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Chinmedomics

The Integration of Serum Pharmacochemistry and Metabolomics to Elucidate the Scientific Value of Traditional Chinese Medicine

1st Edition - July 15, 2015

Authors: Xijun Wang, Aihua Zhang, Hui Sun

Hardback ISBN:

9 7 8 - 0 - 1 2 - 8 0 3 1 1 7 - 9

eBook ISBN:

9 7 8 - 0 - 1 2 - 8 0 3 1 1 8 - 6

Chinmedomics: The Integration of Serum Pharmacochemistry and Metabolomics to Elucidate the Scientific Value of Traditional Chinese Medicine uses new experimental… Read more

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Chinmedomics: The Integration of Serum Pharmacochemistry and Metabolomics to Elucidate the Scientific Value of Traditional Chinese Medicine uses new experimental techniques and research to open doors in drug discovery and development related to traditional Chinese medicine (TCM). This book features a unique approach that combines chemometric analysis with metabolomics studies to illuminate significant changes that have occurred in syndrome states while simultaneously analyzing the efficacy of chemical ingredients in herbal medicines. Chapters provide cutting-edge information on traditional medicine, analytical technology, natural products, metabolomics, bioinformatics and their applications. This book provides a valuable resource for pharmacologists, pharmaceutical scientists, medicinal plant researchers, pharmacognosists and chemists working with TCM and highlights ways to further research and advances in this area in the future.

List of Contributors
About the Editor
Preface
Chapter 1: Origin of Chinmedomics
- Abstract
- 1.1. Introduction
- 1.2. Application and Challenges of TCM
- 1.3. Metabolomics: An Overview
- 1.4. Process of the Serum Pharmacochemistry of TCM
- 1.5. Establishment and Evolution of Chinmedomics
- 1.6. Potential Value of Chinmedomics
- 1.7. Future Perspectives
Chapter 2: Methods and Protocols of Chinmedomics
- Abstract
- 2.1. Introduction
- 2.2. Analytical Technologies
- 2.3. Sampling
- 2.4. Data Extraction and Analysis
- 2.5. Marker Identification and Validation
- 2.6. Correlation Analysis between Marker Metabolites and Absorbed Chemical Components
- 2.7. Goals for Chinmedomics
- 2.8. Chinmedomics for Yinchenhao Tang: A Case Study
- 2.9. Conclusions
Chapter 3: Chinmedomics Advancing Drug Discovery and Development from Yinchenhao Tang
- Abstract
- 3.1. Introduction
- 3.2. Experimental Detail
- 3.3. Results and Discussions
- 3.4. Conclusions
Chapter 4: Chinmedomics Approach Dissects Therapeutic Properties of ShenQiWan Acting on ShenYangXu Syndrome
- Abstract
- 4.1. Introduction
- 4.2. Experimental Detail
- 4.3. Results and Discussions
- 4.4. Conclusions
Chapter 5: Metabolic Profiling and Biomarkers Analysis of Jaundice Syndrome
- Abstract
- 5.1. Introduction
- 5.2. Materials and Methods
- 5.3. Results
- 5.4. Discussion
- 5.5. Conclusions
Chapter 6: Metabolic Profiling and Biomarkers Analysis of the GanYu PiXu Syndrome
- Abstract
- 6.1. Introduction
- 6.2. Materials and Methods
- 6.3. Results
- 6.4. Discussion
Chapter 7: Metabolic Profiling and Biomarkers of Yinhuang Syndrome and Evaluation of Yinchensini Tang
- Abstract
- 7.1. Introduction
- 7.2. Methods
- 7.3. Result and Discussion
Chapter 8: Metabolite Profiling and Biomarkers Analysis of Jaundice Syndrome-Related Animal Models
- Subchapter 8.1. Jaundice Syndrome Rats Induced by d-Galactosamine
- Subchapter 8.2. Jaundice Syndrome Rats Induced by Alcohol
- Subchapter 8.3. Jaundice Syndrome Rats Induced by Alpha-Naphthylisothiocyanate
- Subchapter 8.4. Jaundice Syndrome in Rats Induced by Carbon Tetrachloride
Chapter 9: Metabolomic Evaluation of Hepatoprotective Effect of Yinchenhao Tang and its Major Bioactive Constituents
- Abstract
- 9.1. Introduction
- 9.2. Experimental
- 9.3. Results
- 9.4. Conclusions
Chapter 10: Metabolomics and Proteomics Annotate Therapeutic Mechanisms of Geniposide
- Abstract
- 10.1. Introduction
- 10.2. Materials and Methods
- 10.3. Results
- 10.4. Discussion
Chapter 11: Metabolic Profiling and Potential Biomarkers of ShenYinXu Syndrome and the Therapeutic Effect of Liuweidihuang Wan
- Abstract
- 11.1. Introduction
- 11.2. Experimental
- 11.3. Results
- 11.4. Discussion
- 11.5. Conclusions
Chapter 12: Metabolic Profiling of Healthy Persons Treated with Liuweidihuang Wan
- Abstract
- 12.1. Introduction
- 12.2. Experimental
- 12.3. Results
- 12.4. Discussion
- 12.5. Conclusions
Chapter 13: Metabolic Profiling and Potential Biomarkers Analysis of ShenYangXu Syndrome
- Abstract
- 13.1. Introduction
- 13.2. Materials and Methods
- 13.3. Results
- 13.4. Discussion
- 13.5. Conclusions
Chapter 14: Metabolic Evaluation of ShenQiWan Nourishing ShenYangXu Syndrome
- Abstract
- 14.1. Introduction
- 14.2. Materials and methods
- 14.3. Results
- 14.4. Discussion
- 14.5. Conclusions
Chapter 15: Metabolic Profiling and Biomarkers Analysis of XinQiXu Syndrome
- Abstract
- 15.1. Introduction
- 15.2. Materials and Methods
- 15.3. Results
- 15.4. Discussion
- 15.5. Conclusions
Chapter 16: Active Constituents Screening Based on Correlation Analysis Between Marker Metabolites and the Absorbed Constituents in WenXin Formulae
- Abstract
- 16.1. Introduction
- 16.2. Experimental
- 16.3. Results and Discussion
- 16.4. Conclusions
Chapter 17: Targeted Synergism Effects of the Combined Active Constituents of Yinchenhao Tang
- Abstract
- 17.1. Introduction
- 17.2. Materials and Methods
- 17.3. Results
- 17.4. Discussion
Chapter 18: Metabolic Profiling and Biomarkers of Type 2 Diabetes and the Effective Evaluation of the Tianqi Jiangtang Capsule
- Abstract
- 18.1. Introduction
- 18.2. Materials and Methods
- 18.3. Results
- 18.4. Discussion
- 18.5. Conclusions
Chapter 19: Metabolic Biomarkers of Alcohol Liver Damage and the Intervention Effect of Yinchenhao Tang
- Abstract
- 19.1. Introduction
- 19.2. Experimental
- 19.3. Results
- 19.4. Discussions
- 19.5. Conclusions
Chapter 20: Metabolic Profiling and Biomarkers Analysis of Insomnia, and the Intervention Effects of Suanzaoren Decoction, and its Related Active Ingredients
- Abstract
- 20.1. Introduction
- 20.2. Materials and Methods
- 20.3. Results
- 20.4. Conclusions
Chapter 21: Metabolic Biomarkers of Nonbacterial Prostatitis, and the Treatment Evaluation of Phellodendri Amurensis Cortex and its Main Components
- Abstract
- 21.1. Introduction
- 21.2. Experimental Methods
- 21.3. Results
- 21.4. Conclusions
Chapter 22: Metabolic Profiling Provides a System for the Understanding of Alzheimer’s Disease in Rats Post-Treatment With Kaixin San
- Abstract
- 22.1. Introduction
- 22.2. Experimental
- 22.3. Results and Discussions
- 22.4. Conclusions
Chapter 23: Metabolic Profiles Delineate the Effect of Shengmai San on Alzheimer’s Disease in Rats
- Abstract
- 23.1. Introduction
- 23.2. Experimental
- 23.3. Results and Discussion
- 23.4. Conclusions
Subject Index