prize for Institution Building in Durban, South Africa in October 2009 in recognition of his contributions for bringing about revolutionary changes in the higher education sector in Pakistan. He was awarded the Engro Excellence Award in Science & Technology 2011 for meritorious contributions.
He is President of Network of Academies of Sciences of Islamic Countries (NASIC) and the Vice-President (Central & South Asia) of the Academy of Sciences for the Developing World (TWAS) Council, and Foreign Fellow of Korean Academy of Sciences. Prof. Atta-ur-Rahman was the President of the Pakistan Academy of Sciences (2003–06), and was again elected President of Pakistan Academy of Sciences in January 2011.
He was the Federal Minister for Science and Technology (14 March 2000 – 20 November 2002), Federal Minister of Education (2002) and Chairman of the Higher Education Commission with the status of a Federal Minister from 2002-2008. The Austrian government also honoured him with its highest civil award ("Das Große Goldene Ehrenzeichen am Bande", 2007) in recognition of his eminent contributions.
Prof. Atta-ur-Rahman was the Coordinator General of COMSTECH, an OIC Ministerial Committee comprising the 57 Ministers of Science & Technology from 57 OIC member countries during 1996-2012. He is also the Patron of International Centre of Chemical and Biological Sciences (which comprises a number of institutes, including the Hussain Ebrahim Jamal Research Institute of Chemistry and the Dr. Panjwani Center of Molecular Medicine and Drug Development) at Karachi University.
He established a research center on Genomics in Karachi University. In recognition of the eminent contributions of Prof. Atta-ur-Rahman, a number of institutions have been named after him within and outside Pakistan. These include a natural product chemistry institute (Atta-ur-Rahman Research Institute of Natural Product Discovery, RiND) at the University of Technology Mara in Malaysia, Atta-ur-Rahman School of Applied Biosciences at National University of Science & Technology in Islamabad, and Dr. Atta-ur-Rahman Building at the International Centre for Chemical and Biological Sciences, University of Karachi. The Academy of Sciences in the Developing World (TWAS) based in Trieste, Italy has introduced a Dr. Atta-ur-Rahman Prize in Chemistry to a scientist from the developing world each year. The Prize carries a cash award of $ 5,000 and a Certificate.
Affiliations and expertise
University of Karachi, PakistanRead Studies in Natural Products Chemistry on ScienceDirect