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Elsevier

Books in Chemistry

Chemistry topic areas include: physical and theoretical, computational, organic, organometallic and inorganic, pharmaceutical and medicinal, analytical and bioanalytical, nuclear, general, nanochemistry, geochemistry, materials and polymer, as well as environmental, green and sustainable chemistry.

  • Experimental Organic Chemistry

    Laboratory Manual
    • 1st Edition
    • Joaquín Isac-García + 3 more
    • English
    Experimental Organic Chemistry: Laboratory Manual is designed as a primer to initiate students in Organic Chemistry laboratory work. Organic Chemistry is an eminently experimental science that is based on a well-established theoretical framework where the basic aspects are well established but at the same time are under constant development. Therefore, it is essential for future professionals to develop a strong background in the laboratory as soon as possible, forming good habits from the outset and developing the necessary skills to address the challenges of the experimental work. This book is divided into three parts. In the first, safety issues in laboratories are addressed, offering tips for keeping laboratory notebooks. In the second, the material, the main basic laboratory procedures, preparation of samples for different spectroscopic techniques, Microscale, Green Chemistry, and qualitative organic analysis are described. The third part consists of a collection of 84 experiments, divided into 5 modules and arranged according to complexity. The last two chapters are devoted to the practices at Microscale Synthesis and Green Chemistry, seeking alternatives to traditional Organic Chemistry.

  • Essential Chemistry for Formulators of Semisolid and Liquid Dosages

    • 1st Edition
    • Vitthal S. Kulkarni + 1 more
    • English
    A needed resource for pharmaceutical scientists and cosmetic chemists, Essential Chemistry for Formulators of Semisolid and Liquid Dosages provides insight into the basic chemistry of mixing different phases and test methods for the stability study of nonsolid formulations. The book covers foundational surface/colloid chemistry, which forms the necessary background for making emulsions, suspensions, solutions, and nano drug delivery systems, and the chemistry of mixing, which is critical for further formulation of drug delivery systems into semisolid (gels, creams, lotions, and ointments) or liquid final dosages. Expanding on these foundational principles, this useful guide explores stability testing methods, such as particle size, rheological/viscosit... microscopy, and chemical, and closes with a valuable discussion of regulatory issues. Essential Chemistry for Formulators of Semisolid and Liquid Dosages offers scientists and students the foundation and practical guidance to make and analyze semisolid and liquid formulations.

  • Principles and Applications of Quantum Chemistry

    • 1st Edition
    • V.P. Gupta
    • English
    Principles and Applications of Quantum Chemistry offers clear and simple coverage based on the author’s extensive teaching at advanced universities around the globe. Where needed, derivations are detailed in an easy-to-follow manner so that you will understand the physical and mathematical aspects of quantum chemistry and molecular electronic structure. Building on this foundation, this book then explores applications, using illustrative examples to demonstrate the use of quantum chemical tools in research problems. Each chapter also uses innovative problems and bibliographic references to guide you, and throughout the book chapters cover important advances in the field including: Density functional theory (DFT) and time-dependent DFT (TD-DFT), characterization of chemical reactions, prediction of molecular geometry, molecular electrostatic potential, and quantum theory of atoms in molecules.

  • Advances in Clinical Chemistry

    • 1st Edition
    • Volume 72
    • English
    Advances in Clinical Chemistry, Volume 72, the latest installment in this internationally acclaimed series contains chapters authored by world-renowned clinical laboratory scientists, physicians, and research scientists. The serial discusses the latest and most up-to-date technologies related to the field of clinical chemistry and is the benchmark for novel analytical approaches in the clinical laboratory.

  • Electron Paramagnetic Resonance Investigations of Biological Systems by Using Spin Labels, Spin Probes, and Intrinsic Metal Ions Part B

    • 1st Edition
    • Volume 564
    • English
    Electron Paramagnetic Resonance Investigations of Biological Systems by Using Spin Labels, Spin Probes, and Intrinsic Metal Ions Part A & B, are the latest volumes in the Methods in Enzymology series, continuing the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods centered on the use of Electron Paramagnetic Resonance (EPR) techniques to study biological structure and function.

  • How to Scale-Up a Wet Granulation End Point Scientifically

    • 1st Edition
    • Michael Levin
    • English
    How to Scale-Up a Wet Granulation End Point Scientifically provides a single-source devoted to all relevant information on the scale-up of a wet granulation end point. Contents include a general description, problem identification, and theoretical background with supporting literature, case studies, potential solutions, and more. By outlining issues related to scale-up and end-point determination, and then using practical examples and advice to address these issues, How to Scale-Up a Wet Granulation End Point Scientifically is a valuable and essential resource for all those pharmaceutical scientists and technologists engaged in the granulation process.

  • Advances in Organometallic Chemistry

    • 1st Edition
    • Volume 64
    • Pedro J. Perez
    • English
    Advances in Organometallic Chemistry contains authoritative reviews on the field of organometallic chemistry, covering topics in organometallic synthesis, reactions, mechanisms, homogeneous catalysis, and more. The book will benefit a wide range of researchers involved in organometallic chemistry, including synthetic protocols, mechanistic studies, and practical applications.

  • Electron Paramagnetic Resonance Investigations of Biological Systems by Using Spin Labels, Spin Probes, and Intrinsic Metal Ions Part A

    • 1st Edition
    • Volume 563
    • English
    Electron Paramagnetic Resonance Investigations of Biological Systems by Using Spin Labels, Spin Probes, and Intrinsic Metal Ions Part A & B, are the latest volumes in the Methods in Enzymology series, continuing the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods centered on the use of Electron Paramagnetic Resonance (EPR) techniques to study biological structure and function.

  • Progress in Heterocyclic Chemistry

    • 1st Edition
    • Volume 27
    • English
    Progress in Heterocyclic Chemistry (PHC), Volume 27, is an annual review series commissioned by the International Society of Heterocyclic Chemistry (ISHC). Volumes in the series contain both highlights of the previous year’s literature on heterocyclic chemistry and articles on new developing topics of particular interest to heterocyclic chemists. The highlight chapters in Volume 27 are all written by leading researchers and these chapters constitute a systematic survey of the important original material reported in the literature of heterocyclic chemistry in 2014. Additional articles in this volume are “The Use of Propargyl Vinyl Ethers in Heterocycle Synthesis” and “Recent Progress of Phosphonium Coupling in Heterocyclic and Medicinal Chemistry." As with previous volumes in the series, Volume 27 will enable academic and industrial chemists, and advanced students, to keep abreast of developments in heterocyclic chemistry in a convenient way.

  • Descriptive Inorganic Chemistry

    • 3rd Edition
    • James E. House + 1 more
    • English
    House’s Descriptive Inorganic Chemistry, Third Edition, provides thoroughly updated coverage of the synthesis, reactions, and properties of elements and inorganic compounds. Ideal for the one-semester (ACS-recommended) sophomore or junior level course in descriptive inorganic chemistry, this resource offers a readable and engaging survey of the broad spectrum of topics that deal with the preparation, properties, and use of inorganic materials. Using rich graphics to enhance content and maximize learning, the book covers the chemical behavior of the elements, acid-base chemistry, coordination chemistry, organometallic compounds, and numerous other topics to provide a coherent treatment of the field. The book pays special attention to key subjects such as chemical bonding and Buckminster Fullerenes, and includes new and expanded coverage of active areas of research, such as bioinorganic chemistry, green chemistry, redox chemistry, nanostructures, and more.

  • Metabolic Analysis Using Stable Isotopes

    • 1st Edition
    • Volume 561
    • English
    Metabolic Analysis Using Stable Isotopes, the newest volume in Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in metabolic analysis using stable isotopes.

  • Transition Metal Catalyzed Furans Synthesis

    Transition Metal Catalyzed Heterocycle Synthesis Series
    • 1st Edition
    • Xiao-Feng Wu
    • English
    Transition Metal Catalyzed Furans Synthesis provides an overview of Furans, describing properties of these heterocycle compounds and covering traditional synthetic procedures for them. This book then explores catalyzed procedures for Furans synthesis in greater detail and depth then is currently available in published Reviews. Finally, this useful short work discusses natural products and bio-active compounds containing Furans, information of particular interest for their applications to medicinal and pharmaceutical chemistry. The short series Transition Metal Catalyzed Heterocycles Synthesis Series, authored by Xiao-Feng Wu, summarizes recent achievements on heterocycles synthesis with transition metal as the catalysts, with each volume dedicated to one heterocycle compound.

  • Chlorine

    International Thermodynamic Tables of the Fluid State
    • 1st Edition
    • S. Angus + 2 more
    • English
    Chlorine: International Thermodynamic Tables of the Fluid State-8 is a four-chapter book that covers available and estimated data on chlorine; estimation of the element's properties; the correlating equations for the element; and how the tabulated properties are calculated from chosen equation. The tables in this book give the volume, entropy, enthalpy, isobaric heat capacity, compression factor, fugacity/pressure ratio, Joule-Thomson coefficient, ratio of the heat capacities, and speed of sound as a function of pressure and temperature. Given in the tables as well are the pressure, entropy, internal energy, and isochoric heat capacity as functions of density and temperature, for the gas and liquid states from 0.025 MPa to 25 MPa at temperatures from 180 K to 900 K.

  • Sulfur Dioxide, Chlorine, Fluorine and Chlorine Oxides

    Solubility Data Series
    • 1st Edition
    • Colin L. Young
    • English
    Solubility Data Series, Volume 12: Sulfur Dioxide, Chlorine, Fluorine and Chlorine Oxides presents the solubility data of the title compounds in pure liquids, liquid mixtures, aqueous solutions, and miscellaneous fluids and fluid mixtures. This volume is composed of five chapters and begins with definition of pertinent terms related to gas solubility. The first three chapters provide the critical evaluation of the solubility of sulfur dioxide, chlorine, and fluorine in inorganic and organic substrates. The last two chapters present the solubility values of chlorine monoxide and dioxide. This book will be of value to students and researchers.

  • Process Chromatography

    A Guide to Validation
    • 1st Edition
    • Gail K. Sofer + 1 more
    • English
    Research and development into biological products for therapeutic use has increased dramatically over the last 10 years. With this, strict regulatory requirements have been imposed by authorities such as the U.S. Food & Drug Administration, so that today validation has become a key issue in the biopharmaceutical industry.This concise book addresses validation issues in the chromatography of biotherapeutics. It covers process design, qualification and validation, including an overview of analytical techniques commonly used in the validation of processes. A concluding section comments on product changeover and presents four case studies.

  • Organic Synthesis Using Biocatalysis

    • 1st Edition
    • Animesh Goswami + 1 more
    • English
    Organic Synthesis Using Biocatalysis provides a concise background on the application of biocatalysis for the synthesis of organic compounds, including the important biocatalytic reactions and application of biocatalysis for the synthesis of organic compounds in pharmaceutical and non-pharmaceutical areas. The book provides recipes for carrying out various biocatalytic reactions, helping both newcomers and non-experts use these methodologies. It is written by experts in their fields, and provides both a current status and future prospects of biocatalysis in the synthesis of organic molecules.

  • Rotating Fluids in Engineering and Science

    • 1st Edition
    • J P Vanyo
    • English
    Presents theory and physical concepts necessary to follow exciting new developments in the fields of rotating fluids and vorticity. Includes nine chapters devoted to specific engineering and earth science applications, such as centrifuges, wings,turbomachinery... liquids in spacecraft, river meandering, and atmospheric and oceanic flows. Useful in many engineering and science curricula and for practising engineers and scientists in a wide variety of industrial and research settings.

  • Side Reactions in Peptide Synthesis

    • 1st Edition
    • Yi Yang
    • English
    Side Reactions in Peptide Synthesis, based on the author’s academic and industrial experience, and backed by a thorough review of the current literature, provides analysis of, and proposes solutions to, the most frequently encountered side reactions during peptide and peptidomimetic synthesis. This valuable handbook is ideal for research and process chemists working with peptide synthesis in diverse settings across academic, biotech, and pharmaceutical research and development. While peptide chemistry is increasingly prevalent, common side reactions and their causes are often poorly understood or anticipated, causing unnecessary waste of materials and delay. Each chapter discusses common side reactions through detailed chemical equations, proposed mechanisms (if any), theoretical background, and finally, a variety of possible solutions to avoid or alleviate the specified side reaction.

  • Pericyclic Reactions

    A Mechanistic and Problem-Solving Approach
    • 1st Edition
    • Sunil Kumar + 2 more
    • English
    Pericyclic Reactions: A Mechanistic and Problem-Solving Approach provides complete and systematic coverage of pericyclic reactions for researchers and graduate students in organic chemistry and pharmacy programs. Drawing from their cumulative years of teaching in the area, the authors use a clear, problem-solving approach, supplemented with colorful figures and illustrative examples. Written in an accessible and engaging manner, this book covers electrocyclic reactions, sigmatropic reactions, cycloaddition reactions, 1,3-dipolar reactions, group transfer, and ene reactions. It offers an in-depth study of the basic principles of these topics, and devotes equal time to problems and their solutions to further explore those principles and aid reader understanding. Additional practice problems are provided for further study and course use.

  • Inorganic Controlled Release Technology

    Materials and Concepts for Advanced Drug Formulation
    • 1st Edition
    • Xiang Zhang + 1 more
    • English
    Inorganic Controlled Release Technology: Materials and Concepts for Advanced Drug Formulation provides a practical guide to the use and applications of inorganic controlled release technology (iCRT) for drug delivery and other healthcare applications, focusing on newly developed inorganic materials such as bioresorbable glasses and bioceramics. The use of these materials is introduced for a wide range of applications that cover inorganic drug delivery systems for new drug development and the reformulation of existing drugs. The book describes basic concepts, principles, and industrial practices by discussing materials chemistry, physics, nano/microstructure, formulation, materials processing, and case studies, as well as the evaluation and characterization of iCRT systems commonly investigated during industrial R&D.

  • Solving Problems with NMR Spectroscopy

    • 2nd Edition
    • Atta-ur Rahman + 2 more
    • English
    Solving Problems with NMR Spectroscopy, Second Edition, is a fully updated and revised version of the best-selling book. This new edition still clearly presents the basic principles and applications of NMR spectroscopy with only as much math as is necessary. It shows how to solve chemical structures with NMR by giving many new, clear examples for readers to understand and try, with new solutions provided in the text. It also explains new developments and concepts in NMR spectroscopy, including sensitivity problems (hardware and software solutions) and an extension of the multidimensional coverage to 3D NMR. The book also includes a series of applications showing how NMR is used in real life to solve advanced problems beyond simple small-molecule chemical analysis. This new text enables organic chemistry students to choose the most appropriate NMR techniques to solve specific structures. The problems provided by the authors help readers understand the discussion more clearly and the solution and interpretation of spectra help readers become proficient in the application of important, modern 1D, 2D, and 3D NMR techniques to structural studies.

  • Annual Reports on NMR Spectroscopy

    • 1st Edition
    • Volume 86
    • English
    Annual Reports on NMR Spectroscopy provides a thorough and in-depth accounting of progress in nuclear magnetic resonance (NMR) spectroscopy and its many applications. Nuclear magnetic resonance (NMR) is an analytical tool used by chemists and physicists to study the structure and dynamics of molecules. In recent years, no other technique has gained as much significance as NMR spectroscopy. It is used in all branches of science in which precise structural determination is required and in which the nature of interactions and reactions in solution is being studied. Annual Reports on NMR Spectroscopy has established itself as a premier means for the specialist and non-specialist alike to become familiar with new techniques and applications of NMR spectroscopy.

  • Advances in Heterocyclic Chemistry

    • 1st Edition
    • Volume 116
    • English
    Advances in Heterocyclic Chemistry is the definitive series in the field—one of great importance to organic chemists, polymer chemists, and many biological scientists. Because biology and organic chemistry increasingly intersect, the associated nomenclature also is being used more frequently in explanations. Written by established authorities in the field from around the world, this comprehensive review combines descriptive synthetic chemistry and mechanistic insight to yield an understanding of how chemistry drives the preparation and useful properties of heterocyclic compounds.

  • Strategies and Tactics in Organic Synthesis

    • 1st Edition
    • Volume 11
    • Michael Harmata
    • English
    Strategies and Tactics in Organic Synthesis provides a forum for investigators to discuss their approach to the science and art of organic synthesis. Rather than a simple presentation of data or a secondhand analysis, this classic provides stories that vividly demonstrate the power of the human endeavor known as organic synthesis and the creativity and tenacity of its practitioners. Firsthand accounts of each project tell of the excitement of conception, the frustration of failure, and the joy experienced when either rational thought or good fortune gives rise to the successful completion of a project. This book series shows how synthesis is really done. Readers will be educated, challenged, and inspired by these accounts, which portray the idea that triumphs do not come without challenges. This innovative approach also helps illustrate how challenges to further advance the science and art of organic synthesis can be overcome, driving the field forward to meet the demands of society by discovering new reactions, creating new designs, and building molecules with atom and step economies that provide functional solutions to create a better world.

  • Periodate Oxidation of Diol and Other Functional Groups

    Analytical and Structural Applications
    • 1st Edition
    • Glenn Dryhurst
    • R. Belcher + 1 more
    • English
    Periodate Oxidation of Diol and Other Functional Groups: Analytical and Structural Applications deals with the chemistry of organic periodate oxidations with special reference to the study of carbohydrates, along with their analytical and structural applications. This book explores the mechanistic aspects of the periodate reaction; its historical development; the nature of the so-called anomalous reactions; and some of the synthetic uses of periodate oxidation. This book is comprised of seven chapters and opens with a historical background on periodate oxidation, followed by a discussion on the preparation and properties of periodates. The reader is then introduced to the mechanism of periodate oxidation, with particular reference to 1,2-diols and 1,2-hydroxycarbonyl compounds as well as 1,2-diketones, 1,2-aminoalcohols, and active methylene groups. The remaining chapters consider the structure of carbohydrates and related materials; anomalous periodate oxidations; the analytical aspects and applications of periodate oxidation; and a number of tested and generally well-tried analytical procedures such as the Fleury-Lange method, Malaprade method, ion exchange, and spectrophotometric and polarographic techniques. This monograph will be a useful resource for organic chemists and advanced undergraduate students of chemistry.

  • Absorption Spectra and Chemical Bonding in Complexes

    • 1st Edition
    • C. K. Jørgensen
    • English
    Absorption Spectra and Chemical Bonding in Complexes focuses on chemical bonding in transition group complexes and molecules, including molecular orbitals, absorption bands, and energy levels. The book first outlines the history of chemical bonding, giving emphasis to different theories that paved the way for further studies in this field. The text then examines the energy levels of a configuration and molecular orbitals and microsymmetry. The publication takes a look at the interelectronic repulsion in M.O. configurations, the characteristics of absorption bands, and spectrochemical series. Electron transfer spectra, energy levels in complexes with almost spherical symmetry, molecular orbitals lacking spherical symmetry, and chemical bonding are also discussed. The book examines the determination of complex species in solution and their formation constants; survey of the chemistry of heavy, metallic elements; and tables of absorption spectra. The manuscript is a dependable source of data for physicists and group theorists interested in absorption spectra and chemical bonding.

  • Helium and Neon

    Gas Solubilities
    • 1st Edition
    • H. Lawrence Clever
    • English
    Solubility Data Series, Volume 1: Helium and Neon - Gas Solubilities provides the best available experimental solubility data of helium and neon gas in liquids as reported in the scientific literature, and tables of smoothed mole fraction solubility data for the systems which were studied over a temperature interval. This book is composed of four chapters; each chapter presents solubility values of helium and neon gases up to and above two bar. This book will prove useful to analytical chemistry researchers.

  • Introduction to Petroleum Chemicals

    Based on Lectures Given at the Manchester College of Science and Technology
    • 1st Edition
    • H. Steiner
    • English
    Introduction to Petroleum Chemicals emerged from a series of lectures on the petroleum chemical industry given at the Manchester College of Science and Technology during the fall and winter of 1959. The book does not claim to be an exhaustive treatment of petroleum chemicals, but attempts to a survey of the important aspects of the industry at its present level of development. The course was given by chemists and chemical engineers engaged in the chemical industry of Britain, giving the text a British and European, as distinct from American, flavor. The book begins with a discussion of the cracking to olefins of liquid hydrocarbons. This is followed by separate chapters on separation processes for olefins; derivatives of ethylene and propylene; olefin polymerization process; and properties of polyethylenes and polypropylenes. Subsequent chapters cover the production and utilization of butadiene and isobutylene; aromatics production; manufacturing, properties, and uses of styrene and polystyrene; production of acetylene from hydrocarbons; and the carbon black industry.

  • CACGP Symposium on Tropospheric Chemistry with Emphasis on Sulphur and Nitrogen Cycles and the Chemistry of Clouds and Precipitation

    A Selection of Papers
    • 1st Edition
    • P. Goldsmith
    • English
    CACGP Symposium on Tropospheric Chemistry contains papers presented at the Symposium on ""Tropospheric Chemistry with Emphasis on Sulphur and Nitrogen Cycles and the Chemistry of Clouds and Precipitation"". Organized into 24 chapters, this book begins with a discussion on the trace gas and aerosol measurements at a remote site in the northeast U.S.; satellite measurements of aerosol mass and transport; and measurements of reactive nitrogen compounds in the free troposphere. Subsequent chapters explore kinetic study of reactions of some organic sulfur compounds with OH radicals; analysis of precipitation collected on a sequential basis; and measurements of the chemical composition of stratiform clouds. The book also discusses sulfur isotope ratio studies in a geothermal region; the oxidation of isoprene in the troposphere; a 2-D model of global aerosol transport; and theoretical studies of intermediates in sulfur oxidation cycle.

  • Advances in Structure and Activity Relationship of Coumarin Derivatives

    • 1st Edition
    • Santhosh Penta
    • English
    Advances in Structure and Activity Relationship of Coumarin Derivatives covers the structural behavior of various coumarin derivatives for various potential pharmaceutical applications. Based on substitution targeted for active sites, the book takes a rational approach for designing new and specific potent drugs, optimizing existing ones, and developing novel reactions. This focused primer describes the chemical structure and activity of coumarin derivatives to explore the effects of different substituents at specific positions, and their properties for effective bioactivity.

  • Fundamentals and Analytical Applications of Multiway Calibration

    • 1st Edition
    • Volume 29
    • English
    Fundamentals and Analytical Applications of Multi-Way Calibration presents researchers with a set of effective tools they can use to obtain the maximum information from instrumental data. It includes the most advanced techniques, methods, and algorithms related to multi-way calibration and the ways they can be applied to solve actual analytical problems. This book provides a comprehensive coverage of the main aspects of multi-way analysis, including fundamentals and selected applications of chemometrics that can resolve complex analytical chemistry problems through the use of multi-way calibration.

  • Advances in Clinical Chemistry

    • 1st Edition
    • Volume 70
    • English
    Volume 70 in the internationally acclaimed Advances in Clinical Chemistry contains chapters authored by world renowned clinical laboratory scientists, physicians and research scientists. The serial provides the latest and most up-to-date technologies related to the field of clinical chemistry and is the benchmark for novel analytical approaches in the clinical laboratory.

  • Cholesterol

    Chemistry, Biochemistry, and Pathology
    • 1st Edition
    • Robert P. Cook
    • English
    Cholesterol: Chemistry, Biochemistry, and Pathology focuses on the properties, characteristics, compositions, and reactions of cholesterol. The selection first offers information on the history of cholesterol, including occurrence of cholesterol, early chemistry, related compounds, and analytical methods. The text then surveys the chemistry of cholesterol; methods of isolation and estimation of sterols; and distribution of sterols in organisms and in tissues. Discussions focus on quantitative determination of sterols, isolation procedures, distribution in animal tissues, sterols in plants, and sterol content of foodstuffs. The publication ponders on the physiology of the circulating cholesterol and lipoproteins and the biosynthesis of cholesterol. The manuscript then takes a look at the metabolism of cholesterol and other sterols in animal organisms; conversion of cholesterol to steroid hormones; microscopical localization of cholesterol in cells and tissues; and pathological manifestations of abnormal cholesterol metabolism. The selection is a valuable reference for readers interested in the properties and reactions of cholesterol.

  • Prodrug Design

    Perspectives, Approaches and Applications in Medicinal Chemistry
    • 1st Edition
    • Vivekkumar K Redasani + 1 more
    • English
    Prodrug Design: Perspectives, Approaches and Applications in Medicinal Chemistry provides a focused overview of this critical area of drug discovery, as that continuous process strives not only to discover new drug compounds but also to modify the existing ones. This valuable primer supports this mission of drug development and its goal of reducing undesired effects and improving therapeutic effectiveness of drug compounds. Providing a unique compilation of data, insightful case studies, and review of existing literature in the area, the book will promote innovation in medicinal and pharmaceutical chemistry research, exploring the limitations of existing drugs and their improvement. Prodrug Design reviews marketed compounds, the safety of promoieties, and a detailed classification of prodrugs organized by therapeutic area for easy reference.

  • Hybrid Retrosynthesis

    Organic Synthesis using Reaxys and SciFinder
    • 1st Edition
    • Michael B. Smith + 1 more
    • English
    Designed to supplement existing organic textbooks, Hybrid Retrosynthesis presents a relatively simple approach to solving synthesis problems, using a small library of basic reactions along with the computer searching capabilities of Reaxys and SciFinder. This clear, concise guide reviews the essential skills needed for organic synthesis and retrosynthesis, expanding reader knowledge of the foundational principles of these techniques, whilst supporting their use via practical methodologies. Perfect for both graduate and post-graduate students, Hybrid Retrosynthesis provides new applied skills and tools to help during their organic synthesis courses and future careers, whilst simultaneously acting as useful resource for those setting tutorial and group problems, and as a helpful go-to guide for organic chemists involved in either industry or academia.

  • The Practice of Medicinal Chemistry

    • 4th Edition
    • Camille Georges Wermuth + 3 more
    • English
    The Practice of Medicinal Chemistry, Fourth Edition provides a practical and comprehensive overview of the daily issues facing pharmaceutical researchers and chemists. In addition to its thorough treatment of basic medicinal chemistry principles, this updated edition has been revised to provide new and expanded coverage of the latest technologies and approaches in drug discovery.With topics like high content screening, scoring, docking, binding free energy calculations, polypharmacology, QSAR, chemical collections and databases, and much more, this book is the go-to reference for all academic and pharmaceutical researchers who need a complete understanding of medicinal chemistry and its application to drug discovery and development.

  • Anthropic Awareness

    The Human Aspects of Scientific Thinking in NMR Spectroscopy and Mass Spectrometry
    • 1st Edition
    • Csaba Szantay Jr.
    • English
    Anthropic Awareness: The Human Aspects of Scientific Thinking in NMR Spectroscopy and Mass Spectrometry blends psychology, philosophy, physics, mathematics, and chemistry, describing a human-centered philosophy of the essence of scientific thinking in the natural sciences and in everyday life. It addresses the reasons why we are prone to make errors in our conclusions and how to avoid such mistakes, also exploring a number of the "mental traps" that can lead to both individual mistakes and mass misconceptions. The book advocates that by understanding the nature of these mental traps we can adopt tactics to safely evade them. It includes Illustrative examples of common scientific misunderstandings and mental traps in both the theory and real-life application of NMR spectroscopy and mass spectrometry.

  • Advances in Heterocyclic Chemistry

    • 1st Edition
    • Volume 115
    • English
    Advances in Heterocyclic Chemistry is the definitive series in this area—one of great importance to organic chemists, polymer chemists, and many biological scientists. As the disciplines of biology and organic chemistry increasingly intersect, the nomenclature of organic chemistry is increasingly used in explanations across a variety of applications and areas of study. Users will find this comprehensive update of the subject matter to be a valuable addition to their library of reference materials.

  • Advances in Heterocyclic Chemistry

    • 1st Edition
    • Volume 114
    • English
    Advances in Heterocyclic Chemistry is the definitive series in this area—one of great importance to organic chemists, polymer chemists and many biological scientists. As biology and organic chemistry increasingly intersect, the nomenclature of organic chemistry is increasingly used in explanations. This volume, number 114, covers topics including Diels-Alder of furans for synthesis, metal carbenoids, electron-rich heterocycles, synthesis of heterocyclic natural products, viridin and Wortmannin, and dihydropyridine intermediates.

  • Chemical Imaging Analysis

    • 1st Edition
    • Volume 69
    • Freddy Adams + 1 more
    • English
    Chemical Imaging Analysis covers the advancements made over the last 50 years in chemical imaging analysis, including different analytical techniques and the ways they were developed and refined to link the composition and structure of manmade and natural materials at the nano/micro scale to the functional behavior at the macroscopic scale. In a development process that started in the early 1960s, a variety of specialized analytical techniques was developed – or adapted from existing techniques – and these techniques have matured into versatile and powerful tools for visualizing structural and compositional heterogeneity. This text explores that journey, providing a general overview of imaging techniques in diverse fields, including mass spectrometry, optical spectrometry including X-rays, electron microscopy, and beam techniques.

  • Mechanics

    Classical and Quantum
    • 1st Edition
    • T. T. Taylor
    • D. ter Haar
    • English
    Mechanics: Classical and Quantum explains the principles of quantum mechanics via the medium of analytical mechanics. The book describes Schrodinger's formulation, the Hamilton-Jacobi equation, and the Lagrangian formulation. The author discusses the Harmonic Oscillator, the generalized coordinates, velocities, as well as the application of the Lagrangian formulation to systems that are partially or entirely electromagnetic in character under certain conditions. The book examines waves on a string under tension, the isothermal cavity radiation, and the Rayleigh-Jeans result pertaining to the enumeration of electromagnetic modes. Other topics include Planck's quantum hypothesis and Bohr's explanation of the hydrogen spectrum. The book describes the two branches of quantum theory, namely. matrix mechanics ,and wave mechanics; it also covers other topics such as waves, wave packets and the Schrodinger equation. The book cites some applications of the time-independent Schrodinger equation; the author then analyzes the separation of center-of mass-motion from relative motion relating to the hydrogen atom. Nuclear physicists, scientists, and academicians in the field of nuclear physics or quantum mechanics will find this book highly valuable.

  • Recent Advances in Medicinal Chemistry, Volume 1

    • 1st Edition
    • Atta-ur Rahman + 2 more
    • English
    Originally published by Bentham and now distributed by Elsevier, Recent Advances in Medicinal Chemistry, Volume 1 covers leading-edge research and recent developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, drug targets, and natural product research and structure-activity relationship studies. The fourteen updated reviews include unique experimental data and references, and each article highlights an important topic in current medicinal chemistry research. Topics covered include: aureolic acid group of anti-cancer antibiotics and non-steroidal anti-inflammatory drugs; aromatase inhibitors in adjuvant endocrine treatment of early-stage breast cancer in postmenopausal women; Rho GTPases and statins in targeting and developing therapies for tumors; and more.

  • Profiles of Drug Substances, Excipients and Related Methodology

    • 1st Edition
    • Volume 40
    • English
    Volumes in this widely revered series present comprehensive reviews of drug substances and additional materials, with critical review chapters that summarize information related to the characterization of drug substances and excipients. This organizational structure meets the needs of the pharmaceutical community and allows for the development of a timely vehicle for publishing review materials on this topic. The scope of the Profiles series encompasses review articles and database compilations that fall within one of the following six broad categories: Physical profiles of drug substances and excipients; Analytical profiles of drug substances and excipients; Drug metabolism and pharmacokinetic profiles of drug substances and excipients; Methodology related to the characterization of drug substances and excipients; Methods of chemical synthesis; and Reviews of the uses and applications for individual drug substances, classes of drug substances, or excipients.

  • Advances in Organometallic Chemistry

    • 1st Edition
    • Volume 63
    • English
    This volume contains authoritative reviews regarding the field of organometallic chemistry. It covers topics in organometallic synthesis, reactions, mechanisms, homogeneous catalysis, and more, and will benefit a wide range of researchers involved in organometallic chemistry, including synthetic protocols, mechanistic studies, and practical applications.

  • Annual Reports on NMR Spectroscopy

    • 1st Edition
    • Volume 85
    • English
    Nuclear magnetic resonance (NMR) is an analytical tool used by chemists and physicists to study the structure and dynamics of molecules. In recent years, no other technique has gained such significance as NMR spectroscopy. It is used in all branches of science in which precise structural determination is required and in which the nature of interactions and reactions in solution is being studied. Annual Reports on NMR Spectroscopy has established itself as a premier means for the specialist and non-specialist alike to become familiar with new techniques and applications of NMR spectroscopy.

  • Advanced Mass Spectrometry for Food Safety and Quality

    • 1st Edition
    • Volume 68
    • English
    Advanced Mass Spectrometry for Food Safety and Quality provides information on recent advancements made in mass spectrometry-based techniques and their applications in food safety and quality, also covering the major challenges associated with implementing these technologies for more effective identification of unknown compounds, food profiling, or candidate biomarker discovery. Recent advances in mass spectrometry technologies have uncovered tremendous opportunities for a range of food-related applications. However, the distinctive characteristics of food, such as the wide range of the different components and their extreme complexity present enormous challenges. This text brings together the most recent data on the topic, providing an important resource towards greater food safety and quality.

  • Advanced Fluoride-Based Materials for Energy Conversion

    • 1st Edition
    • Tsuyoshi Nakajima + 1 more
    • English
    Advanced Fluoride-Based Materials for Energy Conversion provides thorough and applied information on new fluorinated materials for chemical energy devices, exploring the electrochemical properties and behavior of fluorinated materials in lithium ion and sodium ion batteries, fluoropolymers in fuel cells, and fluorinated carbon in capacitors, while also exploring synthesis applications, and both safety and stability issues. As electronic devices, from cell phones to hybrid and electric vehicles, are increasingly common and prevalent in modern lives and require dependable, stable chemical energy devices with high-level functions are becoming increasingly important. As research and development in this area progresses rapidly, fluorine compounds play a critical role in this rapid progression. Fluorine, with its small size and the highest electronegativity, yields stable compounds under various conditions for utilization as electrodes, electrolytes, and membranes in energy devices. The book is an ideal reference for the chemist, researcher, technician, or academic, presenting valuable, current insights into the synthesis of fluorine compounds and fluorination reactions using fluorinating agents.

  • Medicinal Chemistry of Anticancer Drugs

    • 2nd Edition
    • Carmen Avendaño + 1 more
    • English
    Medicinal Chemistry of Anticancer Drugs, Second Edition, provides an updated treatment from the point of view of medicinal chemistry and drug design, focusing on the mechanism of action of antitumor drugs from the molecular level, and on the relationship between chemical structure and chemical and biochemical reactivity of antitumor agents. Antitumor chemotherapy is a very active field of research, and a huge amount of information on the topic is generated every year. Cytotoxic chemotherapy is gradually being supplemented by a new generation of drugs that recognize specific targets on the surface or inside cancer cells, and resistance to antitumor drugs continues to be investigated. While these therapies are in their infancy, they hold promise of more effective therapies with fewer side effects. Although many books are available that deal with clinical aspects of cancer chemotherapy, this book provides a sorely needed update from the point of view of medicinal chemistry and drug design.

  • Studies in Natural Products Chemistry

    • 1st Edition
    • Volume 46
    • English
    Natural products present in the plant and animal kingdom offer a huge diversity of chemical structures, which are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, it has become possible to isolate and then determine the structures and biological activity of natural products rapidly, thus opening up to the pharmaceutical industry exciting opportunities in the field of new drug development. The series covers all of the above as well as the synthesis, testing and recording of the medicinal properties of natural products. With articles written by leading authorities in their respective fields of research, Studies in Natural Products Chemistry, Volume 46 presents current frontiers and future guidelines for research based on important discoveries made in the field of bioactive natural products. It is a valuable resource for all those working in natural product and medicinal chemistry.

  • Alkaloids

    Chemistry, Biology, Ecology, and Applications
    • 2nd Edition
    • Tadeusz Aniszewski
    • English
    Alkaloids - Secrets of Life: Alkaloid Chemistry, Biological Significance, Applications and Ecological Role, Second Edition provides knowledge on structural typology, biosynthesis and metabolism in relation to recent research work on alkaloids, considering an organic chemistry approach to alkaloids using biological and ecological explanation. The book approaches several questions and unresearched areas that persist in this field of research. It provides a beneficial text for academics, professionals or anyone who is interested in the fascinating subject of alkaloids. Each chapter features an abstract. Appendices, a listing of alkaloids, and plants containing alkaloids are all included, as are basic protocols of alkaloid analysis.

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