Back to School Savings: Save up to 30% on print books and eBooks. No promo code needed.
Back to School Savings: Save up to 30%
Chinmedomics
The Integration of Serum Pharmacochemistry and Metabolomics to Elucidate the Scientific Value of Traditional Chinese Medicine
1st Edition - July 15, 2015
Authors: Xijun Wang, Aihua Zhang, Hui Sun
Hardback ISBN:9780128031179
9 7 8 - 0 - 1 2 - 8 0 3 1 1 7 - 9
eBook ISBN:9780128031186
9 7 8 - 0 - 1 2 - 8 0 3 1 1 8 - 6
Chinmedomics: The Integration of Serum Pharmacochemistry and Metabolomics to Elucidate the Scientific Value of Traditional Chinese Medicine uses new experimental… Read more
Purchase Options
Save 50% on book bundles
Immediately download your ebook while waiting for your print delivery. No promo code is needed.
Chinmedomics: The Integration of Serum Pharmacochemistry and Metabolomics to Elucidate the Scientific Value of Traditional Chinese Medicine uses new experimental techniques and research to open doors in drug discovery and development related to traditional Chinese medicine (TCM). This book features a unique approach that combines chemometric analysis with metabolomics studies to illuminate significant changes that have occurred in syndrome states while simultaneously analyzing the efficacy of chemical ingredients in herbal medicines. Chapters provide cutting-edge information on traditional medicine, analytical technology, natural products, metabolomics, bioinformatics and their applications. This book provides a valuable resource for pharmacologists, pharmaceutical scientists, medicinal plant researchers, pharmacognosists and chemists working with TCM and highlights ways to further research and advances in this area in the future.
Presents a practical guide for new practitioners of Chinmedomics with insights on the current use and future development of this method
Each chapter includes an introduction, method, references to the latest literature, possible mechanisms of action and applications
Edited by the leading experts of research related to Chinmedomics
Pharmacologists, drug developers, medicinal plant researchers and pharmacognosists, researchers of traditional medicines and natural product chemistry, researchers studying metabolomics and biomarkers and analytical chemists
List of Contributors
About the Editor
Preface
Chapter 1: Origin of Chinmedomics
Abstract
1.1. Introduction
1.2. Application and Challenges of TCM
1.3. Metabolomics: An Overview
1.4. Process of the Serum Pharmacochemistry of TCM
1.5. Establishment and Evolution of Chinmedomics
1.6. Potential Value of Chinmedomics
1.7. Future Perspectives
Chapter 2: Methods and Protocols of Chinmedomics
Abstract
2.1. Introduction
2.2. Analytical Technologies
2.3. Sampling
2.4. Data Extraction and Analysis
2.5. Marker Identification and Validation
2.6. Correlation Analysis between Marker Metabolites and Absorbed Chemical Components
2.7. Goals for Chinmedomics
2.8. Chinmedomics for Yinchenhao Tang: A Case Study
2.9. Conclusions
Chapter 3: Chinmedomics Advancing Drug Discovery and Development from Yinchenhao Tang
Abstract
3.1. Introduction
3.2. Experimental Detail
3.3. Results and Discussions
3.4. Conclusions
Chapter 4: Chinmedomics Approach Dissects Therapeutic Properties of ShenQiWan Acting on ShenYangXu Syndrome
Abstract
4.1. Introduction
4.2. Experimental Detail
4.3. Results and Discussions
4.4. Conclusions
Chapter 5: Metabolic Profiling and Biomarkers Analysis of Jaundice Syndrome
Abstract
5.1. Introduction
5.2. Materials and Methods
5.3. Results
5.4. Discussion
5.5. Conclusions
Chapter 6: Metabolic Profiling and Biomarkers Analysis of the GanYu PiXu Syndrome
Abstract
6.1. Introduction
6.2. Materials and Methods
6.3. Results
6.4. Discussion
Chapter 7: Metabolic Profiling and Biomarkers of Yinhuang Syndrome and Evaluation of Yinchensini Tang
Abstract
7.1. Introduction
7.2. Methods
7.3. Result and Discussion
Chapter 8: Metabolite Profiling and Biomarkers Analysis of Jaundice Syndrome-Related Animal Models
Subchapter 8.1. Jaundice Syndrome Rats Induced by d-Galactosamine
Subchapter 8.2. Jaundice Syndrome Rats Induced by Alcohol
Subchapter 8.3. Jaundice Syndrome Rats Induced by Alpha-Naphthylisothiocyanate
Subchapter 8.4. Jaundice Syndrome in Rats Induced by Carbon Tetrachloride
Chapter 9: Metabolomic Evaluation of Hepatoprotective Effect of Yinchenhao Tang and its Major Bioactive Constituents
Abstract
9.1. Introduction
9.2. Experimental
9.3. Results
9.4. Conclusions
Chapter 10: Metabolomics and Proteomics Annotate Therapeutic Mechanisms of Geniposide
Abstract
10.1. Introduction
10.2. Materials and Methods
10.3. Results
10.4. Discussion
Chapter 11: Metabolic Profiling and Potential Biomarkers of ShenYinXu Syndrome and the Therapeutic Effect of Liuweidihuang Wan
Abstract
11.1. Introduction
11.2. Experimental
11.3. Results
11.4. Discussion
11.5. Conclusions
Chapter 12: Metabolic Profiling of Healthy Persons Treated with Liuweidihuang Wan
Abstract
12.1. Introduction
12.2. Experimental
12.3. Results
12.4. Discussion
12.5. Conclusions
Chapter 13: Metabolic Profiling and Potential Biomarkers Analysis of ShenYangXu Syndrome
Abstract
13.1. Introduction
13.2. Materials and Methods
13.3. Results
13.4. Discussion
13.5. Conclusions
Chapter 14: Metabolic Evaluation of ShenQiWan Nourishing ShenYangXu Syndrome
Abstract
14.1. Introduction
14.2. Materials and methods
14.3. Results
14.4. Discussion
14.5. Conclusions
Chapter 15: Metabolic Profiling and Biomarkers Analysis of XinQiXu Syndrome
Abstract
15.1. Introduction
15.2. Materials and Methods
15.3. Results
15.4. Discussion
15.5. Conclusions
Chapter 16: Active Constituents Screening Based on Correlation Analysis Between Marker Metabolites and the Absorbed Constituents in WenXin Formulae
Abstract
16.1. Introduction
16.2. Experimental
16.3. Results and Discussion
16.4. Conclusions
Chapter 17: Targeted Synergism Effects of the Combined Active Constituents of Yinchenhao Tang
Abstract
17.1. Introduction
17.2. Materials and Methods
17.3. Results
17.4. Discussion
Chapter 18: Metabolic Profiling and Biomarkers of Type 2 Diabetes and the Effective Evaluation of the Tianqi Jiangtang Capsule
Abstract
18.1. Introduction
18.2. Materials and Methods
18.3. Results
18.4. Discussion
18.5. Conclusions
Chapter 19: Metabolic Biomarkers of Alcohol Liver Damage and the Intervention Effect of Yinchenhao Tang
Abstract
19.1. Introduction
19.2. Experimental
19.3. Results
19.4. Discussions
19.5. Conclusions
Chapter 20: Metabolic Profiling and Biomarkers Analysis of Insomnia, and the Intervention Effects of Suanzaoren Decoction, and its Related Active Ingredients
Abstract
20.1. Introduction
20.2. Materials and Methods
20.3. Results
20.4. Conclusions
Chapter 21: Metabolic Biomarkers of Nonbacterial Prostatitis, and the Treatment Evaluation of Phellodendri Amurensis Cortex and its Main Components
Abstract
21.1. Introduction
21.2. Experimental Methods
21.3. Results
21.4. Conclusions
Chapter 22: Metabolic Profiling Provides a System for the Understanding of Alzheimer’s Disease in Rats Post-Treatment With Kaixin San
Abstract
22.1. Introduction
22.2. Experimental
22.3. Results and Discussions
22.4. Conclusions
Chapter 23: Metabolic Profiles Delineate the Effect of Shengmai San on Alzheimer’s Disease in Rats
Abstract
23.1. Introduction
23.2. Experimental
23.3. Results and Discussion
23.4. Conclusions
Subject Index
No. of pages: 408
Language: English
Published: July 15, 2015
Imprint: Academic Press
Hardback ISBN: 9780128031179
eBook ISBN: 9780128031186
XW
Xijun Wang
Xijun Wang, PhD, is a Professor of Pharmacology of Traditional Chinese Medicine (TCM) and Vice President at Heilongjiang University of Chinese Medicine in China. Dr. Wang has published more than 150 papers in peer-reviewed journals, received the National Science and Technology Progress Award and National Technological Invention Award and holds 20 patents. His research focuses on serum Pharmacochemistry of Traditional Chinese Medicines. By integrating metabolomics with serum Pharmacochemistry of TCM Dr. Wang has developed and established the theory and research methods of Chinmedomics, whereby the clinical efficacy of TCM formulae can be measured and analyzed.
Affiliations and expertise
Professor and General Director, National Traditional Chinese Medicine (TCM) Key Laboratory of Serum Pharmacochemistry, Laboratory of Metabolomics and Chinmedomics
Vice President, Heilongjiang University of Chinese Medicine, Harbin, China
AZ
Aihua Zhang
Affiliations and expertise
National Traditional Chinese Medicine (TCM) Key Laboratory of Serum Pharmacochemistry, Laboratory of Metabolomics and Chinmedomics, Harbin, China
HS
Hui Sun
Affiliations and expertise
National Traditional Chinese Medicine (TCM) Key Laboratory of Serum Pharmacochemistry, Laboratory of Metabolomics and Chinmedomics, Harbin, China