Studies in Natural Products Chemistry
- 1st Edition, Volume 42 - February 24, 2014
- Imprint: Elsevier
- Editor: Atta-ur- Rahman
- Language: English
- Hardback ISBN:9 7 8 - 0 - 4 4 4 - 6 3 2 8 1 - 4
- eBook ISBN:9 7 8 - 0 - 4 4 4 - 6 3 2 8 2 - 1
Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the… Read more
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Request a sales quoteNatural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then determine the structures and biological activity of natural products rapidly, thus opening up exciting new opportunities in the field of new drug development to the pharmaceutical industry.The series also covers the synthesis or testing and recording of the medicinal properties of natural products, providing cutting edge accounts of the fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis and pharmacology of a diverse array of natural products.
- Describes the chemistry of bioactive natural products
- Contains contributions by leading authorities in the field
- Presents exciting sources of new pharmacophores
Natural product chemists, medicinal chemists, pharmacologists as well as researchers particularly those in academia and in the pharmaceutical industry
Contributors
Preface
Chapter 1: Glycosphingolipid Ligands for Invariant Natural Killer T cells as Immunostimulants
Abstract
Introduction
Synthesis of KRN7000
X-Ray Crystallographic Analysis
Stereostructure of the Sphingosine Part of KRN7000
SAR Studies on KRN7000
Th1-Type Analogs of KRN7000
Th2-Type Analogs of KRN7000
Summary of SAR Study
Evaluation of the Binding Affinity by SPR Spectroscopy
Molecular Dynamics Simulation Study
Research Intended to Discover the Natural Microbial and Endogenous Ligands of NKT Cells
Concluding Remarks
Acknowledgments
Chapter 2: Synthesis of Imidazole Alkaloids Originated in Marine Sponges
Abstract
Introduction
Syntheses of Naamidines A–I
Syntheses of Preclathridine A and Clathridine A
Syntheses of Naamines
Syntheses of Isonaamines and Isonaamidines
Synthesis of Pyronaamidine
Discovered, but not yet Synthesized Imidazole Alkaloids
Chapter 3: Cerebrosides from Marine Organisms
Abstract
Introduction
Isolation and Purification
Structural Elucidation
Chemical Structures
Conclusions
Acknowledgments
Chapter 4: Isolation and Analysis of Lignin–Carbohydrate Complexes Preparations with Traditional and Advanced Methods: A Review
Abstract
Introduction
Isolation of LCC Preparations from Wood and Pulps
LCC Analysis
Quantification of LCC Linkages
General Discussion
Implementation of Enzymes in LCC Studies
Conclusions
Chapter 5: Isolation, Characterization, and Biological Activities of Polysaccharides from Medicinal Plants and Mushrooms
Abstract
Introduction
Molecular Basis of Cancer Formation and Development
Isolation and Purification of Polysaccharides
Polysaccharide Structure–Function Relationship and Mechanism of Action
Rational and Targeted Design and Screening Programs for Chemotherapeutics
Polysaccharides from Plants and Mushrooms with Immunomodulatory and Anticancer Activities
Concluding Remarks and Direction for Future Research
Chapter 6: Natural Compounds (Small Molecules) as Potential and Real Drugs of Alzheimer's Disease: A Critical Review
Abstract
Introduction
Pathophysiology of AD
Perspectives of Small Molecules Effect Study
Conclusion
Acknowledgments
Chapter 7: Natural Antiviral Compounds
Abstract
Introduction
Virus
Concluding Remarks
Chapter 8: Chemopreventive Properties of Fruit Phenolic Compounds and Their Possible Mode of Actions
Abstract
Introduction
Cancer
Fruit Phenolic Compounds
Chemoprevention
Chemopreventive Properties of Fruit Phenolic Compounds
Conclusion
Acknowledgments
Chapter 9: Plant Secondary Metabolites: Structure–Activity Relationships in Human Health Prevention and Treatment of Common Diseases
Abstract
Introduction
Nutraceuticals
Plant Chemical Defenses
Natural Products in Medicine
Phenolic Compounds
α,β-Unsaturated δ-Lactones
Terpenoids
Nitrogen Compounds
Sulfur Compounds
Concluding Remarks
Acknowledgments
Chapter 10: Assignment of Regio- and Stereochemistry of Natural Products Using Mass Spectrometry Chlorogenic Acids and Derivatives as a Case Study
Abstract
Introduction
Chlorogenic Acids
MS and Identification of CGAs
LC–MS and LC–MSn Identification of CGAs in Green Coffee Beans
Identification of Monoacyl Quinic Acids
Identification of Di- and Triacyl Quinic Acids
Mechanistic Considerations
Assignment of Side Chain Regiochemistry Feruloyl Versus Isoferuloylquinic Acids
Cinnamoyl Shikimic Acids
Quinic Acid Lactones
Quinic Acid Esters
Epimers of Quinic Acid—Distinction of Diastereoisomeric Compounds
Distinguishing Multiple Isomers in Direct Infusion Experiments
Energy-Resolved Mass Spectra
General Experimental Considerations in Tandem MS
Outlook and Conclusion
Chapter 11: Tetrapyrrole Compounds of Cyanobacteria
Abstract
Introduction
Synthesis of Macrocyclic and Linear Tetrapyrrole Compounds
Corrinoid Compounds in Edible Cyanobacteria
Physiological Functions of Corrinoid Compounds in Cyanobacteria
Phycobilins in Edible Cyanobacteria
Concluding Remarks
Chapter 12: Recent Progress in the Synthesis of 2,6-Disubstituted Hydroxypiperidine Alkaloids
Abstract
Introduction
Metal-Catalyzed Formation of the Piperidine Ring
Piperidine Ring Formation via Intramolecular Nucleophilic Attack
Piperidine Ring Formation by Intramolecular Nucleophilic Displacement
Piperidine Ring Formation from Furan Derivatives
Piperidine Ring Formation via Amidomercuration
Other Methods for Formation of the Piperidine Ring
Concluding Remarks
Acknowledgment
Chapter 13: Structure, Biological Properties, and Total Synthesis of Polyhydroxylated Pyrrolizidines of the Hyacinthacines Family
Introduction
Natural Occurrence, Isolation, and Structure Determination of Hyacinthacines
Biological Activities of Hyacinthacines
Total Syntheses of Hyacinthacines
Conclusion
Chapter 14: The Synthesis of Seven-Membered Rings in Natural Products
Abstract
Introduction
Synthetic Methodology Directed to Seven-Membered Rings
One-Carbon Ring Expansion Methodologies
Natural Product Syntheses with Seven-Membered Ring Incorporation
Conclusion and Perspectives
Acknowledgments
Index
- Edition: 1
- Volume: 42
- Published: February 24, 2014
- No. of pages (eBook): 500
- Imprint: Elsevier
- Language: English
- Hardback ISBN: 9780444632814
- eBook ISBN: 9780444632821
AR
Atta-ur- Rahman
Atta-ur-Rahman, FRS, D.Phil., TI, SI HI, NI, is a leading scientist and scholar in the field of organic chemistry from Pakistan, especially renowned for his research in the various areas relating to natural product chemistry. With over 909 publications in the field of his expertise including 116 books largely published by leading publishers in Europe and USA and 27 patents, he is also credited for reviving the higher education and research practices in Pakistan.
Prof. Rahman was elected as Fellow of Royal Society (London) in July 2006 thereby becoming one of the 4 scientists from the Muslim world to have ever won this honor in the last 350 years when the Royal Society was established. He is also the only scientist from the Muslim world to have been conferred the UNESCO Science Prize in 1999.[11] He has been conferred honorary doctorate degrees by many universities including the degree of Doctor of Science (Sc.D.) by Cambridge University (UK) (1987) and an Honorary degree of Doctor of Education by Coventry University UK in November 2007. He was elected Honorary Life Fellow of Kings College, Cambridge University, UK in 2007. Prof. Atta-ur-Rahman was conferred the TWAS Prize for Institution Building in Durban, South Africa in October 2009 in recognition of his contributions for bringing about revolutionary changes in the higher education sector in Pakistan. He was awarded the Engro Excellence Award in Science & Technology 2011 for meritorious contributions.
He is President of Network of Academies of Sciences of Islamic Countries (NASIC) and the Vice-President (Central & South Asia) of the Academy of Sciences for the Developing World (TWAS) Council, and Foreign Fellow of Korean Academy of Sciences. Prof. Atta-ur-Rahman was the President of the Pakistan Academy of Sciences (2003–06), and was again elected President of Pakistan Academy of Sciences in January 2011.
He was the Federal Minister for Science and Technology (14 March 2000 – 20 November 2002), Federal Minister of Education (2002) and Chairman of the Higher Education Commission with the status of a Federal Minister from 2002-2008. The Austrian government also honoured him with its highest civil award ("Das Große Goldene Ehrenzeichen am Bande", 2007) in recognition of his eminent contributions.
Prof. Atta-ur-Rahman was the Coordinator General of COMSTECH, an OIC Ministerial Committee comprising the 57 Ministers of Science & Technology from 57 OIC member countries during 1996-2012. He is also the Patron of International Centre of Chemical and Biological Sciences (which comprises a number of institutes, including the Hussain Ebrahim Jamal Research Institute of Chemistry and the Dr. Panjwani Center of Molecular Medicine and Drug Development) at Karachi University.
He established a research center on Genomics in Karachi University. In recognition of the eminent contributions of Prof. Atta-ur-Rahman, a number of institutions have been named after him within and outside Pakistan. These include a natural product chemistry institute (Atta-ur-Rahman Research Institute of Natural Product Discovery, RiND) at the University of Technology Mara in Malaysia, Atta-ur-Rahman School of Applied Biosciences at National University of Science & Technology in Islamabad, and Dr. Atta-ur-Rahman Building at the International Centre for Chemical and Biological Sciences, University of Karachi. The Academy of Sciences in the Developing World (TWAS) based in Trieste, Italy has introduced a Dr. Atta-ur-Rahman Prize in Chemistry to a scientist from the developing world each year. The Prize carries a cash award of $ 5,000 and a Certificate.
Affiliations and expertise
University of Karachi, PakistanRead Studies in Natural Products Chemistry on ScienceDirect